No records
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488 |
Djaja Y.P., Prasetia R., Santoso A., Rahyussalim A.J., Mustamsir E., Dilogo I.H. |
57191042059;57196246350;57194659467;55212166100;57196246488;56161962800; |
A decade of evolution in Indonesian orthopedic publication: A bibliographic report |
2021 |
Journal of Clinical Orthopaedics and Trauma |
15 |
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110 |
116 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092623352&doi=10.1016%2fj.jcot.2020.10.016&partnerID=40&md5=54bca8c1ea47f4019dfac052838cc471 |
Department of Orthopedic & Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Faculty of Medicine, Department of Orthopaedic Surgery, Universitas Padjadjaran, Bandung, Indonesia; Department of Orthopaedic and Traumatology, Sebelas Maret University, Prof Dr R Soeharso Orthopaedic Hospital, Solo, Indonesia; Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia |
Djaja, Y.P., Department of Orthopedic & Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Prasetia, R., Faculty of Medicine, Department of Orthopaedic Surgery, Universitas Padjadjaran, Bandung, Indonesia; Santoso, A., Department of Orthopaedic and Traumatology, Sebelas Maret University, Prof Dr R Soeharso Orthopaedic Hospital, Solo, Indonesia; Rahyussalim, A.J., Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mustamsir, E., Department of Orthopaedics and Traumatology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia; Dilogo, I.H., Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
During the past decade, there was an increasing interest in orthopedic research in Indonesia. Therefore we aimed to investigate the profile of Indonesian orthopedic trend publication from 2010 to 2019. Systematic research was conducted to identify all orthopedic articles authored by Indonesian orthopedic surgeons. Article details (number of authors, authors’ affiliation, publishing journal), type of author's affiliation, affiliate collaboration, study field, type, and level of evidence (LOE) were recorded and evaluated. Publishing journal metric and author h-index were also recorded. Descriptive statistics were used to summarize the data. Two hundred and twenty articles were included in our study. Clinical studies were the most common article type, followed by case reports and basic science. Among clinical articles, therapeutic studies were found significantly more frequent. On the other hand, economic studies were not found in this study period. The most popular field was oncology, followed by knee and spine. The average number of authors per article was 5.23 with a total of 205 individuals who had contributed during this decade. University hospital was the most common affiliation found and single-center study was the most common affiliate collaboration. The most common level of evidence was level V (case reports). Eighty-seven specific publishing journals were identified. More than 42% of the articles were published in journals with SJR between 0.25 and 0.50. The average author h-index was 3.56 (0–7). Although there was an increasing trend and quantity of publications among Indonesian authors, most articles had level 5 evidence (case reports) and the quality of publishing journals was mostly Q3 with a low-moderate SJR. Improvement of the article's quality and institutional collaboration will be needed for future contribution in global orthopedic society. © 2020 Delhi Orthopedic Association |
Bibliographic; Indonesia; Orthopedic article; Publication trend |
adult; female; human; human experiment; Indonesia; knee; major clinical study; male; orthopedic surgeon; publishing; review; spine; university hospital |
Elsevier B.V. |
09765662 |
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Review |
Q3 |
471 |
10597 |
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489 |
Pranata R., Tondas A.E., Huang I., Lim M.A., Siswanto B.B., Meyer M., Mitrovic V. |
57201973901;57211111907;57208576645;57216039756;14422648800;57217373886;36008843300; |
Potential role of telemedicine in solving ST-segment elevation dilemmas in remote areas during the COVID-19 pandemic |
2021 |
American Journal of Emergency Medicine |
42 |
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242 |
243 |
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10 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086651966&doi=10.1016%2fj.ajem.2020.06.012&partnerID=40&md5=c3d261a0e2fe3a8f2757142babbe0759 |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia; Biomedicine Doctoral Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas, Jakarta, Indonesia; Department of Cardiology, Kerckhoff-Klinik, Bad Nauheim, Germany |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Tondas, A.E., Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia, Biomedicine Doctoral Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Meyer, M., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas, Jakarta, Indonesia; Mitrovic, V., Department of Cardiology, Kerckhoff-Klinik, Bad Nauheim, Germany |
[No abstract available] |
