No records
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337 |
Pontoh L.A.P., Rahyussalim A.J., Fiolin J. |
57192907426;55212166100;57194498274; |
Patient Height may Predict the Length of the Anterior Cruciate Ligament: A Magnetic Resonance Imaging Study |
2021 |
Arthroscopy, Sports Medicine, and Rehabilitation |
3 |
3 |
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e733 |
e739 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113913987&doi=10.1016%2fj.asmr.2021.01.012&partnerID=40&md5=f360a46041bd0cd832150f6f545b6417 |
Knee Division of Department of Orthopaedic and Traumatology, Fatmawati General Hospital–Faculty of Medicine Universitas Indonesia, Jakarta, Selatan, Indonesia; Spine Division of Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine Universitas Indonesia, Jakarta, Pusat, Indonesia; Jakarta Knee, Shoulder and Orthopaedic Sport Clinic, Pondok Indah Hospital, Jakarta, Indonesia |
Pontoh, L.A.P., Knee Division of Department of Orthopaedic and Traumatology, Fatmawati General Hospital–Faculty of Medicine Universitas Indonesia, Jakarta, Selatan, Indonesia; Rahyussalim, A.J., Spine Division of Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine Universitas Indonesia, Jakarta, Pusat, Indonesia; Fiolin, J., Jakarta Knee, Shoulder and Orthopaedic Sport Clinic, Pondok Indah Hospital, Jakarta, Indonesia |
Purpose: The purpose of this study was to measure the length and width of anterior cruciate ligament (ACL) tibial footprint using magnetic resonance imaging (MRI) and to evaluate correlation between patients’ weight and height with the tibial footprint size. Methods: In total, 207 eligible patients underwent MRI scanning from June 2018 to June 2020. One hundred seventeen knees from patients aged 18 to 40 years old with intact ACL were included in this study. Data of weight, height, body mass index (BMI) from physical examination and tibial footprint length and width from MRI were obtained. Relationship of ACL tibial footprint length <14 mm and association between ACL tibial footprint sizes of MRI with height, weight, and BMI were analyzed. Results: The ACL tibial footprint length and width were, respectively, 11.9 ± 1.8 mm and 10 ± 1.5 mm. Proportion of ACL footprint <14 mm in length was 89.7%. Patient height ≥170 cm was the best predictor of ACL tibial footprint length <14 mm (P =.025). There was a statistically significant relationship between the height of the patients and the length of the ACL tibial footprint. The length of the ACL tibial footprint could be predicted by the formula: length = −7.362 + 11.48 × (height in meters). Conclusion: The height of the patients may predict the length of the ACL tibial footprint. Although patient's age, sex, and BMI correlate poorly with ACL tibial footprint width, there was no correlation between patient's weight and ACL tibial footprint size. Clinical Relevance: Before ACL reconstruction surgery, an estimation of ACL tibial footprint size might aid in the graft harvesting preparation. © 2021 Arthroscopy Association of North America |
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adult; anterior cruciate ligament; anterior cruciate ligament reconstruction; article; body mass; body weight; clinical evaluation; controlled study; female; graft harvesting; human; major clinical study; male; nuclear magnetic resonance imaging; physical examination |
Elsevier Inc. |
2666061X |
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Article |
#N/A |
#N/A |
#N/A |
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338 |
SITOHANG I.B.S., SOEBARYO R.W., KANOKO M. |
56734569200;6506868173;6507911148; |
Acne lesion extraction versus oral doxycycline for moderate acne vulgaris: A randomized clinical trial |
2021 |
Journal of Clinical and Aesthetic Dermatology |
14 |
6 |
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E61 |
E65 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113565099&partnerID=40&md5=84d3ad669270477356a8236dc4266b13 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
