No records
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561 |
Nadzir M.M., Nurhayati R.W., Idris F.N., Nguyen M.H. |
8668648100;55748436600;57194239683;55319059400; |
Biomedical applications of bacterial exopolysaccharides: A review |
2021 |
Polymers |
13 |
4 |
530 |
1 |
25 |
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9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101211712&doi=10.3390%2fpolym13040530&partnerID=40&md5=0563148d938735dbc6e7b156a85abe90 |
School of Chemical Engineering, Engineering Campus, Universiti Sains Malaysia, Nibong Tebal, 14300, Malaysia; Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Faculty of Biotechnology, Chemistry and Environmental Engineering, Phenikaa University, Hanoi, 12116, Viet Nam; Bioresource Research Center, Phenikaa University, Hanoi, 12116, Viet Nam |
Nadzir, M.M., School of Chemical Engineering, Engineering Campus, Universiti Sains Malaysia, Nibong Tebal, 14300, Malaysia; Nurhayati, R.W., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Idris, F.N., School of Chemical Engineering, Engineering Campus, Universiti Sains Malaysia, Nibong Tebal, 14300, Malaysia; Nguyen, M.H., Faculty of Biotechnology, Chemistry and Environmental Engineering, Phenikaa University, Hanoi, 12116, Viet Nam, Bioresource Research Center, Phenikaa University, Hanoi, 12116, Viet Nam |
Bacterial exopolysaccharides (EPSs) are an essential group of compounds secreted by bacteria. These versatile EPSs are utilized individually or in combination with different materials for a broad range of biomedical field functions. The various applications can be explained by the vast number of derivatives with useful properties that can be controlled. This review offers insight on the current research trend of nine commonly used EPSs, their biosynthesis pathways, their characteristics, and the biomedical applications of these relevant bioproducts. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Alginate; Bacteria; Biomedical; Cellulose; Dextran; Exopolysaccharides; Gellan; Hyaluronic acid; Levan; Xanthan gum |
Biochemistry; Bioproducts; Medical applications; Biomedical applications; Biomedical fields; Biosynthesis pathways; Exopolysaccharides; Research trends; Useful properties; Polysaccharides |
MDPI AG |
20734360 |
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Review |
Q1 |
770 |
6319 |
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562 |
Hanafi E., Siste K., Limawan A.P., Sen L.T., Christian H., Murtani B.J., Adrian, Siswidiani L.P., Suwartono C. |
56737010600;55644113100;57202712511;57219034101;57209266195;57216652176;57216932703;57219029296;15078359800; |
Alcohol- and Cigarette-Use Related Behaviors During Quarantine and Physical Distancing Amid COVID-19 in Indonesia |
2021 |
Frontiers in Psychiatry |
12 |
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622917 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100903075&doi=10.3389%2ffpsyt.2021.622917&partnerID=40&md5=eb7936d1479358e8922064492a38ba78 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Limawan, A.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Christian, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Adrian, Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Siswidiani, L.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suwartono, C., Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
Background: In light of the coronavirus disease 2019 (COVID-19) pandemic, Indonesia implemented large-scale social restrictions (pembatasan sosial berskala besar/PSBB) to combat the spread of COVID-19, which might influence addictive behaviors. The current study aimed to explore the fluctuation of substance use during the pandemic and association of physical distancing and related factors toward consumption of alcohol and cigarettes. Method: An online survey was conducted from April 28 to June 1, 2020. Data regarding sociodemographic information, physical distancing profile, alcohol and cigarette usages, Alcohol Use Disorders Identification Test (AUDIT), Cigarette Dependence Scale (CDS), Symptom Checklist-90, and Pittsburg Sleep Quality Index (PSQI) were collected. A total of 4,584 respondents from all 34 provinces in Indonesia completed the survey. Data were summarized descriptively and analyzed using chi-square, ANOVA, and multinomial regression on SPSS 23.0 for Windows. Results: This study found that during the COVID-19 pandemic in Indonesia alcohol consumption was 9.50% and daily cigarette smoking was 20.3%. Around 44.5% and 47.6% of respondents reported stable alcohol consumption and