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239 |
Sobri F.B., Bachtiar A., Panigoro S.S., Rahmaania J.C., Yuswar P.W., Krisnuhoni E., Tandiari N. |
57217500979;56683183900;56790104300;57252632900;57253490900;35310982200;57252633000; |
Strategy for diagnosing breast cancer in Indonesia during the COVID-19 pandemic: Switching to ultrasound-guided percutaneous core needle biopsy |
2021 |
Kesmas |
16 |
3 |
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151 |
157 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114650507&doi=10.21109%2fkesmas.v16i3.4359&partnerID=40&md5=dbf4756507a59d7c2f87cc7eb69f6787 |
Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Department of Surgical Oncology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pathology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Department of Radiology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia |
Sobri, F.B., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia, Department of Surgical Oncology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Bachtiar, A., Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Panigoro, S.S., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmaania, J.C., Department of Surgery, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Yuswar, P.W., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Krisnuhoni, E., Department of Pathology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Tandiari, N., Department of Radiology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia |
In this era of COVID-19, suspected breast cancer patients experience delay in diagnosis due to the fear of contracting the virus and reduction of non-COVID-19 health services. Furthermore, it may lead to potential increase in the incidence of advanced cancers in the future. Ultrasound-guided (US-guided) percutaneous core needle biopsy (CNB) is a great option for the diagnosis of cancer but it is poorly utilized. This study aimed to prove that the US-guided CNB is accurate when performed in a local setting and a potential solution for diagnosing breast cancer patients in this pandemic. In addition, it was a single health center cross-sectional study, and the participants were all breast cancer patients that had US-guided CNB from 2013-2019. The pathology results from US-guided CNB were compared to specimens from post-CNB surgeries. The data were collected from medical records and the immunohistochemistry (IHC) examinations were carried out for malignancy. There were 163 patients who were included in this study, 86 had malignancies and 77 had benign tumor reported in their CNB results. The US-guided CNB had 100% sensitivity and specificity compared to surgery. With its lower cost, time usage, and patient exposure to the hospital environment, US-guided CNB should replace open surgery biopsy for diagnosing suspicious breast cancers during the pandemic in Indonesia. Copyright © 2021, Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal). |
Breast cancer; Core needle biopsy; COVID-19; Health cost; Resources |
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Universitas Indonesia, Faculty of public health |
19077505 |
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Article |
Q4 |
146 |
23606 |
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240 |
Nathania M., Sunardi D. |
57245860300;57192075078; |
The importance of balanced nutrition to fortify the immune system during the covid-19 outbreak [La importancia de una nutrición equilibrada para aumentar el sistema inmunológico durante el brote de covid-19] |
2021 |
Revista Chilena de Nutricion |
48 |
4 |
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620 |
629 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114246311&doi=10.4067%2fS0717-75182021000400620&partnerID=40&md5=c999acae5c75b659b516d0fbb8b1815b |
Department of Nutrition, Faculty of Medicine, University of Indonesia-Ciptomangunkusumo National Hospital, Jakarta Pusat, 10430, Indonesia |
Nathania, M., Department of Nutrition, Faculty of Medicine, University of Indonesia-Ciptomangunkusumo National Hospital, Jakarta Pusat, 10430, Indonesia; Sunardi, D., Department of Nutrition, Faculty of Medicine, University of Indonesia-Ciptomangunkusumo National Hospital, Jakarta Pusat, 10430, Indonesia |
COVID-19, first reported in December 2019 in Wuhan, China, quickly spread worldwide and was announced as a pandemic in March 2020. As symptoms and outcomes are varied, the elderly and those who have at least one comorbidity (diabetes, cardiovascular disorders or other chronic diseases) are considered to be at high risk and are generally have lower immunity. An optimal immune system is critical for survival, as it protects the body against infectious agents. Nutrition is an essential factor in the immune system, contributing to components in physical barriers, biochemical, innate and adaptive immunity. Research advances show that nutritional deficiencies, namely the inadequacy of energy, macronutrients and micronutrients, affect the immune system and increase infection risk. The following discussion explains the comprehensive role of nutrition in the immune system, nutrition recommendations that can be used as precautions and the need for supplementation during this outbreak. © 2021, Sociedad Chilena de Nutricion Bromatologia y Toxilogica. All rights reserved. |
