No records
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179 |
Gamalliel N., Saminarsih D., Taher A. |
57222183873;57223010643;7005269743; |
Indonesia's second wave crisis: medical doctors' political role is needed more than ever |
2021 |
The Lancet |
398 |
10303 |
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839 |
840 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114086978&doi=10.1016%2fS0140-6736%2821%2901807-9&partnerID=40&md5=ee813e67f093a1a11797cba6ffb2072e |
Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Urology, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia; World Health Organization, Geneva, Switzerland |
Gamalliel, N., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Saminarsih, D., World Health Organization, Geneva, Switzerland; Taher, A., Department of Urology, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia |
[No abstract available] |
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SARS-CoV-2 vaccine; coronavirus disease 2019; discourse analysis; disease transmission; health care delivery; health care need; health care planning; health care policy; health care system; human; Indonesia; Letter; physician attitude; population health; vaccination; Indonesia; patient advocacy; physician; politics; COVID-19; Humans; Indonesia; Patient Advocacy; Physicians; Politics |
Elsevier B.V. |
01406736 |
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34384538 |
Letter |
#N/A |
#N/A |
#N/A |
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185 |
Kartika R.W., Alwi I., Suyatna F.D., Yunir E., Waspadji S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Reksodiputro M.H., Bardosono S. |
57223447932;15055173800;56039633100;36520254800;8678136400;57272979000;56275255400;57016857300;6507225348;35090488800;21933841000; |
The Role Of Vegf, Pdgf And Il-6 On Diabetic Foot Ulcer After Platelet Rich Fibrin Þ Hyaluronic Therapy |
2021 |
Heliyon |
7 |
9 |
e07934 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120851420&doi=10.1016%2fj.heliyon.2021.e07934&partnerID=40&md5=0080e19d2c656e3452c7827d2fab24ba |
Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Thorcic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kartika, R.W., Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thorcic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Current standard management of diabetic foot ulcers (DFUs) consists of surgical debridement followed by soak NaCl 0.9% gauzes tight infection and glycaemic control. Nowadays the use of advanced plateletrich fibrin (A-PRF) has emerged as an adjunctive method for treating DFUs. This study was conducted to demonstrate the ability of combine A-PRF þ HA as a complementary therapy in DFUs healing related with angiogenesis,inflammation and granulation index process. Methods: This open label randomized controlled trial was conducted in Koja District Hospital and Gatot Soebroto Hospital Jakarta, Indonesia on July 2019–April 2020. DFUs patients with wound duration of three months, Wagner-2, with size of ulcer less than 40 cm2 were included in the study. The number of subjects was calculated based on the rule of thumb and allocated randomly into three groups, namely topical A-PRF þ HA, A-PRF an Sodium Chloride 0.9% as a control, for each of 10 subjects. A-PRF made by 10 mL venous blood, centrifuge 200 G in 10 min, meanwhile A-PRF þ HA though mix both them with vertex machine around 5 min. Biomarker such as VEGF, PDGF and IL-6 examined from DFU taken by cotton swab and analysis using ELISA. Granulation Index was measured using ImageJ. Biomarkers and granulation index were evaluated on day 0, 3, 7 and 14. Data were analysed using SPSS version 20 with Anova and Kruskal Wallis test to compare the angiogenesis and inflammation effect between the three groups. Result: In topical dressing A-PRF þ HA, there is an increase in delta VEGF on day-3 (43.1 pg/mg protein) and day-7 (275,8 pg/mg protein) compared to A-PRF on day-3 (1.8 pg/mg protein) and day-7 (104.7 pg/mg protein), also NaCl (control) on day-3 (-4.9 pg/mg protein) and day-7 (28.3 pg/mg protein). So that the delta VEGF of A-PRF þ HA group increase significantly compared with others on day-3 (p ¼ 0.003) and day-7 (p < 0.001). Meanwhile APRF þ AH group, there is also a decrease in delta IL-6 after therapy on day-3 (-10.9 pg/mg protein) and day-7 (-18.3 pg/mg protein) compared to A-PRF in delta IL-6 on day-3 (-3.7 pg/mg protein) and on day-7 (-7.8 pg/ mg protein). In NaCl (control) group there is a increase delta IL-6 on day-3 (4.3 pg/mg protein) and on day-7 (35.5 pg/mg protein). So that the delta IL-6 of A-PRF þ HA group decrease significantly compared with others only on day-7 (p ¼ 0.015). In PDGF le level analysis, A-PRF þ HA group increase significantly (p ¼ 0.012) only in day -7 compare with other group (5.5 pg/mg protein). Conclusion: The study shows the superior role of combined A-PRF þ HA in the treatment DFU though increase angiogenesis and decrease inflammation pathway. The advantage of using A-PRF þ HA is that it accelerates wound healing by increasing granulation tissue compared to A-PRF alone © 2021 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
Diabetic foot ulcer; Hyaluronic acid; Platelet-rich fibrin |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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198 |
Kartika R.W., Alwi I., Yunir E., Waspadji S., Suyatna F.D., Bardosono S., Immanuel S., Sungkar S., Rachmat J., Silalahi T., Reksodiputro M.H. |
57223447932;15055173800;36520254800;8678136400;56039633100;21933841000;57272979000;57016857300;6507225348;56275255400;35090488800; |
Efficacy of Combining Hyaluronic Acid and Platelet-Rich Fibrin in Diabetic Foot Ulcer |
2021 |
Jordan Journal of Biological Sciences |
14 |
3 |
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607 |
611 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115791952&partnerID=40&md5=76c1dc1bbdde331f901d412f6b6a83ba |
