Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Sandhiutami N.M.D., Arozal W., Louisa M., Rahmat D.
56692904000;32067462200;41461551400;36673726800;
Determine Curcumin Concentration in Organ Rats and in Ovaries at Ovarian Cancer Model Rats Using Ultra Performance Liquid Chromatography-Mass Spectrometry (Ms)/Ms
2021
Pharmaceutical Sciences Asia
48
1
37
45
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Sandhiutami, N.M.D., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmat, D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia
Curcumin has several pharmacological effects including anti-inflammatory, reduce kidney damage, hepatoprotector, and inhibiting tumor growth in ovarian cancer. The use of curcumin is limited because it has low bioavailability and low capacity to reach target organs. This limitation is overcome by making it in the form of nanoparticles. This study aim to determine curcumin levels on some organ in healthy rat groups and on ovaries at ovarian cancer models rat that given curcumin and curcumin nanoparticles. Measurement of curcumin levels using UPLC-MS/MS. Determination of curcumin level in the organ was carried out in 2 treatment groups, group that received curcumin and group that received curcumin nanoparticles orally with a single dose of 100 mg/kg Body Weight (BW). At 180 minutes, rats were decapitated for liver, kidney and ovaries. The ovarian cancer rats were also divided into 2 groups and given curcumin and curcumin nanoparticles with repeated doses of 100 mg/kgBW/day and after 30 days, ovarian cancer rats were decapitated for the ovaries. In the group that received curcumin, the concentration of curcumin in the liver, kidney and ovaries were less than the detection limit, whereas in the group that received curcumin nanoparticles, the levels of curcumin are 1,866.6±22.60 ng/g in liver, 114.87±13.36 ng/g in kidney and 136.864±11.15 ng/g in ovaries. In ovarian cancer rats, levels of curcumin in the group receiving curcumin is 2.29±1.15 ng/g and 17.76±4.85 ng/g in the group receiving curcumin nanoparticles. Curcumin nanoparticles can increase the distribution of curcumin in liver, kidney, ovaries in healthy rats and in ovaries at ovarian cancer model rats. © 2020. All Rights Reserved.
curcumin; curcumin nanoparticles; ovarian cancer rats; rats organ; UPLC MS/MS
curcumin; nanoparticle; animal experiment; animal model; animal tissue; Article; cancer model; controlled study; drug determination; drug distribution; drug liver level; female; kidney homogenate; limit of detection; limit of quantitation; liquid chromatography-mass spectrometry; liver homogenate; measurement accuracy; measurement precision; nonhuman; ovary; ovary cancer; rat; repeated drug dose; single drug dose
Mahidol University - Faculty of Pharmacy
25868195
Article
Q3
144
23834