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849 |
Pontoh L.A.P., Rahyussalim A.J., Widodo W., Fiolin J., Rhatomy S. |
57192907426;55212166100;57208941551;57194498274;57204509883; |
Anthropometric study as a predictor of anterior cruciate ligament sizes in Asian Indonesian population |
2021 |
Journal of Orthopaedic Surgery |
29 |
1 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102931782&doi=10.1177%2f23094990211000462&partnerID=40&md5=115eb91e8582294904d6485d349881e8 |
Department of Orthopaedics and Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Pondok Indah General Hospital, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Dr Soeradji Tirtonegoro General Hospital, Klaten, Indonesia; Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Pontoh, L.A.P., Department of Orthopaedics and Traumatology, Fatmawati General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahyussalim, A.J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Orthopaedics and Traumatology, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widodo, W., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Orthopaedics and Traumatology, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Fiolin, J., Department of Orthopaedics and Traumatology, Pondok Indah General Hospital, Jakarta, Indonesia; Rhatomy, S., Department of Orthopaedics and Traumatology, Dr Soeradji Tirtonegoro General Hospital, Klaten, Indonesia, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Objectives: To evaluate whether anthropometric data can predict anterior cruciate ligament (ACL) sizes on magneti resonance imaging (MRI) in Asian population. Background: Reconstruction of ACL has been performed over a decade ago. Recently, more individualized ACL reconstruction is performed taking account of each patient’s ACL characteristics. However, there has been limited study regarding ACL sizes in Asian Indonesian population. This study aimed to evaluate the role of anthropometric data in ACL sizes using MRI in Asian Indonesian population. Study Design: Retrospective Study. Method: A series of 531 knees from 420 patients with knee pain and intact ACL confirmed by MRI study. Length, width and inclination angle of ACL were measured using a T2-weighted sagittal MRI 3.0 Tesla Magnetom Skyra. Height, weight, body mass index (BMI) and age were recorded. Multiple regression analysis was used to determine relationship between the anthropometric data and size of ACL measurements. Result: ACL length and width were significantly different between male and female, consecutively. Mean ACL length was 35.36 ± 3.63 mm, male was significantly longer (36.59 ± 3.24 mm) compared to female (32.77 ± 2.99 mm), p < 0.0001. Mean ACL width was 10.23 ± 1.84 mm, male was significantly wider (10.85 ± 1.59 mm) compared to female (8.93 ± 1.64 mm), p < 0.0001. The mean ACL inclination angle was 47.75° ± 3.07° (range 40.17°–57.12°). The strongest correlation for ACL length was height and weight (r = 0.437; r = 0.341 consecutively, p < 0.0001). Females had stronger correlation compared to males for ACL length (R2 = 0.489 vs R2 = 0.418). ACL width showed weak correlation with anthropometric data. The following regression analysis equation was obtained for ACL length: ACL length = 60.697 − 0.11*age + 0.461*weight (kg) − 16.522*height (meter) − 1.093*BMI (R2 = 0.539; p < 0.0001). Conclusion: Anthropometric data can be utilized as a predictor of ACL length in Asian Indonesian population. The ACL length in Asian Indonesian population is shorter than that in Western population study. © The Author(s) 2021. |
ACL sizes; anthropometric data; Asian population; magnetic resonance imaging |
adult; anterior cruciate ligament; anthropometry; Article; body height; body mass; body weight; clinical evaluation; female; human; Indonesian; knee pain; major clinical study; male; nuclear magnetic resonance imaging; population research; prediction; retrospective study; sex difference; adolescent; anatomy and histology; anterior cruciate ligament; Asian continental ancestry group; diagnostic imaging; epidemiology; Indonesia; knee; morphometry; organ size; pathology; procedures; young adult; Adolescent; Adult; Anterior Cruciate Ligament; Asian Continental Ancestry Group; Body Mass Index; Body Weights and Measures; Female; Humans; Indonesia; Knee; Knee Joint; Magnetic Resonance Imaging; Male; Organ Size; Retrospective Studies; Young Adult |
SAGE Publications Ltd |
10225536 |
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33745362 |
Article |
Q3 |
457 |
10873 |
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850 |
Prasetyono T.O.H. |
26646993900; |
Indonesian plastic surgeons’ attitude during early period of the covid-19 pandemic |
2021 |
Archives of Craniofacial Surgery |
22 |
1 |
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17 |
