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Auer S., Haelterman N.A., Weissgerber T.L., Erlich J.C., Susilaradeya D., Julkowska M., Gazda M.A., Schwessinger B., Jadavji N.M., Abitua A., Niraulu A., Shahb A., Clyburne-Sherinb A., Guiquel B., Alicea B., Lamanna C., Ganguly D., Perkins E., Jambor H., Li I.M.H., Tsang J., Kamens J., Teytelman L., Paul M., Cronin M., Schmelling N., Crisp P., Kutum R., Phuyal S., Sarabipour S., Roy S., Bachle S.M., Tran T., Ford T., Steeves V., Ilangovan V., Baburamani A., Bachle S. |
57224755481;43961196400;6506688349;54396932600;57208325289;54787902500;57194268384;24438486300;8866064800;57224999223;57224994032;57224999963;57224992543;57224993799;51563211500;57225409050;56514870300;57224997775;25421754600;57224994090;57224992895;57224995287;57205247619;57216221631;57224995069;57193626389;36933973000;56871221600;55388614600;16053538000;57224999908;55516154900;57224994106;57224992308;57092624000;57216037751;26867552100;55516154900; |
Science forum: A community-led initiative for training in reproducible research |
2021 |
eLife |
10 |
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e64719 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108881951&doi=10.7554%2feLife.64719&partnerID=40&md5=86ee0e85a4e402a7d89730773f6396b8 |
Department of Plant Physiology, Institute of Botany, Faculty of Biology, TU Dresden, Dresden, Germany; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States; Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center, Berlin, Germany; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China; Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Boyce Thompson Institute, United States; CIBO/InBIOO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Portio, Campus Agrário de Vairão, Porto, Portugal; Departamento de Biologia, Faculdade de Ciências, Universidade do Portio, Porto, Portugal; Research School of Biology, Australian National University, Canberra, Australia; Department of Biomedical Science, Midwestern University, Glendale, United States; Addgene, Boston, United States; Neuroscience Graduate Program, Ohio State UniversityOH, United States; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States; Reproducibility for EveryoneNY, United States; Addgene, London, United Kingdom; Orthogonal Research and Education Laboratory, Champaign, United States; Research School of Biology, Australian National University, Canberra, Australia; Centre for Regenerative Therapies Dresden, Dresden, Germany; Massachusetts General Hospital, Harvard University, Boston, United States; Protocols.io, San Francisco, United States; Psychology of Language Group, University of Gottingen, Gottingen, Germany; Institute for Synthetic Microbiology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany; Institute of Basic Medical Science, University of Oslo, Oslo, Norway; Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; Plant Biotechnology, Tennessee State University, Nashville, United States; School of Mechanical & Aerospace Engineering, Nanyang Technological University, Nanyang, Singapore; Picture as Portal, San Francisco, United States; Research Data Management and Reproducibility, New York UniversityNY, United States; Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany; Centre for the Development of Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom; Department of Neuroscience, Carleton University, Ottawa, Canada |
Auer, S., Department of Plant Physiology, Institute of Botany, Faculty of Biology, TU Dresden, Dresden, Germany; Haelterman, N.A., Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States; Weissgerber, T.L., Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center, Berlin, Germany; Erlich, J.C., NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China; Susilaradeya, D., Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Julkowska, M., Boyce Thompson Institute, United States; Gazda, M.A., CIBO/InBIOO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Portio, Campus Agrário de Vairão, Porto, Portugal, Departamento de Biologia, Faculdade de Ciências, Universidade do Portio, Porto, Portugal; Schwessinger, B., Research School of Biology, Australian National University, Canberra, Australia; Jadavji, N.M., Department of Biomedical Science, Midwestern University, Glendale, United States, Department of Neuroscience, Carleton University, Ottawa, Canada; Abitua, A., Addgene, Boston, United States; Niraulu, A., Neuroscience Graduate Program, Ohio State UniversityOH, United States; Shahb, A., The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States; Clyburne-Sherinb, A., Reproducibility for EveryoneNY, United States; Guiquel, B., Addgene, London, United Kingdom; Alicea, B., Orthogonal Research and Education Laboratory, Champaign, United States; Lamanna, C., Addgene, Boston, United States; Ganguly, D., Research School of Biology, Australian