COVID-19; Immune; Nutrition; Pandemic; Supplementation |
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Sociedad Chilena de Nutricion Bromatologia y Toxilogica |
07177518 |
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Review |
Q4 |
182 |
20570 |
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241 |
Dharmawan Y., Fuady A., Korfage I., Richardus J.H. |
57189353850;37085331400;6506984424;7003977198; |
Individual and community factors determining delayed leprosy case detection: A systematic review |
2021 |
PLoS Neglected Tropical Diseases |
15 |
8 |
e0009651 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114085346&doi=10.1371%2fjournal.pntd.0009651&partnerID=40&md5=cd44ee5b8798b15d9e0def1be72603ab |
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Faculty of Public Health, Universitas Diponegoro, Semarang, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Dharmawan, Y., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, Faculty of Public Health, Universitas Diponegoro, Semarang, Indonesia; Fuady, A., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Korfage, I., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Richardus, J.H., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands |
Background The number of new leprosy cases is declining globally, but the disability caused by leprosy remains an important disease burden. The chance of disability is increased by delayed case detection. This review focusses on the individual and community determinants of delayed leprosy case detection. Methods This study was conducted according to the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). The study protocol is registered in PROS-PERO (code: CRD42020189274). To identify determinants of delayed detection, data was collected from five electronic databases: Embase.com, Medline All Ovid, Web of Science, Cochrane CENTRAL, and the WHO Global Health Library. Results We included 27 papers from 4315 records assessed. They originated in twelve countries, had been published between January 1, 2000, and January 31, 2021, and described the factors related to delayed leprosy case detection, the duration of the delayed case, and the percentage of Grade 2 Disability (G2D). The median delay in detection ranged from 12 to 36 months, the mean delay ranged from 11.5 to 64.1 months, and the percentage of G2D ranged from 5.6 to 43.2%. Health-service-seeking behavior was the most common factor associated with delayed detection. The most common individual factors were older age, being male, having a lower disease-symptom perception, having multibacillary leprosy, and lack of knowledge. The most common socioeconomic factors were living in a rural area, perform-ing agricultural labor, and being unemployed. Stigma was the most common social and community factor. Conclusions Delayed leprosy case detection is clearly correlated with increased disability and should therefore be a priority of leprosy programs. Interventions should focus on determinants of delayed case detection such as health-service-seeking behavior, and should consider rele-vant individual, socioeconomic, and community factors, including stigmatization. Further study is required of the health service-related factors contributing to delay. : © 2021 Dharmawan et al. |
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age distribution; attitude to health; awareness; delayed diagnosis; diagnosis time; disability; educational status; geographic distribution; help seeking behavior; human; leprosy; multibacillary leprosy; occupation; Review; risk perception; sex ratio; social belief; social determinants of health; social stigma; socioeconomics; systematic review; unemployment; complication; delayed diagnosis; disabled person; leprosy; patient attitude; psychology; risk factor; time to treatment; Delayed Diagnosis; Disabled Persons; Humans; Leprosy; Patient Acceptance of Health Care; Risk Factors; Social Stigma; Socioeconomic Factors; Time-to-Treatment |
Public Library of Science |
19352727 |
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34383768 |
Review |
Q1 |
1990 |
1322 |
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242 |
Bintoro D.A., Nareswari I. |
57237633100;57194336586; |
The Role of Electroacupuncture in the Regulation of Appetite-Controlling Hormone and Inflammatory Response in Obesity |
2021 |
Medical Acupuncture |
33 |
4 |
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264 |
268 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113821541&doi=10.1089%2facu.2020.1500&partnerID=40&md5=b4a919cddf828d9f0978d90ea651ac42 |
Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Central Jakarta, Jakarta, Indonesia |
Bintoro, D.A., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Central Jakarta, Jakarta, Indonesia; Nareswari, I., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Central Jakarta, Jakarta, Indonesia |