25 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102865686&doi=10.7181%2facfs.2020.00451&partnerID=40&md5=a8e6d8b196710b9f9880783cbcb51fba |
Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Prasetyono, T.O.H., Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: This study aims to report how the practice of plastic surgeons and their attitude was during the first measure period of coronavirus disease 2019 (COVID-19) pandemic. Methods: A survey study was held among members of the Indonesian Association of Plastic Re-constructive and Aesthetic Surgeons during week 5 after the first report of COVID-19. A 10 multi-ple-choice questions (MCQs) and 1 essay covered key questions on the area of surgery and operating room, clinics, internal meeting, and consultation. The only open-ended question relates to the last MCQ addresses a future “flipped” medical practice. Results: Response rate was 45.6% among 228 members, with 89.4% did no practice or limited their service to emergency and urgent cases only. Only 1.9% kept their official meeting as usual, while the majority modified it. The practice in the operating theatre and clinic were also altered to comply with the measures; with 21.2% from the total respondents only allowed patients with ex-posure to come for visit after taking 14 days of self-quarantine. Teleconsultation was practiced by 50% of the respondents, while 41.3% agreed and 10.6% disagreed upon the future “flipped” medical practice. Conclusion: In general plastic surgeons have made supportive actions during the pandemic. Surgery was performed with all precautions at the utmost as a reflection of high alert of viral infec-tion. Teleconsultation has been embraced via existing social media. Agreement upon the future “flipped” medical practice is reasonable. All in all, the actions were considered as most relevant. © 2021 Korean Cleft Palate-Craniofacial Association. |
Pandemics; Surgery, plastic; Surveys and questionnaires; Viruses |
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Korean Cleft Palate-Craniofacial Association |
22871152 |
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Article |
Q4 |
192 |
19848 |
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851 |
Yunir E., Kurniawan F., Rezaprasga E., Wijaya I.P., Suroyo I., Matondang S., Irawan C., Soewondo P. |
36520254800;57202309006;57222478699;57193731572;57204106272;57192085914;28767651600;23475336100; |
Autologous Bone-Marrow vs. Peripheral Blood Mononuclear Cells Therapy for Peripheral Artery Disease in Diabetic Patients |
2021 |
International Journal of Stem Cells |
14 |
1 |
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21 |
32 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102786540&doi=10.15283%2fijsc20088&partnerID=40&md5=91f35aa55f974c266100f150613cc086 |
Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Yunir, E., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kurniawan, F., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rezaprasga, E., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wijaya, I.P., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suroyo, I., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Matondang, S., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Irawan, C., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soewondo, P., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Diabetes mellitus (DM) remains one of the most important risk factors for peripheral artery disease (PAD), with approximately 20% of DM patients older than 40 years old are affected with PAD. The current standard management for severe PAD is endovascular intervention with or without surgical bypass. Unfortunately, up to 40% of patients are unable to undergo these revascularization therapies due to excessive surgical risk or adverse vascular side effects. Stem cell therapy has emerged as a novel therapeutic strategy for these ‘no-option’ patients. Several types of stem cells are utilized for PAD therapy, including bone marrow mononuclear cells (BMMNC) and peripheral blood mononuclear cells (PBMNC). Many studies have reported the safety of BMMNC and PBMNC, as well as its efficacy in reducing ischemic pain, ulcer size, pain-free walking distance, ankle-brachial index (ABI), and transcutaneous oxygen pressure (TcPO2). However, the capacity to establish the efficacy of reducing major amputation rates, amputation free survival, and all-cause mortality is limited, as shown by several randomized placebo-controlled trials. The present literature review will focus on comparing safety and efficacy between BMMNC and PBMNC as cell-based management in diabetic patients with PAD who are not suitable for revascularization therapy. Copyright © 2021 by the Korean Society for Stem Cell Research |