National University, Canberra, Australia; Perkins, E., Addgene, Boston, United States; Jambor, H., Centre for Regenerative Therapies Dresden, Dresden, Germany; Li, I.M.H., Massachusetts General Hospital, Harvard University, Boston, United States; Tsang, J., Addgene, Boston, United States; Kamens, J., Addgene, Boston, United States; Teytelman, L., Protocols.io, San Francisco, United States; Paul, M., Psychology of Language Group, University of Gottingen, Gottingen, Germany; Cronin, M., Addgene, Boston, United States; Schmelling, N., Institute for Synthetic Microbiology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany; Crisp, P., Research School of Biology, Australian National University, Canberra, Australia; Kutum, R., Institute of Basic Medical Science, University of Oslo, Oslo, Norway; Phuyal, S., Institute of Basic Medical Science, University of Oslo, Oslo, Norway; Sarabipour, S., Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; Roy, S., Plant Biotechnology, Tennessee State University, Nashville, United States; Bachle, S.M., Addgene, Boston, United States, Addgene, Boston, United States; Tran, T., School of Mechanical & Aerospace Engineering, Nanyang Technological University, Nanyang, Singapore; Ford, T., Picture as Portal, San Francisco, United States; Steeves, V., Research Data Management and Reproducibility, New York UniversityNY, United States; Ilangovan, V., Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany; Baburamani, A., Centre for the Development of Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom; Bachle, S., Addgene, Boston, United States, Addgene, Boston, United States |
Open and reproducible research practices increase the reusability and impact of scientific research. The reproducibility of research results is influenced by many factors, most of which can be addressed by improved education and training. Here we describe how workshops developed by the Reproducibility for Everyone (R4E) initiative can be customized to provide researchers at all career stages and across most disciplines levels and across disciplines with education and training in reproducible research practices. The R4E initiative, which is led by volunteers, has reached more than 2000 researchers worldwide to date, and all workshop materials, including accompanying resources, are available under a CC-BY 4.0 license at www.repro4everyone.org. © 2021, eLife Sciences Publications Ltd. All rights reserved. |
Accessible protocols; FAIR data; Reproducibility; Rigor; Transparency; Transparent data processing |
biomaterial; Article; bioinformatics; FAIR principles; reproducibility; software; training; education; human; medical research; methodology; personnel; procedures; reproducibility; Biomedical Research; Humans; Reproducibility of Results; Research Design; Research Personnel |
eLife Sciences Publications Ltd |
2050084X |
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34151774 |
Article |
Q1 |
5879 |
219 |
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354 |
Wangsaputra V.K., Syarinta S., Louisa M. |
57215576000;57224977663;41461551400; |
Alpha-mangostin Reduces Cell Viability in Sorafenib-surviving Cells by Modulating Multiple Drug Transporters in Hepg2 Hepatocellular Carcinoma Cells |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
6 |
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105 |
110 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108813859&doi=10.7324%2fJAPS.2021.110612&partnerID=40&md5=eec4655af84852758d672bc24d8bc83b |
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Wangsaputra, V.K., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Syarinta, S., Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
A previous study showed that alpha-mangostin (AM) showed benefit when given to sorafenib (SOR)-surviving cells. However, the mechanism was not fully understood. The present study aimed to understand the effect of AM on SOR-surviving cells and its agent concerning drug transporters. SOR-surviving cells were treated with SOR 10 μM. Surviving cells were divided into four groups of treatment, namely, vehicle only dimethyl sulfoxide (DMSO), SOR 10 μM, AM 20 μM, or combination of SOR 10 μM-AM 20 μM. As controls, HepG2 naïve cells were treated with DMSO only or AM 20 μM. Cell viability was counted using trypan blue exclusion assay. Simultaneously, the mRNA expressions of P-glycoprotein (P-gp), ABCG2, MRP2, MRP3, OCT1, and OATP1B3 drug transporters were examined with quantitative reverse transcriptase-polymerase chain reaction. Decreased mRNA expression of P-gp was found in SOR-surviving cells treated with SOR. In contrast, AM alone or SOR's combination caused a significant increase in both efflux and influx transporters, no difference in fold increase of all transporters evaluated in AM versus SOR-AM combinations. Generally, AM treatment increased the mRNA expression of all the drug transporters. © 2021 Vincent Kharisma Wangsaputra et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). |