cigarette consumption, respectively. The mean AUDIT score was 3.52 ± 4.66 and the mean CDS score was 24.73 ± 8.86. Physical distancing was not correlated to any substance use changes. Increased alcohol consumption was negatively correlated with being unmarried and positively correlated with a higher PSQI score. Decreased alcohol use positively correlated with living in PSBB-implementing provinces and higher AUDIT scores when compared to stable alcohol drinking. Increased cigarette smoking was positively correlated with being male, unmarried, and higher CDS scores. Reduced cigarette smoking was negatively correlated with living in provinces implementing PSBB, higher CDS scores, and phobic anxiety, hostility, and psychoticism subscales of SCL-90. Discussion and Conclusion: The prevalence of alcohol and cigarette consumption changes showed a similar trend with other available studies in other countries. This study established that substance use was mainly sustained with a smaller proportion of respondents amplifying their substance usages. The changes were correlated with PSBB policy but not the practice of physical distancing. Psychiatry and addiction services in Indonesia should be strengthened to cope with the increased burden of psychological distress. Future studies should conduct more comparisons to determine whether the overall rising intensity of consumption was maintained post-pandemic and delineate acute psychopathologies' effects on substance use. © Copyright © 2021 Hanafi, Siste, Limawan, Sen, Christian, Murtani, Adrian, Siswidiani and Suwartono. |
alcohol; cigarette; large-scale social restriction; physical distancing; prevalence |
alcohol; addiction; adult; alcohol consumption; Alcohol Use Disorders Identification Test; alcoholism; analysis of variance; Article; chi square test; Cigarette Dependence Scale; cigarette smoking; controlled study; coronavirus disease 2019; demography; distress syndrome; drinking behavior; female; hostility; human; Indonesia; lockdown; major clinical study; male; mental disease; pandemic; phobia; Pittsburgh Sleep Quality Index; policy; prevalence; psychiatry; psychometry; psychosis; scoring system; sleep disorder; social distancing; social media; substance use; Symptom Checklist 90 |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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563 |
Arozal W., Diliana D., Wikanendra G.B., Purwantyastuti P., Rusli A. |
32067462200;57225946044;57204105059;57205722372;57225950729; |
Clinical characteristics of recurrent tuberculosis patients from a Jakarta hospital-based survey |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S58 |
S61 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109803544&partnerID=40&md5=629bb068125f26ed38057da8c963846e |
Department of Pharmacology and Therapeutics Faculty of Medicine Universitas Indonesia, Indonesia; Clinical Pharmacology Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacy, Sanata Dharma University, Jogyakarta, Indonesia; Infection Disease Hospital, Prof. Dr Sulianti Saroso, Jakarta, Indonesia |
Arozal, W., Department of Pharmacology and Therapeutics Faculty of Medicine Universitas Indonesia, Indonesia; Diliana, D., Clinical Pharmacology Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wikanendra, G.B., Department of Pharmacy, Sanata Dharma University, Jogyakarta, Indonesia; Purwantyastuti, P., Department of Pharmacology and Therapeutics Faculty of Medicine Universitas Indonesia, Indonesia; Rusli, A., Infection Disease Hospital, Prof. Dr Sulianti Saroso, Jakarta, Indonesia |
Objective: To analyse factors affecting the recurrence of TB in a tertiary hospital in Jakarta, Indonesia. Methods: This is a hospital-based survey, located in Jakarta, in the period of January 2014-December 2018. All patients with recurrent TB were included in the study, while the samples with successful treatment in the same period were chosen by consecutive sampling. Statistical analysis of clinical characteristics of both study groups was conducted. Results: The medical records of 2322 TB patients who presented to Sulianti Saroso Hospital were analysed retrospectively. Ninety-four cases of recurrent TB that met inclusion and exclusion criteria were included in the study. It was observed that factors affecting recurrence of TB were medication compliance (p = .007, odds ratio (OR) 0.38 [CI 95% 0.19-0.76]) and appearance of lung cavity lesions in the first thorax x-ray examination (p < .001, OR 0.08 [CI 95% 0.03-0.20]). Conclusion: There was a relationship between recurrent TB and medication compliance and the appearance of lung cavity lesions in the first thorax x-ray examination. © 2021 Pakistan Medical Association. All rights reserved. |
