No records
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406 |
Kristianto H., Waluyo A., Gayatri D., Yunir E., Blow D. |
56121348500;57211433568;57197786176;36520254800;57192313241; |
Neuromuscular taping treatment of diabetic foot: A concept analysis |
2021 |
Clinica Terapeutica |
72 |
3 |
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231 |
235 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105531246&doi=10.7417%2fCT.2021.2320&partnerID=40&md5=c143037b6dd7fff4b19b4ba2e89b5b93 |
Department of Medical Surgical Nursing, School of Nursing, Faculty of Medicine, Universitas Brawijaya, Indonesia; Faculty of Nursing, Universitas Indonesia, Indonesia; Faculty of Medicine, Universitas Indonesia, Indonesia; NeuroMuscular Taping Institute, Rome, Italy; Universitas Brawijaya, Indonesia; Universitas, Indonesia |
Kristianto, H., Department of Medical Surgical Nursing, School of Nursing, Faculty of Medicine, Universitas Brawijaya, Indonesia, Faculty of Nursing, Universitas Indonesia, Indonesia, Universitas Brawijaya, Indonesia, Universitas, Indonesia; Waluyo, A., Faculty of Nursing, Universitas Indonesia, Indonesia; Gayatri, D., Faculty of Nursing, Universitas Indonesia, Indonesia; Yunir, E., Faculty of Medicine, Universitas Indonesia, Indonesia; Blow, D., NeuroMuscular Taping Institute, Rome, Italy |
Objective. The definition of neuromuscular taping (NMT) has yet to be clearly analysed as a possible treatment for diabetic foot. Case studies, theoretical analysis and results of existing research may lead to varying perceptions on the definition of NMT and its possible effects on diabetic foot. This article aims to analyse the definition of the NMT concept and furthermore as a basis for future research development on diabetic foot. Methods. The procedure for reference source search include the principal data bases using “neuromuscular taping” and “diabetic foot” keywords for the period of 2010-2019. The concept analysis uses an 8-step approach with the Walker and Avant's method. Results. Analysis of the NMT concept on diabetic foot obtained attributes of elastic tape, skin, pain, edema, injury, sensorimotor, circulation, drainage, relaxation, local, proprioceptive, motion function, strength, contraction, stabilisation, reflex, rehabilitation, care, musculoskeletal, nerve, muscles, tendons, fascia, joints, lymphatic, longitudinal, wrinkles. There were four groups of attributes, namely inflammatory response, vascularity, neuromusculoskeletal function and musculoskeletal system. NMT application benefits for diabetic foot can be attributed to improving walking function, leg position, decreasing pain response, improving body function index, improving leg muscle strength and motor function, increasing range of movement (ROM), maintaining stability of leg joint function, preventing injury, increasing strength and improving position of ankle joints, reducing stiffness, reducing edema and helping wound healing processes. Conclusions. NMT is a decompression application of an elastic tape on the skin on the diabetic foot that has the effect of reducing the inflammatory response, improving vascularity and neuromusculoskeletal function. It aims to improve neuromusculoskeletal and lymphatic system functioning due to the presence of wrinkles, indicating dilation, with local effects on the sensorimotor and proprioceptive senses in conditions of care, rehabilitation and injury. Copyright © Società Editrice Universo (SEU) |
Concept analysis; Diabetic foot; Neuromuscular taping; Operational definition |
cerebral palsy; concept analysis; diabetic foot; edema; fascia; hemiplegia; human; hypertension; inflammation; joint function; leg muscle; lymphatic drainage; motor performance; rehabilitation care; Review; systematic review; tendon; wound healing; wrinkle; athletic tape; diabetes mellitus; diabetic foot; edema; physiology; skeletal muscle; walking; Athletic Tape; Diabetes Mellitus; Diabetic Foot; Edema; Humans; Muscle, Skeletal; Walking |
Societa Editrice Universo |
00099074 |
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33956043 |
Review |
Q3 |
450 |
11019 |
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412 |
Pulungan A., Andarie A.A., Soesanti F., Yassien M.R., De Bruin C., Wijaya A., Firmansyah A., Wit J.M. |
57192905981;57195935134;37068080600;57223039155;57028043300;57225459566;6602915502;7101895972; |
Anthropometric, biochemical and hormonal profiles of the partially admixed pygmoid group in Rampasasa (Flores, Indonesia) |
2021 |
Journal of Pediatric Endocrinology and Metabolism |
34 |
5 |
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547 |