Alpha-mangostin; drug transporters; OCT1; P-glycoprotein; sorafenib resistance |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
Q2 |
286 |
15310 |
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355 |
Purwoningsih E., Pawitan J.A. |
57224985986;6508348067; |
Mesenchymal stem cells: Potential application in covid-19 patients with acute respiratory distress syndrome (ards) |
2021 |
International Medical Journal |
28 |
3 |
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303 |
306 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108812441&partnerID=40&md5=0feffaf110f53271a8fb3d884ed44c7c |
Biomedical Science, Faculty of Medicine, Universitas Indonesia, Indonesia; Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia |
Purwoningsih, E., Biomedical Science, Faculty of Medicine, Universitas Indonesia, Indonesia, Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia |
Objective: To highlight the potential of mesenchymal stem cells (MSCs) as an adjuvant therapy for severe COVID-19 patient. Materials and Methods: We searched Pubmed and Google Scholar, using keywords: 'MSC AND lung injury', 'MSC AND ARDS', 'MSC AND COVID-19', 'Stem cell AND Lung injury' and 'Stem cell AND ARDS', on 19 Mei and 19 July 2020. Results and Discussions: Severe manifestations in COVID-19 patients are due to immune system response. MSCs have immunomodulatory and anti-inflammatory effect and therefore may be beneficial to alleviate acute respiratory distress syndrome (ARDS). A small published study showed that MSCs had beneficial effect on COVID-19 patients, who showed clinical symptom improvements. Further, application of MSCs from several sources such as bone marrow, menstrual blood, and umbilical cord-derived MSCs, which were used in patients suffering from lung injury/ARDS due to conditions other than COVID-19, showed that a dose of up to 1.0 x 107 cells/kg body weight was well tolerated. Conclusion: administration of MSCs to COVID-19 patients showed improvement in clinical symptoms, and a dose up to 1.0 x 107 cells/kg body weight showed tolerance in ARDS patients with moderate to severe conditions. However, the results came from studies with small number of patients, so the results need to be interpreted with caution, and more well design studies with a larger number of patients are needed. © 2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation. |
Coronavirus; COVID-19; Mesenchymal stem cell; Stem cells |
alpha interferon; angiopoietin; angiotensin converting enzyme 2; beta interferon; bradykinin; C reactive protein; cytokine; gamma interferon inducible protein 10; granulocyte colony stimulating factor; interferon; interleukin 1; interleukin 10; interleukin 13; interleukin 1beta; interleukin 2 receptor; interleukin 4; interleukin 6; keratinocyte growth factor; monocyte chemotactic protein 1; receptor binding domain; toll like receptor; transmembrane protease serine 2; tumor necrosis factor; unclassified drug; vasculotropin; viral protein; virus spike protein; adjuvant therapy; adult respiratory distress syndrome; angiogenesis; Article; B lymphocyte; CD8+ T lymphocyte; cell differentiation; coronavirus disease 2019; cytokine storm; dendritic cell; exosome; genetic transcription; human; immun |
Japan International Cultural Exchange Foundation |
13412051 |
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Article |
Q4 |
183 |
20490 |
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356 |
Fadilah F., Erlina L., Paramita R.I., Istiadi K.A. |
56966708600;57190181680;54882436900;57224568113; |
Immunoinformatics Studies and Design of Breast Cancer Multiepitope Peptide Vaccines: Diversity Analysis Approach |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
6 |
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035 |
045 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108795156&doi=10.7324%2fJAPS.2021.110604&partnerID=40&md5=36bb41265fd86ae6763c0ce748625cb9 |
Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Fadilah, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Erlina, L., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Paramita, R.I., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Istiadi, K.A., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Breast cancer is one of the most diagnosed cancers in women; the number of cases continues to rise. The high prevalence and increased incidence need more attention in developing effective therapy. Current passive therapy has several drawbacks that have not yet been resolved. Thus, an alternative and preventive therapy for cancer is needed by utilizing vaccines. Immunoinformatics approach is one of the promising methods predicting epitopes in vaccine research. This approach could accelerate the initial study