Bone marrow mononuclear cells; Diabetes mellitus; Peripheral artery disease; Peripheral blood mononuclear cells; Stem cell therapy |
Article; autologous bone marrow transplantation; bone marrow derived mononuclear cell; clinical trial (topic); comparative effectiveness; diabetes mellitus; diabetic patient; human; patient safety; peripheral blood mononuclear cell; peripheral occlusive artery disease; stem cell transplantation |
Sungkyunkwan University |
20053606 |
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Article |
Q4 |
569 |
8885 |
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852 |
Birowo P., Raharja P.A.R., Atmoko W., Rasyid N. |
6504153311;57201013616;57193125664;56245069300; |
X-ray-free endoscopic combined intrarenal surgery for complex proximal ureteral stone: A case report |
2021 |
Research and Reports in Urology |
13 |
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121 |
125 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102769053&doi=10.2147%2fRRU.S299707&partnerID=40&md5=032063a30ddb79b23195d2c16a6aaa56 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Birowo, P., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Raharja, P.A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Atmoko, W., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
X-ray-free endoscopic combined intra renal surgery (ECIRS) is a feasible alternative to avoid radiation exposure to both surgical teams and patients, but has not been reported prior. The aim of this report is to present our first-hand experience of performing X-ray-free ECIRS for complex ureteral stone. A 57-year-old female presented with right flank pain, fever, dysuria, and leukocytosis. The computed tomography scan showed right impacted proximal ureteral stone sized 33 ´17 mm and grade IV hydrone-phrosis. Percutaneous nephrostomy was performed immediately. With improvement of clinical symptoms two days after nephrostomy, X-ray-free ECIRS was performed. The patient was placed in a Galdakao-modified supine position. During ureteroscopy (URS), there was noted right ureteral stenosis in the distal part of the stone, which could be passed. However, the stone was impacted and the semi-rigid URS was not able to push it. Therefore, antegrade approach with percutaneous nephrolithotomy was performed. Previous nephrostomy tract was used as percutaneous access. Tract dilatation was performed under direct visualization from the URS. The 28 Fr rigid nephroscope was used during the ECIRS procedure. The stone was fragmented using shock-pulse litho-tripters. There was no residual stone or infundibular laceration after the procedure. A 6 Fr double J stent was inserted retrogradely due to ureteral stenosis. There was no complication during and after the procedure. The patient was discharged on post-operative day three. X-ray free ECIRS for complex proximal ureteral stone was possible and showed good results. © 2021 Birowo et al. |
ECIRS; Modified procedure; Supine position; Ureterolithiasis |
creatinine; esterase; hemoglobin; levofloxacin; adult; Article; case report; clinical article; computer assisted tomography; creatinine blood level; diagnostic test accuracy study; dysuria; endoscopic surgery; Escherichia coli; female; fever; flank pain; hemoglobin blood level; human; human tissue; hydronephrosis; hydroureter; injection site reaction; kidney calyx; kidney surgery; leukocytosis; middle aged; nausea and vomiting; neutrophil; operation duration; operative blood loss; percussion; percutaneous nephrolithotomy; percutaneous nephrostomy; radiation exposure; supine position; ureter obstruction; ureter stone; ureteroscopy; urinalysis; X ray; x-ray computed tomography |
Dove Medical Press Ltd |
22532447 |
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Article |
Q2 |
506 |
9983 |
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854 |
Kirana A.N., Prafiantini E., Hardiany N.S. |
57222361321;57193088368;57192910605; |
Protein intake and loss of proteostasis in the eldery |
2021 |
Ukrainian Biochemical Journal |
93 |
1 |
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30 |
39 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102434761&doi=10.15407%2fubj93.01.030&partnerID=40&md5=e09be01091937944ac8ad3197ad54b2c |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Indonesia |
Kirana, A.N., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Prafiantini, E., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Indonesia |
