No records
|
447 |
Nugroho P., Lydia A., Suhardjono S., Harimurti K. |
55987056300;8451287200;57218776121;23473513200; |
Association of BsmI Polymorphisms in the Vitamin D Receptor Gene Among Indonesian Population with Diabetic Kidney Disease |
2021 |
Acta medica Indonesiana |
53 |
2 |
|
149 |
155 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111468637&partnerID=40&md5=791ec67dac5f5065a522a04484329da4 |
Division of Nephrology and Hypertension, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo HospitalJakarta, Indonesia |
Nugroho, P., Division of Nephrology and Hypertension, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo HospitalJakarta, Indonesia; Lydia, A.; Suhardjono, S.; Harimurti, K. |
BACKGROUND: Diabetic kidney disease (DKD), as a common cause of end-stage renal disease (ESRD), is a chronic complication of diabetes mellitus (DM). It has been established that vitamin D deficiency is one of DKD risk factors, which may be related to vitamin D receptor (VDR) polymorphisms. This study aimed to analyze the association between VDR polymorphisms and DKD in Indonesian population, also risk factors that influence it. METHODS: a cross-sectional study was conducted in Type 2 DM patients who visited internal medicine outpatient clinic at Dr. Cipto Mangunkusumo Hospital, Jakarta, from November 2014 until March 2015. Data collection includes characteristics of subjects and laboratory examination, including BsmI polymorphisms in the vitamin D receptor gene. Patients with acute and severe disease were excluded from the study. Bivariate and multivariate analyses were done. RESULTS: of 93 DM subjects, 42 (45.2%) subjects were without DKD and 51 (54.8%) subjects had DKD. Most of the subjects had the Bb genotype (89.2%), with no subject having the BB genotype. The proportions of the B and b alleles were 44.6% and 55.4%, respectively. There is no association between BsmI polymorphisms in the vitamin D receptor gene and DKD (OR = 1.243; CI 95% 0.334-4.621; p value = 0.751). CONCLUSION: the profile of BsmI polymorphisms in the vitamin D receptor gene in the Indonesian population were genotypes Bb (89.2%) and bb (10.8%). There was no association between BsmI polymorphisms in the vitamin D receptor gene and DKD. Duration of DM more than five years influenced the association between those variables. |
BsmI; diabetic kidney disease; Indonesia-Malay race; polymorphisms; vitamin D receptor (VDR) gene |
calcitriol receptor; VDR protein, human; aged; blood; case control study; complication; cross-sectional study; diabetic nephropathy; female; genetic polymorphism; genetics; genotype; human; Indonesia; male; middle aged; non insulin dependent diabetes mellitus; risk factor; very elderly; Aged; Aged, 80 and over; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Genotype; Humans; Indonesia; Male; Middle Aged; Polymorphism, Genetic; Receptors, Calcitriol; Risk Factors |
NLM (Medline) |
01259326 |
|
34251342 |
Article |
Q3 |
321 |
14162 |
|
|
448 |
Syam A.F., Pitoyo C.W., Suhendro S., Zulkarnain B., Indrasari N.D., Aditianingsih D., Irawan C., Susilo A., Rumende C.M., Wijaya I.P., Ibrahim F., Rasmin M., Alwi I., Makmun D. |
8443384400;26022606900;8443626100;57226403717;6506289872;56312263600;28767651600;57217867079;14325966300;57221504958;57226400046;15754578700;15055173800;16638046900; |
Tocilizumab as a Treatment for 'Cytokine Storm Syndrome' in COVID-19: A Case Report |
2021 |
Acta medica Indonesiana |
53 |
2 |
|
194 |
201 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111460182&partnerID=40&md5=9fddc7ae8a7dbf93ea0a07158c0ab2b2 |
Fellow of the American College of Physicians; Division of Gastroenterology, Dept. of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Syam, A.F., Fellow of the American College of Physicians; Division of Gastroenterology, Dept. of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pitoyo, C.W.; Suhendro, S.; Zulkarnain, B.; Indrasari, N.D.; Aditianingsih, D.; Irawan, C.; Susilo, A.; Rumende, C.M.; Wijaya, I.P.; Ibrahim, F.; Rasmin, M.; Alwi, I.; Makmun, D. |
