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289 |
Kartika R.W., Alwi I., Suyatna F.D., Yunir E., Waspadji S., Immanuel S., Bardosono S., Sungkar S., Rachmat J., Hediyati M., Silalahi T. |
57223447932;15055173800;56039633100;36520254800;8678136400;57272979000;21933841000;57016857300;6507225348;57310558800;56275255400; |
Wound Healing in Diabetic Foot Ulcer Patients Using Combined Use of Platelet Rich Fibrin and Hyaluronic Acid, Platelet Rich Fibrin and Placebo: An Open Label, Randomized Controlled Trial |
2021 |
Acta medica Indonesiana |
53 |
3 |
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268 |
275 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117847076&partnerID=40&md5=089bf13006cbe4a09ad0a915462eec3b |
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Kartika, R.W., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Alwi, I.; Suyatna, F.D.; Yunir, E.; Waspadji, S.; Immanuel, S.; Bardosono, S.; Sungkar, S.; Rachmat, J.; Hediyati, M.; Silalahi, T. |
BACKGROUND: Autologous platelet-rich fibrin (A-PRF) is an adjunctive method for diabetic foot ulcer (DFU) in addition to glycaemic control and debridement. This study aimed to evaluate the role of A-PRF + hyaluronic acid (HA), A-PRF and sodium chloride 0.9% (control) in DFU wound healing. Nowaday, the use of PRF autologous consider as adjuvant therapy in DFU treatment. METHODS: This open-label randomized controlled trial was conducted at Koja District Hospital and Gatot Soebroto Hospital from July 2019 to April 2020. DFU patients with wound duration of three months, Wagner-2, and ulcer size < 40 cm2 were recruited and randomly assigned into A-PRF + AH, A-PRF and control group. On day-0, day-3 and day -7, samples and photographs were taken. Samples were analysed with ELISA and photographs were analysed with ImageJ to calculate granulation index (GI). Statistical analysis was performed using SPSS version 20. RESULTS: Topical therapy with A-PRF + AH was associated with a significant increase in VEGF from day 0 (232.8 pg/mg) vs day 7 (544.5 pg/mg) compared to A-PRF on day 0 (185.7 pg/mg) vs day 7 (272.8 pg/mg), and the controls on day 0 (183.7 pg/mg) vs day 7 (167.4 pg/mg). On evaluation of VEGF swab, there is increasing significantly in A-PRF+HA group compare others group in day -3 ( p=0.022) and day -7 (p= 0.001).In the A-PRF + AH group, there was a significant decrease in IL-6 from day 0 (106.4 pg/mg) vs day 7 (88.7 pg/mg) compared with PRF on day 0 (91.9 pg/mg) vs day 7 (48,8 pg/mg). IL-6 was increased in the control group from day 0 (125.3 pg/mg) vs day 7 (167.9 pg/mg). On evaluation of IL-6 swab, there is decreasing significantly in A-PRF+HA group compare others group in day -7 (p= 0.041). CONCLUSION: The PRF + HA combination increased angiogenesis and reduced inflammation in DFUs and may represent a new DFU therapy. |
diabetic foot ulcer; hyaluronic acid; platelet-rich fibrin |
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NLM (Medline) |
01259326 |
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34611065 |
Article |
Q3 |
321 |
14162 |
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291 |
Rosana M., Asmara O.D., Pribadi R.R., Kalista K.F., Harimurti K. |
57310736300;57311469800;57194732282;57200425631;23473513200; |
Internal Medicine Residents' Perceptions of Point-of-Care Ultrasound in Residency Program: Highlighting the Unmet Needs |
2021 |
Acta medica Indonesiana |
53 |
3 |
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299 |
307 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117823517&partnerID=40&md5=913ad9734aff00b93a00fe56082dca20 |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General HospitalJakarta, Indonesia |
Rosana, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Asmara, O.D.; Pribadi, R.R.; Kalista, K.F.; Harimurti, K. |
BACKGROUND: Point-of-care ultrasound (POCUS) is increasingly used in internal medicine field. Ultrasound training has been part of the training provided in the Internal Medicine Residency Program (IMRP). The aim of this study is to examine the residents' needs and perceptions regarding their competency and needs of POCUS. METHODS: We conducted a cross-sectional descriptive study using secondary data from a survey among internal medicine residents at the Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital. The survey was conducted to evaluate and improve the curriculum in IMRP. RESULTS: A total of 175 out of 197 residents (88.8%) completed the questionnaire. Almost all the residents (99.4%) agreed that POCUS is a beneficial must-have skill during residency. Nevertheless, only 40% of residents identified themselves as competent in POCUS. Sixty-two percent residents reckoned that the training received during the residency program is insufficient. They indicated that the most useful skills are US of hepatobiliary, lungs, heart, kidneys, and US-guided procedures. CONCLUSION: This study confirms that there is a need for POCUS training for IM residents, as the majority perceived themselves as unable to perform US. It is necessary to optimize the training provided to ensure proficiency. |