557 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104614948&doi=10.1515%2fjpem-2020-0526&partnerID=40&md5=64730b2ca3a487374a34509077be3f0d |
Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands; Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia |
Pulungan, A., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Andarie, A.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soesanti, F., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yassien, M.R., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; De Bruin, C., Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands; Wijaya, A., Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia; Firmansyah, A., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wit, J.M., Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands |
Objectives: We performed a cross-sectional study on anthropometric and laboratory characteristics of inhabitants of Rampasasa (Flores, Indonesia). Adults were categorised according to ancestry into three groups: pygmoid (P/P, offspring of pygmoid parents, n=8), mixed pygmoid (P/N, offspring of pygmoid and non-pygmoid parents, n=12) and non-pygmoid (N/N, n=10). Children (n=28) were P/N. Methods: Measurements included height, weight, sitting height, arm span, head circumference, haematological analysis and serum albumin, calcium, vitamin D, insulinlike growth factor-I (IGF-I) and IGF binding protein 3 (IGFBP-3). Pubertal stage and bone age was assessed in children. Anthropometric data were expressed as standard deviation score (SDS) for age. IGF-I, IGFBP-3 and IGF-I/ IGFBP-3 ratio were expressed as SDS for age, bone age and pubertal stage. Results: Mean height SDS showed a gradient from P/P (-4.0) via P/N (-3.2) to N/N (-2.3) (-3.4, -3.1 and -2.2 adjusted for age-associated shrinking). Sitting height and head circumference showed similar gradients. Serum IGF-I SDS was similar among groups (approximately -1 SDS). IGFBP-3 SDS tended toward a gradient from P/P (-1.9) via P/N (-1.5) to N/N (-1.1), but IGF-I/IGFBP-3 ratio was normal in all groups. In P/P and P/N, mean head circumference SDS was >2 SD greater than mean height SDS. Children showed a progressive growth failure and bone age delay, delayed female pubertal onset and an initial low serum IGF-I, normal IGFBP-3 and low IGF-I/IGFBP-3 ratio. Conclusions: P/P showed proportionate short stature with relative macrocephaly and relatively low IGFBP-3; P/N presented an intermediate pattern. P/N children were progressively short, showed delayed skeletal maturation, delayed puberty in girls and low IGF-I and IGF-I/IGFBP-3. © 2021 De Gruyter. All rights reserved. |
Growth; Head circumference; IGF-I; IGFBP-3; Negritos; Pygmies; Short stature; Vitamin D deficiency |
albumin; calcium; somatomedin binding protein 3; somatomedin C receptor; vitamin D; IGFBP3 protein, human; somatomedin binding protein 3; somatomedin C; adult; albumin blood level; analytical parameters; anthropology; anthropometry; Article; biochemistry; blood analysis; bone age; calcium blood level; child; controlled study; cross-sectional study; crossover procedure; female; head circumference; hormone determination; human; Indonesia; macrocephaly; male; molecular dynamics; population research; protein blood level; puberty; pygmy; scoring system; vitamin blood level; anthropometry; blood; body mass; body weight; bone disease; ethnic group; follow up; growth disorder; infant; metabolism; middle aged; newborn; pathology; preschool child; prognosis; Adult; Anthropometry; Body Mass Index; Bo |
De Gruyter Open Ltd |
0334018X |
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33851527 |
Article |
Q2 |
502 |
10041 |
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417 |
Yunir E., Soewondo P., Soelistijo S.A., Rudijanto A. |
36520254800;23475336100;57211324846;23499422500; |
Knowledge and behavior changes in clinician after training of partnership for Diabetes Control in Indonesia |
2021 |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
15 |
3 |
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719 |
724 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103636919&doi=10.1016%2fj.dsx.2021.03.012&partnerID=40&md5=69390ed0f1d97f773993433ca4e7d1d0 |
Division of Endocrinology and Metabolism, Department of Internal Medicine Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Surabaya Diabetes and Nutrition Centre, Department of Internal Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo No.47, Surabaya, 60132, Indonesia; Division of Endocrinology and Metabolism, Department of Internal Medicine, Universitas Brawijaya, Jl. Veteran Malang, Malang, 65145, Indonesia |