Coronavirus disease 19 (COVID-19) which is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been a problem worldwide, particularly due to the high rate of transmission and wide range of clinical manifestations. Acute respiratory distress syndrome (ARDS) and multiorgan failure are the most common events observed in severe cases and can be fatal. Cytokine storm syndrome emerges as one of the possibilities for the development of ARDS and multiorgan failure in severe cases of COVID-19. This case report describes a case of a 53-year-old male patient who has been diagnosed with COVID-19. Further evaluation in this patient showed that there was a marked increase in IL-6 level in blood accompanied with hyperferritinemia, which was in accordance with the characteristic of cytokine storm syndrome. Patient was treated with tocilizumab, a monoclonal antibody and is an antagonist to IL-6 receptor. The binding between tocilizumab and IL-6 receptors effectively inhibit and manage cytokine storm syndrome. Although this case report reported the efficacy of tocilizumab in managing cytokine storm syndrome, tocilizumab has several adverse effects requiring close monitoring. Further clinical randomized control trial is required to evaluate the efficacy and safety of tocilizumab administration in participants with various clinical characteristics and greater number of subjects. |
acute respiratory distress syndrome (ARDS); COVID-19; SARS-CoV-2; Tocilizumab |
biological marker; interleukin 6; monoclonal antibody; tocilizumab; blood; case report; complication; cytokine release syndrome; human; male; middle aged; Antibodies, Monoclonal, Humanized; Biomarkers; COVID-19; Cytokine Release Syndrome; Humans; Interleukin-6; Male; Middle Aged; SARS-CoV-2 |
NLM (Medline) |
01259326 |
|
34251348 |
Article |
Q3 |
321 |
14162 |
|
|
449 |
Rumende C.M. |
14325966300; |
Pulmonary Fibrosis Caused by Severe COVID-19 Infection: Discharge May Not Be The End of Treatment |
2021 |
Acta medica Indonesiana |
53 |
2 |
|
141 |
142 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111424385&partnerID=40&md5=313ffbbdaf35e6b4ca2305e0cfcfa1a4 |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Rumende, C.M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Since December 2019, COVID-19 caused by SARS-CoV-2 infection has been spread rapidly in the world. Beside acute respiratory distress syndrome found in acute phase of infection, there is also pulmonary fibrosis as a chronic complication due to COVID-19. With the global pandemic of COVID-19, more and more autopsy and puncture histopathological results have been published.Until now there is no specific therapy to handle post-inflammatory pulmonary fibrosis due to COVID-19 infection. Several studies are ongoing to determine an effective treatment for this chronic complication. While ARDS appears to be the main cause of pulmonary fibrosis in COVID-19, the pathogenesis of ARDS caused by SARS-CoV-2 is different from the typical ARDS. Some therapies may be considered for reducing the fibrosis process in lung after COVI-19 infection namely pirfenidone, nintedanib and mesenchymal stem cells. Many patients are still recovering spontaneously in the first six weeks after acute COVID-19 infection and do not generally require fast-track entry into a pulmonary rehabilitation programme. However, those who have significantly persistent respiratory illness may need to be supported by pulmonary rehabilitation. Multidisciplinary intervention based on personalized evaluation and treatment which includes exercise training, education and behavioral modification can be given to improve the physical and psychological condition of patients with post-COVID pulmonary fibrosis. |
COVID-19; Indonesia; pulmonary fibrosis |
complication; hospital discharge; human; lung fibrosis; pandemic; virology; virus pneumonia; COVID-19; Humans; Pandemics; Patient Discharge; Pneumonia, Viral; Pulmonary Fibrosis; SARS-CoV-2 |
NLM (Medline) |
01259326 |
|
34251340 |
Editorial |
Q3 |
321 |
14162 |
|
|
450 |
Pujianto D., Oktarina M., Sharma Sharaswati I., Yulhasri Y. |
8745734300;57225172840;57225177505;57225180520; |
Hydrogen peroxide has adverse effects on human sperm quality parameters, induces apoptosis, and reduces survival |
2021 |
Journal of Human Reproductive Sciences |
14 |
2 |
|
121 |
128 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109421886&doi=10.4103%2fjhrs.jhrs_241_20&partnerID=40&md5=b51e205fbcc1300b22e8e8898e7a1c02 |
Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pujianto, D., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktarina, M., Master Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sharma Sharaswati, I., Master Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: One of the causes of male fertility disorders is the exposure of oxidative stress on the human sperm. Understanding the mechanism of disturbance is important to develop a better treatment for infertile or subfertile patients. Aims: The aim of this study was to analyze the effects of hydrogen peroxide (H2O2) on human sperm quality parameters and cell survival. Settings and Design: This study used an experimental design. Materials and Methods: Sperm cells from 15 donors were washed in a Percoll gradient and dissolved in Biggers, Whitter, and Whittingham medium. Cells were incubated with H2O2at various concentrations from 0 to 250 μM for 2 h. Sperm viability was examined by eosin assay, sperm kinetic by computer-assisted sperm analyzer, sperm penetration by cervical mucus penetration assay, and membrane integrity by hypo-osmotic swelling test. Sperm capacitation, apoptosis, and cell survival were analyzed using western immunoblotting. Statistical Analysis Used: One-way ANOVA on SPSS 21 combined with post hoc LSD test was used to analyze differences among the groups. A P < 0.05 was considered significant. Results: Sperm viability and kinetic were significantly reduced at H2O2concentrations of 200 and 250 μM. H2O2reduced sperm capability to penetrate cervical mucus and also damage cell membrane integrity at all concentrations used. H2O2significantly inhibited sperm capacitation, indicated by reduced total tyrosine phosphorylation. H2O2exposure stimulated activation of caspase 3 and significantly reduced phosphorylated AKT at all concentrations used. Conclusions: H2O2comprehensively inhibits sperm qualities related to the capacity to fertilize oocyte, stimulates caspase activity, and inhibits cell survival. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
AKT; capacitation; caspase; hydrogen peroxide; sperm |
caspase 3; hydrogen peroxide; malonaldehyde; protein kinase B; adverse event; analysis of variance; apoptosis; Article; cell survival; clinical article; densitometry; human; human cell; immunoblotting; kinetics; lipid peroxidation; male; male infertility; oxidative stress; post hoc analysis; protein phosphorylation; sperm capacitation; sperm preparation; sperm quality; sperm viability; spermatozoon penetration; uterine cervix mucus |
Wolters Kluwer Medknow Publications |
09741208 |
|
|
Article |
Q3 |
484 |
10359 |
|
|
451 |
Christian, Puruhita N., Himawan A., Muis S.F., Fasitasari M., Pangarsa E.A., Panigoro S.S., Sutandyo N. |
57224896360;57224902090;57224910728;57193264578;57192872474;57204907532;56790104300;26028099200; |
Fat intake in Javanese breast cancer patients: Any difference? |
2021 |
Bali Medical Journal |
10 |
1 |
|
320 |
324 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108565233&doi=10.15562%2fbmj.v10i1.2173&partnerID=40&md5=7840397cf684896b0d8d5929cbb1e87c |
Resident of Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Clinical Nutrition Department, SMC Telogorejo Hospital, Semarang, Indonesia; Faculty of Medicine, Universitas Islam Sultan Agung-Sultan Agung Islamic Hospital Semarang, Indonesia; Hematology-Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Oncology Surgery Division, Surgery Department, Faculty of Medicine, Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Hematology-Oncology Division, Internal Medicine Department, Dharmais National Cancer Centre Hospital, Jakarta, Indonesia |
Christian, Resident of Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Puruhita, N., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia, Clinical Nutrition Department, SMC Telogorejo Hospital, Semarang, Indonesia; Himawan, A., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia, Clinical Nutrition Department, SMC Telogorejo Hospital, Semarang, Indonesia; Muis, S.F., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Fasitasari, M., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia, Faculty of Medicine, Universitas Islam Sultan Agung-Sultan Agung Islamic Hospital Semarang, Indonesia; Pangarsa, E.A., Hematology-Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Panigoro, S.S., Oncology Surgery Division, Surgery Department, Faculty of Medicine, Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Sutandyo, N., Hematology-Oncology Division, Internal Medicine Department, Dharmais National Cancer Centre Hospital, Jakarta, Indonesia |