(JPMA 71: S-58 [Suppl. 2]; 2021); Clinical characteristics; Recurrent tb; Tuberculosis |
ethambutol; isoniazid; tuberculostatic agent; adult; clinical feature; clinical outcome; Conference Paper; diabetes mellitus; female; human; incidence; lung cavity; lung compliance; major clinical study; male; medication compliance; nutritional status; prospective study; tertiary care center; thorax radiography; treatment duration; tuberculosis |
Pakistan Medical Association |
00309982 |
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Conference Paper |
Q4 |
242 |
17081 |
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564 |
Ahlam Syakirah W.N., Shafie W.M., Mansyur M., Nor N.Md. |
57223025872;57223022488;37085506800;57209597416; |
A Systematic Review on Precision Nutrition for Prevention and Management of Obesity during COVID-19 |
2021 |
Pakistan Journal of Medical and Health Sciences |
15 |
2 |
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223 |
230 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104525366&partnerID=40&md5=abe25d87c69c1fb5f8ba0283e4701cc2 |
Centre of Nutrition and Dietetics Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Malaysia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Maternal, Infant & Young Child Nutrition (MiChild) Research Group, Faculty of Health Sciences, Universiti Teknologi MARA, Malaysia |
Ahlam Syakirah, W.N.; Shafie, W.M., Centre of Nutrition and Dietetics Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Malaysia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Nor, N.Md., Centre of Nutrition and Dietetics Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Malaysia, Maternal, Infant & Young Child Nutrition (MiChild) Research Group, Faculty of Health Sciences, Universiti Teknologi MARA, Malaysia |
The COVID-19 pandemic is now catching the country by surprise. The disease has had a huge influence worldwide, and the nation has been put in lockdown by this health crisis. The psychological health, physical health and economic condition of individuals are adversely impacted by quarantine and lockdown. As mobility is reduced, there will be a dramatic shift in the population's lifestyle, where the people's physical activity level will decrease. Low levels of physical exercise can lead to a large number of obesity cases. Therefore, steps for obesity prevention and management need to be taken. One approach is to administer nutrition with accuracy through precision nutrition. Therefore, this research aims to review articles on precision nutrition for the treatment and control of obesity towards a restricted movement order during the COVID-19 health crisis. The literature search was conducted from May 2020 until January 2021 using Scopus and Science Direct as the main databases. The articles included follow the inclusion criteria published in English language, including nutrition intervention for prevention and management of obesity, focus on health crisis, and no restriction of time and study design. Various studies show that precision nutrition has a potential benefit in preventing or controlling obesity prevalence due to restricted movement order or quarantine upon health crisis. © 2021 Lahore Medical And Dental College. All rights reserved. |
COVID-19; Lockdown; Obesity; Precision nutrition; Quarantine |
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Lahore Medical And Dental College |
19967195 |
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Review |
Q4 |
114 |
27922 |
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565 |
Stefani S., Andayani D.E. |
57205176413;57222706544; |
Nutritional medical therapy in cachexia patient with oesophageal adenocarcinoma metastases on dexamethasone therapy: A case report |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S143 |
S145 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103746346&partnerID=40&md5=919fefbd8857fb0a86a2a2c0b96e5cf1 |
