No records
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459 |
Muchtar N.J., Helianthi D.R., Nareswari I. |
57216550449;57194729482;57194336586; |
Effectiveness of Electroacupuncture for Management of Young Patients with Overactive Bladder at 1-Year Follow-Up |
2021 |
Medical Acupuncture |
33 |
2 |
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169 |
174 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104703311&doi=10.1089%2facu.2020.1462&partnerID=40&md5=14af8a2c96999e7428dd5cd493b4ac4d |
Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Daerah Khusus Ibukota Jakarta, Indonesia |
Muchtar, N.J., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Daerah Khusus Ibukota Jakarta, Indonesia; Helianthi, D.R., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Daerah Khusus Ibukota Jakarta, Indonesia; Nareswari, I., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Daerah Khusus Ibukota Jakarta, Indonesia |
Background: Overactive bladder (OAB) is defined as urgency (a sudden compelling desire to pass urine with or without urge incontinence) usually associated with frequency and nocturia. OAB is a chronic condition that affects quality of life (QoL) significantly in patients. Acupuncture can help in the treatment of OAB for patients who cannot take certain medications. Case: A 32-year-old a female patient was diagnosed with OAB. She came to the department of medical acupuncture with a chief complaint of frequent urination for 15 years. Urinalysis test results were normal. Before acupuncture, a bladder ultrasound (US) showed a postvoid residual volume (PVR) of 53 mL, and a uroflowmetry test showed a maximum flow rate of 20.6 mL/s, with an average flow rate of 12.1 mL/s and a voided volume of 71 mL. Her OAB Symptom Score (OABSS) was 13 and the King's Health Questionnaire result was (KHQ) was 87. She was treated with electroacupuncture (EA). Results: After 12 EA sessions, 3 times per week, this patient's bladder US showed a PVR of 3 mL; a uroflowmetry test showed a maximum flow rate of 30.5 mL/s, with an average flow rate of 15.3 mL/s and a voided volume of 120 mL. Her OABSS score was 7. Her KHQ score was 0. Conclusions: OAB can be treated with EA to improve QoL, as seen by this patient's decreasing OABSS and KHQ scores, reduced PVR, and increase the voided volume. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
acupuncture; bladder hyperactivity; electroacupuncture; incontinence; nocturia; Overactive bladder |
albumin; bilirubin; glucose; ketone; urobilinogen; abdominal surgery; adult; appendicitis; Article; asepsis; case report; cesarean section; clinical article; echography; electroacupuncture; female; flow rate; follow up; human; informed consent; laboratory test; micturition; overactive bladder; patient comfort; pollakisuria; postvoid residual urine volume; priority journal; social life; urinalysis; uroflowmetry; vaginal delivery; voided volume |
Mary Ann Liebert Inc. |
19336586 |
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Article |
Q2 |
281 |
15498 |
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460 |
Darmaputra D.C., Zaman F.Y., Khu Y.L., Nagalingam V., Liew D., Aung A.K. |
57223041347;57208759841;57208757691;57215386437;7003970080;55117996600; |
Cost-analysis of opportunistic influenza vaccination in general medical inpatients |
2021 |
Internal Medicine Journal |
51 |
4 |
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591 |
595 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104572736&doi=10.1111%2fimj.15270&partnerID=40&md5=6be726bbda46f6b4342a09dd962a3b11 |
Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia |
Darmaputra, D.C., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Zaman, F.Y., Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia; Khu, Y.L., Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia; Nagalingam, V., Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia; Liew, D., School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia, Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia; Aung, A.K., School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia, Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia |
Influenza vaccination is an important preventative health measure in the elderly and those with medical comorbidities. It has been shown to reduce hospitalisations, cardiovascular and respiratory complications. A significant proportion of patients admitted to general medicine are eligible for opportunistic inpatient influenza vaccination. This study explores the cost-effectiveness of such a strategy in reducing subsequent healthcare utilisation costs. © 2021 Royal Australasian College of Physicians |
cost-analysis; elderly; influenza; inpatient; vaccination |
aged; article; cost effectiveness analysis; health care utilization; hospital patient; human; influenza vaccination; cost benefit analysis; hospital patient; hospitalization; influenza; vaccination; influenza vaccine; Aged; Cost-Benefit Analysis; Hospitalization; Humans; Influenza Vaccines; Influenza, Human; Inpatients; Vaccination |
Blackwell Publishing |
14440903 |
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33890379 |
Article |