Background: Breast cancer is the second most prevalent women’s malignancy in Central Java. The risk of breast cancer incidence drops by 2.5 times for breast cancer if fat consumption is reduced by 50%, although not all types of fat intake increase the risk of breast cancer incidence. Fat consumption in Indonesia increased by 11% in the last 7 years. The study aims to analyze the differences in fat intake between breast cancer subjects and healthy subjects. Methods: This study is a cross-sectional study. We invited 45 outpatients diagnosed with breast cancer in Kariadi Hospital from January to August 2019 as well as 45 healthy subjects who are relatives or friends of the patients who met the inclusion criteria to participate in this study. Various types of fat intake were measured with quantitative food frequency questionnaires. The statistical analysis employed a chi-square test and Mann-Whitney test for non-parametric tests and an independent t-test for parametric data. Results: There was a significant difference in polyunsaturated fatty acid (PUFA) intake between breast cancer patients and healthy subjects (p=0.022). This study found no significant differences in total fat intake (p=0.677), saturated fatty acid (SFA) (p=0.368), monounsaturated fatty acid (MUFA) (p=0.593), omega 3 (p=0.095), omega 6 (p=0.092), and TFA (p=0.669) between breast cancer patients and healthy subjects. Conclusion: There is a significant difference in PUFA intake, but not in the other types of fat between breast cancer patients and healthy subjects. For further study, more precise and objective fat intake measurements may be achieved in studies with animal models. © 2021, Sanglah General Hospital. All rights reserved. |
Breast cancer; Fat; Intake; Nutrition |
|
Sanglah General Hospital |
20891180 |
|
|
Article |
#N/A |
#N/A |
#N/A |
|
|
452 |
Jusuf A.A., Viventius Y., Djaali W. |
57192275719;57223088537;57212479564; |
Comparison between the effectiveness of manual acupuncture and laser acupuncture at ex-b3 weiwanxiashu in a rat model of type 2 diabetes |
2021 |
JAMS Journal of Acupuncture and Meridian Studies |
14 |
2 |
|
75 |
81 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107546334&doi=10.51507%2fj.jams.2021.14.2.75&partnerID=40&md5=e5fc6b12ab3bd259eeccdf3c7d1658af |
Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Acupuncture, RSUPN Dr. CiptoMangunkusumo, Jakarta, Indonesia; Universitas Negeri Jakarta, Jakarta, Indonesia |
Jusuf, A.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Viventius, Y., Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Acupuncture, RSUPN Dr. CiptoMangunkusumo, Jakarta, Indonesia; Djaali, W., Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Negeri Jakarta, Jakarta, Indonesia |
Background: Diabetes mellitus (DM) is a chronic metabolic disease characterized by increased blood sugar levels. The current management of DM to date has a target of controlling blood glucose, but the therapy cannot be separated from long-term drug side effects. Acupuncture can be an option as an adjunct therapy for DM. Objectives: The purpose of this study was to compare the effectiveness between manual acupuncture and laser acupuncture. Methods: This study was a randomized control experimental study with a pretest and posttest design using 24 male Sprague-Dawley rats divided into 4 groups: A normal group, a diabetes group, an acupuncture group, and a laser group. Manual acupuncture and laser acupuncture were performed 6 times in two weeks. Fasting blood glucose (FBG) levels, the cell density of Langerhans islets, and side effects were assessed and compared among the 4 groups. Results: The highest mean cell density of Langerhans islets was found in the laser and acupuncture group, and the lowest was found in the diabetes group. In the post hoc analysis, the normal, acupuncture, and the laser groups had a significantly higher mean cell density than the diabetes group. The lowest mean FBG level was in the laser group, followed by the acupuncture group, and the highest was in the diabetes group, but this difference was not significant. There were no serious side effects from the use of manual acupuncture or laser acupuncture. Conclusion: Both manual acupuncture and laser acupuncture can improve the histological findings of Langerhans islets in type 2 diabetic rats, and both are safe to use. © 2021 Korean Pharmacopuncture Institute. All rights reserved. |
