Prognostic Scoring System for Mortality of Hospitalized COVID-19 Patients in Resource-Limited Settings: A Multicenter Study from COVID-19 Referral Hospitals
Clinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo HospitalJakarta, Indonesia
Saldi, S.R.F., Clinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo HospitalJakarta, Indonesia; Safitri, E.D.; Setiati, S.; Ranakusuma, R.W.; Marsigit, J.; Azwar, M.K.; Astuti, P.; Sari, C.Y.I.; Istanti, R.; Yulianti, M.; Rumende, C.M.; Yunihastuti, E.; Susilo, A.; Harimurti, K.; Liastuti, L.D.; Trimartani, T.; Restuti, R.D.; Syam, A.F.
BACKGROUND: Many studies identified the risk factors and prognostic factors related to in-hospital COVID-19 mortality using sophisticated laboratory tests. Cost and the availability of supporting blood tests may be problematic in resource-limited settings. This multicenter cohort study was conducted to assess the factors associated with mortality of COVID-19 patients aged 18 years and older, based on history taking, physical examination, and simple blood tests to be used in resource-limited settings. METHODS: The study was conducted between July 2020 and January 2021 in five COVID-19 referral hospitals in Indonesia. Among 1048 confirmed cases of COVID-19, 160 (15%) died during hospitalization. RESULTS: Multivariate analysis showed eight predictors of in-hospital mortality, namely increased age, chronic kidney disease, chronic obstructive pulmonary disease, fatigue, dyspnea, altered mental status, neutrophil-lymphocyte ratio (NLR) ≥ 5.8, and severe-critical condition. This scoring system had an Area-under-the-curve (AUC) of 84.7%. With cut-off score of 6, the sensitivity was 76.3% and the specificity was 78.2%. CONCLUSION: The result of this practical prognostic scoring system may be a guide to decision making of physicians and help in the education of family members related to the possible outcome.