process of vaccine development and reduce research costs. Epitope conservancy and vaccine coverage are important parameters in vaccine research due to addressing the variability and diversity of cancer genomics. This study will be carried out on the multiepitope characterization of potential T cells against the protein mechanism in breast cancer. Proteins used in this study are Mucin-4, Phosphatase And Tensin Homolog, and Receptor tyrosine-protein kinase erbB-2. CTL epitopes, antigenicity, immunogenicity, allergenicity, and toxicity were predicted for the peptide vaccine. Immunoinformatics analysis generates a multiepitope sequence consisting of seven epitopes: DPVALVAPF, SVAYRLGTL, SQINTLNTL, RFRELVSEF, VTSANIQEF, RPRFRELVS, and MYFEFPQPL by AAY linker. The docking and molecular dynamics analyses were conducted to confirm the interactions between the multiepitope vaccine molecule and TLR-4-MD. The multiepitope vaccine construct can be an appropriate choice for further experiments. © 2021 Fadilah Fadilah et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). |
Breast cancer; immunoinformatics; multiepitope; peptide vaccine design; vaccine |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
Q2 |
286 |
15310 |
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357 |
Yuniar I. |
57222295046; |
Restrictive versus liberal fluid bolus therapy in septic shock children: An evidence-based case report |
2021 |
Critical Care and Shock |
24 |
3 |
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143 |
152 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108644226&partnerID=40&md5=42389d8b506d8b4bbacd5ec1431f9c34 |
Division of Pediatric Emergency and Hospitalization, Departement of Child Health, dr. Cipto, Mangunkusumo General Hospital, Faculty of Medicine, University of Indonesia, Indonesia |
Yuniar, I., Division of Pediatric Emergency and Hospitalization, Departement of Child Health, dr. Cipto, Mangunkusumo General Hospital, Faculty of Medicine, University of Indonesia, Indonesia |
Fluid bolus therapy (FBT) is one of prime management in early goal-directed therapy (EGDT) to achieve adequate cardiac output. The Fluid Expansion as Supportive Therapy (FEAST) tri-al, a randomized-clinical trial that was used as an evidence to support fluid resuscitation rec-ommendation in Surviving Sepsis Campaign (SSC) 2020, must be discontinued because of . increasing mortality in the group that received higher volume of FBT. We present a case of a 9-year-old girl, 15 kg, came to emergency ward with refractory septic shock and became fluid overload after the second FBT. This proceeding aimed to deliver evidence-based case practice if the comparison between liberal versus restrictive FBT in children with septic shock. © 2021, The Indonesian Foundation of Critical Care Medicine. All rights reserved. |
Fluid; Liberal; Pediatric; Restrictive; Resuscitation; Shock |
cefotaxime; dobutamine; furosemide; oxygen; paracetamol; procalcitonin; Ringer lactate solution; vasoactive agent; Article; case report; child; clinical article; comparative effectiveness; drug dose titration; dyspnea; early goal-directed therapy; emergency ward; evidence based practice; female; fluid bolus therapy; fluid resuscitation; forward heart failure; heart afterload; heart muscle contractility; heart preload; hemodynamic monitoring; human; hypervolemia; hypotension; hypovolemic shock; mortality; pediatric intensive care unit; pericardial effusion; school child; septic shock; tachycardia |
The Indonesian Foundation of Critical Care Medicine |
14107767 |
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Article |
Q4 |
134 |
24890 |
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358 |
Notonegoro C., Nareswari I. |
57224857889;57194336586; |
A Single Session of Acupuncture Therapy with Combination of Balance Method and Distal Point for the Treatment of Shoulder Calcific Tendinitis: A Case Report |
2021 |
Medical Acupuncture |
33 |
3 |
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240 |
245 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108429586&doi=10.1089%2facu.2020.1454&partnerID=40&md5=9462d25f59bc3264416a9e97290ac99e |
Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia; Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia |
Notonegoro, C., Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia, Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia; Nareswari, I., Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia, Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia |
Background: Tendinitis is a term that is often used to describe various regional musculoskeletal conditions that are common and often occur, which are described mainly by pain and disability at the affected site. In calcareous (or calcific) tendinitis (CT) of the shoulder, a calcified deposit (hydroxyapatite) is located within 1 or more of the rotator cuff tendons (commonly the supraspinatus). CT is found in 10%-42% of chronic shoulder pain. Conservative treatment is always the first line of treatment. Acupuncture has been widely accepted by patients who experience musculoskeletal pain compared with other nonsurgical modalities and it is a minimal risk intervention. Case: A 56-year-old woman was diagnosed with shoulder CT. Physical examination revealed limited range of motion (ROM) in abduction (78.6°) and lateral rotation (82.5°) of the right shoulder joint with a pain scale using numeric rating scale (NRS) assessment score of 5 (with diclofenac sodium 2 × 50 mg since 1 day ago). She received single session of acupuncture with balance method and distal point with a total of 10 needles, then all needles were retained for 45 minutes and the therapy was done only unilaterally. Then follow-up was made 2 days later. Results: After the session ended, NRS assessment score reduced from 5 to 2, ROM in abduction and lateral rotation of the right shoulder was improved, respectively, to 179.2° and 150.4°. In follow-up 2 days after, ROM in abduction and lateral rotation became 168.9° and 147.8°, respectively, and NRS was still 2. Conclusions: Acupuncture with the use of the balance method and distal point effectively relieved the pain and improved ROM of CT even after 2 days. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
acupuncture; balance method; calcific tendinitis; shoulder pain |
analgesic agent; diclofenac; abduction; acupuncture; adult; Article; blood pressure; case report; clinical article; female; follow up; human; jianjing acupoint; middle aged; numeric rating scale; pain assessment; physical examination; range of motion; rotation; shoulder disease; shoulder pain; tendinitis |
Mary Ann Liebert Inc. |
19336586 |
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Article |
Q2 |
281 |
15498 |
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359 |
Priyatini T., Roziana |
57192265423;57218684529; |
A case report: Common channel anomaly with vaginal agenesis and rectal stone after posterior sagittal anorectoplasty (PSARP) |
2021 |
International Journal of Surgery Case Reports |
83 |
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106032 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107780089&doi=10.1016%2fj.ijscr.2021.106032&partnerID=40&md5=28cc4fe008ececf074994d080ed05597 |
Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/ Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Priyatini, T., Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/ Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Roziana, Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/ Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: We reported a case of common channel anomaly complicated with vaginal agenesis and rectal stone, which is a long-term complication of PSARP, a combination of very rare conditions with high morbidity and especially difficult treatment. Presentation of case: A 15-year-old female presented with a chief complaint of cyclic abdominal pain. The patient had no history of menstruation before. Physical examination showed a common channel. The diameter of the common channel was approximately 1 cm and 0.3 cm in length. A sound (±2 mm thickness) was inserted to the small opening between the urethra and anal mucosa with the length of the canal 6 cm. At the end of the opening, a stone-like structure was felt. The management of this case was abdominal hysterectomy with right salpingectomy and stone evacuation. Discussion: Cloacal malformation is thought to be associated with vaginal agenesis since both malformations are considered to have a similar pathophysiologic background. Treatment can be performed using posterior sagittal combined with laparotomy approach. After surgery, patients will need a long-term follow-up since the conditions may be associated with many possible urologic and gynecologic comorbidities, including recurrent urinary tract infections, hematosalpinx, and vesicourethral reflux, including stone formation. Conclusion: Our case was considered one of the most complex common channel anomalies because it was complicated with a rare condition called vaginal agenesis and rectal stone after PSARP. A multidiscipline approach was necessary. © 2021 The Authors |
Common channel anomaly; Rectal stone; Vaginal agenesis |
analgesic agent; abdominal hysterectomy; abdominal pain; adolescent; anal canal; anal mucosa; anus surgery; Article; case report; chronic inflammation; clinical article; colostomy; cystoscopy; echography; enterolithiasis; female; follow up; goblet cell; hematometra; histopathology; human; human tissue; labia minora; nuclear magnetic resonance imaging; physical examination; posterior sagittal anorectoplasty; pubic hair; rectal tissue; salpingectomy; treatment outcome; urethra; uterus; uterus cavity; vagina aplasia; vagina atresia |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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364 |