Q3 |
596 |
8475 |
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461 |
Prasetyo M., Adistana I.M., Setiawan S.I. |
57192905252;57223019188;57195939543; |
Tuberculous septic arthritis of the hip with large abscess formation mimicking soft tissue tumors: A case report |
2021 |
Heliyon |
7 |
4 |
e06815 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104438407&doi=10.1016%2fj.heliyon.2021.e06815&partnerID=40&md5=e543449bd0c6c3d5e0c816cffc92a0e4 |
Department of Radiology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Prasetyo, M., Department of Radiology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Adistana, I.M., Department of Radiology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Setiawan, S.I., Department of Radiology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Background: Tuberculous septic arthritis is an infection that occurs inside the joint or synovial fluid and joint tissues caused by Mycobacterium tuberculosis. It may show wide variability of clinical symptoms and imaging appearance, ranging from asymptomatic with a normal radiographic examination to severe joint pain along with joint destruction, osteomyelitis, and abscess formation. This article presents radiographic and MR imaging appearance from a case of tuberculous septic arthritis with large abscess formation mimicking soft tissue tumor. Case presentation: We reported a 32-year-old female with a slowly enlarging lump on her right proximal thigh within the last 4 months along with slowly progressing joint pain. Both radiographic and MR images showed destruction of the femoral head and acetabular roof, with a formation of large rim-enhanced abscess that extending superficially and distally until mid-thigh. The patient underwent open drainage surgery and excisional biopsy. Histopathological examination showed chronic granulomatous inflammation caused by tuberculous infection. Conclusion: MR imaging combined with radiographic and clinical information played a very important role in the diagnosis of tuberculous septic arthritis with abscess, and to differentiate it from soft tissue neoplasms. © 2021 The Author(s) |
Abscess; Infectious arthritis; Septic arthritis; Tuberculosis |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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463 |
Nurhayati F., Anggriani Y., Syahruddin E., Ramadaniati H.U., Kusumaeni T. |
57222957631;57144482600;6507688750;56380618600;57196083946; |
Cost-effectiveness analysis of tyrosine kinase inhibitors (erlotinib vs. gefitinib vs. afatinib) in non-small-cell lung cancer |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
4 |
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88 |
95 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104274393&doi=10.7324%2fJAPS.2021.110411&partnerID=40&md5=b2ac85fabd74afa9ddcab3ce12766f43 |
Pharmacy Department, Persahabatan Government Hospital, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta Selatan, Indonesia; Division of Thoracic Oncology Department of Pulmonology Respiratory Medicine Faculty of Medicine, Universitas Indonesia Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Nurhayati, F., Pharmacy Department, Persahabatan Government Hospital, Jakarta, Indonesia; Anggriani, Y., Faculty of Pharmacy, University of Pancasila, Jakarta Selatan, Indonesia; Syahruddin, E., Division of Thoracic Oncology Department of Pulmonology Respiratory Medicine Faculty of Medicine, Universitas Indonesia Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Ramadaniati, H.U., Faculty of Pharmacy, University of Pancasila, Jakarta Selatan, Indonesia; Kusumaeni, T., Pharmacy Department, Persahabatan Government Hospital, Jakarta, Indonesia |
Tyrosine kinase inhibitors (TKIs; e.g., erlotinib, gefitinib, and afatinib) are the first-line therapy for non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) (+) common mutation. The study’s objective was to analyze the cost-effectiveness of erlotinib, gefitinib, and afatinib in NSCLC patients. The subjects of the study were NSCLC patients with EGFR (+) mutation receiving either erlotinib, gefitinib, or afatinib from January 2017 to December 2019. The exclusion criteria were patients receiving the respective therapy for less than 2 months and patients unable to complete the treatment until after December 2019. The parameter of treatment effectiveness was progression-free survival (PFS), which was measured as the time from initiation of the therapy until disease progression occurred or a patient became deceased. Direct medical costs, from the hospital perspective, were calculated during the treatment. A nonparametric Kruskal-Wallis test was conducted to compare the median PFS and direct medical cost between the three treatment groups. The median PFS of patients receiving erlotinib, gefitinib, and afatinib was 8 months, 12 months, and 5 months, respectively. There were significant differences in the monthly direct medical costs between the study groups: erlotinib (IDR 13,545,116), gefitinib (IDR 14,727,887), and afatinib (IDR 12,146,834). The cost-effectiveness ratio of the study groups was as follows: erlotinib IDR 1,693,139.50/months; gefitinib IDR 1,227,323.92/months; and afatinib IDR 2,429,366.80/months. Gefitinib was the most cost-effective TKI, followed by erlotinib and afatinib. © 2021. Fitri Nurhayati et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). All rights reserved. |