SITOHANG, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; SOEBARYO, R.W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; KANOKO, M., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Acne vulgaris is a polymorphic skin condition comprising inflamed and noninflamed lesions. In addition to topical retinoids, systemic antibiotics play a role as a main therapy for acne with inflamed papules and cysts. However, due to the increasing tendency for bacterial resistance, alternatives to antibiotics are needed. OBJECTIVE: The aim of this study was to evaluate the effectiveness of acne lesion extraction compared to oral doxycycline for moderate acne vulgaris and to explore the impact of both treatments on Hypoxia-inducible factor (HIF)-1 alpha. METHODS: This randomized clinical trial was conducted in two teaching hospitals in 2016. Subjects with moderate acne vulgaris (N=140) were divided into two groups. Each subject in both groups received 0.05% tretinoin cream, applied to the entire face each night, and 2.5% benzoyl peroxide gel, applied to the acne lesions in the morning and afternoon. One group was also treated with oral doxycycline 100mg once daily and the other was treated with acne lesion extraction performed on all facial lesions every two weeks; the patients were evaluated via patient-reported self-assessment and lesion counts every two weeks for six weeks. HIF-1 alpha expression of the biopsied lessions was examined via immunohistochemistry. RESULTS: 128 subjects completed the study. Among these 128 subjects there was a prominent decrease in inflamed lesions at Week 6 in the lesion extraction group compared to the oral doxycycline group (p<0.05). HIF-1 alpha expression of the biopsied lesions was found in 7 of 9 samples taken from the oral doxycycline group, while 3 of 4 samples in the lesion extraction group were found negative. CONCLUSION: According to our results, acne lesion extraction appeared to be more effective than oral doxycycline in treating this sample of patients with moderate acne vulgaris. Additionally, HIF-1 alpha expression appeared to be decreased after acne lesion extraction. © 2021 Matrix Medical Communications. All rights reserved. |
Acne lesion extraction; Hypoxia-inducible factor-1 alpha; Moderate acne vulgaris; Oral doxycycline |
benzoyl peroxide; doxycycline; hypoxia inducible factor 1alpha; retinoic acid; acne vulgaris; adult; Article; clinical evaluation; comparative effectiveness; controlled study; disease severity; extraction; face; female; histopathology; human; human tissue; immunohistochemistry; major clinical study; male; night; protein expression; randomized controlled trial; self evaluation |
Matrix Medical Communications |
19412789 |
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Article |
Q2 |
600 |
8425 |
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340 |
Rah J.H., Melse-Boonstra A., Agustina R., van Zutphen K.G., Kraemer K. |
8298189500;6603151574;57214141404;57200080421;24724460700; |
The Triple Burden of Malnutrition Among Adolescents in Indonesia |
2021 |
Food and Nutrition Bulletin |
42 |
1_suppl |
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S4 |
S8 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111111554&doi=10.1177%2f03795721211007114&partnerID=40&md5=863a09d51aa051b285f86121637fe0a5 |
UNICEF Indonesia, Jakarta, Indonesia; Division of Human Nutrition and Health, Wageningen University Research, Wageningen, Netherlands; Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Center (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sight and Life, Basel, Switzerland; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States |
Rah, J.H., UNICEF Indonesia, Jakarta, Indonesia; Melse-Boonstra, A., Division of Human Nutrition and Health, Wageningen University Research, Wageningen, Netherlands; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Center (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; van Zutphen, K.G., Division of Human Nutrition and Health, Wageningen University Research, Wageningen, Netherlands, Sight and Life, Basel, Switzerland; Kraemer, K., Sight and Life, Basel, Switzerland, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States |
Background: Indonesia is a prime example of the triple burden of malnutrition. Indonesian adolescents are among the hardest hit, with approximately one in four adolescent girls suffering from anemia, while nearly one in seven adolescents is overweight or obese. Objectives: The present editorial provides a snapshot of the various research papers included in this Supplement, which calls for increased attention to adolescent nutrition in Indonesia and beyond. Results: Despite major steps to reduce undernutrition and overweight, including a renewed focus on anemia among adolescent girls, major gaps remain in our understanding of various nutrition issues concerning adolescents. These include various drivers and determinants of the triple burden of malnutrition, evidence-based interventions that are supported by large-scale implementation research and evaluation, and effective delivery platforms to reach the most vulnerable groups of adolescents. Conclusion: The time has come to position adolescent nutrition as central to development, and mainstream it into health sector plans, strategies, and policies. It is our hope that this issue will stimulate the urgently needed interventions, implementation research and required programs that will safeguard the nutritional wellbeing of today's forgotten generation. © The Author(s) 2021. |