Yunir, E., Division of Endocrinology and Metabolism, Department of Internal Medicine Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Soewondo, P., Division of Endocrinology and Metabolism, Department of Internal Medicine Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Soelistijo, S.A., Surabaya Diabetes and Nutrition Centre, Department of Internal Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo No.47, Surabaya, 60132, Indonesia; Rudijanto, A., Division of Endocrinology and Metabolism, Department of Internal Medicine, Universitas Brawijaya, Jl. Veteran Malang, Malang, 65145, Indonesia |
Background and aims: One of the main determinants of successful diabetes management is the quality of healthcare provider including general practitioner and internist which can be increased through medical training. This study aimed to describe the changes of clinician's knowledge and behavior of comprehensive diabetes management training program around Indonesia. Method: We conducted a three-day training program for general practitioners and internists for 3.5 years, 2013 to 2016. All clinicians invited as voluntary participant to send their patient data from medical record. Each participant was expected to submit a minimum of 25 type 2 diabetes (T2DM) set patient data before and 6 months after training program to analyze the impact of program in physician knowledge and behavior related to diabetes management. Result: 120 of 489 voluntary participants submitted completed baseline data with 4676 patient data. Meanwhile, only 32 participants that submitted completed data of 6 months before after training with 886 patient data. Most of parameters were improve before and after program. The greatest and lowest improvement were on A1c measurement (21%) and smoking assessment (2%). Conclusion: Intensive seminar and training was not enough to empower diabetes management. This research might push the creation of clinical practice program that were tailored to each care facilities and integrated within routine care aimed at continual improvement of its healthcare worker. © 2021 |
Behavior; Diabetes; Knowledge; Training |
fibric acid derivative; hemoglobin A1c; antidiabetic agent; biological marker; glycosylated hemoglobin; hemoglobin A1c protein, human; adult; aged; Article; behavior; behavior change; controlled study; diabetes control; diabetes mellitus; diabetic complication; female; general practitioner; health personnel attitude; human; Indonesia; internist; major clinical study; male; medical education; middle aged; non insulin dependent diabetes mellitus; patient coding; priority journal; retrospective study; smoking; young adult; attitude to health; blood; clinical competence; education; follow up; glucose blood level; health care personnel; internal medicine; medical education; non insulin dependent diabetes mellitus; procedures; professional practice; prognosis; psychology; Adult; Aged; Biomarkers |
Elsevier Ltd |
18714021 |
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33813247 |
Article |
Q2 |
684 |
7304 |
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419 |
Iwai M., Tulafu M., Togo S., Kawaji H., Kadoya K., Namba Y., Jin J., Watanabe J., Okabe T., Hidayat M., Sumiyoshi I., Itoh M., Koyama Y., Ito Y., Orimo A., Takamochi K., Oh S., Suzuki K., Hayashizaki Y., Yoshida K., Takahashi K. |
56357096800;55818028100;9533914900;57196621148;57193562606;55413965500;57221345975;57202019639;57208252941;56435992700;57202003876;57218355452;57202921569;57225926629;56922531400;57070836300;56922435100;57221017119;57216108710;55725231300;57226207751; |
Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression |
2021 |
Molecular Oncology |
15 |
5 |
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1507 |
1527 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103164588&doi=10.1002%2f1878-0261.12937&partnerID=40&md5=b2e053e6ecbd024c8cbcf42081179238 |
Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Japan; Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Department of Respiratory and Critical Care Medicine, National Center of Gerontology, Beijing Hospital, China; Department of Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine, Jakarta, Indonesia; Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Japan; Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan |
