Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Safri A.Y., Pawitan J.A.
57091699300;6508348067;
Nerve tissue engineering in peripheral nerve injury
2021
International Medical Journal
28
1
16
19
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Neurology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine, Universitas Indonesia, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia
Safri, A.Y., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Departement of Neurology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine, Universitas Indonesia, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia
Objective: This article aims to explain the mechanism of recovery of peripheral nerve injury, current management and progress in nerve tissue engineering, which are promising to overcome the problems of peripheral nerve injury. Materials and Methods: we searched various sources, i.e. Pubmed, Scopus, and Google scholar to collect relevant publica-tions of peripheral nerve injury and its management, including nerve tissue engineering. Results: The development of tissue engineering has made it possible to regenerate nerve tissue by a combination of cell ther-apy, appropriate design of scaffolds and the use of supporting elements. Discussion: Under current management, severe peripheral nerve injury especially injury to the proximal and large diameter nerves still has a poor prognosis. Poor prognosis is mainly due to a mismatch in nerve autograft in both structure and diameter to the host nerve. The advantage of tissue engineering techniques in the management of peripheral nerve injuries is that the engineered nerve tissue can be designed according to the structure and diameter of the damaged nerve. Conclusion: Nerve tissue engineering might overcome the problems in peripheral nerve regeneration by a combination of stem cell therapy, and appropriate design of scaffolds to provide nerve conduits. © 2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation.
Peripheral nerve injury; Scaffolds; Stem cell; Tissue engineering
Article; autograft; cell body; cell differentiation; ganglion; human; nerve cell; nerve fiber regeneration; nerve regeneration; nervous system; peripheral nerve injury; stem cell transplantation; systematic review; tissue engineering; tissue regeneration
Japan International Cultural Exchange Foundation
13412051
Article
Q4
183
20490