adolescents; anemia; health; Indonesia; nutrition; overweight |
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SAGE Publications Inc. |
03795721 |
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34282654 |
Editorial |
Q1 |
649 |
7743 |
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344 |
Susantiningsih T., Makkiyah F.A., Thadeus M.S., Yulianti R., Hadi S. |
57192907038;57210232162;57226238484;57201696813;26534077400; |
Progressive acute liver damage induced by repeated 2-nitropropane: Focused on obese mice |
2021 |
Biomedical and Pharmacology Journal |
14 |
2 |
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695 |
700 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110971235&doi=10.13005%2fbpj%2f2172&partnerID=40&md5=d967f0ab42728fa05df28dd316a8f615 |
Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Chemistry, Universitas Lampung, Bandar Lampung, 35145, Indonesia |
Susantiningsih, T., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Makkiyah, F.A., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Thadeus, M.S., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Yulianti, R., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Hadi, S., Department of Chemistry, Universitas Lampung, Bandar Lampung, 35145, Indonesia |
Obesity is linked to more deaths worldwide. In obesity, there will be a dysregulation of growth signals such as tumorigenesis. Despite the fact that obesity is tend to progress to acute liver damage, not many study using 2-nitropropane (2NP) as a hepatoxicity agent are undertaken especially in obese mice. This study aimed to determine the regime of 2NP that causes acute liver damage. This is an experimental research using a post-test control design group only, with 3 groups of mice ie O1 (obesity), O2+2-NP 1x (induced by 2NP 100 mg/kg BW once), and O2+2-NP 2x (induced by 2NP 100 mg/kg BW twice). At 10 weeks, rats were sacrificed and 100 mg liver tissue were collected for MDA, GSH, MnSOD and CAT enzymes analysis. Analysis statistics were performed by SPSS by one-way Anova and post hoc Tukey. MDA levels of mice were found to be increased in 2NP group than control (3.768 ± 0.407 nmol/ mg) (p < 0,01). Liver GSH, MnSOD and CAT levels of both single injection 2-NP and repeated injection 2-NP groups decreased compared to those of controls (p<0,01). Repeated injection of 2-NP worsen the acute liver damage in obese mice. © 2021 Oriental Scientific Publishing Company. All rights reserved. |
2-NP; CAT; GSH; MDA; MnSOD; Obesity |
2 nitropropane; catalase; glutathione peroxidase; ketamine; manganese superoxide dismutase; oxygen; reactive oxygen metabolite; superoxide dismutase; triacylglycerol; xylazine; analysis of variance; animal model; animal tissue; Article; body weight; carcinogenesis; centrifugation; controlled study; data analysis software; DNA damage; enzyme activity; liver injury; liver tissue; male; mouse; nonhuman; obesity; oxidative stress; post hoc analysis; protein content; repeated drug dose |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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345 |
Parikesit D., Witjaksono F., Mochtar C.A., Rasyid N., Hamid A.R.A.H. |
57163830300;57070455800;6506558321;56245069300;57202054669; |
Impact of metabolic syndrome on lower urinary tract symptoms in patients with benign prostate hyperplasia |
2021 |
Medical Journal of Indonesia |
30 |
2 |
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138 |
142 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110781511&doi=10.13181%2fmji.oa.214256&partnerID=40&md5=1ca9a518c25b6145dc4dc6f550d2833e |
Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, West Java, Depok, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Parikesit, D., Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, West Java, Depok, Indonesia; Witjaksono, F., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mochtar, C.A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hamid, A.R.A.H., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND Studies evaluating the relationship between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) in men with benign prostate hyperplasia (BPH) are lacking in Indonesia. This study aimed to discover the association of LUTS and MetS in men with BPH. METHODS Subjects who underwent biopsy were recruited from Cipto Mangunkusumo Hospital, Jakarta, Indonesia from January 2014 to January 2018, but only men who had biopsy-proven BPH were included. Body mass index, waist circumference, fasting blood glucose, triglyceride, high-density lipoprotein, prostate volume (PV), and international prostate symptom score (IPSS) were collected before the biopsy. MetS criteria were based on the National Cholesterol Education Program Adult Treatment Panel III. IPSS was assessed for LUTS and consisted of irritative and obstructive symptoms and quality of life (QoL). Independent t-test or Mann–Whitney test was used to analyze numerical data. RESULTS Of 227 men with biopsy-proven BPH, 87 (38.3%) were diagnosed with MetS. PV was similar in men with or without MetS (54.4 [20.3–100] versus 49.9 [19.5–100] cm3, p = 0.239). Men with MetS generally had more LUTS (15 [1–30] versus 11 [0–35], p = 0.005), more irritative symptoms (8 [0–20] versus 6 [0–20], p = 0.007), and lower QoL (4 [0–6] versus 3 [0–6], p = 0.018). CONCLUSIONS BPH patients with MetS had greater LUTS, particularly irritative symptoms and QoL score. @ 2021 Authors. |
Benign prostate hyperplasia; Lower urinary tract symptoms; Metabolic syndrome |
high density lipoprotein cholesterol; triacylglycerol; Article; body mass; cross-sectional study; glucose blood level; human; human tissue; lower urinary tract symptom; major clinical study; male; metabolic syndrome X; prostate hypertrophy; prostate volume; quality of life; questionnaire; waist circumference |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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347 |
Moegni F., Ocsilia Wengkang I.F. |
55450456100;57226112377; |
Correlation of levator ani muscle strength measurement between Modified Oxford Grading Scale and perineometer on pelvic organ prolapse patient |
2021 |
Urogynaecologia International Journal |
33 |
1 |
268 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110513972&doi=10.4081%2fUIJ.2021.268&partnerID=40&md5=f4aa2afc9d600b8716b8e0217ad613a6 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Moegni, F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ocsilia Wengkang, I.F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pelvic Organ Prolapse (POP) is a debilitating condition affecting about half of all women aged of more than 60 years globally. Reduced levator ani muscle strength in POP is associated with worse symptoms and prognosis. Measurement of levator ani muscle strength can be done with several tools such as perineometer and digital palpation. However, there is currently no study regarding conformity between tests. The aim of this study is to determine the correlation between tests in POP patients. An analytic observational study using cross sectional design was done to determine conformity between perineometer and digital examination using Modified Oxford Grading Scale (MOS) in Dr Cipto Mangunkusumo National General Hospital, Indonesia during the period of July, 2018 to June, 2020. Correlation between tests was determined using Spearman test. Cut-off of perineometer reading for each MOS score was also determined. A total of 110 subjects examined with both perineometer and digital palpation were recruited to the study. Positive correlation was observed between perineometer reading and Modified Oxford Grading Scale (r = 0.790, p < 0.001). According to the result, values between 0.01 – 9.64 cmH2O correspond to very weak pressure (MOS 1); 9.65 – 22.49 cmH2O represent weak pressure (MOS 2); 22.5 – 35.24 cmH2O represent moderate pressure (MOS 3); ≥ 35.25 cmH2O represent good pressure (MOS 4). There was a strong correlation between MOS and perineometer result for measuring levator ani strength in POP patients. Non ©Copyright: the Author(s), 2021 Licensee PAGEPress, Italy |
Levator ani muscle strength; Modified Oxford Grading Scale, pelvic organ prolapse; Perineometer |
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Page Press Publications |
20388314 |
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Article |
Q4 |
103 |
30394 |
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348 |