Objective: Obesity, a condition with serious complications, needs special attention. It is a complex and multifactorial problem and regulation of calorie balance involving various humoral and central factors is the main key for managing obesity. In addition, there is an increase in various proinflammatory cytokines and an increase in oxidative stress. There is a need to discover a useful therapy for obesity management. The goal of this review was to examine the literature on electroacupuncture (EA) as a potential therapy. Methods: This review explores the literature on EA, which has proven to be effective for inducing weight loss in experimental human and animal studies. Both continuous and dense-disperse EA waves have their own roles in hormone regulation of obesity using ST 25, CV 9, CV 12, CV 4, SP 6, ST 36, and ST 44; this is discussed the associated mechanism related to this is through suppression of various orexigenic peptides, enhancement of anorexigenic peptides, suppression of inflammatory factors, and improvement in the balance of pro-oxidants and antioxidants. Conclusions: The absence of another definitive therapy for obesity and EA's minimal side-effects make it a potential therapy for managing obesity. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
electroacupuncture; inflammation; obesity; oxidative stress |
ghrelin; acupuncture; appetite; body weight loss; electroacupuncture; food intake; human; inflammation; nonhuman; obesity; oxidative stress; pathophysiology; Review |
Mary Ann Liebert Inc. |
19336586 |
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Review |
Q2 |
281 |
15498 |
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243 |
Nareswari I., Lestari S.W., Notonegoro C. |
57194336586;55980501200;57224857889; |
Acupuncture Therapy for Severe Oligoasthenoteratozoospermia |
2021 |
Medical Acupuncture |
33 |
4 |
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302 |
305 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113775889&doi=10.1089%2facu.2020.1513&partnerID=40&md5=04fcbc629e9b71da58c0b69ee5116b7c |
Department of Medical Acupuncture, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Anna Hospital, Pekayon, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Nareswari, I., Department of Medical Acupuncture, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Anna Hospital, Pekayon, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Lestari, S.W., Anna Hospital, Pekayon, Indonesia, Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Notonegoro, C., Department of Medical Acupuncture, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Infertility affects ∼15%-20% of couples. Of the 16.7% infertility rate reported based on Word Health Organisation questionnaire data, 6.4% of cases are associated with male factors. Male infertility can result from abnormal semen parameters; oligoasthenoteratozoospermia (OAT) is the most common diagnosis. Acupuncture is an ancient method that has been used for centuries to treat and prevent various conditions. In modern medicine, it is gaining popularity as a complementary infertility therapy. Case: A 41-year-old male presented to the Medical Acupuncture Department of Dr. Cipto Mangunkusumo Hospital (in Jakarta, Indonesia) because he wanted to have a child. His semen was analyzed, and he was diagnosed with severe OAT. Manual acupuncture therapy was performed at CV 3, CV 4, CV 5, CV 6, CV 7, ST 29, SP 6, SP 3, ST 36, and KI 3, alternating with KI 7 5 days per week and at LR 8 once per week, for a total of 28 sessions. Results: Semen analysis after 2 series of manual acupuncture treatments revealed improvement, especially in sperm motility, from 25% to 33% and then to 67% after the first and second serial therapies, respectively, changing the diagnosis from severe OAT to severe oligoteratozoospermia. Conclusions: Manual acupuncture combined with medication improves male fertility, especially sperm motility. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
Acupuncture; Male Infertility; Oligoasthenoteratozoospermia |
alpha tocopherol; ascorbic acid; beta carotene; clomifene citrate; glutathione; lycopene; mineral; selenium; ubidecarenone; zinc; acupuncture; acupuncture point; adult; Article; case report; clinical article; follow up; high fiber diet; human; Indonesia; male; male infertility; oligoasthenoteratozoospermia; semen analysis; spermatozoon motility; Tribulus terrestris |
Mary Ann Liebert Inc. |
19336586 |
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Article |
Q2 |
281 |
15498 |
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244 |
Djaali W. |
57212479564; |
How Do You Treat Non-Insulin Dependent Diabetes in Your Practice? |
2021 |
Medical Acupuncture |
33 |
4 |
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306 |
308 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113733355&doi=10.1089%2facu.2021.29182.cpl&partnerID=40&md5=d5215d516a5077a554bb640392817b63 |
Universitas Negeri Jakarta Jl. Rawamangun Muka East Jakarta, Jakarta, 13220, Indonesia; Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo Central Jakarta, Jakarta, Indonesia |
Djaali, W., Universitas Negeri Jakarta Jl. Rawamangun Muka East Jakarta, Jakarta, 13220, Indonesia, Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo Central Jakarta, Jakarta, Indonesia |