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troponin; acute coronary syndrome; blood clot lysis; cardiologist; cardiovascular risk; coronavirus disease 2019; echocardiography; electrocardiography; heart ventricle wall motion; human; incidence; Letter; myocarditis; pandemic; practice guideline; priority journal; risk factor; ST segment elevation; ST segment elevation myocardial infarction; takotsubo cardiomyopathy; telecardiology; telemedicine; epidemiology; health care delivery; organization and management; prevention and control; rural health care; ST segment elevation myocardial infarction; telemedicine; COVID-19; Health Services Accessibility; Humans; Rural Health Services; ST Elevation Myocardial Infarction; Telemedicine |
W.B. Saunders |
07356757 |
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32561139 |
Letter |
Q1 |
725 |
6828 |
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490 |
Oswari H., Kresnawati W., Yani A., Handjari D.R., Alatas F.S. |
12777323800;57210461975;57215433374;56160657900;57217150164; |
Abdominal Injury-Induced Gastric Outlet Obstruction in Primary Hypertrophic Pyloric Stenosis in Adolescent |
2021 |
Indian Journal of Surgery |
83 |
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264 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080887785&doi=10.1007%2fs12262-020-02097-y&partnerID=40&md5=341dca515f2fe3bdfc0a38dee8ba2ddb |
Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Department of Pediatric Surgery, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathology Anatomy, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Oswari, H., Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Kresnawati, W., Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Yani, A., Department of Pediatric Surgery, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handjari, D.R., Department of Pathology Anatomy, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Alatas, F.S., Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia |
[No abstract available] |
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Springer |
09722068 |
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Letter |
Q4 |
183 |
20483 |
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491 |
Susanto A.D., Triyoga P.A., Isbaniah F., Fairuz A., Cendikiawan H., Zaron F., Aryanti I., Irbah S.N., Hidayat M. |
57190425587;57222896246;36489441300;57222895896;57222896833;57222896488;57222896415;57222896232;56435992700; |
Lung fibrosis sequelae after recovery from COVID-19 infection |
2021 |
Journal of Infection in Developing Countries |
15 |
3 |
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360 |
365 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104167707&doi=10.3855%2fjidc.13686&partnerID=40&md5=622edaeb2b1f79f472a58df7a7dfdca2 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Lung Clinic, Eka Hospital Cibubur, West Java, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Faculty of Medicine, University of Mataram, Mataram, West Nusa Tenggara, Indonesia |
Susanto, A.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia, Lung Clinic, Eka Hospital Cibubur, West Java, Indonesia; Triyoga, P.A., Lung Clinic, Eka Hospital Cibubur, West Java, Indonesia; Isbaniah, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Fairuz, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cendikiawan, H., Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Zaron, F., Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Aryanti, I., Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Irbah, S.N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hidayat, M., Faculty of Medicine, University of Mataram, Mataram, West Nusa Tenggara, Indonesia |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that causes coronavirus diseases 2019 (COVID-19). The SARS-CoV-2 is very contagious and nobody is known to be immune to it. The post-infected lung would leave a scar known as fibrosis, a scar tissue. A study from Wuhan, China suggested the development of fibrosis, though it was too early to label these lung changes as irreversible fibrosis in a time range of 3 weeks. The occurrence of fibrosis indicates a chronic infection which greatly contributes to the hallmark symptom of COVID-19 induced ARDS such as shortness of breath and chest pain. However, many of those studies have not yet explained the condition of the patient's lung after total recovery from the COVID-19. This report demonstrates the clinical symptoms, chest CT scan, spirometry, and blood gas analysis of patient after total recovery from the COVID-19 with appearance lung fibrosis. Copyright © 2021 Susanto et al. |
COVID-19; Lung fibrosis; Recovery |
ascorbic acid plus vitamin B complex; azithromycin; beta 2 adrenergic receptor stimulating agent; chloroquine; corticosteroid; hemoglobin; levofloxacin; meropenem; oseltamivir; adult; adult respiratory distress syndrome; Article; blood gas analysis; breathing rate; case report; cell count; clinical article; computer assisted tomography; coronavirus disease 2019; coughing; dyspnea; fever; forced expiratory volume; forced vital capacity; ground glass opacity; headache; hospitalization; human; lung examination; lung fibrosis; male; middle aged; nose smear; oropharyngeal swab; oxygen saturation; oxygen therapy; physical examination; pneumonia; quality of life; real time polymerase chain reaction; rhinorrhea; Severe acute respiratory syndrome coronavirus 2; spirometry; thorax pain; thorax radio |
