Publikasi Scopus 2024 per tanggal 30 April 2024 (334 artikel)

Santoso P.; Ilyas S.; Midoen Y.H.; Maliza R.; Belahusna D.F.
Santoso, Putra (56082215500); Ilyas, Syafruddin (55980597400); Midoen, Yurnadi Hanafi (57197805109); Maliza, Rita (56181685900); Belahusna, Dinda Fadhillah (58489795700)
56082215500; 55980597400; 57197805109; 56181685900; 58489795700
Predictive bioactivity of compounds from Vitis gracilis leaf extract to counteract doxorubicin-induced cardiotoxicity via sirtuin 1 and adenosine monophosphate-activated protein kinase: An in-silico study
2024
Journal of Applied Pharmaceutical Science
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Biology Department, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Santoso P., Biology Department, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia; Ilyas S., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia; Midoen Y.H., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Maliza R., Biology Department, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia; Belahusna D.F., Biology Department, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia
Doxorubicin is a potent chemotherapy drug. However, it is known to cause cardiotoxicity via inhibition of sirtuin 1 (SIRT1) and adenosine monophosphate protein kinase (AMPK) activity in the cardiomyocytes. This research aimed to explore the pharmacokinetics, safety, and bioactivity of compounds from Vitis gracilis leaves in their interaction with SIRT1 and AMPK to counteract doxorubicin-induced cardiotoxicity. A total of 13 selected compounds from V. gracilis leaf extract were screened for their pharmacokinetics, toxicity, and interactions with SIRT1 and AMPK using in silico approach. It was found that the majority of the compounds are easily absorbed by the human intestine, mostly avoiding liver enzyme CYP2D6 interaction and kidney protein OCT2 inhibition. They span nontoxic to harmful, some posing hepatoxic, carcinogenic, and immunotoxic risks, while 12 meet drug-likeness criteria. Finally, molecular docking revealed that several compounds exhibit high binding affinities to the proteins SIRT1 and AMPK, with some even outperforming the standard drug resveratrol such as 3’,4’-dimethoxy-alpha-naphthoflavone, 5-[6-hydroxy-5-(3-methylbut-2-enyl)-1-benzofuran-2-yl]benzene-1,3-diol, 4,4-dimethyl-5alpha-cholesta-8,14,24- trien-3beta-ol, and norethindrone acetate. Therefore, the compounds could be considered as candidates of drug to counteract doxorubicin-induced cardiotoxicity via SIRT1 and AMPK activation. © 2024 Putra Santoso et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/)
AMPK; cancer; chemotherapy drug; doxorubicin; resveratrol; SIRT1
alanine aminotransferase; aspartate aminotransferase; cytochrome P450 2D6; doxorubicin; hydroxymethylglutaryl coenzyme A reductase kinase; organic cation transporter 2; plant extract; sirtuin 1; unclassified drug; Vitis gracilis leaf extract; Article; biological activity; blood brain barrier; cancer chemotherapy; cardiotoxicity; chemical structure; computer model; drug absorption; drug distribution; drug excretion; drug interaction; drug metabolism; drug toxicity; human; molecular docking; pharmacokinetics; screening; Vitaceae; Vitis gracilis
Universitas Andalas; Universitas Indonesia, UI, (29/UN16.19/PT.01.03/KO-RKI Skema A (Mitra)/2023, 1/UNS.2.3.1/ PPM/KPRKI/2023); Universitas Sumatera Utara, USU, (NKB-1065/UN2.RST/HKP.05.00/2023)
Andalas University, Universitas Sumatra Utara, and Universitas Indonesia through the Indonesian Collaborative Research Program (RKI) provided the funds for this study (Contract No. 29/UN16.19/PT.01.03/KO-RKI Skema A (Mitra)/2023 for Andalas University; Contract No. 1/UNS.2.3.1/ PPM/KPRKI/2023 For Universitas Sumatra Utara; and contract No. NKB-1065/UN2.RST/HKP.05.00/2023 for Universitas Indonesia)
Open Science Publishers LLP Inc.
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