Department of Clinical Nutrition, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Stefani, S., Department of Clinical Nutrition, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Andayani, D.E., Department of Clinical Nutrition, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Gastroesophageal adenocarcinomas have a high risk of brain metastases. Patients with oesophageal cancer often present with symptoms of gastrointestinal (GI) obstruction and bleeding. On the other hand, high-dose steroids are used to supress brain oedema in cases of brain tumour, resulting in a drastic rise in appetite. Parenteral nutrition appears to reduce the appetite of humans, so it can be used in palliative patients who receive hypocaloric food to combat hunger. A man, 53 years old with intracranial metastasis space-occupying lesions (SOL) from oesophageal adenocarcinoma and cachexia, received 3x10 mg dexamethasone followed by tapering. Acute upper GI bleeding occurred during hospitalisation; thus, enteral feeding was delayed, and intravenous feeding was otherwise given. After two weeks of hospitalisation, we found that there was a decrease in hunger, change in clinical condition, tolerance to food, and functional ability. © 2021 Pakistan Medical Association. All rights reserved. |
Brain neoplasm.; Cachexia; Nutrition; Oesophageal adenocarcinoma |
dexamethasone; adenocarcinoma; cachexia; case report; complication; esophagus tumor; human; male; middle aged; parenteral nutrition; Adenocarcinoma; Cachexia; Dexamethasone; Esophageal Neoplasms; Humans; Male; Middle Aged; Parenteral Nutrition |
Pakistan Medical Association |
00309982 |
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33785960 |
Conference Paper |
Q4 |
242 |
17081 |
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566 |
Hariyanto N.I., Purwandhita R.P., Syahrani R.A., Louisa M., Wanandi S.I. |
57222706851;57202377042;57204103147;41461551400;36099320700; |
Role of TGF-?1 in human breast cancer stem cells |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S84 |
S89 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103745958&partnerID=40&md5=425118184fecd5818a6435ec48e67ad8 |
Master Program in BioMedical Sciences, Universitas Indonesia, Jakarta, Indonesia; Department of Molecular Biology and Proteomics, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology, Universitas Indonesia, Jakarta, Indonesia; Department of BioChemistry and Molecular Biology, Universitas Indonesia, Jakarta, Indonesia |
Hariyanto, N.I., Master Program in BioMedical Sciences, Universitas Indonesia, Jakarta, Indonesia; Purwandhita, R.P., Department of Molecular Biology and Proteomics, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Syahrani, R.A., Department of Pharmacology, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of BioChemistry and Molecular Biology, Universitas Indonesia, Jakarta, Indonesia; Wanandi, S.I., Master Program in BioMedical Sciences, Universitas Indonesia, Jakarta, Indonesia |
Objective: To investigate the auto-induction of transforming growth factor-b1 (TGF-?1) in breast cancer stem cells (BCSCs) and its effect on cell viability and stemness. Methods: Human BCSCs (aldehyde dehydrogenase positive; ALDH+) were grown in serum-free Dulbecco's Modified Eagle Medium/Nutrient Mixture F12 (DMEM/F12) and treated for periods of 1, 2 and 4 hours with 0.1 ng/ml recombinant human TGF-?1 protein (rhTGF-?1). The medium was then replaced with serum-free DMEM/F12 without rhTGF-?1 for 24 hours. Cell viability was determined using a trypan blue exclusion assay. Type 1 TGF-? receptor (T?R1), TGF-?1, octamer-binding transcription factor 4 (OCT4) and aldehyde dehydrogenase 1 family member A1 (ALDH1A1) messenger RNA (mRNA) expression levels were analysed using quantitative real-Time reverse-Transcriptase polymerase chain reaction (RT-qPCR). The TGF-? protein level in the culture medium was determined using an enzyme-linked immunosorbent assay (ELISA). Results: The expression levels of rhTGF-?1, TGF-?1 and T?R1 mRNA significantly increased in BCSCs compared to control after treatment for 1 and 2 hours but decreased after 4 hours. This is in line with alteration of stemness gene, OCT4 and ALDH1A1 mRNA expressions. However, the secretion of newly synthesised TGF-?1 significantly increased after 2 hours. In contrast, viable BCSCs decreased after 1 hour and then gradually increased 2.7 times compared to control after 4 hours. Conclusion: TGF-?1 treatment in low concentration and for short period of time triggers its auto-induction in BCSCs, leading to increased cell viability and stemness gene expression via autocrine signalling. © 2021 Pakistan Medical Association. All rights reserved. |
Aldehyde Dehydrogenase. (JPMA 71: S-84 [Suppl. 2]; 2021); Breast Neoplasms; Neoplastic Stem Cells; Octamer Transcription Factor-3; Transforming Growth Factor beta1 |
transforming growth factor; transforming growth factor beta; transforming growth factor beta1; breast tumor; cancer stem cell; human; Breast Neoplasms; Humans; Neoplastic Stem Cells; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factors |
