No records
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435 |
Widyaningrum A.R., Prakoso N.M., Priambodo R., Aswin Y.A., Hafifah C.N., Sjarif D.R. |
57211929162;57214084050;57190937999;57222721787;57204112129;6506242684; |
Identification of novel mutations in exon 1 of iduronate-2-sulfatase gene from mucopolysaccharidosis type II patient in Indonesia |
2021 |
AIP Conference Proceedings |
2331 |
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050026 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103846997&doi=10.1063%2f5.0042045&partnerID=40&md5=23bc8c1777e9bfa31dccebb034820f8e |
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia; Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Widyaningrum, A.R., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia; Prakoso, N.M., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Priambodo, R., Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia; Aswin, Y.A., Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia, Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Hafifah, C.N., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia; Sjarif, D.R., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia |
Mucopolysaccharidosis type II (MPS II, OMIM 309900) is an X-linked recessive lysosomal storage disorder caused by the accumulation of heparan sulfate and dermatan sulfate due to iduronate-2-sulfatase (IDS) enzyme deficiency. To detect IDS gene mutation, DNA samples are obtained from 10 MPS II patients and 50 normal individuals, then the exon 1 of IDS gene was analyzed with Sanger sequencing. Two novel mutations are found from one male patient at the site of c.22C>A (p.Arg8=) and c.54C>A (p.Ser18Arg). Both mutations are not located in the bases which are responsible as the signal peptide cleavage site. Amino acid substitution c.54C>A (p.Ser18Arg) does not change the hydrophobic characteristic as both amino acids are hydrophobic. Therefore, those mutations do not change IDS enzyme structure nor alter the signaling pathway of IDS mRNA-ribosome complex to the endoplasmic reticulum. This study of exon 1 is the first to be performed in Indonesia. The novel mutations found in this study can contribute to a single nucleotide polymorphism (SNP) database of MPS II patients from all over the world, thus it leads to a deeper understanding of this rare disease at the molecular level. Therefore, a genotype study is needed to get a full profile of MPS II patients in Indonesia. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735440753 |
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Conference Paper |
- |
177 |
20880 |
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436 |
Pustimbara A., Prakoso N.M., Priambodo R., Ariani Y., Arianto S., Pangestika Y., Bowolaksono A., Sjarif D.R. |
57217086984;57214084050;57190937999;57200504713;57190933807;57204110196;57205093224;6506242684; |
Variant analysis for exon 2 and 5 of iduronate 2-sulfatase gene on mucopolysaccharidosis type II patients in Indonesia |
2021 |
AIP Conference Proceedings |
2331 |
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050027 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103846040&doi=10.1063%2f5.0042046&partnerID=40&md5=1aea65a5d9d11be167de0e0b76440cc5 |
Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia |
Pustimbara, A., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Prakoso, N.M., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Priambodo, R., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Ariani, Y., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia, Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Arianto, S., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Pangestika, Y., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Bowolaksono, A., Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Sjarif, D.R., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia |
Mucopolysaccharidosis type II (MPS II or Hunter Syndrome) is one of lysosomal storage disorder caused by the presence of pathogenic variant in IDS gene. The variant can be found in various exon locations. This research aimed to identify the presence of disease-causing variant that may occurs at exon 2 and 5 of IDS gene on MPS II patient, especially in Indonesia. Based on the previous research that has been conducted in a number of countries, exon 2 and 5 are the exons with the most number of variations. Analysis was conducted on 7 MPS II patient of Indonesian origin and 50 normal individuals as control that consist of 25 male or 25 female individuals. Analysis was done by going through steps of DNA isolation, amplification by polymerase chain reaction (PCR), visualization by electrophoresis, and sequencing. Research result shows that IDS gene from whole samples were successfully analyzed. This study discovered an adenine base deletion c.708+72delA in intron 5 of one healthy individual. The variant is novel and classified as likely benign. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735440753 |
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Conference Paper |
- |
177 |
20880 |
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437 |
Sulaiman R.A.R., Aji R.P., Prakoso N.M., Priambodo R., Aswin Y.A., Hafifah C.N., Sjarif D.R. |
57203195674;57214097675;57214084050;57190937999;57222721787;57204112129;6506242684; |
