Publikasi Scopus FKUI 2021 per tanggal 30 April 2021 (299 artikel)

Ginanjar E., Alwi I., Lydia A., Immanuel S., Yamin M., Indrajaya T., Harimurti K.
23472616600;15055173800;8451287200;12777341300;23475706300;54994136500;23473513200;
The Association of β2-Microglobulin and Fibroblast Growth Factor 23 with Major Adverse Cardiac Event in Acute Coronary Syndrome Patients with Chronic Kidney Disease
2021
Acta medica Indonesiana
53
1
5
12
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia
Ginanjar, E., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Alwi, I.; Lydia, A.; Immanuel, S.; Yamin, M.; Indrajaya, T.; Harimurti, K.
BACKGROUND: chronic kidney disease (CKD) increases the severity and risk of mortality in acute coronary syndrome (ACS) patients. The role of β2-M as a filtration and inflammation marker and FGF23 as a CKD-MBD process marker might be significant in the pathophysiology in ACS with CKD patients. This study aims to determine the association of β2-M and FGF23 with major adverse cardiac event (MACE) in ACS patients with CKD. METHODS: we used cross sectional and retrospective cohort analysis for MACE. We collected ACS patients with CKD consecutively from January until October 2018 at Dr. Cipto Mangunkusumo General Hospital. Data were analyzed using logistic regression and Cox's Proportional Hazard Regression. RESULTS: a total of 117 patients were selected according to the study criteria. In bivariate analysis, β2-M, FGF23, and stage of CKD had significant association with MACE (p = 0.014, p = 0.026, p = 0.014, respectively). In multivariate analysis, β2-M - but not FGF 23- was significantly associated with MACE (adjusted HR 2.16; CI95% 1.15-4.05; p = 0.017). CONCLUSION: β2-M was significantly associated with MACE, while FGF23 was not so. This finding supports the role of inflammation in cardiovascular outcomes in ACS with CKD patient through acute on chronic effect.
Acute Coronary Syndrome; Beta2-Microglobulin; Fibrioblast Growth Factor 23; Major Adverse Cardiac Event
NLM (Medline)
01259326
33818401
Article
Q3
354
12840