afatinib; Cost-effectiveness; erlotinib; gefitinib; non-smallcell lung cancer. |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
Q2 |
286 |
15310 |
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464 |
Cahyono A.T., Louisa M., Mayang Permata T.B., Handoko, Nuryadi E., Kodrat H., Wibowo H., Hariandy Hamid A.R.A., Sekarutami S.M., Gondhowiardjo S.A. |
57222900545;41461551400;57197808751;57209984822;57197806814;57210639849;57217690943;57202054669;56576294500;6508327402; |
The potential of gallic acid as a radiosensitizer on human prostate cancer: A systematic review of preclinical studies |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
2 |
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246 |
254 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104201486&partnerID=40&md5=aff7e4b57216dc4b88ee83f02823372e |
Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Cahyono, A.T., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mayang Permata, T.B., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Handoko, Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, H., Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hariandy Hamid, A.R.A., Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekarutami, S.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Prostate adenocarcinoma accounts for majority of prostate cancer cases, and it was found to be highly radioresistant. Gallic acid is a phenolic acid naturally occurring in many plants, reported to exhibit biological activities in eliminating cancer cell lines and xenografts. The purpose of this study is to review gallic acid as a potential radiosensitizer agent in prostate cancer treatment. Article search was conducted in PubMed, EBSCO, and Scopus. 11 studies using different cell lines including DU145, PC-3, LNCaP, and 22Rv1 xenograft of human prostate cancer were reviewed in this paper. Gallic acid acts as a radiosensitizer mainly by increasing caspase-3 and caspase-9 activation resulting in apoptosis, while also reducing intracellular CDKs, cyclins, and cdc25 phosphatases ultimately causing G2-M cell cycle arrest. Gallic acid has a potential to be a new radiosensitizer compound in prostate cancer treatment. Additional clinical studies using gallic acid derivatives with lower hydrophilicity are needed. © 2021 UPM Press. All rights reserved. |
Apoptosis; Gallic acid; Prostate cancer; Radiobiology; Radiotherapy |
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Universiti Putra Malaysia Press |
16758544 |
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Review |
Q4 |
144 |
23823 |
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465 |
Mochtar I., Adi N.P., Hardjono A.W., Mansyur M. |
57222902121;57023786200;57222902350;37085506800; |
Return to work assessment in a radiographer assistant suffering a hemianopsia due to an ischemic stroke |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
2 |
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301 |
304 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104187321&partnerID=40&md5=cad74495ef91661c388194494f7d4e58 |
Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Indonesian Occupational Medicine Specialist Association, Jakarta, 10350, Indonesia |
Mochtar, I., Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Adi, N.P., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Hardjono, A.W., Indonesian Occupational Medicine Specialist Association, Jakarta, 10350, Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
Return to work assessment (RTWA) has been performed to a radiographer assistant suffering a hemianopsia due to an ischemic stroke. Stroke occurred two months prior to the examination. The general condition of the patient was good. The systemic examination was unremarkable except the presence of a partial vision loss in the left eye and often feeling fatigue and down. Perimetry Full-field 120 Point Screening Test confirmed a left temporal hemianopsia while Patient Health Questionnaire’s score (PHQ-9) indicated a moderate depression. The two conditions were not fully compatible with the job demand of a radiographer assistant, which required a complete and clear visual field as well as a good mental status. Risk assessment indicated that the patient might encounter health and safety issues if he resumed duty without work adjustment. The clinic still wanted to employ the patient and agreed to provide support. The patient was declared ‘fit’ to resume his duty with some recommendations. © 2021 UPM Press. All rights reserved. |
Hemianopsia; Return to work; Stroke |
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Universiti Putra Malaysia Press |
16758544 |
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Article |
Q4 |
144 |
23823 |
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466 |
Sen L.T., Hutauruk P.M.S., Putra M.R.A., Maulida S.B., Ramadhan A., Sugiharto A. |
57219034101;57222897908;57222899118;57222902406;57220357068;57204117635; |