Ageing is a process of declining bodily function and a major risk factor of chronic diseases. The declining bodily function in ageing can cause loss of proteostasis (protein homeostasis), which is a balance between protein synthesis, folding, modification and degradation. For the elderly, adequate protein intake is necessary to prevent sarcopenia, frailty, fracture and osteoporosis as well as reduced resistance to infection. However, increasing the protein intake can enhance the risk of oxidized protein formation, loss of proteostasis and degenerative disorder occurrence. On the other hand, several studies show that protein restriction would increase longevity. The aim of this review was to explain the importance of determining the right amount and composition of protein intake for the elderly. Oxidative stress and molecular mechanism of proteostasis loss in ageing cells as well as its suppression pathway by protein restriction are discussed in this review. © 2021 Kirana A. N. et al. |
Ageing; Dietary proteins; MTOR; Oxidative stress; Proteostasis loss |
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Palladin Institute of Biochemistry of the NASU |
24094943 |
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Article |
Q4 |
173 |
21241 |
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857 |
Sahar N., Muharam R., Pradhita A.D., Thuffi R., Zulhulaifah W.O., Birowo P. |
57212464367;57191492732;57212471291;57212475033;57222324817;6504153311; |
Expression of E-Cadherin in Pig-Tailed Monkey (Macaca nemestrina) Endometrium after Controlled Ovarian Hyperstimulation |
2021 |
BioMed Research International |
2021 |
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8824614 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102282318&doi=10.1155%2f2021%2f8824614&partnerID=40&md5=174042679bf5a7630610257f7a24b9a7 |
Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia; Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia |
Sahar, N., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muharam, R., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia; Pradhita, A.D., Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Thuffi, R., Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zulhulaifah, W.O., Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Department of Urology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia |
An increase of steroid hormones in controlled ovarian hyperstimulation (COH) procedures is reducing the success rate in assisted reproductive technology (ART), and this includes the pregnancy rate and/or implantation rate. Research has found that the decrease in the success rate occurred due to the decreased expression of the protein that is needed to prepare the endometrium so that the embryo could attach. The aim of the study was to analyse the changes in E-chaderin expression due to COH and its relations with increased level of steroid hormones as one of the proteins in the endometrium. There were 13 samples of stored biological tissue from Macaca nemestrina endometrial tissue; came from one group of natural cycles as the control group (n=4) and three groups of stimulated cycles. The first stimulated cycle group was injected by a 30 IU dose of rFSH (n=2). The second stimulated cycle group was injected by a 50 IU dose of rFSH (n=4). The third stimulated cycle group was injected by a 70 IU dose of rFSH (n=3). The expression of E-cadherin was measured by the immunohistochemistry (IHC) technique. Estradiol (E2) and progesterone (P4) levels were assessed using ELISA and have already been done. The IHC staining expression of E-cadherin was found in the cytoplasm of glandular epithelium. Immunostaining measurement used the H_SCORE. We found that the expression of E-cadherin within the group was not significantly different (p value: 0.178). Similarly, both the correlation between the estradiol level with E-cadherin and the correlation between the progesterone level with E-cadherin were not significantly different (p value: 0.872 and p value: 0.836). The conclusion is that the level of E-Cadherin expression in the endometrium that were taken in themiddle secretion phase not affected by the dose regimen that given. In addition, the level of expression is not influenced by the increase of serum E2 and P4 levels. © 2021 Nurhuda Sahar et al. |
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buserelin; chorionic gonadotropin; estradiol; progesterone; recombinant follitropin; uvomorulin; cadherin; animal experiment; animal tissue; Article; comparative study; controlled study; cytoplasm; endometrium; enzyme linked immunosorbent assay; estradiol blood level; female; follicular phase; immunohistochemistry; Macaca nemestrina; mitosis; nonhuman; ovary hyperstimulation; progesterone blood level; protein expression; retrospective study; animal; biosynthesis; endometrium; metabolism; ovulation induction; Animals; Cadherins; Endometrium; Female; Macaca nemestrina; Ovulation Induction |
Hindawi Limited |
23146133 |
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33708995 |
Article |
Q2 |
772 |
6290 |