Journal of Infection in Developing Countries |
20366590 |
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33839710 |
Article |
Q3 |
322 |
14136 |
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494 |
Turu' Allo I.J., Santoso A., Findyartini A. |
57222645159;36905206100;56543777300; |
Cardiology trainees' attitudes towards clinical supervision: a scale development study |
2021 |
International journal of medical education |
12 |
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38 |
44 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103608400&doi=10.5116%2fijme.604a.4964&partnerID=40&md5=d05fe194366331389db166e4ab3e2b62 |
Medical Education Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Cardiology-Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Centre-Harapan Kita HospitalJakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Turu' Allo, I.J., Medical Education Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Santoso, A., Department of Cardiology-Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Centre-Harapan Kita HospitalJakarta, Indonesia; Findyartini, A., Department of Medical Education, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Objectives: This study aims to explore the construct validity, dimensionality, and internal consistency of a new attitude scale for measuring cardiology trainees' attitudes towards clinical supervision. Methods: A multi-centred, cross-sectional study involving 388 Indonesian cardiology trainees from eight universities was conducted using convenience sampling. Twenty-nine items have been generated based on an extensive literature review and conceptual framework of effective clinical supervision. Ten clinical experts reviewed the items to ensure the Cardiology Clinical Supervision Scale (CCSS) adequately represents the construct under study. An exploratory factor analysis using principal axis factoring (PAF) with oblique rotation was run to identify the internal structure of the scale. Items with factor loading <0.50 were deleted. In addition, inter-item correlations and items' communalities were analysed. Each subscale's internal consistency was assessed using Cronbach's alpha score. Results: The content validity index provided evidence for CCSS' validity (G-coefficient=0.71). Scrutinising the experts' comments, we finalised the scale to include 27 items. Further, four items were deleted due to low inter-item correlation and communality. PAF analysis resulted in a two-factor model comprising the "Supervisory Interaction and Facilitation" factor (n=10 items) and the "Role Modelling" factor (n=9 items); four items were deleted due to low factor loading. The Cronbach's alpha score for SIF and RM factors were 0.93 and 0.89, respectively. Conclusions: The study's results support the validity, internal structure, and internal consistency of the new clinical supervision scale for cardiology training. Further studies are required to investigate other validity and reliability evidence for CCSS, including its cross-cultural validity. |
cardiology training; clinical supervision; scale development |
attitude; cardiology; cross-sectional study; human; psychometry; questionnaire; reproducibility; Attitude; Cardiology; Cross-Sectional Studies; Humans; Psychometrics; Reproducibility of Results; Surveys and Questionnaires |
NLM (Medline) |
20426372 |
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33772563 |
Article |
Q2 |
592 |
8541 |
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521 |
Gunardi E.R., Putri R.A., Pasidri Y. |
57192910998;57226166006;57226151144; |
A prospective study of effectivity, expulsion, and acceptability of post-placental iud cu t380a insertion using clamp in a tertiary hospital |
2021 |
Journal of SAFOG |
13 |
2 |
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92 |
96 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110568167&doi=10.5005%2fjp-journals-10006-1884&partnerID=40&md5=fce9faf05542751a7f70c62d508122a7 |
Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Putri, R.A., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pasidri, Y., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Aim: Intrauterine device (IUD) has a high effectivity of long-term contraception method. Post-placental IUD increases the number of contraception use and decreases the unmet need for contraception. The purposes of this study were to evaluate the effectivity, expulsion, acceptability, and side effects of post-placental IUD insertion using a clamp at Dr. Cipto Mangunkusumo National General Hospital. Materials and methods: This prospective longitudinal observational study was conducted at a tertiary teaching hospital (Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia) from April 2018 to March 2019. Post-placental IUD was inserted using a clamp. We interviewed the patients at 3 months and 6 months after insertion to evaluate the outcome. A total of 94 women were included in this study. Results: The effectivity was 100%. The expulsion rate was 2.13, 3.45, and 0% at 6 weeks, 3 months, and 6 months, respectively. The total acceptability rate at 6 weeks, 3 months, and 6 months was 96.81, 93.3, and 90.8%, respectively. Most of the subjects were satisfied with the IUD contraception at 3 months and 6 months. Conclusion: Post-placental IUD insertion using a clamp had good safety, effectivity, acceptance, and satisfaction. This data could be used for family planning counseling in daily practice. Post-placentaI IUD insertion should be routinely offered to all eligible postpartum women undergoing institutional deliveries. © Jaypee Brothers Medical Publishers. |