Polanunu N.F.A., Wahyuni S., Hamid F. |
57224315257;6507185545;35933184500; |
Seroprevalence and associated risk factors of Toxoplasma gondii infection among pregnant mother in Makassar, Indonesia |
2021 |
PLoS ONE |
16 |
6 June |
e0245572 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107384287&doi=10.1371%2fjournal.pone.0245572&partnerID=40&md5=a1249aa5d1b5b981fec180a4502291de |
Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Muslim Indonesia, Makassar, South Sulawesi, Indonesia; Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia |
Polanunu, N.F.A., Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Muslim Indonesia, Makassar, South Sulawesi, Indonesia; Wahyuni, S., Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia, Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hamid, F., Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia |
The protozoan parasite, Toxoplasma gondii is estimated to infect one-third of the world's population. Infection in pregnant women can cause severe conditions for their babies. Until now, there is no data regarding Toxoplasma infection from Makassar pregnant mothers. This study aims to obtain information on Toxoplasma specific antibodies and to measure the risk factor associate with parasite infection. This cross-sectional study conducted in 9 of 47 primary health centres (Puskesmas) in Makassar. Blood samples and questionnaires were collected from 184 pregnant women aged 15-42 years old from September to October 2020. ELISA technique was used to examine the IgG and IgM antibodies. Univariable and multivariable analyses were carried out to measure factors that independently associate with Toxoplasma antibody positivity. Our result showed the range of Toxoplasma IgM and IgG are 0.06-1.01 and 0.09-3.01, respectively. While no one of our participants has an acute Toxoplasma gondii infection (IgM positive), we found 32,6% pregnant mothers are exposed to parasite (positive IgG). Contact with cats [OR(95%CI): 10.45(3.77-28.99)], consume chicken satay [OR(95%CI): 9.72(3.71-25.48)] and consume un-boiled water/ filtered water [OR(95%CI): 5.98(1.77-20.23)] are independently associate with positive Toxoplasma IgG antibody. Based on the result, we conclude that pregnant women in Makassar are exposed to T. gondii and the oocyst and tissue cyst of parasite contaminates food and water in Makassar. Copyright: © 2021 Polanunu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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immunoglobulin G antibody; immunoglobulin M antibody; immunoglobulin G; immunoglobulin M; protozoon antibody; adolescent; adult; Article; blood sampling; controlled study; cross-sectional study; disease association; enzyme linked immunosorbent assay; exposure; female; food contamination; human; Indonesia; oocyst; pregnant woman; risk factor; seroprevalence; toxoplasmosis; water contamination; adverse event; animal; environmental exposure; immunology; mother; parasitology; pathogenicity; pregnancy; pregnancy complication; seroepidemiology; Toxoplasma; toxoplasmosis; young adult; Adolescent; Adult; Animals; Antibodies, Protozoan; Cross-Sectional Studies; Environmental Exposure; Female; Humans; Immunoglobulin G; Immunoglobulin M; Indonesia; Mothers; Pregnancy; Pregnancy Complications, Parasit |
Public Library of Science |
19326203 |
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34086692 |
Article |
Q1 |
990 |
4434 |
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368 |
Fuady A. |
37085331400; |
Call for more investment in cost-effective tuberculosis care |
2021 |
The Lancet Regional Health - Western Pacific |
11 |
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100157 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105966355&doi=10.1016%2fj.lanwpc.2021.100157&partnerID=40&md5=7437dce7d74e8d800265cc28c5c9af76 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands |
Fuady, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands |
[No abstract available] |
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Elsevier Ltd |
26666065 |
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369 |
Yugo D., Lo L.-W., Wu Y.-H., Chung F.-P., Lin Y.-J., Chang S.-L., Hu Y.-F., Chao T.-F., Liao J.-N., Chang T.-Y., Lin C.-Y., Tuan T.-C., Kuo L., Wu C.-I., Liu C.-M., Liu S.-H., Cheng W.-H., Lugtu I.C., Jain A., Chen S.-A. |
57215499689;25224685100;57150405500;40560956700;56512618600;57154909400;57219519883;35335897300;55179923000;56763173800;56469967500;7005704090;57193883698;56320807100;57202736753;57191375309;26025932500;57212467736;57216788165;57211727582; |
Case series on stereotactic body radiation therapy in non-ischemic cardiomyopathy patients with recurrent ventricular tachycardia |
2021 |