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858 |
Eldafira E., Prasasty V.D., Abinawanto A., Syahfirdi L., Pujianto D.A. |
57204963791;56019989700;55625129700;57222327356;8745734300; |
Polymorphisms of estrogen receptor-α and estrogen receptor-β genes and its expression in endometriosis [Östrojen reseptör-α ve östrojen reseptör-β genlerinin polimorfizmi ve endometriozisde ifadelenmeleri] |
2021 |
Turkish Journal of Pharmaceutical Sciences |
18 |
1 |
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91 |
95 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102272548&doi=10.4274%2ftjps.galenos.2019.94914&partnerID=40&md5=ca75ed564cc74a659022ab862e0096b8 |
Universitas Indonesia, Faculty of Medicine, Department of Medical Biology, Depok, Indonesia; Universitas Indonesia, Faculty of Mathematics and Natural Sciences, Department of Biology, Jakarta, Indonesia; Atma Jaya Catholic University of Indonesia, Faculty of Biotechnology, Jakarta, Indonesia |
Eldafira, E., Universitas Indonesia, Faculty of Medicine, Department of Medical Biology, Depok, Indonesia, Universitas Indonesia, Faculty of Mathematics and Natural Sciences, Department of Biology, Jakarta, Indonesia; Prasasty, V.D., Atma Jaya Catholic University of Indonesia, Faculty of Biotechnology, Jakarta, Indonesia; Abinawanto, A., Universitas Indonesia, Faculty of Mathematics and Natural Sciences, Department of Biology, Jakarta, Indonesia; Syahfirdi, L., Universitas Indonesia, Faculty of Mathematics and Natural Sciences, Department of Biology, Jakarta, Indonesia; Pujianto, D.A., Universitas Indonesia, Faculty of Medicine, Department of Medical Biology, Depok, Indonesia |
Objectives: Endometriosis is a common gynecological disorder, characterized by the presence of endometrial-like tissue in the extrauterine location. The increasing estradiol concentration can influence endometriosis risk and estrogen receptor (ER) activity. Polymorphism in ER causes gene expression alteration and influences hormone-receptor interaction. This research aims to determine ER genetic polymorphisms in endometriosis pathogenesis. Materials and Methods: This study was performed on case-control polymorphisms, which compared 83 women with endometriosis and 76 women without endometriosis. However, the samples used for ER gene expression analysis and estrogen level measurement were obtained from 18 women with endometriosis and 18 women without endometriosis. Polymerase chain reaction-restriction fragment length polymorphism was used to determine ER genetic polymorphisms. Chi-square, Mann-Whitney test, Spearman’s correlation (p), t-independent, and two-tailed tests were used to analyze the data. Results: Association between the allele ERα rs9340799 A/G and endometriosis was significantly different (p=0.012), whereas rs2234693 T/C polymorphism showed no association with endometriosis. The correlation between the genotype frequencies of allele ERβ rs4986938 G/A and endometriosis was found significantly different (p=0.015; p=0.034). Conclusion: Estradiol level and ERβ expression increases, polymorphism genotypes and alleles of ERβ rs4986938 G/A gene and allele frequency of ERα rs9340799 A/G gene have roles in endometriosis. © Turk J Pharm Sci, Published by Galenos Publishing House. |
Endometriosis; Estradiol (E2); Estrogen receptor (ERα and ERβ) |
ammonium acetate; dodecyl sulfate sodium; estradiol; estrogen; estrogen receptor alpha; estrogen receptor beta; genomic DNA; adult; agar gel electrophoresis; allele; Article; case control study; centrifugation; controlled study; DNA extraction; DNA polymorphism; endometriosis; female; gene; gene amplification; gene frequency; genotype; human; illumination; intron; major clinical study; polymerase chain reaction; receptor gene; restriction fragment length polymorphism; rs2234693 gene; rs4986938 gene; spectrophotometry |
Turkish Pharmacists Association |
1304530X |
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Article |
Q3 |
241 |
17155 |
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861 |
Umas R.A., Supriadi S., Whulanza Y., Hasan A.A.A.F., Kreshanti P. |
57222252781;16040272500;36807053500;57222257599;36192866200; |
Evaluating the Gear Stress of Novel Reverse Rotation Bit Manual Screwdriver Design for Miniscrew Implants |
2021 |
Journal of Mechanical Engineering |
18 |
1 |
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175 |
192 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102086175&partnerID=40&md5=0196752c2bad6ab9b05bb97c07712c5b |
Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Cleft and Craniofacial Center Cipto Mangunkusumo Hospital, Plastic and Reconstructive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Indonesia |
