Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Victor A.A., Yandandri V.R., Gondowiardjo T.D., Dharma R., Jusman S.W., Prihartono J.
57191055282;57226248415;54956727400;12777817700;36518792100;6602605635;
Effect of laser photocoagulation before vitrectomy to hypoxia inducible factor-1alfa and intracellular adhesive molecule-1 in diabetic patients: A randomized clinical trial
2021
Retina-Vitreus
30
2
204
211
Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Ophthalmology, DKI Jakarta, Indonesia; Faculty of Medicine, Clinical Pathology, DKI Jakarta, Jakarta, Indonesia; Faculty of Medicine, Biochemistry Department, Faculty of Medicine, University of Indonesia, DKI Jakarta, Indonesia; Faculty of Medicine, Community Department, Faculty of Medicine, University of Indonesia, DKI Jakarta, Indonesia
Victor, A.A., Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Ophthalmology, DKI Jakarta, Indonesia; Yandandri, V.R., Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Ophthalmology, DKI Jakarta, Indonesia; Gondowiardjo, T.D., Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Ophthalmology, DKI Jakarta, Indonesia; Dharma, R., Faculty of Medicine, Clinical Pathology, DKI Jakarta, Jakarta, Indonesia; Jusman, S.W., Faculty of Medicine, Biochemistry Department, Faculty of Medicine, University of Indonesia, DKI Jakarta, Indonesia; Prihartono, J., Faculty of Medicine, Community Department, Faculty of Medicine, University of Indonesia, DKI Jakarta, Indonesia
Purpose: The vitreous concentration of Hypoxia-inducible Factor-1α (HIF-1α) and Intercellular Adhesive Molecule-1 (ICAM-1) were related to the permeability of retinal vessels and the grades of macular edema in proliferative diabetic retinopathy (PDR). Prior studies have showed that pan-retinal photocoagulation (PRP) is benefi cial in treating PDR. The aim of this study is to determine how pre-treatment with PRP before vitrectomy affect the vitreous level of HIF-1 and ICAM-1 in patients with PDR. Materials and Methods: A randomized clinical trial study was conducted to 22 eyes in Cipto Mangunkusumo National General Hospital, Indonesia. At the beginning of PRP, just before vitrectomy, and at 2, 4, and 12 weeks after vitrectomy, central macular thickness (CMT) was measured using optical coherence tomography (OCT). Undiluted vitreous humour was extracted during vitrectomy to obtain HIF-1α and ICAM-1 concentration. Results: In the control and the photocoagulation group, the average level of HIF-1α (ng/mL) were 0.152±0.015 and 0.164±0.033 respectively. The average level of ICAM-1 (ng/mL) in control group and pre-treated group were 17,840±14,140 and 27,027±10,452 respectively. No statistically signifi cant difference was seen in the level of HIF-1α and ICAM-1 between each group. The correlation between vitreous ICAM- 1 and HbA1c was statistically signifi cant (r=0.463, p=0.03). No signifi cant differences for CMT at pre-vitrectomy, or 2 and 4 weeks after vitrectomy. Statistically signifi cant difference was observed at 12 weeks after follow-up (p=0.049). The correlation between vitreous level of HIF-Iα and CMT in the control and laser group are r = 0.447 and r = 0.32, respectively. Conclusion: Laser photocoagulation 1-2 weeks prior to vitrectomy did not lower vitreous concentration of HIF-1α and ICAM-1. © 2021 Gazi Eye Foundation. All rights reserved.
Diabetic retinopathy; Hypoxia-Inducible Factor 1; Intercellular Adhesion Molecule-1; Light coagulation
hypoxia inducible factor 1alpha; intercellular adhesion molecule 1; adult; Article; cataract; central macular thickness; controlled study; diabetic patient; female; follow up; glaucoma; human; hyphema; laser coagulation; major clinical study; male; middle aged; optical coherence tomography; pars plana vitrectomy; proliferative diabetic retinopathy; randomized controlled trial; retina blood vessel; retina detachment; vitrectomy; vitreous body; vitreous hemorrhage
Gazi Eye Foundation
13001256
Article
Q4
110
28729