Riset dan Pengabdian Masyarakat
Do Research Sosial Service and Innovation
Publikasi Scopus FKUI 2021 per tanggal 31 Agustus 2021 (582 artikel)
Publikasi Scopus FKUI 2021 per tanggal 31 Agustus 2021 (582 artikel)
HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia-Pacific region: a longitudinal cohort study
2021
Journal of the International AIDS Society
24
5
e25736
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106697623&doi=10.1002%2fjia2.25736&partnerID=40&md5=5b62ec1b7839280e4b8e69702122c64a
Kirby Institute, UNSW, Sydney, Australia; HIV-NAT, Thai Red Cross AIDS Research CentreBangkok, Thailand; Department of Social and Preventive Medicine, Faculty of Medicine, University of MalayaKuala Lumpur, Malaysia; Centre of Excellence for Research in AIDS (CERiA), University of MalayaKuala Lumpur, Malaysia; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of MedicineSeoul, South Korea; National Hospital for Tropical DiseasesHanoi, Viet Nam; Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General HospitalJakarta, Indonesia; Bach Mai HospitalHanoi, Viet Nam; Faculty of Medicine, Udayana University & Sanglah HospitalBali, Indonesia; Hospital Sungai Buloh, Sungai Buloh, Malaysia; Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityBangkok, Thailand; Beijing Ditan Hospital, Capital Medical UniversityBeijing, China; Taipei Veterans General HospitalTaipei, Taiwan; Queen Elizabeth Hospital, Hong Kong, China; Research Institute for Health SciencesChiang Mai, Thailand; Tan Tock Seng Hospital, Tan Tock Seng, Singapore; Chiangrai Prachanukroh HospitalChiang Rai, Thailand; Research Institute for Tropical Medicine, Philippines; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; BJ Government Medical College and Sassoon General Hospital, Pune, India; TREAT Asia, amfAR - The Foundation for AIDS ResearchBangkok, Thailand; Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand
INTRODUCTION: Data on HIV treatment outcomes in people who inject drugs (PWID) in the Asia-Pacific are sparse despite the high burden of drug use. We assessed immunological and virological responses, AIDS-defining events and mortality among PWID receiving antiretroviral therapy (ART). METHODS: We investigated HIV treatment outcomes among people who acquired HIV via injecting drug use in the TREAT Asia HIV Observational Database (TAHOD) between January 2003 and March 2019. Trends in CD4 count and viral suppression (VS, HIV viral load <1000 copies/mL) were assessed. Factors associated with mean CD4 changes were analysed using repeated measures linear regression, and combined AIDS event and mortality were analysed using survival analysis. RESULTS: Of 622 PWID from 12 countries in the Asia-Pacific, 93% were male and the median age at ART initiation was 31 years (IQR, 28 to 34). The median pre-ART CD4 count was 71 cells/µL. CD4 counts increased over time, with a mean difference of 401 (95% CI, 372 to 457) cells/µL at year-10 (n = 78). Higher follow-up HIV viral load and pre-ART CD4 counts were associated with smaller increases in CD4 counts. Among 361 PWID with ≥1 viral load after six months on ART, proportions with VS were 82%, 88% and 93% at 2-, 5- and 10-years following ART initiation. There were 52 new AIDS-defining events and 50 deaths during 3347 person-years of follow-up (PYS) (incidence 3.05/100 PYS, 95% CI, 2.51 to 3.70). Previous AIDS or TB diagnosis, lower current CD4 count and adherence <95% were associated with combined new AIDS-defining event and death. CONCLUSIONS: Despite improved outcomes over time, our findings highlight the need for rapid ART initiation and adherence support among PWID within Asian settings. © 2021 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society.
NLM (Medline)
17582652
34021711
Article
Q1
2724
762