[No abstract available] |
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hemoglobin A1c; acupuncture; acupuncture point; adult; Article; case report; clinical article; evaluation study; evidence based practice; fatigue; glucose blood level; histology; human; male; middle aged; non insulin dependent diabetes mellitus; Research Diagnostic Criteria; signal transduction; somnolence; treatment planning |
Mary Ann Liebert Inc. |
19336586 |
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Article |
Q2 |
281 |
15498 |
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245 |
Yunihastuti E., Hariyanto R., Sulaiman A.S., Harimurti K. |
57221273925;57226819413;57216938482;23473513200; |
Hepatitis C continuum of care: Experience of integrative hepatitis C treatment within a human immunodeficiency virus clinic in Indonesia |
2021 |
PLoS ONE |
16 |
8 August |
e0256164 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112781600&doi=10.1371%2fjournal.pone.0256164&partnerID=40&md5=97994b56bdf101c196e7c76dcd7be446 |
Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; HIV Integrated Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Yunihastuti, E., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, HIV Integrated Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hariyanto, R., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sulaiman, A.S., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harimurti, K., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction Direct-acting antiviral drugs (DAAs) have changed the paradigm of hepatitis C therapy for both HCV/HIV co-infected and HCV mono-infected patients. We aimed to describe the HCV continuum of care of HIV-infected patients treated in an HIV clinic after a free DAA program in Indonesia and identify factors correlated with sofosbuvir-daclatasvir (SOF-DCV) treatment failure. Methods We did a retrospective cohort study of adult HIV/HCV co-infected patients under routine HIV-care from November 2019 to April 2020 in the HIV integrated clinic of Cipto Mangunkusumo Hospital, Jakarta, Indonesia. We evaluated some factors correlated with sofosbuvir-daclatasvir treatment failure: gender, diabetes mellitus, previous IFN failure, cirrhosis, concomitant ribavirin use, high baseline HCV-RNA, and low CD4 cell count. Results and discussion Overall, 640 anti-HCV positive patients were included in the study. Most of them were male (88.3%) and former intravenous drug users (76.6%) with a mean age of 40.95 (SD 4.60) years old. Numbers and percentages for the stages of the HCV continuum of care were as follows: HCV-RNA tested (411; 64.2%), pre-therapeutic evaluation done (271; 42.3%), HCV treatment initiated (210; 32.8%), HCV treatment completed (207; 32.2%), but only 178 of these patients had follow-up HCV-RNA tests to allow SVR assessment; and finally SVR12 achieved (178; 27.8%). For the 184 who completed SOF-DCV treatment, SVR12 was achieved by 95.7%. In multivariate analysis, diabetes mellitus remained a significant factor correlated with SOF-DCV treatment failure (adjusted RR 17.0, 95%CI: 3.28–88.23, p = 0.001). Conclusions This study found that in the HCV continuum of care for HIV/HCV co-infected patients, gaps still exist at all stages. As the most commonly used DAA combination, sofosbuvir daclatasvir treatment proved to be effective and well-tolerated in HIV/HCV co-infected patients. Diabetes mellitus was significant factor correlated with not achieving SVR12 in this population. © 2021 Yunihastuti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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antiretrovirus agent; daclatasvir; efavirenz; elbasvir plus grazoprevir; interferon; lopinavir plus ritonavir; nevirapine; ribavirin; simeprevir; sofosbuvir; virus RNA; antivirus agent; adult; Article; CD4 lymphocyte count; cohort analysis; coinfection; controlled study; diabetes mellitus; drug withdrawal; fatigue; female; fever; follow up; gastrointestinal disease; gender; headache; hepatitis C; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; Indonesia; injection drug user; liver cirrhosis; major clinical study; male; multivariate analysis; myalgia; nausea; patient care; pruritus; retrospective study; RNA analysis; sleep disorder; sustained virologic response; university hospital; virus load; coinfection; drug effect; Hepacivirus; hepatitis C; |
Public Library of Science |
19326203 |
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34383853 |
Article |
Q1 |
990 |
4434 |
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246 |
Ichwan S., Ningsih H.L., Aman R.A., Tandian D., Ashari S., Gunawan K., Nugroho S.W. |
57192906639;57226696258;36848942500;57192891173;57195942105;57195935319;57460519700; |
O6-methylguanine-dna methyltransferase (Mgmt) promoter methylation status of high-grade and low-grade gliomas |
2021 |
Bali Medical Journal |
10 |
2 |
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644 |
647 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112380308&doi=10.15562%2fbmj.v10i2.2316&partnerID=40&md5=c8e8a17690a11b9cc2f1729ff7a40de8 |
Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Ichwan, S., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Ningsih, H.L., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aman, R.A., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Tandian, D., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Ashari, S., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gunawan, K., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Nugroho, S.W., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Background: O6-methylguanine-DNA methyltransferase (MGMT) is a DNA-repair enzyme that correlates with tumor resistance mechanism to chemotherapy. Methylation of the MGMT promoter inhibits the cells from producing MGMT and is useful to predict chemotherapy’s effectiveness with alkylating agents. This study aims to evaluate the MGMT promoter methylation of low-grade and high-grade glioma in the Neurosurgery Department of Cipto Mangunkusumo National General Hospital. Methods: We evaluated MGMT promoter methylation status using methylation-specific polymerase chain reaction in low and high-grade glioma patients who underwent surgical resection in the Neurosurgery Department of Cipto Mangunkusomo Hospital Jakarta. The result then correlated with age, sex, Karnofsky Performance Scale (KPS), and glioma grading. Data were analyzed using SPSS version 20 for Windows. Results: MGMT promoter methylation was observed more often in patients diagnosed with age more than 40 years old than in patients less than 40 years old (85.7% vs. 50.0%), also more in men than women (77.7% vs. 50.0%). In patients with KPS more than 70 and KPS 70 or less, methylation of MGMT promoter was observed in 70.0% and 57.1%, respectively. Based on tumor grading, MGMT promoter methylation was observed more often in low-grade gliomas (WHO grade II) than high-grade gliomas (WHO grade II and IV) (85.7% vs. 50.0%). There was no significant relationship between gender, age, KPS, malignancy degree, and Overall Survival (OS) to the MGMT promoter methylation (p>0.05). Conclusion: MGMT promoter methylation was observed less in the higher grade of tumors (grade IV), lower KPS, younger age at the time of diagnosis, and female patients, although the differences were not statistically significant. MGMT promoter methylation was observed more often in gliomas with oligodendroglioma components. © 2021, Sanglah General Hospital. All rights reserved. |
High-grade glioma; Low-grade glioma; Methylation; MGMT; Promoter |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
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#N/A |
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247 |
Isa M.M., Thayeb A., Meildi M., Hutagalung M.B.Z. |
57218775163;57219243978;57226686555;57210153230; |
Complete tubular duplication of colon presenting as rectovestibular fistula: A case report |
2021 |
Bali Medical Journal |
10 |
2 |
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526 |
528 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112379837&doi=10.15562%2fbmj.v10i2.2386&partnerID=40&md5=d43bedd4e25f7ac4c1c60fafddc9df64 |
Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Syiah Kuala/Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Syiah Kuala/Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia |
Isa, M.M., Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Syiah Kuala/Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Thayeb, A., Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Meildi, M., Department of Surgery, Faculty of Medicine, Universitas Syiah Kuala/Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Hutagalung, M.B.Z., Department of Surgery, Faculty of Medicine, Universitas Syiah Kuala/Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia |
Background: Duplication of the gastrointestinal tract is a rare congenital disorder in pediatric patients. Complete resection in case of a total tubular duplication that requires total or subtotal colectomy is undesirable in children. Case Presentation: This case presented a simple surgical technique for treating complete colonic duplication without colonic resection. A 2 months old female baby with abdominal distention and stool complaint came out from her vaginal vestibular and normal anus. A digital rectal exam showed a palpable mass in the posterior region. Abdominal CT Scan showed a rounded mass with size 2x2 cm in the left posterolateral of rectum region. The initial diagnosis was suspected sacrococcygeal tumor type 4 with rectovestibular fistula. Intraoperative findings showed duplication of the caecum, appendix, total colon (ascending to sigmoid) and rectum (one directed to the vagina and the other to anus). The ileostomy was done 20 cm from the ileocaecal junction as a temporary treatment to relieving distention with definitive repair planned in the following months. The second stage repair was performed after 1-year-old with posterosagital anorectoplasty followed by distal separation of the duplicated colon using a 12 cm linear stapler. For this case, the third stage repair was done one year after the previous surgery to close the remaining ileostomy. The patient’s outcome showed good results with normal defecating function and no complication. Conclusion: Complete tubular duplication is a rare case without specific clinical symptoms, but the assessment of the diagnosis can be assisted by radiology such as abdominal CT and barium enema. We hope this article could illustrate management for complete tubular duplication of colon presenting as rectovestibular fistula, thus reflect how important clinical judgment and initial diagnostic in our health care system. © 2021, Sanglah General Hospital. All rights reserved. |