Scrutinizing the knowledge and stigma of HIV/AIDS in the community level in Indonesia and the correlation to risk groups aversion to screening |
2021 |
IOP Conference Series: Earth and Environmental Science |
716 |
1 |
012089 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104173128&doi=10.1088%2f1755-1315%2f716%2f1%2f012089&partnerID=40&md5=cd113c28d7b8389535c7d2bf89f521fd |
Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Sen, L.T., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Hutauruk, P.M.S., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Putra, M.R.A., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Maulida, S.B., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Ramadhan, A., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Sugiharto, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Human immunodeficiency virus (HIV) has continuously been considered a scourge in Indonesia. Negative societal stance might be attributed to the poor biological, psychological, and emotional knowledge of HIV. Here we aimed to demonstrate the level of knowledge, stigma, and barriers for accessing HIV services. We conducted a cross-sectional survey in December 2019 in Kemayoran District, Jakarta, Indonesia. The survey consisted of a demographic section, HIV-Knowledge Questionnaire 18, and Stigma Questionnaires. An in-depth interview was conducted with eight subjects representing high-risk HIV and healthcare professionals; in-vivo and thematic analysis were employed. Overall, 83 respondents participated, 50.6% male, and 61.7% aged 26-45 years old. Instrumental, symbolic, and civility stigma were significantly higher in 25.9%, 19.8%, and 17.3% of samples, respectively. Stigma was associated with HIV knowledge (λ: 0.887, df: 3, partial η2: 0.113), and high knowledge level decreased the odds of instrumental stigma (OR: 0.292, 95% CI 0.095-0.900, p<0.05). Fear of discrimination and limited information was identified as intrinsic factors, while media portrays HIV and extraneous screening hours as extrinsic factors. The knowledge on HIV is still low at the community level in the Indonesian capital, which correlates to higher stigma and inhibits the high-risk population from accessing HIV medical services. © Published under licence by IOP Publishing Ltd. |
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Diagnosis; Planning; Risk assessment; Surveys; Sustainable development; Viruses; Cross-sectional surveys; Extrinsic factors; Health care professionals; Human immunodeficiency virus; In-depth interviews; Intrinsic factors; Limited information; Thematic analysis; Diseases |
IOP Publishing Ltd |
17551307 |
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Conference Paper |
- |
179 |
20770 |
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467 |
Miftahussurur M., Doohan D., Syam A.F., Nusi I.A., Subsomwong P., Waskito L.A., Maulahela H., Akil F., Uwan W.B., Siregar G., Fauzia K.A., Rezkitha Y.A.A., Rahman A., Wibawa I.D.N., Saudale A.M.J., Richardo M., Sugihartono T., Chomariyati A., Bramantoro T., Uchida T., Yamaoka Y. |
56323903000;57204644036;8443384400;56543515200;57113712700;57192177367;57189612709;35191671700;57093988500;56483277100;57204649404;56543533600;57212819255;6504449940;57192179505;57207621686;57194156387;57222871823;57196010143;35286123100;55183784100; |
Cyp2c19 polymorphisms in indonesia: Comparison among ethnicities and the association with clinical outcomes |
2021 |
Biology |
10 |
4 |
300 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104101307&doi=10.3390%2fbiology10040300&partnerID=40&md5=5c1d7696c67d83bbcf546211d5004bf0 |
Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia; Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia; Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Aomori, Hirosaki, 036-8562, Japan; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Center of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Department of Internal Medicine, Santo Antonius Hospital, Pontianak, 78243, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia; Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, 60113, Indonesia; Department of Internal Medicine, Kolaka General Hospital, Kolaka, 93511, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Udayana, Denpasar, 80232, Indonesia; Department of Internal Medicine, Prof. Dr. W. Z. Johannes General Hospital, Kupang, 85111, Indonesia; Department of Internal Medicine, Merauke City General Hospital, Merauke, 99613, Indonesia; Department of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 60131, Indonesia; Department of Molecular Pathology, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Global Oita Medical Advanced Research Center for Health, Oita University, Yufu, 879-5593, Japan; Department of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX 77030, United States |
