Publikasi Scopus FKUI 2021 per tanggal 31 Agustus 2021 (582 artikel)

Eldafira E., Prasasty V.D., Abinawanto A., Syahfirdi L., Pujianto D.A.
57204963791;56019989700;55625129700;57222327356;8745734300;
Polymorphisms of estrogen receptor-α and estrogen receptor-β genes and its expression in endometriosis [Östrojen reseptör-α ve östrojen reseptör-β genlerinin polimorfizmi ve endometriozisde ifadelenmeleri]
2021
Turkish Journal of Pharmaceutical Sciences
18
1
91
95
Universitas Indonesia, Faculty of Medicine, Department of Medical Biology, Depok, Indonesia; Universitas Indonesia, Faculty of Mathematics and Natural Sciences, Department of Biology, Jakarta, Indonesia; Atma Jaya Catholic University of Indonesia, Faculty of Biotechnology, Jakarta, Indonesia
Eldafira, E., Universitas Indonesia, Faculty of Medicine, Department of Medical Biology, Depok, Indonesia, Universitas Indonesia, Faculty of Mathematics and Natural Sciences, Department of Biology, Jakarta, Indonesia; Prasasty, V.D., Atma Jaya Catholic University of Indonesia, Faculty of Biotechnology, Jakarta, Indonesia; Abinawanto, A., Universitas Indonesia, Faculty of Mathematics and Natural Sciences, Department of Biology, Jakarta, Indonesia; Syahfirdi, L., Universitas Indonesia, Faculty of Mathematics and Natural Sciences, Department of Biology, Jakarta, Indonesia; Pujianto, D.A., Universitas Indonesia, Faculty of Medicine, Department of Medical Biology, Depok, Indonesia
Objectives: Endometriosis is a common gynecological disorder, characterized by the presence of endometrial-like tissue in the extrauterine location. The increasing estradiol concentration can influence endometriosis risk and estrogen receptor (ER) activity. Polymorphism in ER causes gene expression alteration and influences hormone-receptor interaction. This research aims to determine ER genetic polymorphisms in endometriosis pathogenesis. Materials and Methods: This study was performed on case-control polymorphisms, which compared 83 women with endometriosis and 76 women without endometriosis. However, the samples used for ER gene expression analysis and estrogen level measurement were obtained from 18 women with endometriosis and 18 women without endometriosis. Polymerase chain reaction-restriction fragment length polymorphism was used to determine ER genetic polymorphisms. Chi-square, Mann-Whitney test, Spearman’s correlation (p), t-independent, and two-tailed tests were used to analyze the data. Results: Association between the allele ERα rs9340799 A/G and endometriosis was significantly different (p=0.012), whereas rs2234693 T/C polymorphism showed no association with endometriosis. The correlation between the genotype frequencies of allele ERβ rs4986938 G/A and endometriosis was found significantly different (p=0.015; p=0.034). Conclusion: Estradiol level and ERβ expression increases, polymorphism genotypes and alleles of ERβ rs4986938 G/A gene and allele frequency of ERα rs9340799 A/G gene have roles in endometriosis. © Turk J Pharm Sci, Published by Galenos Publishing House.
Endometriosis; Estradiol (E2); Estrogen receptor (ERα and ERβ)
Turkish Pharmacists Association
1304530X
Article
Q3
241
17155