Djuardi Y., Lazarus G., Stefanie D., Fahmida U., Ariawan I., Supali T. |
6507800820;57214599425;57193121018;14420783500;8840573400;6602742029; |
Soil-transmitted helminth infection, anemia, and malnutrition among preschool-age children in nangapanda subdistrict, indonesia |
2021 |
PLoS Neglected Tropical Diseases |
15 |
6 |
e0009506 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110433985&doi=10.1371%2fjournal.pntd.0009506&partnerID=40&md5=acf6b372e3919f6422f75ae7d13a1c91 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON), Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Department of Biostatistics and Population Studies, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia |
Djuardi, Y., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stefanie, D., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fahmida, U., Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON), Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Ariawan, I., Department of Biostatistics and Population Studies, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Supali, T., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background Soil-transmitted helminth (STH) infections are still prevalent in Indonesia, with roughly one-third of infected population being preschool-age children (PSC), which are generally at higher risk of morbidity such as malnutrition and anemia. This study aimed to investigate the association of STH infections with nutritional status and anemia among PSC in Nangapanda subdistrict, Ende, East Nusa Tenggara. Methods A cross-sectional survey involving PSC ranging from 12 to 59 months old from Nangapanda subdistrict, Ende district, East Nusa Tenggara was performed. Socio-demographic, breastfeeding, and complementary feeding information was obtained from structured questionnaires, while nutritional and anemia status was determined from anthropometry and hemoglobin measurements, respectively. Anthropometric z-scores were calculated based on the World Health Organization 2006 standards and stool samples were examined using Kato-Katz method. Results A total of 393 PSC randomly selected from 22 villages were examined. The prevalence of underweight, stunting, wasting, and anemia were 33.1%, 40.2%, 17.1%, and 60.3%, respectively. STH infection, predominated by Ascaris lumbricoides, was found in 160 (58.8%) PSC. Single STH infection, but not multiple infection, was independently associated with a lower risk of anemia (odds ratio [OR] 0.320, 95% confidence interval [CI]: 0.126– 0.809, p = 0.016). Similar association with anemia was also found on mild STH infection (OR 0.318 [95% CI: 0.114–0.887], p = 0.029). On the other hand, younger children were found to have a higher risk of anemia and stunting. None of the examined variables were independently associated with underweight and wasting. Conclusion STH infection as well as anemia and malnutrition were prevalent in this region. However in this study, current STH infections seemed to have minimal negative impact on children’s nutritional status. © 2021 Djuardi et al. |
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edetic acid; hemoglobin; hemoglobin; anemia; anthropometry; antiretroviral therapy; Article; body mass; breast feeding; child; complementary feeding; controlled study; cross-sectional study; disorder of sex development; endoscopic retrograde cholangiopancreatography; feces analysis; female; flotation; food frequency questionnaire; food intake; helminthiasis; human; major clinical study; male; malnutrition; mass spectrometry; morbidity; nutritional status; obesity; preschool child; questionnaire; randomized controlled trial; risk factor; Strongyloides stercoralis; structured questionnaire; stunting; underweight; vitamin intake; vitamin supplementation; World Health Organization; anemia; animal; Ascaris lumbricoides; growth disorder; helminthiasis; Indonesia; infant; malnutrition; parasitolo |
Public Library of Science |
19352727 |
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34138863 |
Article |
Q1 |
1990 |
1322 |
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350 |
Herawati F., Jaelani A.K., Wijono H., Rahem A., Setiasih, Yulia R., Andrajati R., Soemantri D. |
57194722742;57372559200;57222260570;57204655643;57209025002;56768083700;9940247700;36640659100; |
Antibiotic stewardship knowledge and belief differences among healthcare professionals in hospitals: A survey study |
2021 |
Heliyon |
7 |
6 |
