Publikasi Scopus FKUI 2021 per tanggal 30 April 2021 (299 artikel)

Utomo M.S., Nadhif M.H., Bayani G.F.E., Whulanza Y.
56180933900;57189057498;57222627409;36807053500;
A low cost, off-the-shelf bioreactor as enabling technology for physiological modeling
2021
AIP Conference Proceedings
2344
050017
Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Physiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia
Utomo, M.S., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Bayani, G.F.E., Department of Physiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia
Nowadays, tissue engineering has become a primary option for clinical treatment involving tissue damage or organ failure. One important enabling technological aspect for tissue engineering to produce successful outcomes is bioreactor where cells could be grown under certain conditions mimicking real physiological conditions and be prepared for in vivo integration before implantation to the patients. Physical stimulation by mechanical and electrical means could improve the development of engineered tissue to mimic the actual tissue. Mechanical stimulation could improve cellular function by improving the integrity and organization of the engineered tissue while electrical stimulation can improve the conductivity and contractility of tissue construction. The electric field would stimulate cellular calcium activity which could stimulate cell integration and gap junction formation. Thus, it is necessary to develop a bioreactor that is capable to provide a well-controlled environment and proper combination of mechanical and electrical stimulation to optimize the process of tissue engineering. Here we build a bioreactor that is capable to stimulate the engineered tissue mechanically and electrically to improve the tissue's contractile performance and functional maturity through an isovolumic contraction. The mechanical stimulation is generated by harmonic inflation and deflation of a balloon while the electrical stimulation is generated from a pair of carbon electrodes. The mechanical and electrical stimulations could function independently to each other. The bioreactor was successfully constructed and passed the functional test and ready for actual application for tissue engineering. © 2021 Author(s).
American Institute of Physics Inc.
0094243X
9.78074E+12
Conference Paper
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190
19092