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Publikasi Scopus FKUI 2021 per tanggal 31 Agustus 2021 (582 artikel)
Publikasi Scopus FKUI 2021 per tanggal 31 Agustus 2021 (582 artikel)
Alcohol consumption and cause-specific mortality in Cuba: prospective study of 120 623 adults
2021
EClinicalMedicine
33
100692
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102626908&doi=10.1016%2fj.eclinm.2020.100692&partnerID=40&md5=379be44a40d2f0b3e189516f974772f4
National Institute of Cardiology and Cardiovascular Surgery, Havana, Cuba; Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Institute of Hygiene, Epidemiology and Microbiology, Ministry of Public Health, Havana, Cuba; Cuban Commission Against Smoking, Ministry of Public Health, Havana, Cuba; Directorate of Medical Records and Health Statistics, Ministry of Public Health, Havana, Cuba; George Institute for Global Health, University of Oxford, United Kingdom; MRC Population Heath Research Unit, NDPH, University of Oxford, United Kingdom; Provincial Center of Hygiene, Epidemiology and Microbiology, Matanzas, Cuba; Municipal Center of Hygiene, Epidemiology and Microbiology, Jagüey Grande, Matanzas, Cuba; Municipal Center of Hygiene, Epidemiology and Microbiology, ColónMatanzas, Cuba; Municipal Center of Hygiene, Epidemiology and Microbiology, Camagüey, Cuba; MRC UKM Medical Molecular Biology Institute (UMBI), NDPH, Malaysia
Background: The associations of cause-specific mortality with alcohol consumption have been studied mainly in higher-income countries. We relate alcohol consumption to mortality in Cuba. Methods: In 1996-2002, 146 556 adults were recruited into a prospective study from the general population in five areas of Cuba. Participants were interviewed, measured and followed up by electronic linkage to national death registries until January 1, 2017. After excluding all with missing data or chronic disease at recruitment, Cox regression (adjusted for age, sex, province, education, and smoking) was used to relate mortality rate ratios (RRs) at ages 35–79 years to alcohol consumption. RRs were corrected for long-term variability in alcohol consumption using repeat measures among 20 593 participants resurveyed in 2006-08. Findings: After exclusions, there were 120 623 participants aged 35-79 years (mean age 52 [SD 12]; 67 694 [56%] women). At recruitment, 22 670 (43%) men and 9490 (14%) women were current alcohol drinkers, with 15 433 (29%) men and 3054 (5%) women drinking at least weekly; most alcohol consumption was from rum. All-cause mortality was positively and continuously associated with weekly alcohol consumption: each additional 35cl bottle of rum per week (110g of pure alcohol) was associated with ∼10% higher risk of all-cause mortality (RR 1.08 [95%CI 1.05-1.11]). The major causes of excess mortality in weekly drinkers were cancer, vascular disease, and external causes. Non-drinkers had ∼10% higher risk (RR 1.11 [1.09-1.14]) of all-cause mortality than those in the lowest category of weekly alcohol consumption (<1 bottle/week), but this association was almost completely attenuated on exclusion of early follow-up. Interpretation: In this large prospective study in Cuba, weekly alcohol consumption was continuously related to premature mortality. Reverse causality is likely to account for much of the apparent excess risk among non-drinkers. The findings support limits to alcohol consumption that are lower than present recommendations in Cuba. Funding: Medical Research Council, British Heart Foundation, Cancer Research UK, CDC Foundation (with support from Amgen) © 2021 The Authors
Lancet Publishing Group
25895370
Article
Q1
1915
1435