Variant identification of exon 11 of galactosamine (N-acetyl)-6-sulfatase (GALNS) gene in mucopolysaccharidosis type IVA patients in Indonesia |
2021 |
AIP Conference Proceedings |
2331 |
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050025 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103831975&doi=10.1063%2f5.0042042&partnerID=40&md5=62e2f8987a113373133b39a10f6bba9d |
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia; Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Sulaiman, R.A.R., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia; Aji, R.P., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia; Prakoso, N.M., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Priambodo, R., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Aswin, Y.A., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia, Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Hafifah, C.N., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Sjarif, D.R., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia |
Mucopolysaccharidosis type IVA (MPS IVA) is an autosomal recessive disease, in which lysosomes are unable to catalyze glycosaminoglycans due to deficiency of the enzyme galactosamine (N-acetyl)-6-sulfatase (GALNS), encoded by GALNS gene. The exon 11 of GALNS gene is known as one of the mutation hotspot regions and encode the enzyme scaffolding structure along with exon 8-10 and 12-14. The GALNS enzyme deficiency leads to abnormal accumulation of glycosaminoglycans inside the lysosomes, rendering the cell unable to function properly. Symptoms of MPS IVA are commonly seen as skeletal dysplasia and multi-organ complications. Research on MPS IVA has been done in many countries, but not in Indonesia. This study aims to identify variants that may be present in exon 11 of GALNS gene in MPS IVA patients in Indonesia. The study was conducted using DNA from blood samples of 7 MPS IVA patients and 30 healthy individuals as controls, obtained from Cipto Mangunkusumo Hospital, Jakarta. A set of specific primers of exon 11 was designed and optimized before completing DNA extraction. Then, DNA extraction was performed, further amplified using the polymerase chain reaction technique. PCR products were visualized by electrophoresis and proceeded for Sanger sequencing. The sequencing results indicated that a variant c.1177G>T (p.Ala393Ser) was found in one patient and five healthy individuals. This variant has been reported in Japan before and identified as benign with more than 5% MAF globally. This research may provide additional information to existing databases for research in MPS IVA, especially in Indonesia. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735440753 |
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Conference Paper |
- |
177 |
20880 |
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438 |
Hadi I.A.N., Ekaputri M., Baskoro J.C., Winarsih N.S. |
57345259600;57242005600;57242005500;57211183552; |
Association between duration of untreated psychosis and executive function in early-onset psychosis |
2021 |
Journal of Affective Disorders Reports |
4 |
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100068 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125606448&doi=10.1016%2fj.jadr.2020.100068&partnerID=40&md5=fa88cf50f43a9cc6eaaa94d1676fa411 |
Medical Doctor Graduate, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Psychiatry Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hopsital, Jakarta, Indonesia |
Hadi, I.A.N., Medical Doctor Graduate, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ekaputri, M., Medical Doctor Graduate, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Baskoro, J.C., Medical Doctor Graduate, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Winarsih, N.S., Department of Psychiatry Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hopsital, Jakarta, Indonesia |
Introduction: Psychosis is a severe mental illness that causes impaired executive function (EF). The prolonged duration of untreated psychosis (DUP) is one of the negative factors in the course of psychosis. However, the results of previous studies remain inconsistent. The aim of this study is to find out the association between DUP and all the components of EF, i.e. behavioral regulation and metacognition with all their subdomains. Method: This was a cross-sectional study involving patients with early onset-psychosis aged 5–18 years old. DUP were collected from medical records, whereas sociodemographic data were collected by interview and EF was measured using the Behavior Rating Inventory of Executive Function-Parent Indonesian Version questionnaire. Results: Total 50 subjects were included in the study. The median age of subjects was 15.9 ± 1.9 years old with schizophrenia as majority of diagnosis (58%). Median DUP was 2 (0; 84) months. Subjects were divided into short DUP (≤2 months) and long DUP (>2 months) group. A significant association was found between long DUP (>2 months) and higher Global Executive Composite (GEC) score indicating poorer function, which consisted of Behavioral Regulation Index (BRI) and Metacognition Index (MI) (p = 0.001, p = 0.007, p = 0.001, respectively). All subdomains of BRI and MI, except material organization, showed significant associations with DUP. Conclusion: There was a significant association between long DUP (>2 months) and poorer EF in early-onset psychosis. © 2021 The Author(s) |