internal medicine; Internship; residency; ultrasonography |
adult; article; curriculum; female; general hospital; heart; human; human experiment; Indonesia; internal medicine; kidney; lung; male; perception; point of care ultrasound; questionnaire; resident; skill |
NLM (Medline) |
01259326 |
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34611069 |
Article |
Q3 |
321 |
14162 |
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292 |
Iman R.P., Junita T., Rachman R.I., Syam A.F. |
57218324172;57310672300;57310137500;8443384400; |
Risk factor, diagnosis, and current treatment of H. pylori Infection in Indonesia: A Literature Review |
2021 |
Acta medica Indonesiana |
53 |
3 |
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331 |
338 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117760916&partnerID=40&md5=ce13806d99f6c0a46477f70903de63ef |
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Iman, R.P., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Junita, T.; Rachman, R.I.; Syam, A.F. |
Helicobacter pylori (H. pylori) infection has become an emerging problem in Indonesia despite its relatively low prevalence as opposed to other Southeast Asian and Asian countries. Strains containing less virulent genotypes predominantly found in Indonesia is suggested to be the rationale for why the disease prevalence, as well as its gastric cancer complication, remain inferior in respect of neighboring counterparts. Although endoscopic evaluation is still necessary to determine the gastric mucosal status of those infected with H. pylori, the infection itself can be easily diagnosed with test-and-treat strategy especially in areas with limited resources. Several findings revealed high rates of antibiotic resistance varying among Indonesian regions and ethnicities, suggesting that triple therapy regimen may not be suitable for all population. Whereas treatment should be based on the pattern of resistance in respected region, novel regimens involving furazolidone, rifabutin, and sitafloxacin are proposed as potential drugs of choice to eradicate H. pylori infection. In order to determine the adequate approach for H. pylori infection in Indonesia, further multicenter studies involving larger sample size should be conducted. |
current treatment; diagnosis; Helicobacter pylori; infection; risk factor |
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NLM (Medline) |
01259326 |
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34611074 |
Article |
Q3 |
321 |
14162 |
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294 |
Nelwan E.J., Tunjungputri R.N., Wardani R.S., Wahyuningsih R. |
14527452900;56342194400;47562102900;6507268400; |
Black Fungus Complicated with COVID-19 in a Man with Underlying Non-Hodgkin's Lymphoma |
2021 |
Acta medica Indonesiana |
53 |
3 |
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349 |
351 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117746727&partnerID=40&md5=9ffcb6f5c08a7096c40aca053f41d236 |
1. Division of Tropical and Infectious Disease. Department of Internal Medicine, Indonesia. 2. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Nelwan, E.J., 1. Division of Tropical and Infectious Disease. Department of Internal Medicine, Indonesia. 2. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Tunjungputri, R.N.; Wardani, R.S.; Wahyuningsih, R. |
COVID-19 is a disease reported to suppress cellular immunity. This may lead to the development of opportunistic infections, among others black fungus, or mucormycosis. On the other hand, pre-existing defect in immunity may render patients susceptible to both mucormycosis and COVID-19. Mucormycosis is a relatively rare fungal infection with rapid progression unless diagnosed promptly and treated adequately, and urgent surgical and medical intervention is lifesaving. The manifestation of mucormycosis largely depends on the presence of exposure to the pathogen and the existing risk factor of the host. As black fungus is locally invasive, the majority of cases will involve tissue damage with local destruction and contiguous spread to nearby structure. We here with present a case of black fungus complicated with COVID-19 in a man with underlying non-Hodgkin's lymphoma. |
black fungus; COVID-19; non-hodgkin lymphoma |