PACE - Pacing and Clinical Electrophysiology |
44 |
6 |
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1085 |
1093 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105961876&doi=10.1111%2fpace.14254&partnerID=40&md5=d3ccf6f5cafcbd0b6064e6a5a180d5ce |
Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Cardiology and Vascular Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Arrhythmia Division, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia; Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Heart Institute, Chinese General Hospital and Medical Center, Metro Manila, Philippines; Department of Cardiology, Vardhman Mahavir Medical College, New Delhi, India; Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan |
Yugo, D., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Cardiology and Vascular Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia, Arrhythmia Division, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia; Lo, L.-W., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Wu, Y.-H., Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Chung, F.-P., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Lin, Y.-J., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Chang, S.-L., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Hu, Y.-F., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Chao, T.-F., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Liao, J.-N., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Chang, T.-Y., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Lin, C.-Y., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Tuan, T.-C., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Kuo, L., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Wu, C.-I., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Liu, C.-M., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Liu, S.-H., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Cheng, W.-H., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Lugtu, I.C., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Heart Institute, Chinese General Hospital and Medical Center, Metro Manila, Philippines; Jain, A., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Cardiology, Vardhman Mahavir Medical College, New Delhi, India; Chen, S.-A., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan |
Introduction: The efficacy of stereotactic body radiation therapy (SBRT) as an alternative treatment for recurrent ventricular tachycardia (VT) is still unclear. This study aimed to report the outcome of SBRT in VT patients with nonischemic cardiomyopathy (NICM). Methods: The determination of the target substrate for radiation was based on the combination of CMR results and electroanatomical mapping merged with the real-time CT scan image. Radiation therapy was performed by Flattening-filter-free (Truebeam) system, and afterward, patients were followed up for 13.5 ± 2.8 months. We analyzed the outcome of death, incidence of recurrent VT, ICD shocks, anti-tachycardia pacing (ATP) sequences, and possible irradiation side-effects. Results: A total of three cases of NICM patients with anteroseptal scar detected by CMR. SBRT was successfully performed in all patients. During the follow-up, we found that VT recurrences occurred in all patients. In one patient, it happened during a 6-week blanking period, while the others happened afterward. Re-hospitalization due to VT only appeared in one patient. Through ICD interrogation, we found that all patients have reduced VT burden and ATP therapies. All of the patients died during the follow-up period. Radiotherapy-related adverse events did not occur in all patients. Conclusions: SBRT therapy reduces the number of VT burden and ATP sequence therapy in NICM patients with VT, which had a failed previous catheter ablation. However, the efficacy and safety aspects, especially in NICM cases, remained unclear. © 2021 Wiley Periodicals LLC |
radio-ablation; stereotactic; ventricular tachycardia |
aged; Article; cardiovascular magnetic resonance; case report; clinical article; clinical effectiveness; clinical outcome; computer assisted tomography; death; disease burden; female; follow up; heart pacing; heart ventricle tachycardia; hospital readmission; human; incidence; male; nonischemic cardiomyopathy; recurrent disease; stereotactic body radiation therapy; very elderly; cardiomyopathy; diagnostic imaging; epicardium mapping; heart ventricle tachycardia; procedures; radiosurgery; radiotherapy dosage; scar; x-ray computed tomography; Aged; Aged, 80 and over; Cardiomyopathies; Cicatrix; Epicardial Mapping; Female; Humans; Male; Radiosurgery; Radiotherapy Dosage; Tachycardia, Ventricular; Tomography, X-Ray Computed |
John Wiley and Sons Inc |
01478389 |
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33932305 |
Article |
Q2 |
686 |
7284 |
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