EX-B3; Laser acupuncture; Manual acupuncture; Type 2 diabetes |
glucose; acupuncture; acupuncture point; animal experiment; animal model; Article; cell density; comparative effectiveness; controlled study; erythema; fasting; glucose blood level; laser therapy; male; meichong acupoint; non insulin dependent diabetes mellitus; nonhuman; pancreas islet; post hoc analysis; rat; streptozotocin-induced diabetes mellitus |
Medical Association of pharmacopuncture Institute |
20052901 |
|
|
Article |
Q2 |
374 |
12741 |
|
|
453 |
Yani A., Dorothy D., Amaliah R. |
57215433374;57224003330;57224001785; |
Influence of Intestinal Strangulation Release on Ischemiareperfusion Injury in Sprague Dawley Rats |
2021 |
Annals of African Surgery |
18 |
2 |
|
90 |
95 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106736281&doi=10.4314%2fAAS.V18I2.6&partnerID=40&md5=611bcf09b29bda5c9a4b2e09279bdd15 |
Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Yani, A., Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Dorothy, D., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Amaliah, R., Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: In intestinal ischemia, reperfusion towards the injured intestine can cause further injury to the intestine itself and to remote organs. This research aimed to evaluate the influence of intestinal strangulation release (SR) before resection on the intestine outside margin of the strangulated intestine compared with subjects without intestinal strangulation release (WSR). Methods: Fourteen male Sprague Dawley rats were subjected to strangulation of one loop of the distal ileum for 4 h. In the SR group, the strangulated intestine was released for 5 min and then resected for necrotic parts. In the WSR group, the strangulated intestine was immediately resected WSR. The control group received a sham laparotomy. Four hours after the second laparotomy, the animals were sacrificed, and intestinal samples were taken for histomorphological analysis and measurement of intestinal malondialdehyde (MDA) level. Results: The injury on the histomorphological intestinal mucosa and intestinal MDA level were insignificantly higher in the SR group than in the WSR group (p>0.05). Conclusion: Intestinal SR before resection causes more tissue injury and oxidative stress on the intestine outside the strangulation section, but the difference is not statistically significant. © 2021 Surgical Society of Kenya. All rights reserved. |
Intestinal ischemia; Intestinal strangulation release; Intestine injury; Ischemia-reperfusion injury; Malondialdehyde |
ketamine; malonaldehyde; xylazine; animal experiment; animal model; animal tissue; Article; controlled study; histopathology; ileum; intestinal strangulation; intestine injury; intestine ischemia; intestine necrosis; laparotomy; male; nonhuman; oxidative stress; rat; reperfusion injury; sham procedure; small intestine obstruction; small intestine resection; Sprague Dawley rat |
Surgical Society of Kenya |
19999674 |
|
|
Article |
Q4 |
114 |
27851 |
|
|
455 |
Wang G., Tanaka A., Zhao H., Jia J., Ma X., Harada K., Wang F.-S., Wei L., Wang Q., Sun Y., Hong Y., Rao H., Efe C., Lau G., Payawal D., Gani R., Lindor K., Jafri W., Omata M., Sarin S.K. |
7407149871;57208572262;57200532284;57218488345;7404550067;57212924064;57216339526;7402950828;55531131800;56402234600;57188750283;8220686600;25122065500;36114075400;7801385732;23495930300;35418813000;23091123700;36043368300;57220191468; |
The Asian Pacific Association for the Study of the Liver clinical practice guidance: the diagnosis and management of patients with autoimmune hepatitis |
2021 |
Hepatology International |
15 |
2 |
|
223 |
257 |
|
7 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105607533&doi=10.1007%2fs12072-021-10170-1&partnerID=40&md5=eef4f926d521f19ad391095aa3af27f0 |