Acceptability; Effectivity; Expulsion; Insertion using a clamp; Post-placental IUD |
abdominal pain; adult; Article; bleeding; cesarean section; clinical outcome; contraception; controlled study; counseling; dyspareunia; family planning; female; follow up; gestational age; health care facility; human; hysterectomy; intrauterine device expulsion; lactation; longitudinal study; major clinical study; menstrual cycle; menstruation disorder; observational study; patient satisfaction; percutaneous coronary intervention; postpartum hemorrhage; postpartum pain; pregnancy; pregnancy outcome; pulse rate; questionnaire; tablet disintegration time; tertiary care center; unwanted pregnancy; vagina bleeding; vagina discharge (disease); vaginal delivery |
Jaypee Brothers Medical Publishers (P) Ltd |
09748938 |
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Article |
Q4 |
108 |
29032 |
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522 |
Purwati N.H., Rustina Y., Supriyatno B. |
57224632280;55387850300;37068046400; |
Knowledge and healthcare-seeking behavior of family caregivers of children with pneumonia: A qualitative study in an urban community in Indonesia |
2021 |
Belitung Nursing Journal |
7 |
2 |
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107 |
112 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108107503&doi=10.33546%2fbnj.1268&partnerID=40&md5=a367278f4ff9f46d380f198e1e3929ee |
Faculty of Nursing, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia; Faculty of Nursing, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purwati, N.H., Faculty of Nursing, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia; Rustina, Y., Faculty of Nursing, Universitas Indonesia, Jakarta, Indonesia; Supriyatno, B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Childhood pneumonia is the leading cause of death. Family caregivers may have a poor understanding of pneumonia, especially related to prevention and treatment. It is crucial to understand country-specific knowledge and healthcare-seeking behaviors of caregivers of children with pneumonia before planning programmatic responses, particularly in an urban community where the culture-social economic status is diverse. Objective: This study aimed to describe the knowledge and healthcare-seeking behavior of family caregivers of children with pneumonia in Indonesia's urban community. Methods: A descriptive qualitative study was conducted at a public hospital in Jakarta, Indonesia, from 10 December 2019 to 28 January 2020. Ten family caregivers of children with pneumonia were included, and a semi-structured interview was conducted for data collection. The audio recording was transcribed verbatim, and the data were analyzed using content analysis. Results: The emerged data indicated low knowledge of the family caregivers, especially mothers, which considered pneumonia a common cold only, and they failed to understand the risk of its transmission. Using traditional medicines was the first stage of healthcare-seeking behavior. If the symptoms worsened, the caregivers brought their children to the nearest health center. If there was no change in the symptoms, they headed to the hospital. The health center's location, condition, services, and staff attitude were considered factors to choose the services. Conclusion: Living in an urban area does not guarantee the family caregivers have better knowledge and good healthcare-seeking behavior. Therefore, nurses should provide comprehensive education about pneumonia, its symptoms, and treatment management to improve family care and prevent pneumonia-related deaths. Integrated management of children with illness is recommended to help the family caregivers of children with pneumonia receive treatment as quickly as possible. © The Author(s) 2021 |
Caregivers; Common cold; Healthcare-seeking behavior; Indonesia; Knowledge; Mothers; Nursing; Pneumonia |
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Belitung Raya Publisher - Belitung Raya Foundation |
24774073 |
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Article |
#N/A |
#N/A |
#N/A |
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523 |
Octaviana F., Bestari A., Loho A., Indrawati L., Wiratman W., Kurniawan M., Sugiarto A., Budikayanti A. |
26029958700;57223262097;57223264641;57205117182;57191920526;57196001182;57189612291;57194713932; |
Nonconvulsive Status Epilepticus in Metabolic Encephalopathy in Indonesia Referral Hospital |