Behavioral regulation; Duration of untreated psychosis; Early-onset psychosis; Executive function; Metacognition |
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Elsevier B.V. |
26669153 |
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Article |
#N/A |
#N/A |
#N/A |
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439 |
Restuti R., Sriyana A., Priyono H., Saleh R. |
55261428300;57203022550;57201550021;57391850200; |
Postauricular Cutaneous Mastoid Fistula Closure with Combination of Bilobed Flap and Fibro-Muscular-Periosteal Flap: A Case Series |
2021 |
Indian Journal of Otology |
27 |
2 |
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116 |
119 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122022487&doi=10.4103%2findianjotol.indianjotol_10_21&partnerID=40&md5=dfd65407309ade3f15f32833b03bb0ef |
Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia |
Restuti, R., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Sriyana, A., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Priyono, H., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Saleh, R., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia |
Chronic suppurative otitis media (CSOM) with cholesteatoma can present with intratemporal complications such as postauricular subperiosteal abscess with or without fistula. In some postauricular cutaneous mastoid fistula cases, direct closure of the wound is not possible due to skin tension, leading to skin necrosis and postoperative recurrent cutaneous fistula. Here, we describe a surgical technique using a combination of a bilobed flap and a fibro-muscular-periosteal flap for fistula closure on a 31-year-old and a 35-year-old female with postauricular cutaneous mastoid fistula due to CSOM. All patients were successfully managed with no fistula recurrence. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Bilobed flap; cholesteatoma; chronic suppurative otitis media; postauricular cutaneous mastoid fistula |
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Wolters Kluwer Medknow Publications |
09717749 |
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Article |
Q4 |
174 |
21127 |
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440 |
Rinaldhy K., Yani A., Tamba R.P. |
57325189500;57215433374;47761736600; |
Papaverine for the prevention of anastomosis leakage after intussusception management in rat model |
2021 |
Surgical Chronicles |
26 |
2 |
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162 |
164 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118534016&partnerID=40&md5=b67121e208a15e9402e0b83764f168b7 |
Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia |
Rinaldhy, K., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia; Yani, A., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia; Tamba, R.P., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia |
Background. The most common complication of surgical management for intussusception is anastomosis leakage. Warm normal saline application, especially on the bowel with a doubtful viability, is thought to cause vasodilation and subsequently reduce the resected bowel requirement. This research compared the effect of topical warm normal saline and papaverine on collagen grading and incidence of anastomosis leakage of the intussusception model in rats. Methods. Ileo-ileal intussusception was created on 21 Sprague-Dawley rats. Groups included control group, normal saline group, and papaverine group. Intussusceptions were then reduced and given topical warm normal saline or papaverine according to each group. Afterward, each bowel was resected, and an end-to-end anastomosis was created. After five days, laparotomy was performed to assess anastomosis leakages. Moreover, a collagen grading assessment was performed on the anastomosis. Results. The papaverine group had the highest collagen grade and no anastomosis leakage. There was no significant association between treatments and the incidence of anastomosis leakage (p=0.174), but treatments were significantly associated with collagen grade (p=0.014). Collagen grade was significantly associated with anastomosis leakage (p=0.01). Conclusion. Findings suggested that the topical application of papaverine is associated with an increase in collagen grading and higher collagen grade is associated with a decrease of anastomosis leakage. © 2021 Surgical Society of Northern Greece. All rights reserved. |
Anastomosis leakage; Collagen; Intussusception; Normal saline; Papaverine. |
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Surgical Society of Northern Greece |
11085002 |
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Article |
Q4 |
102 |
30883 |
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441 |
Sukmawati D., Junaidi H., Syaidah R. |
55615650900;57202926303;55418885900; |
Human platelet-rich plasma as a biological stimulant for proliferation and differentiation of mesenchymal stem cells |
2021 |
Biomedicine (India) |
41 |
2 |
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168 |
173 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117427828&doi=10.51248%2f.v41i2.777&partnerID=40&md5=08fabc44956a1de6990d42feb38813ba |
Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia |
Sukmawati, D., Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Junaidi, H., Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Syaidah, R., Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia |
Platelet is one of the cells within the blood that have potential in regenerative therapy. Recently platelet-related products got special attention due to the abundance of growth factors and easy availability and processing. With the robust in cell-based therapy, platelet-rich plasma (PRP) has been intensively studied for its potential to substitute the fetal bovine serum (FBS) as the supplement in cell culture. Our study aimed to investigate the use of human PRP in mesenchymal stem cells (MSC) culture and its related effect on stem cell biology. We searched in vitro studies that used human PRP as a supplementing factor on human MSCs culture. From the initial 172 studies, 14 studies fulfilled the selection criteria and were analysed. The results showed that the sources of MSCs were varied, including adipose tissue, bone marrow, and dental tissue. The PRP concentration showing the best effects was ranged from 10 to 20%. In addition, most of the studies demonstrated the superiority of PRP to FBS in promoting the proliferation and differentiation of MSCs in vitro. Therefore, PRP could be an alternative to FBS in supporting a xeno-free culture system. Studies are needed to reveal the mechanism of PRP in maintaining the physiology of MSCs. © 2021, Indian Association of Biomedical Scientists. All rights reserved. |
Cell culture; Differentiation; Mesenchymal stem cells; Platelet-rich plasma; Proliferation; Xeno-free |
adipose tissue; Article; bone marrow; cell differentiation; cell proliferation; controlled study; human; human cell; in vitro study; mesenchymal stem cell; thrombocyte rich plasma; tooth tissue; xeno-free culture |
Indian Association of Biomedical Scientists |
09702067 |
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Article |
Q4 |
106 |
29384 |
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442 |
Legiawati L., Raissa, Santoso I.D., Lubis F.F. |
57202804484;57240272100;57219513443;57239954700; |
Comparison between clinical diagnosis with and without dermoscopy in the assessment of hair disorders |
2021 |
Journal of Pakistan Association of Dermatologists |
31 |
2 |
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201 |
205 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113937212&partnerID=40&md5=c56b73079d0a2b354502f693b7d4fa6e |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Tarumanegara, Jakarta, Indonesia |
Legiawati, L., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Raissa, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Santoso, I.D., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Tarumanegara, Jakarta, Indonesia; Lubis, F.F., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Background: Hair dermoscopy or trichoscopy is a tool used to find hair abnormalities more clearly. Morphologic feature of skin and hair abnormalities becomes more visible under this tool compared with naked eye. It helps to diagnose hair disorders faster and can be used for follow up treatment in patients. The purpose of this study is to compare superiority between clinical diagnosis alone and with addition of dermoscopy tool in the assessment of hair disease. Methods: Research was conducted in October 2018 in a boarding school in West Java, Indonesia. This was a cross-sectional descriptive study. Statistical analysis was done using SPSS Statistics 20.0. Data were collected from 127 subjects through anamnesis, general physical examination and dermatological findings, pull test, dermoscopy, and photographs of scalp and hair lesions. Results: The highest incidence of hair disorder in this study found by clinical examination and dermoscopy was pediculosis capitis, with a total of 86 subjects (67.7%). From the comparison between clinical examination and dermoscopy, we found that dermoscopy was superior for diagnosis. As much as 43 cases of hair disorders which were not detected on clinical examination screening were found by dermoscopy. Out of 127 children, there were 49 subjects with hair disorders found in clinical examination and 92 subjects found by dermoscopy. Conclusion: Dermoscopy as a non-invasive tool which plays an important role in determining the diagnosis of hair disorder. © 2021 Pakistan Association of Dermatologists. All rights reserved. |
Dermoscopy; Diagnosis; Hair disease; Lice infestations; Pediculosis capitis |
adolescent; alopecia; Article; child; clinical examination; controlled study; cross-sectional study; descriptive research; epiluminescence microscopy; female; hair; hair disease; human; Indonesia; major clinical study; male; pediculosis capitis; scar; sebaceous nevus; seborrheic dermatitis |
Pakistan Association of Dermatologists |
15609014 |
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Article |
Q4 |
129 |
25503 |
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444 |
Wardoyo E.Y., Nainggolan G., Hustrini N.M., Setiati S. |
57219411333;23498775400;57200424892;14325991900; |
Factors Associated with Arterial Stiffness in Chronic Hemodialysis Patients in Jakarta: The Role of Hemodialysis Frequency and Pentraxin 3 |
2021 |
Acta medica Indonesiana |
