Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Kurnia K.H., Elvioza, Sidik M., Sari T.T., Prihartono J., Sitorus R.S.
57222405280;57205416912;56252760000;36519483600;6602605635;57221587271;
Novel retinal findings in β-thalassemia major: older age and higher ferritin level as the risk factors
2021
Graefe's Archive for Clinical and Experimental Ophthalmology
259
9
2633
2641
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia
Kurnia, K.H., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Elvioza, Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sidik, M., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sari, T.T., Department of Child Health, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Prihartono, J., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sitorus, R.S., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia
Purpose: To investigate retinal changes in β-thalassemia major patients and identify their association with systemic risk factors. Methods: In this prospective study, 120 β-thalassemia major patients received complete ophthalmic examinations (best-corrected visual acuity, contrast sensitivity, color vision, and indirect ophthalmoscopy) and retinal imaging using color fundus photography and fundus autofluorescence imaging. Patients were grouped according to the presence of thalassemia-related retinal changes. The association between systemic risk factors (age, type and duration of iron chelator use, history of splenectomy, hemoglobin level, and ferritin level) and thalassemia-related retinal changes was investigated using logistic regression analysis. Results: Thalassemia-related retinal changes were identified in 36.7% of patients. Several distinct retinal changes were observed, including retinal refractile bodies in 10% of patients and retinal hemorrhage in 5.8% of patients. Fundus autofluorescence imaging showed abnormal patterns in 36.3% of patients with thalassemia-related retinal changes and 18.4% of patients without thalassemia-related retinal changes. Age (odds ratio [OR] = 1.10, 95% confidence interval [CI] 1.03–1.18) and ferritin level (OR 1.16, 95% CI 1.01–1.33) were associated with thalassemia-related retinal changes. Conclusion: Novel retinal changes were observed in β-thalassemia major patients. This study identified older age and higher ferritin level as risk factors for thalassemia-related retinal changes. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Ferritin; Fundus autofluorescence imaging; Iron chelator; Retinal changes; β-Thalassemia major
deferasirox; deferiprone; deferoxamine; ferritin; hemoglobin; ferritin; adult; age; angioid streak; Article; autofluorescence imaging; best corrected visual acuity; blood transfusion; branch retinal vein occlusion; color vision; contrast sensitivity; controlled study; drusen; epithelium hyperplasia; eye fundus; eye photography; female; ferritin blood level; hemoglobin blood level; human; Indonesia; major clinical study; male; melanocytosis; observational study; ophthalmoscopy; optic disk anomaly; optical coherence tomography; papilledema; patient history of surgery; prospective study; retina disease; retina examination; retina hemorrhage; retina pigment degeneration; slit lamp microscopy; splenectomy; subretinal neovascularization; thalassemia major; treatment duration; aged; beta thalasse
Springer Science and Business Media Deutschland GmbH
0721832X
33738624
Article
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1196
3322