adult; biopsy; case report; complication; debridement; diagnosis; disease exacerbation; human; isolation and purification; male; microbiology; Mucorales; mucormycosis; nonhodgkin lymphoma; nose disease; nose septum; pathology; pathophysiology; patient isolation; procedures; therapy; time to treatment; x-ray computed tomography; Adult; Biopsy; COVID-19; Debridement; Disease Progression; Humans; Lymphoma, Non-Hodgkin; Male; Mucorales; Mucormycosis; Nasal Septum; Nose Diseases; Patient Isolation; SARS-CoV-2; Time-to-Treatment; Tomography, X-Ray Computed |
NLM (Medline) |
01259326 |
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34611076 |
Article |
Q3 |
321 |
14162 |
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295 |
Sugiharto P., Ramlan A.A.W. |
57286412100;57195941841; |
Effectiveness of mindfulness-based intervention technique in reducing stress levels of anesthesiology and intensive therapy residents |
2021 |
Bali Journal of Anesthesiology |
5 |
3 |
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166 |
170 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116416960&doi=10.4103%2fbjoa.bjoa_251_20&partnerID=40&md5=ec537b920b0bac4177ea8de114c87660 |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Sugiharto, P., Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Ramlan, A.A.W., Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Background: An anesthesiologist is expected to be able to manage intraoperative crises that can occur at any time. We aimed to determine the effectiveness of mindfulness-based intervention (MBI) technique in reducing stress levels of anesthesiology and intensive therapy residents at the Faculty of Medicine, University of Indonesia. Materials and Methods: This research was an experimental study with paired one group design. The MBI program lasted 4 weeks, consisted of one formal face-to-face training and 4 weeks of informal training (homework). Thirteen study subjects met the inclusion criteria and did not enter the exclusion criteria. One study subject was excluded because the subject did not complete the informal training. Data collection on the Perceived Stress Scale 10-Item (PSS-10) was conducted before and after training. Results: The average age of study subjects was 29.75 years; 75% are women. Four participants were in the 1 st year of education (33%), 3 participants were in the 2 nd year of education (25%), 2 participants were in the 3 rd year of education (16.67%), and 3 participants were in the 4 th year of education (25%). PSS-10 score in the study subjects significantly decreased after applying the MBI technique for 4 weeks (P = 0.001). Conclusion: MBI is effective in reducing stress levels of anesthesiology and intensive therapy residents at the-blinded. © 2020 Bali Journal of Anesthesiology | Published by Wolters Kluwer-Medknow. |
Anesthesiologist; mindfulness; resident; stress |
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Wolters Kluwer Medknow Publications |
25492276 |
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Article |
#N/A |
#N/A |
#N/A |
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296 |
Pudjiadi A.H., Pramesti D.L., Pardede S.O., Djer M.M., Rohsiswatmo R., Kaswandani N. |
18435202300;57286438600;57210394278;12771087900;55533574600;57195941745; |
Validation of the vasoactive-inotropic score in predicting pediatric septic shock mortality: A retrospective cohort study |
2021 |
International Journal of Critical Illness and Injury Science |
11 |
3 |
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117 |
122 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116401748&doi=10.4103%2fIJCIIS.IJCIIS_98_20&partnerID=40&md5=c4a8675dca5d2e706bb5225b224574e6 |
Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Pudjiadi, A.H., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Pramesti, D.L., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Pardede, S.O., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Djer, M.M., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Rohsiswatmo, R., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Kaswandani, N., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Mortality in pediatric septic shock remains very high. Vasoactive-inotropic score (VIS) is widely used to predict prognosis in patients with heart disease. It is a simple method that was initially used as a predictor of morbidity and mortality in postoperative patients with congenital heart diseases. Previous reports showed that high VIS score was associated with high mortality in pediatric sepsis. However, its discriminative value remains unclear. We aim to explore the discriminative value of VIS in predicting mortality in pediatric septic shock patients. Methods: We conducted a retrospective cohort study on medical records of septic shock patients who received care in the pediatric intensive care unit (PICU). We screened medical records of pediatric patients which were diagnosed with septic shock and admitted to the PICU