53 |
2 |
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177 |
183 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111583410&partnerID=40&md5=48c271443cfc8fc3a9b8370bf863e403 |
Department of Internal Medicine, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Wardoyo, E.Y., Department of Internal Medicine, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Nainggolan, G.; Hustrini, N.M.; Setiati, S. |
BACKGROUND: arterial stiffness is a mortality predictor in hemodialysis patients, hemodialysis induces inflammation, marked by an intradialysis increase in the inflammatory marker pentraxin 3 (PTX3). Arterial stiffness in twice-weekly hemodialysis patients in Indonesia is lower than has been found in studies of thrice-weekly patients. This study therefore aims to determine the factors associated with arterial stiffness, focusing on the role of hemodialysis frequency and PTX3. METHODS: a cross-sectional study was conducted at Cipto Mangunkusumo Hospital, Fatmawati Hospital, and Medistra Hospital involving patients with twice- and thrice-weekly hemodialysis. Arterial stiffness was measured by carotid-femoral pulse wave velocity after hemodialysis, and blood samples for PTX3 testing were taken before hemodialysis. Bivariate and multivariate analyses were performed using chi-squared tests and logistic regression. RESULTS: out of 122 subjects, 82 underwent twice-weekly hemodialysis. There was no difference in arterial stiffness between patients with twice- and thrice-weekly hemodialysis. In bivariate analysis, PTX3, cardiovascular disease, dialysis vintage had p values of <0.05, while the subsequent multivariate analysis showed that PTX3>2.3 ng/ml was associated with arterial stiffness (adjusted OR 5.18; 95% CI 1.07-24.91), as well as cardiovascular disease (adjusted OR 3.67; 95% CI 1.40-10.55), LDL (adjusted OR 3.10; 95% CI 1.04-9.24), and dialysis vintage (adjusted OR 2.72; 95% CI 1.001-7.38). CONCLUSION: predialysis PTX3 levels above 2.3 ng/ml were associated with arterial stiffness. There was no difference in arterial stiffness between patients with twice- and thrice-weekly hemodialysis. |
arterial stiffness; hemodialysis frequency; pentraxin 3; pulse wave velocity |
biological marker; C reactive protein; pentraxin 3; serum amyloid P; adult; aged; arterial stiffness; blood; blood flow velocity; chronic kidney failure; clinical trial; cross-sectional study; female; hemodialysis; human; Indonesia; male; metabolism; middle aged; multicenter study; multivariate analysis; physiology; pulse wave; statistical model; Adult; Aged; Biomarkers; Blood Flow Velocity; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Indonesia; Kidney Failure, Chronic; Logistic Models; Male; Middle Aged; Multivariate Analysis; Pulse Wave Analysis; Renal Dialysis; Serum Amyloid P-Component; Vascular Stiffness |
NLM (Medline) |
01259326 |
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34251346 |
Article |
Q3 |
321 |
14162 |
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445 |
Pramono L.A., Yunir E., Tarigan T.J.E., Nusanti S., Aman R.A., Suroyo I. |
37063602400;36520254800;36057746500;57189727162;57226434769;57204106272; |
Giant Recurrence Pituitary Adenoma After Three Times Transphenoidal Removal Surgery, One Craniotomy Procedure, and 30 Doses of External Radiotherapy |
2021 |
Acta medica Indonesiana |
53 |
2 |
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221 |
224 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111572434&partnerID=40&md5=3fbf4691ce27b57e71d3a91134445173 |
1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Indonesia. 2. Department of Public Health and Nutrition, School of Medicine and Health Sciences Universitas Katolik Indonesia Atma Jaya - Department of Internal Medicine St Carolus HospitalJakarta, Indonesia |
Pramono, L.A., 1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Indonesia. 2. Department of Public Health and Nutrition, School of Medicine and Health Sciences Universitas Katolik Indonesia Atma Jaya - Department of Internal Medicine St Carolus HospitalJakarta, Indonesia; Yunir, E.; Tarigan, T.J.E.; Nusanti, S.; Aman, R.A.; Suroyo, I. |
This is a case of 42nd year-old woman with history of sight loss in her both eyes. She experienced headache and visual field decrease gradually since 2014. After several laboratory and imaging examinations, from her dynamic pituitary magnetic resonance imaging (MRI), it is concluded that she had a giant adenoma of the pituitary gland which compressed to her optic chiasm. From her pituitary laboratory hormone panel, it is revealed that the tumor is a non-functioning pituitary adenoma. From the neuro-ophthalmology (campimetry) examinations, she had papillae atrophy in her both eyes and also bilateral temporal hemianopia. |
Giant Recurrence Pituitary Adenoma; Radiotherapy; Transphenoidal Removal Surgery |
adenoma; adult; case report; craniotomy; female; hemianopia; human; hypophysis tumor; nuclear magnetic resonance imaging; optic nerve; pathology; tumor recurrence; Adenoma; Adult; Craniotomy; Female; Hemianopsia; Humans; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Optic Nerve; Pituitary Neoplasms |
NLM (Medline) |
01259326 |
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34251352 |
Article |
Q3 |
321 |
14162 |
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