Iwai, M., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Tulafu, M., Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Togo, S., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Kawaji, H., Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Japan, Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Kadoya, K., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Namba, Y., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Jin, J., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan, Department of Respiratory and Critical Care Medicine, National Center of Gerontology, Beijing Hospital, China; Watanabe, J., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Okabe, T., Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Hidayat, M., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan, Department of Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine, Jakarta, Indonesia; Sumiyoshi, I., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Itoh, M., RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Koyama, Y., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan, Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Japan; Ito, Y., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Orimo, A., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Takamochi, K., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Oh, S., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Suzuki, K., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Hayashizaki, Y., RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Yoshida, K., Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan; Takahashi, K., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan |
Cancer-associated fibroblasts (CAFs) regulate cancer progression through the modulation of extracellular matrix (ECM) and cancer cell adhesion. While undergoing a series of phenotypic changes, CAFs control cancer–stroma interactions through integrin receptor signaling. Here, we isolated CAFs from patients with non-small-cell lung cancer (NSCLC) and examined their gene expression profiles. We identified collagen type XI α1 (COL11A1), integrin α11 (ITGA11), and the ITGA11 major ligand collagen type I α1 (COL1A1) among the 390 genes that were significantly enriched in NSCLC-associated CAFs. Increased ITGA11 expression in cancer stroma was correlated with a poor clinical outcome in patients with NSCLC. Increased expression of fibronectin and collagen type I induced ITGA11 expression in CAFs. The cellular migration of CAFs toward collagen type I and fibronectin was promoted via ERK1/2 signaling, independently of the fibronectin receptor integrin α5β1. Additionally, ERK1/2 signaling induced ITGA11 and COL11A1 expression in cancer stroma. We, therefore, propose that targeting ITGA11 and COL11A1 expressing CAFs to block cancer–stroma interactions may serve as a novel, promising anti-tumor strategy. © 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. |
cancer; cancer-associated fibroblast; collagen type I; collagen type XI α1; integrin alpha-11; non-small-cell lung cancer; stroma interaction; transforming growth factor beta |
alpha11 integrin; collagen type 1; collagen type 1 alpha1; collagen type 11; collagen type 11 alpha1; fibronectin; fibronectin receptor; integrin; mitogen activated protein kinase 3; retrovirus vector; small interfering RNA; transforming growth factor beta1; unclassified drug; very late activation antigen 5; adult; aged; Article; cancer associated fibroblast; cancer recurrence; cell interaction; cell migration; chemotaxis; clinical article; clinical outcome; controlled study; DNA modification; enzyme linked immunosorbent assay; female; gene expression profiling; human; human cell; human tissue; immunohistochemistry; in vitro study; lung adenocarcinoma; lung fibroblast; lung parenchyma; male; non small cell lung cancer; priority journal; protein expression; protein expression level; protein |
John Wiley and Sons Ltd |
15747891 |
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33682233 |
Article |
Q1 |
2332 |
1019 |
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421 |
Teixeira J.C., Jacobs G.S., Stringer C., Tuke J., Hudjashov G., Purnomo G.A., Sudoyo H., Cox M.P., Tobler R., Turney C.S.M., Cooper A., Helgen K.M. |
56290678400;56504646300;7005875885;20435156700;8937651700;56262110300;6603548824;8699959500;55780763900;7003984281;57225849511;6602538000; |
Widespread Denisovan ancestry in Island Southeast Asia but no evidence of substantial super-archaic hominin admixture |
2021 |
Nature Ecology and Evolution |
5 |
5 |
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616 |
624 |
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8 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102829045&doi=10.1038%2fs41559-021-01408-0&partnerID=40&md5=0f530b00ed05b700fb2df18763c0144f |
Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Complexity Institute, Nanyang Technological University, Singapore, Singapore; Department of Archaeology, University of Cambridge, Cambridge, United Kingdom; Centre for Human Evolution Research, Department of Earth Sciences, Natural History Museum, London, United Kingdom; School of Mathematical Sciences, The University of Adelaide, Adelaide, SA, Australia; Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Chronos 14Carbon-Cycle Facility, Earth and Sustainability Science Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia; South Australian Museum, Adelaide, SA, Australia; BlueSky Genetics, Ashton, SA, Australia; Australian Museum Research Institute, Australian Museum, Sydney, NSW, Australia |
Teixeira, J.C., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Jacobs, G.S., Complexity Institute, Nanyang Technological University, Singapore, Singapore, Department of Archaeology, University of Cambridge, Cambridge, United Kingdom; Stringer, C., Centre for Human Evolution Research, Department of Earth Sciences, Natural History Museum, London, United Kingdom; Tuke, J., School of Mathematical Sciences, The University of Adelaide, Adelaide, SA, Australia; Hudjashov, G., Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Purnomo, G.A., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sudoyo, H., Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Cox, M.P., Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Tobler, R., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Turney, C.S.M., Chronos 14Carbon-Cycle Facility, Earth and Sustainability Science Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia; Cooper, A., South Australian Museum, Adelaide, SA, Australia, BlueSky Genetics, Ashton, SA, Australia; Helgen, K.M., ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia, Australian Museum Research Institute, Australian Museum, Sydney, NSW, Australia |
The hominin fossil record of Island Southeast Asia (ISEA) indicates that at least two endemic ‘super-archaic’ species—Homo luzonensis and H. floresiensis—were present around the time anatomically modern humans arrived in the region >50,000 years ago. Intriguingly, contemporary human populations across ISEA carry distinct genomic traces of ancient interbreeding events with Denisovans—a separate hominin lineage that currently lacks a fossil record in ISEA. To query this apparent disparity between fossil and genetic evidence, we performed a comprehensive search for super-archaic introgression in >400 modern human genomes, including >200 from ISEA. Our results corroborate widespread Denisovan ancestry in ISEA populations, but fail to detect any substantial super-archaic admixture signals compatible with the endemic fossil record of ISEA. We discuss the implications of our findings for the understanding of hominin history in ISEA, including future research directions that might help to unlock more details about the prehistory of the enigmatic Denisovans. © 2021, The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature. |
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animal; fossil; genetics; hominid; Homo neanderthalensis; human; island (geological); Southeast Asia; Animals; Asia, Southeastern; Fossils; Hominidae; Humans; Islands; Neanderthals |
Nature Research |
2397334X |
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33753899 |
Article |
Q1 |
5822 |
225 |
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423 |
Sitohang I.B.S., Rahmayunita G., Hosfiar V.A., Ninditya S., Augustin M. |
56734569200;57192909174;57219421454;57216741327;57219417020; |
Effectiveness of water as the neutralising agent for glycolic acid peels in skin phototypes IV-V |
2021 |
Australasian Journal of Dermatology |
62 |
2 |
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e212 |
e216 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092675176&doi=10.1111%2fajd.13486&partnerID=40&md5=a36758f77d6cfee5443e0a9ae6f60fed |
Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rahmayunita, G., Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hosfiar, V.A., Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ninditya, S., Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Augustin, M., Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
