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Publikasi Scopus FKUI 2021 per tanggal 30 April 2021 (299 artikel)
Publikasi Scopus FKUI 2021 per tanggal 30 April 2021 (299 artikel)
Allogeneic umbilical cord-derived mesenchymal stem cells for treating critical-sized bone defects: a translational study
2021
European Journal of Orthopaedic Surgery and Traumatology
31
2
265
273
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089486454&doi=10.1007%2fs00590-020-02765-5&partnerID=40&md5=617ce3dfaeed87e7c027f5f3006ebb43
Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, Jl. Diponegoro 71, Jakarta Pusat, Indonesia; Department Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba 6, Jakarta, Indonesia; Stem Cell and Tissue Engineering Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba 6, Jakarta, Indonesia
Introduction: The current ‘gold-standard’ treatment of critical-sized bone defects (CSBDs) is autografts; however, they have drawbacks including lack of massive bone source donor site morbidity, incomplete remodeling, and the risk of infection. One potential treatment for treating CSBDs is bone marrow-derived mesenchymal stem cells (BM-MSCs). Previously, there were no studies regarding the use of human umbilical cord-mesenchymal stem cells (hUC-MSCs) for treating BDs. We aim to investigate the use of allogeneic hUC-MSCs for treating CSBDs. Method: We included subjects who were diagnosed with non-union fracture with CSBDs who agreed to undergo hUC-MSCs implantation. All patients were given allogeneic hUC-MSCs. All MSCs were obtained and cultured using the multiple-harvest explant method. Subjects were evaluated functionally using the Lower Extremity Functional Scale (LEFS) and radiologically by volume defect reduction. Result: A total of seven (3 male, 4 female) subjects were recruited for this study. The subjects age ranged from 14 to 62 years. All seven subjects had increased LEFS during the end of the follow-up period, indicating improved functional ability. The follow-up period ranged from 12 to 36 months. One subject had wound dehiscence and infection, and two subjects developed partial union. Conclusion: Umbilical cord mesenchymal stem cells are a potential new treatment for CSBDs. Additional studies with larger samples and control groups are required to further investigate the safety and efficacy of umbilical cord-derived mesenchymal stem cells for treating CSBDs. © 2020, Springer-Verlag France SAS, part of Springer Nature.
adolescent; adult; allotransplantation; Article; bone defect; clinical article; clinical outcome; critical sized bone defect; female; follow up; fracture nonunion; functional status; human; human cell; Lower Extremity Functional Scale; male; mesenchymal stem cell transplantation; middle aged; priority journal; surgical infection; time to treatment; umbilical cord mesenchymal stem cell; wound dehiscence; young adult
Springer-Verlag Italia s.r.l.
16338065
32804289
Article
Q2
681
7162