Pakistan Medical Association |
00309982 |
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33785948 |
Conference Paper |
Q4 |
242 |
17081 |
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567 |
Damayanti R., Natsir M.P.W., Annisa I., Trianto D.M., Sungkar S., Friska D. |
57215770702;57225897287;57221960863;57222707452;57016857300;57202805330; |
Protein intake and number of children associated with nutritional status |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
|
S99 |
S102 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103744835&partnerID=40&md5=2bb449c2ed5baffb1b8a0c1b7d2261af |
Undergradute Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Damayanti, R., Undergradute Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Natsir, M.P.W., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Annisa, I., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Trianto, D.M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sungkar, S., Undergradute Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Friska, D., Undergradute Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: This study aimed to evaluate the association between protein intake and number of children in a family, based on nutritional status of children aged 2 to 12 years of age. Methods: This was a cross-sectional study with consecutive sampling. Weight and height were measured, and the 24-hour food recall was gathered with a questionnaire. Nutritional status was assessed using weight-for-Age curve of Centers for Disease Control and Prevention (CDC) growth chart. Protein intake was assessed using NutriSurvey. Data were analysed with chi-square test. Results: There were 99 children, 52 girls and 47 boys. From these, 57 (57.6%) were undernourished and 42 (42.4%) subjects had a good nutritional status. Sixty-five (65.6%) children had poor protein intake, while 34 (34.3%) had adequate protein intake. There was no association between protein intake and nutritional status (p = 0.805) or number of children in the family and nutritional status (p = 0.414). The principal protein source was squid, but squid is often sold for additional income. Conclusion: The nutritional status of children in Pero Konda Village could be considered undernourished. There was no association between protein intake and number of children based on nutritional status. The villagers had poor dietary habits, so good dietary habits should be promoted. © 2021 Pakistan Medical Association. All rights reserved. |
Children; Diet; Nutritional status. (JPMA 71: S-99 [Suppl. 2]; 2021); Protein intake |
body weight; caloric intake; child; cross-sectional study; diet; feeding behavior; female; human; income; male; nutritional status; preschool child; Body Weight; Child; Child, Preschool; Cross-Sectional Studies; Diet; Energy Intake; Feeding Behavior; Female; Humans; Income; Male; Nutritional Status |
Pakistan Medical Association |
00309982 |
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33785951 |
Conference Paper |
Q4 |
242 |
17081 |
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568 |
Manggala S.K., Aditianingsih D., Harijanto E. |
57190962171;56312263600;56059081200; |
Diaphragm function in post-upper abdominal surgery: High-flow nasal cannula (HFNC) versus nasal cannula a pilot study |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S4 |
S9 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103683600&partnerID=40&md5=f3b1bfe03f068ac7f5f515249ea589e8 |
Department of Anesthesiology and Intensive Care, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Manggala, S.K., Department of Anesthesiology and Intensive Care, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aditianingsih, D., Department of Anesthesiology and Intensive Care, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Harijanto, E., Department of Anesthesiology and Intensive Care, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Objective: This pilot study was performed to identify the differences between the effectiveness of HFNC and conventional oxygen therapy. Methods: This study was a part of a more extensive ongoing study in a tertiary care hospital from January to April 2019. Criteria for inclusion were adult patients scheduled for upper-Abdominal surgery. Patients were randomised into two groups: conventional oxygen therapy (n=10) and HFNC therapy (n=10). The differences in (clinical parameters;Mean Arterial Pressure (MAP), heart rate, respiratory rate), diaphragm thickening on ultrasound, air lung distribution on Electrical Impedance Tomography (EIT), and blood