The aim of the study is to evaluate the effectiveness of water as a substitute for sodium bicarbonate plus solution in the neutralisation process of chemical peeling using a 35% glycolic acid solution. This randomised, double-blind, split-face, controlled trial was conducted in an outpatient setting. A total of 126 healthy patients with skin phototypes IV–V aged between 18 and 60 years old were recruited. Chemical peeling was performed with 35% glycolic acid solution. One side of the face was neutralised with water, and the other side of the face was neutralised with a sodium bicarbonate plus solution. The main outcome of this study was measured by the degree of erythema, pruritus and pain scores. Significant difference in the pain score immediately after the neutralisation process of the chemical peeling with glycolic acid was seen. However, there were no significant differences in the degree of erythema or the pruritus score. These results indicate that water can be used as a substitute for sodium bicarbonate plus solution in the neutralisation process of chemical peeling with 35% glycolic acid in patients with skin phototypes IV–V. © 2020 The Australasian College of Dermatologists |
chemexfoliation; glycolic acid peel; skin phototypes IV–V; sodium bicarbonate; split face; water |
bicarbonate; glycolic acid; water; bicarbonate; buffer; keratolytic agent; adult; Article; chemexfoliation; clinical effectiveness; clinical protocol; Clinician Erythema Assessment scale; controlled study; cutaneous parameters; disease severity; documentation; double blind procedure; erythema; female; human; human experiment; male; middle aged; normal human; photosensitivity; pruritus; randomized controlled trial; rating scale; scoring system; visual analog scale; young adult; chemexfoliation; procedures; Adult; Buffers; Chemexfoliation; Double-Blind Method; Female; Glycolates; Humans; Keratolytic Agents; Male; Middle Aged; Sodium Bicarbonate; Water; Young Adult |
John Wiley and Sons Inc |
00048380 |
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33070326 |
Article |
Q2 |
670 |
7459 |
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424 |
Satjakoesoemah A.I., Situmorang G.R., Wahyudi I., Rodjani A. |
57189614677;57190001213;36341995300;6504653529; |
Single-stage urethroplasty: An eight-year single-centre experience and its associated factors for urethrocutaneous fistula |
2021 |
Journal of Clinical Urology |
14 |
3 |
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190 |
195 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088243456&doi=10.1177%2f2051415820941746&partnerID=40&md5=9a30aabea7f642db31b4abbbd426894e |
Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Satjakoesoemah, A.I., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Situmorang, G.R., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Wahyudi, I., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Rodjani, A., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Introduction: This study aimed to describe single-stage urethroplasty and to determine factors associated with urethrocutaneous fistula after the procedure at our institution. Methods: All hypospadias patients without any prior surgery who underwent single-stage urethroplasty from July 2010 to January 2018 were included. In total, 179 patients were followed for at least one year postoperatively. Information on types of hypospadias, operation techniques, chordee degree, preoperative pyuria (urine white blood cell count >5/HPF), urethral defect length and urethrocutaneous fistula formation was collected. Results: We obtained 103 cases of posterior (57.5%), middle (57 cases) and anterior (19 cases) hypospadias on whom onlay preputial island flap (71 cases), tubularized incised plate (46 cases) and Duckett’s transverse preputial island flap (35 cases) were conducted. After 47.1±25.8 months of follow-up, urethrocutaneous fistula were found in 23 (12.8%) patients associated with posterior hypospadias occurrence (p=0.025), longer urethral defect (p=0.007) and preoperative pyuria (p<0.001). Chordee degree (p=0.886) and age (p=0.187) were not significant factors associated with urethrocutaneous fistula formation. Conclusion: Single-stage urethroplasty is a versatile procedure for various hypospadias cases, with a urethrocutaneous fistula rate of 12.8%. Posterior hypospadias, preoperative pyuria and longer urethral defect were associated with urethrocutaneous fistula formation. Level of evidence: Level 2B. © British Association of Urological Surgeons 2020. |
hypospadias; risk factors; Single stage; single-centre experience; urethrocutaneous fistula; urethroplasty |
cefoperazone; cefotaxime; chloramphenicol; adolescent; adult; Article; child; chordee; cohort analysis; cystostomy; follow up; human; hypospadias; infant; island flap; leukocyturia; major clinical study; male; operation duration; preoperative evaluation; pyuria; renal system parameters; retrospective study; skin fistula; ureter fistula; urethral defect length; urethroplasty; urinary tract infection |
SAGE Publications Ltd |
20514158 |
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Article |
Q3 |
192 |
19868 |