2021 |
Neurology India |
69 |
2 |
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354 |
359 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105413010&doi=10.4103%2f0028-3886.314533&partnerID=40&md5=41f369c55e5b08a8b0bd905ac5493afd |
Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Octaviana, F., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Bestari, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Loho, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Indrawati, L., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wiratman, W., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Kurniawan, M., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sugiarto, A., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Budikayanti, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background: Nonconvulsive status epilepticus (NCSE) is often underdiagnosed in patients with metabolic encephalopathy (ME). The diagnosis of ME should be made specifically to recognize the underlying etiology. Delay in seizure identification and making a diagnosis of NCSE contributed to the poor outcome. Objective: This study aimed to find the incidence and outcome of NCSE in patients with ME. Methods and Material: This was an observational prospective cross-sectional study in patients with ME in emergency and critical care units in Cipto Mangunkusumo General Hospital. The diagnosis of NCSE was based on EEG using Salzburg Criteria for Nonconvulsive Status Epilepticus (SCNC). The outcome was assessed within 30 days after the NCSE diagnosis has been made. Results: A total of 50 patients with ME were involved in this study. NCSE was confirmed in 32 subjects (64%). The most common etiology of ME was sepsis (58%). The mortality rate in the NCSE and non-NCSE group was 40.6% vs 44.4%. Multiple aetiologies were risk factors to poor outcome in the NCSE group. Conclusions: The incidence of NCSE among patients with ME at our hospital was high. Despite the anti-epileptic treatment of the NCSE group, the underlying cause of ME is still the main factor that affected the outcome. Therefore, aggressive treatment of anti-epileptic drug (AED) should be very carefully considered knowing the possible side-effect that might worsen the outcome of patients with ME. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Metabolic encephalopathy; mortality; non-convulsive status epilepticus |
diazepam; levetiracetam; midazolam; phenobarbital; phenytoin; propofol; valproic acid; adult; Article; clinical article; cross-sectional study; electroencephalography; epileptic state; female; human; incidence; Indonesia; male; metabolic encephalopathy; mortality rate; nonconvulsive status epilepticus; observational study; prognosis; risk factor; sepsis; epileptic state; hospital; metabolic encephalopathy; patient referral; prospective study; Brain Diseases, Metabolic; Cross-Sectional Studies; Electroencephalography; Hospitals; Humans; Indonesia; Prospective Studies; Referral and Consultation; Status Epilepticus |
Wolters Kluwer Medknow Publications |
00283886 |
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33904451 |
Article |
Q3 |
339 |
13675 |
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524 |
Purwaningsih E.H., Oertl A., Freisleben S.K.U., Freisleben H.-J. |
57186723500;6508320409;57192904042;7003437337; |
How can immunosuppression after organ transplantation be made more effective and safer? - A review on liposomal formulations with consideration of archaeal tetraetherlipid |
2021 |
Biomedical and Pharmacology Journal |
14 |
1 |
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33 |
52 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104470529&doi=10.13005%2fbpj%2f2097&partnerID=40&md5=d0059a38fb0687012c274dcda3c60c0f |
Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia; Faculty of Medicine, Goethe-University Frankfurt/Main, Germany; Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany; Faculty of Natural Sciences, University of Indonesia, Jakarta-Depok, Indonesia |
Purwaningsih, E.H., Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia; Oertl, A., Faculty of Medicine, Goethe-University Frankfurt/Main, Germany, Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany; Freisleben, S.K.U., Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany, Faculty of Natural Sciences, University of Indonesia, Jakarta-Depok, Indonesia; Freisleben, H.-J., Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia, Faculty of Medicine, Goethe-University Frankfurt/Main, Germany |