and received vasoactive/inotropic score for more than 8 h. Other supporting examination results were recorded, such as organ function evaluation for calculation of Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score. The outcome of patients was recorded. The receiver operating curve was constructed to calculate the area under the curve (AUC), sensitivity, and specificity of each cutoff point. Results: We obtained the optimum cutoff point of VIS > 11 with 78.87% sensitivity and 72.22% specificity. AUC positive was 0.779 (P < 0.001); predictive value and negative predictive value were 91.80% and 46.43%, respectively. Conclusion: VIS > 11 has a good ability to predict mortality in children with septic shock. © 2021 International Journal of Critical Illness and Injury Science | Published by Wolters Kluwer-Medknow. |
Mortality; pediatrics; sepsis; vasoactive-inotropic score |
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Wolters Kluwer Medknow Publications |
22295151 |
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Review |
Q3 |
274 |
15730 |
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297 |
Gozal F., Gondhowiardjo S.A., Kodrat H., Wibowo W.E. |
57272055100;6508327402;57210639849;57271503300; |
Dosimetric analysis of three-dimensional conformal radiotherapy, intensity-modulated radiotherapy-step and shoot, helical tomotherapy, and volumetric modulated arc therapy in prostate cancer radiotherapy |
2021 |
Journal of Cancer Research and Therapeutics |
17 |
4 |
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893 |
900 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115716207&doi=10.4103%2fjcrt.JCRT_57_19&partnerID=40&md5=dd9c0144cb3b9a97d6b48eed122e1ba2 |
Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Gozal, F., Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Gondhowiardjo, S.A., Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kodrat, H., Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wibowo, W.E., Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: There is limited study comparing dosimetry parameters in detail. In regard to prostate cancer, there are four different techniques, namely three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy-step and shoot (IMRT-SS), IMRT-helical tomotherapy (HT), and volumetric-modulated arc therapy (VMAT). Materials and Methods: Experimental study with intervention on ten prostate cancer patients’ computed tomography planning data. 78 Gy dose in 39 fractions was given for planning target volume. Results: The mean V75 Gy rectum and bladder between 3D-CRT and the other three abovementioned techniques all showed significant results (P < 0.05). V5 Gy remaining volume at risk (RVR) between 3D-CRT versus VMAT and HT, IMRT-SS versus HT, and VMAT versus HT is statistically significant (P < 0.0001). The longest radiation time was done with HT (mean 4.70 ± 0.84 min). Conclusion: V75 Gy rectum bladder between 3D-CRT techniques differ significantly compared to the three other techniques and may not be suitable to the implementation of escalation doses. The HT technique produced the highest V5 Gy RVR and needed the highest monitor unit amount and the longest radiation duration. The VMAT technique was considered capable of realizing dose escalation in prostate cancer radiotherapy by minimizing toxicity in the rectum and bladder with the shortest radiation duration. © 2020 Journal of Cancer Research and Therapeutics. |
Helical tomotherapy; Intensity-modulated radiotherapy-step and shoot; Prostate cancer; Three-dimensional conformal radiotherapy; Volumetric-modulated arc therapy |
adult; aged; anisotropic analytical algorithm; Article; bladder; bladder capacity; cancer radiotherapy; clinical article; clinical target volume; computer assisted tomography; conformal radiotherapy; controlled study; dosimetry; health care; human; intensity modulated radiation therapy; male; middle aged; planning; planning target volume; prostate cancer; radiotherapy dosage; rectum; tomotherapy; volumetric modulated arc therapy; conformal radiotherapy; diagnostic imaging; follow up; intensity modulated radiation therapy; organs at risk; pathology; procedures; prognosis; prostate tumor; radiation response; radiotherapy planning system; spiral computer assisted tomography; Aged; Follow-Up Studies; Humans; Male; Middle Aged; Organs at Risk; Prognosis; Prostatic Neoplasms; Radiotherapy Dosage |
Wolters Kluwer Medknow Publications |
09731482 |
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34528538 |
Article |
Q3 |
475 |
10526 |
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298 |
Sutandi N., Lee F. |
57201654034;57262177400; |
Vitreoretinal abnormalities in corona virus disease 2019 patients: What we know so far |
2021 |
Taiwan Journal of Ophthalmology |
11 |