e07377 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109492428&doi=10.1016%2fj.heliyon.2021.e07377&partnerID=40&md5=5c399c28320a996c1e4e405a6c2d8169 |
Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Pharmacy, RSUD Bangil, Pasuruan, 67153, Indonesia; Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Community Pharmacy Department, Faculty of Pharmacy, Airlangga University, Surabaya, 60115, Indonesia; Laboratory for Developmental Psychology, Faculty of Psychology, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Herawati, F., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Jaelani, A.K., Department of Pharmacy, RSUD Bangil, Pasuruan, 67153, Indonesia; Wijono, H., Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Rahem, A., Community Pharmacy Department, Faculty of Pharmacy, Airlangga University, Surabaya, 60115, Indonesia; Setiasih, Laboratory for Developmental Psychology, Faculty of Psychology, Universitas Surabaya, Surabaya, 60293, Indonesia; Yulia, R., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Andrajati, R., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Soemantri, D., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Background: Collaborative practice in healthcare has been recommended to improve the quality of antimicrobial stewardship interventions, a behavioral change in antimicrobial use. Insufficient knowledge regarding antibiotic resistance, the fear of complications from infections, and how providers perceive antibiotic use and resistance are likely to influence prescribing behavior. This study's objective was to identify the knowledge and belief healthcare professionals' differences about antibiotic stewardship. Methods: This cross-sectional survey study of three hospitals in the East Java province, Indonesia utilized a 43-item questionnaire to assess antimicrobial stewardship knowledge and belief. There were 12 knowledge questions (total possible score: 12) and 31 belief questions (total possible score: 155). The Kuder Richardson 20 (KR-20) and Cronbach alpha values of the questionnaire were 0.54 and 0.92, respectively. Results: Out of the 257 respondents, 19% (48/257) had a low scores of knowledge, and 39% (101/257) had low scores on belief about antibiotic stewardship (101/257). Most midwives had a low scores on knowledge (25/61) and low scores on belief (46/61). Respondents with high scores on belief were 17% (10/59) physicians, 15% (4/27) pharmacists, 8% (5/65) nurses, and 3% (2/61) midwives. Conclusion: Among healthcare professionals, knowledge and belief differences concerning antibiotic stewardship vary widely. These differences will affect their capability, behavior, and contribution to the healthcare team collaboration and performance. Further studies are needed to evaluate the correlation between the level of inter-professional collaboration and the quality of the antibiotic stewardship implementation. © 2021 The Author(s) |
Antibiotic stewardship; Belief; Knowledge |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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351 |
Wijaya A.N., Margiana R., Kusumaningtyas S., Furqonita D. |
57225105688;56685900600;57193925307;57191057597; |
Comparison of decomposition rate of hind limbs of preserved mice with ethanol-glycerin and formaldehyde of advanced fixative solution |
2021 |
Anatomy and Cell Biology |
54 |
2 |
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225 |
231 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109181614&doi=10.5115%2facb.20.314&partnerID=40&md5=b084cc2abbf0ad3096da22401b79fe9b |
Undergraduate Program of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Wijaya, A.N., Undergraduate Program of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusumaningtyas, S., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Furqonita, D., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Learning anatomy in medical school is still closely based on the use of cadavers. The burial of preserved cadaver poses a problem, specifically, it contaminates the soil with formalin. Many studies have been conducted to find an alternative fixative to update or modify formalin usage. One of them is ethanol-glycerin (EG), which suggests promising results. Despite that fact, there has yet to be any research comparing the decomposition rate between EG and formalin. This study is conducted to compare the rate of decomposition between the two fixative solutions, EG and 4% formalin on the hind limb of mice. The mice were first preserved using a standard primary fixative