Colon Duplication; Repair; Surgery |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
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#N/A |
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248 |
Goh K.-L., Lee Y.-Y., Leelakusolvong S., Makmun D., Maneerattanaporn M., Quach D.T., Raja Ali R.A., Sollano J.D., Tran V.H., Wong R.K.-M. |
7201860992;56191149300;6602285199;16638046900;16638087300;37099075800;40762153700;6602099153;56448091600;57226554480; |
Consensus statements and recommendations on the management of mild-to-moderate gastroesophageal reflux disease in the Southeast Asian region |
2021 |
JGH Open |
5 |
8 |
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855 |
863 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111938998&doi=10.1002%2fjgh3.12602&partnerID=40&md5=4a62cd64a09fae57e0e5ba1fbcccc112 |
Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia; Division of Gastroenterology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Internal Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam; Gastroenterology Unit, Department of Medicine and Gut Research Group, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bangi, Malaysia; Department of Gastroenterology, University of Santo Tomas, Manila, Philippines; Department of Gastroenterology, Hue University of Medicine and Pharmacy, Hue University, Hue City, Viet Nam; Department of Medicine, Faculty of Medicine, National University of Singapore, Singapore |
Goh, K.-L., Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Lee, Y.-Y., Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia; Leelakusolvong, S., Division of Gastroenterology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Makmun, D., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Maneerattanaporn, M., Division of Gastroenterology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Quach, D.T., Department of Internal Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam; Raja Ali, R.A., Gastroenterology Unit, Department of Medicine and Gut Research Group, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bangi, Malaysia; Sollano, J.D., Department of Gastroenterology, University of Santo Tomas, Manila, Philippines; Tran, V.H., Department of Gastroenterology, Hue University of Medicine and Pharmacy, Hue University, Hue City, Viet Nam; Wong, R.K.-M., Department of Medicine, Faculty of Medicine, National University of Singapore, Singapore |
This paper reports the proceedings from the first consensus meeting on the management of mild-to-moderate gastroesophageal reflux disease (GERD) in the Southeast Asian (SEA) region. Seventeen statements were drawn up by a steering committee that focused on epidemiology, mechanism of action, diagnostic investigations, and treatment. Voting on the recommendations used the Delphi method with two rounds of voting among the 10 panel members. The consensus panel agreed that GERD is mostly a mild disease in the SEA region with predominantly non-erosive reflux disease (NERD). Complicated GERD and Barrett's esophagus are infrequently seen. The panel recommended endoscopy in patients with alarm or refractory symptoms but cautioned that the incidence of gastric cancer is higher in SEA. pH and impedance measurements were not recommended for routine assessment. The acid pocket is recognized as an important pathogenic factor in GERD. Lifestyle measures such as weight reduction, avoidance of smoking, reduction of alcohol intake, and elevation of the head of the bed were recommended but strict avoidance of specific foods or drinks was not. Alginates was recommended as the first-line treatment for patients with mild-to-moderate GERD while recognizing that proton-pump inhibitors (PPIs) remained the mainstay of treatment of GERD. The use of alginates was also recommended as adjunctive therapy when GERD symptoms were only partially responsive to PPIs. © 2021 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
alginates; consensus recommendations; mild-to-moderate gastroesophageal reflux disease; proton-pump inhibitors |
alginic acid; antacid agent; proton pump inhibitor; alcohol consumption; Article; Barrett esophagus; body mass; body weight loss; consensus development; Delphi study; dysphagia; endoscopy; esophagitis; evidence based practice; gastroesophageal reflux; gastroscopy; Helicobacter pylori; hiatus hernia; human; intestine metaplasia; lower esophagus sphincter; metaplasia; non erosive reflux disease; population research; prevalence; quality of life; questionnaire; smoking reduction; Southeast Asia; strategic reserve |
John Wiley and Sons Inc |
23979070 |
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546 |
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