Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Gunardi W.D., Timotius K.H., Natasha A., Evriarti P.R.
57222314683;24299781600;57211428938;57226004232;
Biofilm targeting strategy in the eradication of burkholderia infections: A mini-review
2021
Open Microbiology Journal
15
1
51
57
Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia; Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiolgy, Health Labortory of Makassar (BBLK Makassar), Makassar, Indonesia
Gunardi, W.D., Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia; Timotius, K.H., Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia; Natasha, A., Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Evriarti, P.R., Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Microbiolgy, Health Labortory of Makassar (BBLK Makassar), Makassar, Indonesia
Burkholderia are intracellular pathogenic bacteria which can produce biofilm. This biofilm protects the intracellular pathogenic bacteria from antibiotic treatment and the immunological system of the host. Therefore, this review aims to describe the capacity of Burkholderia to form a biofilm, the regulation of its biofilm formation, the efficacy of antibiotics to eradicate biofilm, and the novel therapy which targets its biofilm. Burkholderia's biofilm is characterized by its lipopolysaccharides, exopolysaccharides (EPSs), biofilm-associated proteins, and eDNA. Its regulation is made by quorum sensing, c-di-AMP, sRNA, and two component systems. Many antibiotics have been used as sole or mixture agents; however, they are not always effective in eradicating the biofilm-forming Burkholderia. Inhibitors of quorum sensing and other non-conventional antibiotic approaches are promising to discover effective treatment of Burkholderia infections. © 2021, Bentham Science Publishers. All rights reserved.
Antibiotic; Biofilm; Burkholderia; Exopolysaccharide; Lipid A; Quorum sensing
acetazolamide; amoxicillin; antibiotic agent; cefepime; ceftazidime; colistin; echinocandin; exopolysaccharide; gentamicin; imipenem; indisulam; lipopolysaccharide; macrolide; meropenem; piperacillin plus tazobactam; polymyxin B; RANTES; saccharin; sulpiride; tobramycin; topiramate; transcriptome; vancomycin; virulence factor; Acinetobacter baumannii; antibiofilm activity; antibiotic resistance; antibiotic sensitivity; antibiotic therapy; apoptosis; Article; autolysis; bacteremia; bacterial arthritis; bacterial colonization; bacterial gene; bacterial growth; bacterial virulence; Betaproteobacteria; biofilm; Burkholderia cenocepacia; Burkholderia infection; Burkholderia pseudomallei; cell aggregation; DNA damage; Enterococcus faecalis; extracellular matrix; gene; gene expression; Helicobact
Bentham Science Publishers
18742858
Article
Q3
502
10043