Umas, R.A., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Supriadi, S., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Hasan, A.A.A.F., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Kreshanti, P., Cleft and Craniofacial Center Cipto Mangunkusumo Hospital, Plastic and Reconstructive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Indonesia |
One of the problems faced by the screwdrivers used for craniomaxillofacial implant fixation is that the maximum torque required for implant removal is significantly higher than the maximum torque needed for inserting implants. Another problem is that the hand torque produced by a right-handed person is lower in the counterclockwise direction, which is the removal direction for miniscrews. The novel design presented here of a manual screwdriver equipped with an epicyclic gear will produce a reverse bit rotation and provide the mechanical advantage of higher torque output. In this study, simulations were conducted by varying the torque input within the range of 0-1000 Nmm with an applied load in each simulation to be adapted based on the epicyclic gear set. The materials used in this study are AISI 316L and Ti6Al4V. The maximum Von Mises stress value was observed in the sun gear from the second gear set at 522.59 MPa (AISI 316L) and 430.76 MPa (Ti6Al4V) for the maximum torque input, which was followed by the planetary and ring gear from the second gear set and then the planetary gear, ring gear, and sun gear from the first gear set. The total deformation also showed the difference between the two materials; the deformation when using AISI 316L as the material was lower than when using Ti6Al4V. © 2021 Faculty of Mechanical Engineering. All Rights Reserved. |
Epicyclic Gear; Maxillofacial Implant; Surgical Screwdriver |
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UiTM Press |
18235514 |
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Article |
Q3 |
216 |
18402 |
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862 |
Putri M.I.A., Panigoro S.S., Harahap A.S., Pakasi T.A., Brahma B. |
57222261965;56790104300;57218511857;23980778600;55675752700; |
Acetic Acid and Iodine Staining for Determining Malignancy in Solid Tumors |
2021 |
Asian Pacific Journal of Cancer Prevention |
22 |
2 |
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463 |
469 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102041256&doi=10.31557%2fAPJCP.2021.22.2.463&partnerID=40&md5=a2eb3a6ba0cc657be963217a4e5d6cce |
Surgical Oncology Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgical Oncology, Dharmais Cancer Hospital, National Cancer Center, Jakarta, Indonesia |
Putri, M.I.A., Surgical Oncology Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Panigoro, S.S., Surgical Oncology Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap, A.S., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pakasi, T.A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Brahma, B., Department of Surgical Oncology, Dharmais Cancer Hospital, National Cancer Center, Jakarta, Indonesia |
Objective: Surgical margin is an important prognostic factor in solid cancer surgery. Frozen section (FS), the gold standard for intraoperative surgical margin evaluation, requires extensive waiting time and expensive FS devices. The purpose of this diagnostic study was to verify whether multi-staining (MS) method with acetic acid and iodine could be used to differentiate malignant and non-malignant lesions of solid tumor. Methods: The study was conducted on patients with solid tumor who underwent surgery in the Surgical Oncology Division of Dr. Cipto Mangunkusumo General Hospital from December 2017 to April 2018. Samples measuring less than 5 mm, necrotic tissue sample, and patients who did not agree to participate in the study were excluded. Every specimen was divided into two, one side as unstained control and the other side as MS samples. MS samples were sprayed with 10% acetic acid combined with iodine. MS samples and unstained controls were sent for histopathologic results and the pathologist was blinded to group assignment. Acetowhitening reaction in the sample was an indication of a positive MS result, and the presence of malignant foci in the histopathology examination was classified as positive pathological results. Results: Five-hundredand-twenty samples were obtained from 150 patients. MS method was found to have sensitivity and specificity of 82%, and 63.5%, respectively. In subgroup analysis, we found that MS method has a sensitivity and specificity of 100% and 79.3%, respectively for epithelial breast tumor; 65.7% and 83.3%, respectively for thyroid nodules; and 94.1% and 33.3%, respectively for oral cavity tumors. MS method reacts positively to solid malignant tumor and negatively to benign tumor and normal tissue (from margin samples). Highest sensitivity was found for breast and oral cavity malignancy, and high specificity was found for thyroid cancers. Conclusion: This study provided an alternative staining method for intraoperative macroscopic surgical margin evaluation, especially for rural areas without frozen section facilities. © This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. |