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425 |
Pranata R., Vania R., Victor A.A. |
57201973901;57208328436;57191055282; |
Statin reduces the incidence of diabetic retinopathy and its need for intervention: A systematic review and meta-analysis |
2021 |
European Journal of Ophthalmology |
31 |
3 |
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1216 |
1224 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086325738&doi=10.1177%2f1120672120922444&partnerID=40&md5=f6079c079179ae3f2ecc748426833463 |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Vitreo-Retinal Division, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Victor, A.A., Vitreo-Retinal Division, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Purpose: We aimed to perform a systematic literature search on the latest evidence of the role of statin in reducing diabetic retinopathy and its need for intervention. Methods: A comprehensive search on cohort studies/clinical trials that assess statins and diabetic retinopathy up until August 2019 was performed. The outcome measured was the incidence of diabetic retinopathy and its need for intervention. Results: There were 558.177 patients from six studies. Statin was associated with a lower incidence of diabetic retinopathy (hazard ratio: 0.68 (0.55, 0.84), p < 0.001; I2: 95%). For the subtypes of diabetic retinopathy, statin lowers the incidence of proliferative diabetic retinopathy (hazard ratio: 0.69 (0.51, 0.93), p = 0.01; I2: 90%), non-proliferative diabetic retinopathy (hazard ratio: 0.80 (0.66, 0.96), p = 0.02; I2: 93%), and diabetic macular edema (hazard ratio: 0.56 (0.39, 0.80), p = 0.002; I2: 82%). Statin was associated with a reduced need for retinal laser treatment with a hazard ratio of 0.70 (0.64, 0.76) (p < 0.001; I2: 0%), intravitreal injection with a hazard ratio of 0.82 (0.79, 0.85) (p < 0.001; I2: 0%), and vitrectomy with a hazard ratio of 0.64 (0.48, 0.85) (p < 0.001; I2: 75%). Overall, statin was associated with a reduced need for intervention for diabetic retinopathy with a hazard ratio of 0.72 (0.64, 0.80) (p < 0.001; I2: 73%). The regression-based Egger’s test showed statistically significant small-study effects for non-proliferative diabetic retinopathy (p = 0.011) outcomes. Conclusion: Statin was associated with a decreased risk of diabetic retinopathy and its subtypes. Statin also reduced the need for intervention with retinal laser treatment, intravitreal injection, and vitrectomy. © The Author(s) 2020. |
Diabetic maculopathy; diabetic retinopathy; intravitreal injection; retinal laser treatment; statin; vitrectomy |
hydroxymethylglutaryl coenzyme A reductase inhibitor; hydroxymethylglutaryl coenzyme A reductase inhibitor; Article; clinical trial (topic); diabetic macular edema; diabetic retinopathy; hazard ratio; human; incidence; intravitreal drug administration; low level laser therapy; meta analysis; non insulin dependent diabetes mellitus; nonproliferative diabetic retinopathy; proliferative diabetic retinopathy; prospective study; sensitivity analysis; systematic review; vitrectomy; diabetes mellitus; diabetic retinopathy; incidence; macular edema; Diabetes Mellitus; Diabetic Retinopathy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Intravitreal Injections; Macular Edema; Vitrectomy |
SAGE Publications Ltd |
11206721 |
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32530705 |
Article |
Q2 |
790 |
6120 |
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428 |
Soetisna T.W. |
57214887740; |
A new hope of cd133+ bone marrow stem cell for functional exercise capacity improvement in low ejection fraction coronary artery bypass graft patients: A clinical trial |
2021 |
Bali Medical Journal |
10 |
1 |
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229 |
233 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106002523&doi=10.15562%2fbmj.v10i1.2255&partnerID=40&md5=80046a217774aa6ef82836d9a524c4ff |
Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Soetisna, T.W., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Patients with low ejection fraction who are undergoing coronary artery bypass graft (CABG) only have an insignificant improvement in ejection fraction. This condition will make a little hope to achieve an improvement in physical performance. But now, from a view study, CD133+ stem cells offer new hope for this situation. This study evaluates CD133+ bone marrow stem cells’ role for functional exercise capacity improvement in low ejection fraction coronary artery bypass graft patients. Methods: Thirty patients with ischemic heart disease who had ejection fraction<35% at the National Cardiovascular