Miftahussurur, M., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia, Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia; Doohan, D., Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Syam, A.F., Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Aomori, Hirosaki, 036-8562, Japan; Nusi, I.A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia; Subsomwong, P., Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan, Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Aomori, Hirosaki, 036-8562, Japan; Waskito, L.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Maulahela, H., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Akil, F., Center of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Uwan, W.B., Department of Internal Medicine, Santo Antonius Hospital, Pontianak, 78243, Indonesia; Siregar, G., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia; Fauzia, K.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Rezkitha, Y.A.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia, Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, 60113, Indonesia; Rahman, A., Department of Internal Medicine, Kolaka General Hospital, Kolaka, 93511, Indonesia; Wibawa, I.D.N., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Udayana, Denpasar, 80232, Indonesia; Saudale, A.M.J., Department of Internal Medicine, Prof. Dr. W. Z. Johannes General Hospital, Kupang, 85111, Indonesia; Richardo, M., Department of Internal Medicine, Merauke City General Hospital, Merauke, 99613, Indonesia; Sugihartono, T., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia; Chomariyati, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia; Bramantoro, T., Department of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 60131, Indonesia; Uchida, T., Department of Molecular Pathology, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Yamaoka, Y., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan, Global Oita Medical Advanced Research Center for Health, Oita University, Yufu, 879-5593, Japan, Department of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX 77030, United States |
CYP2C19 polymorphisms are important factors for proton pump inhibitor-based therapy. We examined the CYP2C19 genotypes and analyzed the distribution among ethnicities and clinical outcomes in Indonesia. We employed the polymerase chain reaction-restriction fragment length polymorphism method to determine the CYP2C19 genotypes and evaluated inflammation severity with the updated Sydney system. For CYP2C19*2, 46.4% were the homozygous wild-type allele, 14.5% were the homozygous mutated allele, and 39.2% were the heterozygous allele. For CYP2C19*3, 88.6% were the homozygous wild-type allele, 2.4% were the homozygous mutated allele, and 9.0% were the heterozygous allele. Overall, the prevalence of rapid, intermediate, and poor metabolizers in Indonesia was 38.5, 41.6, and 19.9%, respectively. In the poor metabolizer group, the frequency of allele *2 (78.8%) was higher than the frequency of allele *3 (21.2%). The Papuan had a significantly higher likelihood of possessing poor metabolizers than the Balinese (OR 11.0; P = 0.002). The prevalence of poor metabolizers was lower compared with the rapid and intermediate metabolizers among patients with gastritis and gastroesophageal reflux disease. Intermediate metabolizers had the highest prevalence, followed by rapid metabolizers and poor metabolizers. Dosage adjustment should therefore be considered when administering proton pump inhibitor-based therapy in Indonesia. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
CYP2C19; Gastritis; H. pylori; Infectious disease; Polymorphism |
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MDPI AG |
20797737 |
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Article |
Q1 |
1731 |
1747 |
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471 |
Sampurna M.T.A., Rohsiswatmo R., Primadi A., Wandita S., Sulistijono E., Bos A.F., Sauer P.J.J., Hulzebos C.V., Dijk P.H. |
57201733407;55533574600;8422152900;57194904658;57218101844;36839156800;57191375642;6603928053;6701798049; |
The knowledge of Indonesian pediatric residents on hyperbilirubinemia management |
2021 |
Heliyon |
7 |
4 |
e06661 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103706107&doi=10.1016%2fj.heliyon.2021.e06661&partnerID=40&md5=fe30c346677666133417d4195cc4b825 |
Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands |
Sampurna, M.T.A., Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Rohsiswatmo, R., Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Primadi, A., Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Wandita, S., Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Sulistijono, E., Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Bos, A.F., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Sauer, P.J.J., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Hulzebos, C.V., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Dijk, P.H., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands |
Hyperbilirubinemia in the newborn occurs more frequently in Indonesia. Therefore, it is important that pediatric residents in Indonesia acquire adequate knowledge of hyperbilirubinemia management. This study aims to determine the pediatric residents' knowledge on hyperbilirubinemia management, whether they follow recommended guidelines, and whether differences exist between five large Indonesian teaching hospitals. We handed out a 25-question questionnaire on hyperbilirubinemia management to pediatric residents at five teaching hospitals. A total of 250 questionnaires were filled in completely, ranging from 14 to 113 respondents per hospital. Approximately 76% of the respondents used the Kramer score to recognize neonatal jaundice. Twenty-four percent correctly plotted the total serum bilirubin levels (TSB) on the phototherapy (PT) nomograms provided by the American Academy of Pediatrics (AAP) and the National Institute for Health and Care Excellence (NICE) for full-term and nearly full-term infants. Regarding preterm infants <35 weeks' gestational age, 66% of the respondents plotted TSB levels on the AAP nomogram, although this nomogram doesn't apply to this category of infants. Seventy percent of residents knew when to perform an exchange transfusion whereas 27% used a fixed bilirubin cut-off value of 20 mg/dL. Besides PT, 25% reported using additional pharmaceutical treatments, included albumin, phenobarbitone, ursodeoxycholic acid and immunoglobulins, while 47% of the respondents used sunlight therapy, as alternative treatment. The limited knowledge of the pediatric residents could be one factor for the higher incidence of severe hyperbilirubinemia and its sequelae. The limited knowledge of the residents raises doubts about the knowledge of the supervisors and the training of the residents since pediatric residents receive training from their supervisors. © 2021 The Author(s) |
Guidelines; Hyperbilirubinemia; Knowledge; Newborn infants; Residents |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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472 |
Kurniawan A., Wijaya T., Hutami W.D. |
57204398223;57222656233;57219938996; |
Spontaneous healing of a traumatic critical radius bone defect in adolescent: A rare case report |
2021 |
International Journal of Surgery Case Reports |
81 |
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105806 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103668624&doi=10.1016%2fj.ijscr.2021.105806&partnerID=40&md5=4c70b264f853582354fc36b39f9dc680 |
Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia |
Kurniawan, A., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Wijaya, T., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Hutami, W.D., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia |
Introduction and importance: Fracture with a critical bone loss is associated with a profound burden of disease impact. Although there are several options exist for its treatment, but still those reconstructive procedures are technically demanding, relatively expensive and sometimes the result is less than what was expected. The objective of this study is to report a rare case of spontaneous healing of a critical radial bone defect in an adolescent. Case presentation: We reported a 15 year old boy with a segmental open fracture of left radius, open fracture of left distal shaft ulna and closed fracture of left intercondylar humerus. The middle fragment of a fractured radius was extruded out, pulled out and then thrown away by his parent. Debridement, open reduction, and internal fixation for ulna were performed as well as reposition and internal fixation for the intercondylar humerus fracture. The plan was to wait until the ulnar fracture and intercondylar fracture to heal without any sign of infection and proceed to overcome the radial critical bone defect. This case report had been reported in line with SCARE criteria. The patient showed up seven months later with solid union of the critical radius bone defect and fully functioning hand with only slight limitation in pronation. Clinical discussion: Osteogenesis in fracture requires osteogenic cells, osteoinductive components, osteoconductive scaffold, and stability. Despite the fact that critical bone defect poses great challenge for its management, intact periosteum and sufficient soft tissue perfusion were able to provide those biologic requirements adequately for fracture healing and ensure spontaneous healing of a traumatic critical bone loss in adolescent without any reconstructive procedure. Conclusion: Spontaneous healing in critical bone defect is possible, provided all the favorable factors present to support this phenomenon. © 2021 The Authors |
Adolescent bone defect; Case report; Critical bone defect; Rare case; Spontaneous healing |
antibiotic agent; adolescent; arm swelling; Article; bone defect; case report; clinical article; debridement; distal humerus; distal radius; elbow; emergency care; falling; follow up; forearm; fracture healing; hand function; hospital admission; human; humerus fracture; male; medical history; metaphysis; open fracture; open fracture reduction; osteolysis; osteosynthesis; outcome assessment; outpatient department; periosteum; physical examination; priority journal; pronation; radial critical bone defect; radius fracture; radius shaft fracture; range of motion; reconstructive surgery; soft tissue; treatment planning; tree; ulna fracture; wound care; wound healing |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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