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Publikasi Scopus 926 artikel (Per 14 Maret 2022)
Publikasi Scopus 926 artikel (Per 14 Maret 2022)
Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults
2021
BMC Research Notes
14
1
411
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118749881&doi=10.1186%2fs13104-021-05823-1&partnerID=40&md5=c2e5f8f0c5b077d184062624f315d2dc
Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Dramaga, Jl. Raya Dramaga, Bogor, West Java 16680, Indonesia; Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia
Objective: Recent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models. Results: Only individuals with the CC genotype had a considerably higher BMI (p < 0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT + TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45–4.06% across various genetic models (dominant: p < 0.010, over-dominant: p < 0.030, additive: p < 0.010). Subjects with TC/CC genotypes had increased dietary monounsaturated fatty acid (MUFA; 1.14%, p = 0.046) and saturated fatty acid (SAFA; 2.06%, p = 0.023) intakes, compared to those with the TT genotype. In conclusion, our study provided evidence for the association between FTO rs1421085 risk allele with higher BMI and individual preferences for consuming more fat, MUFA, and SAFA. This study highlights the important role of FTO gene in food preference, and its influence on body weight. © 2021, The Author(s).
alpha ketoglutarate dependent dioxygenase FTO; fatty acid; FTO protein, human; adult; body mass; genetic predisposition; genetics; genotype; human; Indonesia; single nucleotide polymorphism; Adult; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Body Mass Index; Fatty Acids; Genetic Predisposition to Disease; Genotype; Humans; Indonesia; Polymorphism, Single Nucleotide
BioMed Central Ltd
17560500
34743743
Article
Q2
608
8303