3 |
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232 |
243 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115110995&doi=10.4103%2ftjo.tjo_30_21&partnerID=40&md5=36ea488504463bec350d4e4cb30186ed |
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Sutandi, N., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Lee, F., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
The coronavirus disease 2019 (COVID-19) has become a global pandemic since December 2019. Although COVID-19 primarily affects the respiratory systems, it has become abundantly clear that it involves multiple organs including the heart, kidney, skin, and brain. Neuro-ophthalmic signs and anterior segment inflammation of the eyes were documented in COVID-19 patients recently. Small but growing number of literatures has also reported the cases of new onset vitreoretinal disorders related to COVID-19 infection. A comprehensive search from four online databases was done. Findings show vitreoretinal involvement in COVID-19 patients including the central retinal vein occlusion, central retinal artery occlusion, reactivation of previous uveitis, chorioretinitis, macular hemorrhage, acute macular neuroretinopathy, paracentral acute middle maculopathy, vitritis with outer retinal abnormalities, varicella zoster virus-related acute retinal necrosis in immunocompromised patient, and other posterior segment pathological changes. The hypotheses for potential pathogenesis of these manifestations are direct viral ocular infection and thromboembolic complications secondary to the hyperinflammatory response. This is the first review article, which provides an overview of current evidence regarding the vitreoretinal manifestations in COVID-19 patients. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
COVID-19; funduscopy; posterior segment; SARS-CoV-2; vitreoretinal abnormalities |
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Wolters Kluwer Medknow Publications |
22115056 |
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Review |
Q3 |
519 |
9760 |
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299 |
SITOHANG I.B.S., ANWAR A.I., JUSUF N.K., ARIMUKO A., NORAWATI L., VERONICA S. |
56734569200;57205655192;57188840371;57222706279;57217009388;57217003979; |
Evaluating oral glutathione plus ascorbic acid, alpha-lipoic acid, and zinc aspartate as a skin-lightening agent: An indonesian multicenter, randomized, controlled trial |
2021 |
Journal of Clinical and Aesthetic Dermatology |
14 |
7 |
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E53 |
E58 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113537297&partnerID=40&md5=f7d6f0bdd3408b798182f7ccc399f039 |
Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine Universitas Hasanuddin Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia; Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara-Universitas Sumatera Utara Hospital, Medan, Indonesia; Department of Dermatology and Venereology, Presidential-Army Central Hospital Gatot Soebroto, Jakarta, Indonesia |
SITOHANG, I.B.S., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; ANWAR, A.I., Department of Dermatology and Venereology, Faculty of Medicine Universitas Hasanuddin Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia; JUSUF, N.K., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara-Universitas Sumatera Utara Hospital, Medan, Indonesia; ARIMUKO, A., Department of Dermatology and Venereology, Presidential-Army Central Hospital Gatot Soebroto, Jakarta, Indonesia; NORAWATI, L., Department of Dermatology and Venereology, Presidential-Army Central Hospital Gatot Soebroto, Jakarta, Indonesia; VERONICA, S., Department of Dermatology and Venereology, Presidential-Army Central Hospital Gatot Soebroto, Jakarta, Indonesia |
CLINICALTRIALS.GOV IDENTIFIER: NCT04105504. BACKGROUND: For Asians, especially women with darker skin tones (Fitzpatrick Skin Types IV and V), clear, bright skin is considered highly desirable, and various topical, oral, or injection-based cosmetic skin-lightening agents with different mechanisms of action are widely available across Asia. OBJECTIVE: We sought to investigate the effcacy and safety of an oral glutathione supplement comprising L-glutathione (fermentation), ascorbic acid, alpha-lipoic acid, and zinc (as zinc aspartate) as a skin-lightening agent. METHODS: This randomized, double-blind, controlled clinical trial was carried out at three teaching hospital-based dermatovenereology clinics in Indonesia. Participants were randomized to receive either the glutathione supplement or placebo capsules and were evaluated every four weeks over a 12-week study period. Total reduction in spot ultraviolet, spot polarization, and skin tone were measured and recorded using a Janus Facial Analysis System® (PIE