solution which is 10% formalin, following that procedure is preservation using advanced fixative solution, EG or 4% formalin. Upon completing the preservation steps, the mice were buried for 6 weeks and observed weekly. The stages of decomposition were assessed semi-quantitatively depending on its appearance. The hind limbs of mice that were fixed with EG solution managed to reach the last stage of decomposition, dry & remains, while the 4% formalin group of mice still remained in the previous stage, advanced decay. It is concluded that the mice hind limbs that have been previously preserved with EG advanced fixative solution has a faster decomposition rate compared to 4% formalin. Copyright © 2021. Anatomy & Cell Biology |
Burial; Glycerol; Mice; Preservation |
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Korean Association of Anatomists |
20933665 |
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Article |
Q2 |
366 |
12934 |
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352 |
Kristin E., Endarti D., Khoe L.C., Taroeno-Hariadi K.W., Trijayanti C., Armansyah A., Sastroasmoro S. |
6504458442;56626162000;56586245200;37012289000;57203727260;57225098604;6507794136; |
Economic Evaluation of Adding Bevacizumab to Chemotherapy for Metastatic Colorectal Cancer (mCRC) Patients in Indonesia |
2021 |
Asian Pacific Journal of Cancer Prevention |
22 |
6 |
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1921 |
1926 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109162811&doi=10.31557%2fAPJCP.2021.22.6.1921&partnerID=40&md5=8b230f77f7dbd1e3652b63db9226b4c0 |
Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Respira Hospital, Yogyakarta, Indonesia; Center of Financing and Health Insurance, Ministry of Health, Government of Indonesia, Indonesia; Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kristin, E., Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Endarti, D., Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia; Khoe, L.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Taroeno-Hariadi, K.W., Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Trijayanti, C., Respira Hospital, Yogyakarta, Indonesia; Armansyah, A., Center of Financing and Health Insurance, Ministry of Health, Government of Indonesia, Indonesia; Sastroasmoro, S., Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: Since 2016, bevacizumab has been widely used to treat metastatic colorectal cancer (mCRC) in Indonesia. Nevertheless, the high cost of bevacizumab has raised the question of whether the therapy is considered cost-effective and should be included in the national health insurance system. This study aimed to assess the cost-effectiveness of bevacizumab plus chemotherapy versus chemotherapy alone for the treatment of mCRC patients. Methods: A Markov model was applied using the perspective of the Indonesian healthcare system to assess cost-effectiveness. The health outcomes were expressed in terms of quality-adjusted life years (QALY) using the validated EuroQoL-5D-5L instrument. Data for medical costs were collected from hospital billings in four hospitals located in three different cities in Indonesia. Meanwhile, data for utility were obtained from interviewing 90 patients who came to the hospital. We compared those mCRC patients who received chemotherapy alone either with FOLFOX or FOLFIRI, versus patients who received the addition of bevacizumab. Results: With the perspective of societal, the incremental cost-effectiveness ratio (ICER) of adding bevacizumab was USD 49,312 per QALY gained using secondary data and USD 28,446 per QALY using real world data. Conclusion: Using either a healthcare or societal perspective, the addition of bevacizumab for mCRC treatment was considered not cost-effective. © 2021. All Rights Reserved. |
Metastatic colorectal cancer- bevacizumab- chemotherapy |
antineoplastic agent; bevacizumab; camptothecin; fluorouracil; folinic acid; platinum complex; colorectal tumor; cost benefit analysis; economics; human; Indonesia; Markov chain; metastasis; pathology; quality adjusted life year; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Cost-Benefit Analysis; Fluorouracil; Humans; Indonesia; Leucovorin; Markov Chains; Neoplasm Metastasis; Organoplatinum Compounds; Quality-Adjusted Life Years |
Asian Pacific Organization for Cancer Prevention |
15137368 |
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34181352 |
Article |
Q2 |
512 |
9866 |
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