Immune-suppressive agents such as methylprednisolone and cyclosporine exert tremendous side effects, because of high dosage and long-term application required for immune suppression after organ transplantation. Major side effects of methylprednisolone include bleeding of the gastro-intestinal tract, hypertension, and osteoporosis, whereas cyclosporine is nephrotoxic. Liposomes are phospholipid particles that allow delivery of drugs preferentially to the reticuloendothelial system. They can be prepared from phospholipids, such as lecithin from soybean or egg yolk, other specific or modified lipids or from membrane-spanning tetraether lipid (TEL), which can be extracted and purified from archaeal cell membranes. One advantage in the use of liposomal application is reduced toxicity of many drugs. We report on various liposomal preparations of cyclosporine, methylprednisolone (L-MPL) and its palmitate derivative (L-MPLP). It has been documented that liposomal cyclosporine A (L-CsA), 1.75 mg/kg/ day for seven days has potential for use as an immune-suppressive agent in rats with increased efficacy and decreased nephrotoxicity compared to commercially available forms of intravenous CsA. Liposomal methylprednisolone (L-MPL) 2 mg/kg, intravenously (IV), twice a week shows significantly prolonged cardiac allograft survival in rats and tissue-selective sequestration of the drug in comparison with the same dosage regimen of methylprednisolone in solution, administered daily. We report on organ distribution of L-MPLP in rats after intraperitoneal (IP) administration. Conclusion: Liposomal preparations of immunosuppressants have significantly higher immune-suppressive potential and lower toxicity than non-liposomal preparations. Bipolar TEL can be extracted, fractionated and purified from archaea to form stable liposomes which are extremely resistant, even to gastric fluid. Hence, TEL liposomes allow (besides IV and IP) for oral administration of immunosuppressants after organ transplantation with pharmacological and toxicological advantages over common liposomal phospholipid bilayer preparations. © 2021 Oriental Scientific Publishing Company. All rights reserved. |
Absorption; Allograft; Cyclosporine; Gastrointestinal stability; Immunosuppressant; Liposomes; Methylprednisolone; Oral administration; Organ transplantation; Toxicity |
alamethicin; albumin; cholesterol; coumarin; cyclosporine; dexamethasone; globulin; glucocorticoid; interleukin 1; liposome; lymphokine; methylprednisolone; phosphatidylcholine; phosphatidylglycerol; phospholipid; tumor necrosis factor; affinity chromatography; allograft; archaeon; Article; bioavailability; cytotoxicity; drug release; drug therapy; egg yolk; electron microscopy; encapsulation; fluorescence; gastrointestinal tract; gel filtration chromatography; helper cell; histocompatibility; human; hypertension; immune response; immunological tolerance; immunosuppressive treatment; lipophilicity; liposomal delivery; macrophage; nephrotoxicity; organ transplantation; osteoporosis; phagocytosis; reticuloendothelial system; soybean; stomach juice; T lymphocyte; thin layer chromatography |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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525 |
Pasmanasari E.D., Pawitan J.A. |
57189246168;6508348067; |
The potential of electromyography signals as markers to detect and monitor Parkinson's disease |
2021 |
Biomedical and Pharmacology Journal |
14 |
1 |
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373 |
378 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104382880&doi=10.13005%2fbpj%2f2136&partnerID=40&md5=7df22fa914ed12da461baa35f3e9c2be |
Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia |
Pasmanasari, E.D., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia |
Parkinson disease (PD) is a neurodegenerative disease that causes the loss of dopaminergic neurons in the brain. The imbalance in dopamine production causes motoric disorder that can produce specific electrical signal that can be detected by electromyography. Some methods were developed to diagnose PD and the use of a questionnaire and clinical observation was widely used to diagnose the disease. The limitation of the methods includes the fact that there are some differences in assessment results from clinicians due to the need of experience. The use of electromyography hopefully can obtain an objective assessment that can be easily used by clinicians. Some studies showed differences between normal muscle electric-activity compared to PD related abnormal muscle electric activity. Some methods were developed to use electromyography as a tool to diagnose PD related motoric symptoms, such as rigidity, gait abnormality and tremor. The use of electric signals, which are produce in muscle contraction, as markers to diagnose PD, as well as to monitor complications and the effect of therapy hopefully can be developed. In this review article, we will discuss about the use of electromyography signals that are related to PD. Therefore we will explain about basics of electromyography, the use of electromyography signals to detect tremor and gait abnormalities in PD, the use of electromyography for monitoring PD patients. © 2021 Oriental Scientific Publishing Company. All rights reserved. |
Dysphagia; Electromyography; Gait; Parkinson's disease; Tremor |
biological marker; Article; artificial neural network; dysphagia; electromyography; gait; human; nuclear magnetic resonance imaging; Parkinson disease; positron emission tomography; questionnaire; sensitivity and specificity; single photon emission computed tomography; transcranial Doppler ultrasonography; tremor |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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