Co., Ltd, Suwon-si, Gyeonggido, Korea). RESULTS: Eighty-three participants, aged between 33 and 50 years, completed the study. Reductions in spot ultraviolet in certain subgroups, spot polarization, and skin tone were greater in the glutathione supplement group than in the placebo group, but the difference was not statistically significant. Both the glutathione supplement and placebo groups experienced only mild side effects in the first four weeks. CONCLUSION: The oral glutathione supplement was slightly beneficial for skin lightening in particular subgroups, but the results were not statistically significant. Mild and temporary side effects were reported. Further research is required to more fully evaluate the effcacy of this glutathione supplement as a skin-lightening agent. © 2021 Matrix Medical Communications. All rights reserved. |
Glutathione plus; Skin tone; Skin-lightening agent; Spot polarization; Spot ultraviolet |
ascorbic acid; depigmenting agent; gelatin; glucose; glutathione; keratin; lynae mazthione; placebo; porphyrin; sunscreen; thioctic acid; zinc aspartate; acne; adult; Article; cheek; combination drug therapy; comedo; controlled clinical trial; controlled study; double blind procedure; drug capsule; drug efficacy; drug safety; epigastric pain; eye; female; follow up; forehead; human; Indonesia; major clinical study; melanogenesis; multicenter study; nausea; nose; outcome assessment; pigmentation; pruritus; randomized controlled trial; sebum; side effect; skin bump; skin disease; sun exposure; supplementation; teaching hospital; treatment duration; ultraviolet radiation; wrinkle |
Matrix Medical Communications |
19412789 |
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Article |
Q2 |
600 |
8425 |
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300 |
Muharam R., Rizal M.S. |
57191492732;57226812403; |
Correlation of calprotectin serum levels with degrees of endometriosis: A cross-sectional study |
2021 |
International Journal of Reproductive BioMedicine |
19 |
7 |
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637 |
644 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112743809&doi=10.18502%2fijrm.v19i7.9474&partnerID=40&md5=34cae0bd86e4721b17270090a5a30ef4 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Muharam, R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Rizal, M.S., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Background: Endometriosis is closely associated with delayed diagnosis due to the lack of a definitive and sensitive noninvasive approach. The use of calprotectin in inflammatory process has been demonstrated in various inflammatory diseases. Calprotectin has a significant correlation with high-sensitivity C-reactive protein (hs-CRP) and could be used as an inflammatory marker. No study thus far has evaluated the correlation between calprotectin and endometriosis. Objective: To determine the correlation of calprotectin with the degree of endometriosis in order to help clinicians in establishing better early detection and management. Materials and Methods: In this cross-sectional study, 46 women referred to the Cipto Mangunkusumo, Fatmawati, and Persahabatan Hospitals in Jakarta, Indonesia between July 2017 and April 2018 were enrolled, and their blood serum were taken a day before surgery. Calprotectin serum level was treated using the Phical® ELISA method. After the diagnosis of endometriosis was confirmed through pathological examination, the final diagnosis of endometriosis could be established. The degree of endometriosis was classified according to the revised American Society for Reproductive Medicine (ASRM) classification. Results: The prevalence of minimal, mild, moderate, and severe degrees of endometriosis were 15.2, 39.1, 34.8, and 10.9%, respectively. The median serum calprotectin levels for minimal, mild, moderate, and severe endometriosis were 138.98, 121.49, 124.16, and 122.82 mg/mL, respectively. No correlation was observed between calprotectin and the degrees of endometriosis (r = –0.16, p = 0.278). Conclusion: There is no correlation between calprotectin serum levels and the degrees of endometriosis. © Muharam et al. |
C-reactive protein; Calprotectin; Endometriosis; Inflammation |
biological marker; C reactive protein; calgranulin; adolescent; adult; Article; body mass; correlation coefficient; cross-sectional study; diabetes mellitus; diastolic blood pressure; early diagnosis; endometriosis; enzyme linked immunosorbent assay; female; female infertility; glucose blood level; human; hypertension; major clinical study; protein expression |
Research and Clinical Center for Infertitlity |
24764108 |
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Article |
Q3 |
445 |
11118 |
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