Acetic acid; breast cancer; frozen section; iodine; oral cancer; solid tumor; thyroid cancer; vital staining |
acetic acid; coloring agent; dyes, reagents, indicators, markers and buffers; iodide; Lugol's solution; adolescent; adult; aged; child; cross-sectional study; female; frozen section; human; male; middle aged; neoplasm; pathology; sensitivity and specificity; staining; surgical margin; young adult; Acetic Acid; Adolescent; Adult; Aged; Child; Coloring Agents; Cross-Sectional Studies; Female; Frozen Sections; Humans; Indicators and Reagents; Iodides; Male; Margins of Excision; Middle Aged; Neoplasms; Sensitivity and Specificity; Staining and Labeling; Young Adult |
Asian Pacific Organization for Cancer Prevention |
15137368 |
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33639661 |
Article |
Q2 |
512 |
9866 |
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864 |
Indriyani, Liem I.K., Wuyung P.E., Adnindya M.R., Nasution A.A., Wardiansah, Jusuf A.A. |
57195988823;55802927800;57192889605;57195990858;57195984460;57222188547;57192275719; |
The dynamic of afamin and alpha-fetoprotein expression during rat liver development |
2021 |
OnLine Journal of Biological Sciences |
21 |
1 |
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26 |
32 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101833482&doi=10.3844%2fojbsci.2021.26.32&partnerID=40&md5=63694adea4e7ba46c95652e49c319ed0 |
Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Indonesia; Departement of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Department of Anatomy, Faculty of Medicine and Health Science, Universitas Bengkulu, Bengkulu, Indonesia; Departement of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Indriyani, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, Indonesia; Liem, I.K., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Indonesia; Wuyung, P.E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Departement of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Adnindya, M.R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Nasution, A.A., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine and Health Science, Universitas Bengkulu, Bengkulu, Indonesia; Wardiansah, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Jusuf, A.A., Departement of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Liver has a high level of Alpha-fetoprotein which is assumed to be important for mammalian development. However, Alpha-fetoprotein knockout studies in mice suggested that despite the absence of Alpha-fetoprotein, mice developed normally; the only abnormality observed was infertility in female mice. There are indications that Afamin, a protein that has a gene sequence located on the same chromosome as Alpha-fetoprotein, may compensate for the absence of Alpha-fetoprotein during embryonic development. Nevertheless, research on the dynamics of Afamin expression and its correlation with Alpha-fetoprotein has not been reported. Therefore, it has been done a baseline study to determine the pattern and distribution of Alpha-fetoprotein expression and its correlation with Afamin expression in the developing rat liver. An analytic observational study was performed to study the expression of Afamin and Alpha-fetoprotein in the rat embryos (embryonic day/ED12.5, ED14.5, ED16.5, ED18.5), neonates and adults using an immunohistochemistry technique by assessing the location and intensity of expression using the Immunohistochemistry Optical density score. Afamin started to express in ED18.5 and was evenly distributed in the hepatocytes and was maintained until adulthood. Whereas, Alpha-fetoprotein has been seen at ED12.5 and was distributed evenly in the hepatoblast. At ED18.5, Alpha-fetoprotein expression reached a peak and decreased dramatically after birth. Spearman correlation test showed that both proteins' expressions were correlated in the opposite direction (P<0.05 and r =-0.695). In conclusion, Afamin and Alpha-fetoprotein have an opposite expression during development. The time point of intersection was ED18.5; implying the peak of hepatoblast proliferation to enter the differentiation process. © 2021 Indriyani, Isabella Kurnia Liem, Puspita Eka Wuyung, Msy Rulan Adnindya, Ahmad Azmi Nasution, Wardiansah and Ahmad Aulia Jusuf. |
Afamin; Alpha-Fetoprotein; Hepatoblast; Hepatocytes; Liver Development |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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