Center were randomized into 2 groups. The treatment group undergoes the CABG + CD133+ procedure and the control group undergoes the CABG only. All research subjects underwent follow-up before and 6 months after the procedure. Fraction ejection, scar size, wall motion score index, ventricular dimensions, myocardial perfusion measured by cardiac MRI, 6 Minutes Walking Test (6MWT) and Minnesota Living with Heart Failure Questionnaire (MLHFQ) as an additional parameter for physical performance and quality of life. Data was analyzed using SPSS version 21 for Windows. Results: The results of the fraction ejection parameters showed a significant improvement in the treatment group, from 25.88±5.66% to 34.57%±11.31% compared to CABG only 30.18±3.85% to 31.61±7.89% (p=0.040), in the perfusion defect showed improvement but not significant, left ventricular end-systolic volume and left ventricular end-diastolic volume showed improvement with no significant result, scar size was found to be an improvement in the treatment group 10 persons (76.92%) compared to the control group 5 persons (38, 46%) (p=0.040), the wall motion score index and 6MWT showed a significant improvement in the treatment group (p=0.003 and p=0.03, respectively). The MLHFQ parameter showed improvement but not significant. Conclusion: CD 133+ stem cell implantation in patients with low ejection fraction who undergo CABG provides improved myocardial function and indirectly improves functional exercise capacity and patients’ quality of life. © 2021, Sanglah General Hospital. All rights reserved. |
CABG; CD133+ Stem cell; Functional exercise capacity |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
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#N/A |
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429 |
Ocviyanti D., Putri R.A. |
57189661230;57226166006; |
Biopsychosocial aspect of pregnant women suspected brainstem death [Aspek Biopsikososial pada Perempuan Hamil dengan Kecurigaan Mati Batang Otak] |
2021 |
Indonesian Journal of Obstetrics and Gynecology |
9 |
2 |
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107 |
110 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115419653&doi=10.32771%2finajog.v9i2.1269&partnerID=40&md5=41a14ffbc68b4ced0cd44396ae92afad |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Ocviyanti, D., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Putri, R.A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objective: Diagnosis of brainstem death and the vital organ function support in the pregnant woman to prolong gestation to attain fetal viability is still controversial. The decision is influenced by ethical and legal issue in the country. Another consideration is the hospital cost and health insurance coverage. This article purpose is to report a case and discuss the biopsychosocial aspect of this issue, so the doctors know how to decide a similar case. Methods: We reported a suspected brainstem death in pregnant women and discussed the holistic approach. Case: This case is a-38-year-old women, third pregnancy, 22 weeks of gestation, referred from the secondary hospital in a comatose condition. She was diagnosed with brainstem dysfunction due to intracranial mass and cerebral oedema. She wasn't diagnosed with brainstem death due to the electrolyte imbalance that can cause this condition. We did the multidisciplinary management approach. We decided the termination of pregnancy would only be performed if the fetus reaches 28 weeks of gestational age (with survival rate on perinatology is 31%). From the husband point of view, since the attending doctors have not declared the mother to be dead, then the husband still want to keep the mother in full life support. The patient and the fetus died on the 8th day of hospitalization. The patient was fully paid for by Indonesian Health Insurance. Conclusions: Maternal brainstem dysfunction and brainstem death during pregnancy are rare. In Indonesia, ethical and legal consideration to keep both mother and fetus are appropriate with the general social, cultural, and religious values. However, we recommend managing every single case individually with an intensive multidisciplinary approach due to the possibility of the different personal value of the patient. © Creative Commons Atribuição-Não Comercial 4.0 Internacional |
Brain death; Brainstem dysfunction; Ethic; Fetal; Legal; Pregnancy |
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Indonesian Society of Obstetrics and Gynecology |
23386401 |
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Article |
#N/A |
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