Peking University First Hospital, Beijing, China; Teikyo University School of Medicine, Tokyo, Japan; Beijing Friendship Hospital, Capital Medical University, Beijing, China; Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Kanazawa, Japan; Fifth Medical Center, Chinese PLA General Hospital, Beijing, China; Beijing Tsinghua Changgung Hospital, Beijing, China; Peking University People’s Hospital, Beijing, China; Department of Gastroenterology, Harran University, Åžanlıurfa, Turkey; Humanity and Health Medical Group, Hong Kong; Department of Hepatology, Cardinal Santos Medical Center, Manila, Philippines; Department of Internal Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; College of Health Solutions, Arizona State University, Phoenix, AZ, United States; Aga Khan University, Karachi, Pakistan; Department of Gastroenterology, Yamanashi Prefectural Central Hospital, Kofu-City, Yamanashi, Japan; The University of Tokyo, Tokyo, Japan; Institute of Liver and Biliary Sciences, New Delhi, India; Peking University International Hospital, Beijing, China |
Wang, G., Peking University First Hospital, Beijing, China, Peking University International Hospital, Beijing, China; Tanaka, A., Teikyo University School of Medicine, Tokyo, Japan; Zhao, H., Peking University First Hospital, Beijing, China, Peking University International Hospital, Beijing, China; Jia, J., Beijing Friendship Hospital, Capital Medical University, Beijing, China; Ma, X., Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Harada, K., Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Kanazawa, Japan; Wang, F.-S., Fifth Medical Center, Chinese PLA General Hospital, Beijing, China; Wei, L., Beijing Tsinghua Changgung Hospital, Beijing, China; Wang, Q., Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Sun, Y., Fifth Medical Center, Chinese PLA General Hospital, Beijing, China; Hong, Y., Peking University First Hospital, Beijing, China; Rao, H., Peking University People’s Hospital, Beijing, China; Efe, C., Department of Gastroenterology, Harran University, Åžanlıurfa, Turkey; Lau, G., Humanity and Health Medical Group, Hong Kong; Payawal, D., Department of Hepatology, Cardinal Santos Medical Center, Manila, Philippines; Gani, R., Department of Internal Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Lindor, K., College of Health Solutions, Arizona State University, Phoenix, AZ, United States; Jafri, W., Aga Khan University, Karachi, Pakistan; Omata, M., Department of Gastroenterology, Yamanashi Prefectural Central Hospital, Kofu-City, Yamanashi, Japan, The University of Tokyo, Tokyo, Japan; Sarin, S.K., Institute of Liver and Biliary Sciences, New Delhi, India |
[No abstract available] |
|
6 mercaptopurine derivative; azathioprine; budesonide; corticosteroid; cyclosporine; farnesoid X receptor; infliximab; mycophenolate mofetil; prednisone; rapamycin; tacrolimus; antibody detection; Asia; autoimmune hepatitis; autoimmunity; cataract; chronic liver disease; clinical practice; cytokine production; decompensated liver cirrhosis; diabetes mellitus; disease predisposition; drug efficacy; drug exposure; drug safety; dual energy X ray absorptiometry; environmental factor; gene locus; genetic susceptibility; geographic distribution; human; hypertension; immunoglobulin blood level; immunological tolerance; immunoregulation; incidence; liver biopsy; liver cell carcinoma; liver transplantation; magnetic resonance elastography; nonalcoholic fatty liver; Note; osteoporosis; Pacific islan |
Springer |
19360533 |
|
33942203 |
Note |
Q2 |
1304 |
2874 |
|
|
456 |
Bahtiar A., Setyowati H., Mahanani R., Wati A., Arsianti A., Fadilah F. |
35365874400;57223255498;57223266884;57223271215;36124567000;56966708600; |
Rhaponticin contained Rheum officinale root extract improved Postmenopause symptom of Ovariectomized Rat |
2021 |
Journal of Advanced Pharmaceutical Technology and Research |
12 |
2 |
|
175 |
179 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105384592&doi=10.4103%2fjaptr.JAPTR_324_20&partnerID=40&md5=1f1fbda205bf337ab7c1628298d5d1ba |
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Jl, Salemba Raya, Jakarta, Indonesia |
Bahtiar, A., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Setyowati, H., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Mahanani, R., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Wati, A., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Arsianti, A., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Jl, Salemba Raya, Jakarta, Indonesia; Fadilah, F., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Jl, Salemba Raya, Jakarta, Indonesia |