gas analysis data between both groups were assessed at specific times. Adverse events were recorded and treated during the study. The data collected was analysed using SPSS software version 23.0. Results: During the recuritment of patients, no issues were indentified in this study. Therefore, no clinical or statistical differences in EIT and ultrasound diaphragm thickening between the two groups were observed; no clinical or statistical differences in patterns in clinical parameters were found. The mean arterial PO2 was particulary different at time 1: 137.10 mmHg for patients in the conventional therapy group and 93.95 mmHg in the HFNC group (p = 0.001). A patient in the HFNC group reported a feeling of discomfort. Conclusion: The aim of this study was to observe differences between HFNC and conventional oxygen therapy. Nonetheless, more data are needed in order to achieve a conclusive result. © 2021 Pakistan Medical Association. All rights reserved. |
(JPMA 71: S-4 [Suppl. 2]; 2021); Blood gas analysis; Electric impedance; Oxygen inhalation therapy; Tomography; Ultrasonography |
abdominal surgery; adult; arterial oxygen tension; blood gas analysis; breathing rate; computer assisted impedance tomography; conference paper; controlled study; data analysis software; diaphragm; echography; female; heart rate; high flow nasal cannula therapy; human; lung; major clinical study; male; mean arterial pressure; oxygen therapy; pilot study; randomized controlled trial; surgery; tertiary care center; cannula; diagnostic imaging; diaphragm; oxygen therapy; pilot study; respiratory failure; oxygen; Adult; Cannula; Diaphragm; Humans; Oxygen; Oxygen Inhalation Therapy; Pilot Projects; Respiratory Insufficiency |
Pakistan Medical Association |
00309982 |
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33785933 |
Conference Paper |
Q4 |
242 |
17081 |
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569 |
Kekalih A., Friska D., Nabila D., Harimurti M.E.P. |
55633562200;57202805330;57219359635;57225933113; |
Emotional readiness and weight consequences evaluation for behavioural modification of obese adolescence in jakarta-indonesia |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S46 |
S52 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103683378&partnerID=40&md5=8a3bc30c067e0ec18b7bad582e7abd0b |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Medical Education Program, Faculty of Medicine, Universitas Indonesia, Indonesia |
Kekalih, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Friska, D., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nabila, D., Undergraduate Medical Education Program, Faculty of Medicine, Universitas Indonesia, Indonesia; Harimurti, M.E.P., Undergraduate Medical Education Program, Faculty of Medicine, Universitas Indonesia, Indonesia |
Objective: With increasing incidence of obesity in Indonesia, behavioural modification plays an important role for its management. Applying the Trans-Theoretical Model (TTM) to assess behavioural modification readiness of obese adolescence, this study highlighted two main processes of change in TTM: emotional readiness to change (EmR) and weight consequence evaluation (WCE). Adolescence may develop difference EmR and WCE in handling obesity status especially in high school and college years, due to different phases of physic, autonomy and behavioural development. Methods: A comparative cross-sectional study was conducted using validated Indonesian version of the TTM questionnaire to compare WCE and EmR scores (scale 0-100) between high school students and college freshmen group which included means comparison tests and linear regression. Results: The study involved 116 obese adolescents and majority were at the action (32%) and contemplation (31%) TTM stage. After comparing 59 high school students and 57 college freshmen, EmR and WCE scores were not significantly different (p > 0.05). Both groups had good EmR score. Weight consequences awareness were only slightly higher among college freshmen compared to high school students, scoring at 78 (20-96) and 63 (30-100) respectively. Higher body mass index was associated with better EmR and WCE scores in both groups. Conclusion: Majority of the obese adolescents were already at the action and contemplation phase and also had appropriate emotional readiness to change. However, compared to college students, high school adolescence needed more support to maintain their weight management, in the form of education to raise awareness of obesity consequences. © 2021 Pakistan Medical Association. All rights reserved. |
