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Publikasi Scopus 926 artikel (Per 14 Maret 2022)
Publikasi Scopus 926 artikel (Per 14 Maret 2022)
In vivo antimammary tumor effects of soybean extract with targeted lunasin (ET-Lun)
2021
Pharmacognosy Journal
13
5
1269
1276
2
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115297490&doi=10.5530%2fpj.2021.13.160&partnerID=40&md5=d96a1538654afeda0377ba6b0d8a5e38
Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas INDONESIA, Indonesia
Background/Objective: Lunasin is a peptide, consist of 44 amino acids which have anti-cancer, antioxidant, and anti-inflammatory activity. The price of commercial Lunasin was very expensive due to the high cost of lunasin synthesis and the lack of methods to obtain the pure lunasin weight from plant sources, involving time-consuming analytical instruments. To overcome these problems, the soybean extract with targeted Lunasin (ET-Lun) was made. The aim of this study was to investigate anti-cancer properties of ET-Lun in breast cancer models in vivo. Methods: Effect of ET-Lun was evaluated in 7,12-Dimetilbenz[a]antrasen (DMBA) induced breast cancer rat model. Tumor Mass, volume, and number were measured. The expression of HER2 and EGFR from each treatment group in DMBA-induced rat was evaluated using immunohistochemistry. Results: The results shown that ET-Lun could reduced tumor volume (p=0,021). ET-Lun decreased EGFR expression compared to negative control DMBA (p=0,012). Conclusions: These results indicated that the ET-Lun has anti-breast cancer activity in vivo. © 2021 Phcogj.Com.
dimethylbenz[a]anthracene; epidermal growth factor receptor; epidermal growth factor receptor 2; lunasin; peptide; soybean extract; tamoxifen; unclassified drug; aged; animal experiment; animal model; animal tissue; antineoplastic activity; Article; breast cancer; controlled study; female; immunohistochemistry; in vivo study; nonhuman; protein expression; rat; soybean; tumor number; tumor volume
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