Postmenopausal women have decreased levels of the hormone estrogen. Reduced estrogen levels will often involve many symptoms that reduced quality of life. This research aims to analyze the effects of Rheum officinale root extract on postmenopausal model rats. To this end, thirty rats underwent ovariectomy (OVX) surgery and six rats were operated without having their ovaries removed. The OVX was confirmed by body weight-uterus weight ratio and a vaginal swab. Six groups of the rats were performed: SHAM group and negative control groups are given vehicle; the positive control was assigned tamoxifen; and the extract has been given three doses 7, 35, and 175 mg/200 g BW, respectively, for 30 days. The calcium content of bone ash was measured using atomic absorption spectrophotometer. Blood pressure was evaluated using CODA®, and the metabolites in the blood were assessed using gas chromatography-mass spectrometry (MS) and high-performance liquid chromatography. As a result, using ultra-performance liquid chromatography (UPLC)-MS, we found that the extract's major component was rhaponticin and its metabolites. The bone calcium levels increased with increasing doses of the extract. In the OVX group, the bone calcium content was decreased significantly 51.56% ± 8.9% g compared with the SHAM group 62.97% ±5.6% g, and the administration of Rheum extract could restore the calcium content of the bone to become 69.27% ± 3.8% g. From the above data, we concluded that Rheum root extracts contain astrigin, rhaponticin, rhapontigenin, and desoxyrhaponticin. Rheum root extract could improve calcium content and lipid profiles of OVX rats by stimulation osteoblastogenesis. Rheum root extracts could control the blood pressure of OVX rats by reducing lipid profiles. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Calcium; hypertension; Kalembak; lipid profiles; osteoporosis; postmenopausal; rhaponticin; Rheum officinale |
antihypertensive agent; astringin; calcium; cholesterol; desoxyrhaponticin; high density lipoprotein; low density lipoprotein; rhapontigenin; rhapontin; Rheum officinale extract; tamoxifen; triacylglycerol; unclassified drug; analytical parameters; animal experiment; animal model; animal tissue; antihypertensive activity; Article; atomic absorption spectrometry; blood pressure measurement; body weight; body weight gain; body weight uterus weight ratio; bone density; calcium bone level; comparative study; controlled study; diastolic blood pressure; drug effect; female; high performance liquid chromatography; hypertension; Indonesia; lipid fingerprinting; mass fragmentography; nonhuman; ovariectomy; plant root; postmenopause; priority journal; protein analysis; rat; rat model; retention time |
Wolters Kluwer Medknow Publications |
01105558 |
|
|
Article |
Q3 |
325 |
14045 |
|
|
458 |
Maya E., Viventius Y., Simadibrata C.L., Mihardja H.M. |
57223091162;57223088537;57194343459;57195721818; |
How Do You Treat Psoriasis in Your Practice? (1) |
2021 |
Medical Acupuncture |
33 |
2 |
|
176 |
177 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104761989&doi=10.1089%2facu.2021.29172.cpl&partnerID=40&md5=e14f9573d53cf3e921e8ec273656b471 |
Medistra Hospital, Jl. Gatot Subroto No. 59, RW 4, Kuningan Tim., Kota Jakarta Selatan, Daerah Khusus Ibukota, 12950, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Daerah Khusus Ibukota, Jakarta, 10430, Indonesia; Center of Development and Application of Traditional Medicine, Daerah Khusus Ibukota, Jakarta, 10160, Indonesia |
Maya, E., Medistra Hospital, Jl. Gatot Subroto No. 59, RW 4, Kuningan Tim., Kota Jakarta Selatan, Daerah Khusus Ibukota, 12950, Indonesia; Viventius, Y., Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Daerah Khusus Ibukota, Jakarta, 10430, Indonesia; Simadibrata, C.L., Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Daerah Khusus Ibukota, Jakarta, 10430, Indonesia; Mihardja, H.M., Center of Development and Application of Traditional Medicine, Daerah Khusus Ibukota, Jakarta, 10160, Indonesia |
[No abstract available] |
|
methotrexate; acupuncture; acupuncture point; adult; case report; clinical article; dermatologist; female; hospital admission; human; medical history; Note; physical examination; priority journal; psoriasis; Psoriasis Area and Severity Index |
Mary Ann Liebert Inc. |
19336586 |
|
|
Note |
Q2 |
281 |
15498 |
|
|