(JPMA 71: S-46 [Suppl. 2]; 2021); Adolescent behaviors; Emotional adjustment; Obesity management |
adolescent; adolescent behavior; adolescent obesity; anthropometry; behavior change; body mass; body weight management; college student; comparative study; Conference Paper; cross-sectional study; emotional readiness; female; high school student; human; linear regression analysis; major clinical study; male; obesity management; psychological adjustment; questionnaire; transtheoretical model; weight consequence evaluation; body weight; Indonesia; obesity; Adolescent; Body Mass Index; Body Weight; Cross-Sectional Studies; Humans; Indonesia; Obesity |
Pakistan Medical Association |
00309982 |
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33785941 |
Conference Paper |
Q4 |
242 |
17081 |
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570 |
Zahrah A., Muharam R., Luky Satria Marwali M., Ocktariyana, Deraya I.E., Asmarinah |
57205418186;57191492732;57225892448;57210235127;57216313121;15820317600; |
MRNA expression and DNA methylation level of the MMP-2 gene in peritoneal endometriosis |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S112 |
S115 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103683243&partnerID=40&md5=337ed161f28b3917b291ce8b733e951a |
Master Program of Biomedical Science, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Obstetric and Ginecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Obstetric and Ginecology, Fatmawati Central General Hospital, Jakarta, Indonesia; Department Miwifery, Politeknik Kesehatan Palembang, Ministry of Health, Indonesia; Department of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Zahrah, A., Master Program of Biomedical Science, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Muharam, R., Department of Obstetric and Ginecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Luky Satria Marwali, M., Department of Obstetric and Ginecology, Fatmawati Central General Hospital, Jakarta, Indonesia; Ocktariyana, Department Miwifery, Politeknik Kesehatan Palembang, Ministry of Health, Indonesia; Deraya, I.E., Department of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Asmarinah, Master Program of Biomedical Science, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Objective: Endometriosis is a multifactorial disease that affects 10% of women of childbearing age. Its development is known to be related to the MMP-2 gene. Specifically, the expression of MMP-2 is increase in endometriosis. The aim of this study was to evaluate the correlation between mRNA expression and DNA methylation levels of the MMP-2 gene in peritoneal endometriosis. Methods: This study used a cross-sectional design. The samples included peritoneal endometriosis tissue from women with endometriosis and normal endometrial tissue from women without endometriosis. Twenty samples of each type were taken, and the women were 20-45 years of age. Peritoneal endometriosis tissue was acquired using the laparoscopic technique, while normal endometrial tissue was taken with the microcuretase technique. The mRNA expression of the MMP-2 gene was analysed with qRT-PCR, and the level of DNA methylation of the MMP-2 gene was analysed with a methylation-specific PCR method. Results: The mRNA expression of MMP-2 gene in peritoneal endometriosis tissue was increased, and there were significant differences between peritoneal endometriosis tissue and normal endometrial tissue. The MMP-2 gene was hypermethylated, but there was no significant difference (p = 0.596) between peritoneal endometriosis tissue and endometrial tissue in terms of methylation. This study did not show a significant correlation between mRNA expression and DNA methylation levels of the MMP-2 gene (p = 0.769, r = 0.070). Conclusion: The increase in MMP-2 gene expression in peritoneal endometriosis tissue is likely not only due to hypermethylation; there are other factors that might play a role. © 2021 Pakistan Medical Association. All rights reserved. |
cytoskeleton. (JPMA 71: S-112 [Suppl. 2]; 2021); DNA methylation; endometriosis; MMP-2 |
gelatinase A; messenger RNA; cross-sectional study; DNA methylation; endometriosis; endometrium; female; genetics; human; metabolism; Cross-Sectional Studies; DNA Methylation; Endometriosis; Endometrium; Female; Humans; Matrix Metalloproteinase 2; RNA, Messenger |
Pakistan Medical Association |
00309982 |
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33785954 |
Conference Paper |
Q4 |
242 |
17081 |
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