Publikasi Scopus FKUI 2021 per tanggal 31 Agustus 2021 (582 artikel)

Dewi B.E., Tannardi K., Sudiro T.M.
24076058600;57225010100;6506414225;
The potency of piper betle leave extract as antiviral drug to dengue virus in vitro
2021
Teikyo Medical Journal
44
2
677
686
Department of Microbiology, Faculty of Medicine, Universitas Indonesia–Cipto Mangunkusumo Hospital, Universitas Indonesia, Jl. Pegangsaan Timur No. 16, Jakarta, 10320, Indonesia; Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Undergraduate Program of Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Dewi, B.E., Department of Microbiology, Faculty of Medicine, Universitas Indonesia–Cipto Mangunkusumo Hospital, Universitas Indonesia, Jl. Pegangsaan Timur No. 16, Jakarta, 10320, Indonesia; Tannardi, K., Undergraduate Program of Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sudiro, T.M., Department of Microbiology, Faculty of Medicine, Universitas Indonesia–Cipto Mangunkusumo Hospital, Universitas Indonesia, Jl. Pegangsaan Timur No. 16, Jakarta, 10320, Indonesia, Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia
Up to now, there is no specific medicine known to be effective in treating dengue virus (DENV) infection, there is only supportive treatment geared toward its symptoms. It is known that herbal extracts possess a measure of effectivity against DENV. Piper betle, or sirih, is one of the most common medicinal plant used by Indonesian citizen. Therefore, an in-depth study regarding the effectivity of Piper betle leave extract towards DENV becomes an important topic. Huh 7it-1 cell was cultured on plat 96 and 48 well plate to examine toxicity and effectivity, respectively. Then, the cells were infected with DENV which has been given Piper betle leave extract at various concentration such as 160ug/mL, 80ug/mL, 40ug/mL, 20ug/mL, 10ug/mL, and 5ug/mL. After incubation for 48 hours, supernatant and cell were harvested to conduct focus and MTT assay respectively. From this study we found that Piper betle has an IC50, CC50 and Selectivity Index of 17.662 µg/ml, 486.404µg/ml, and 24.3 respectively. It is indicating that Piper betle has a strong potential in becoming an alternative antiviral agent for dengue virus. Further experimental investigations are needed to determine cytotoxic and effectivity of Piper betle leave extract as an antiviral to DENV in vivo. © 2021 Teikyo University School of Medicine. All rights reserved.
Antiviral drug; CC50; Dengue replication; Dengue virus; IC50; Piper betle leave extract
Teikyo University School of Medicine
3875547
Article
Q4
100
32543