Doctoral Program in Medical Science Faculty of Medicine Universitas Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine Krida Wacana Christian University, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Indonesia; Department of Clinical Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine Krida Wacana Christian University, Jakarta, Indonesia; Department of Otorhinolaryngology, Facial Plastic Reconstructive Division, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Kartika, R.W., Doctoral Program in Medical Science Faculty of Medicine Universitas Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine Krida Wacana Christian University, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Indonesia; Bardosono, S., Department of Clinical Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sungkar, S., Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Faculty of Medicine Krida Wacana Christian University, Jakarta, Indonesia; Reksodiputro, M.H., Department of Otorhinolaryngology, Facial Plastic Reconstructive Division, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Objectives: A chronic complication of type-2 diabetes mellitus (DMT-2) is Diabetic Foot Ulcer (DFU). The main treatment used in DFU is wound cleansing, followed by dressing the wound as a local control to increase tissue granulation and epithelialization. This study aims to compare the efficacy of the combination of Hyaluronic Acid with Platelet Rich Fibrin (HAPRF) and Platelet Rich Fibrin alone in DFU. Methods: We conducted a randomized controlled trial from July 2019 to April 2020. The study was approved by the Ethics Committee of the Faculty of Medicine of Universitas Indonesia ID 0855 / UN2.F1 / ETIK / 2018. Informed consent was obtained from the patients. This was a randomized clinical study to compare the efficacy of HAPRF and PRF in DFU one week post debridement. Twenty DFU samples were collected divided into 2 treatment groups: topical treatment using HAPRF compare with PRF alone. Assessment for wounds improvement was recorded using a digital camera 48 mega pixel with an accuracy of 0.1% on day-0, 3, 7, and 14. The results of the wound photographs were processed using ImageJ software. The granulation area (GA) and wound area (WA) were evaluated by IBM SPSS software v.20. The general data description was presented in median (range) value and parameter’s differences were conducted using Mann–Whitney test Results: The two treatment groups showed insignificant difference in characteristics between both group before intervention. The mean granulation width after two weeks of use HAPRF was 97.4% and PRF was 81.9%. Statistical analysis using Mann Whitney test showed granulation area of HAPRF group was significantly different compared with PRF group on day-3(p=0.047), day-7 ( p = 0.004) and day-14 ( p < 0.001). At the end of the wound healing process, the HAPRF group was significantly different compared with PRF group on Δ day 0−3 ( p=0.048), Δ day 0−7 ( p = 0.039), and Δ day 0−14 ( p = 0.023). Conclusions: HAPRF improves wound healing rate through increasing granulation tissue and epithelialization compared with PRF only in diabetic foot ulcer after 2 weeks post debridement compared to PRF. © 2021, Jordan Journal of Biological Sciences. All Rights Reserved. |
Delta Wound Area; Diabetic ulcer; Granulation Area; Hyaluronic Acid; Platelet Rich Fibrin |
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Hashemite University |
19956673 |
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Article |
Q3 |
216 |
18398 |
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204 |
Heltty H., Sitorus R., Martha E., Nusdwinuringtyas N. |
57262112500;57194329674;55841280100;56608215500; |
Experience of the patient's success in facing post-stroke urinary incontinence: The patient's perspective |
2021 |
Frontiers of Nursing |
8 |
3 |
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291 |
301 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115061619&doi=10.2478%2ffon-2021-0030&partnerID=40&md5=9c066e6d2b1fc65cd5adc1fc8034247d |
Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Faculty of Public Health, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Faculty of Medicine, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia |
Heltty, H., Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Sitorus, R., Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Martha, E., Faculty of Public Health, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Nusdwinuringtyas, N., Faculty of Medicine, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia |
Objective: Post-stroke urinary incontinence (UI) is one of the sequelae of stroke. This situation affects all aspects of the patient's life - physically, psychologically, socially, and spiritually. This study aimed to investigate the experience of patients' success in facing a post-stroke UI. Methods: A qualitative study using the Rapid Assessment Procedure (RAP) approach was used in this study. Informants were selected using purposive sampling. In-depth interviews with as many as 8 patients who had recovered from post-stroke UI and living in the greater area of Southeast Sulawesi (Indonesia) were conducted. In-depth interviews were also conducted with 8 caregivers and 2 nurses. Data were analyzed using a thematic analysis approach and interpretation of data was based on Humanbecoming theory and Self-care deficit theory of nursing. Results: Five successful things the patients experienced during post-stroke UI were identified. The five successes were as follows: they provided information to get to know and understand post-stroke UI, followed the procedures to overcome post-stroke UI, conducted self-control exercises and stayed motivated, performed daily activities independently according to ability, and made use of family support and peers' attention. Conclusions: These findings indicated that persistence, belief, independence, and social support (family and peer) made patients to successfully face their post-stroke UI and improved their quality of life. These findings also became the basis for developing a post-stroke UI management model based on Humanbecoming theory and Self-care deficit theory of nursing. © 2021 Heltty Heltty et al., published by Sciendo. |
experience of patient's success; patient's perspective; post-stroke urinary incontinence |
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Sciendo |
25448994 |
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Review |
Q4 |
152 |
22962 |
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214 |
Mecheva M.D.V., Rieger M., Sparrow R., Prafiantini E., Agustina R. |
57226430480;57205307158;57205017055;57193088368;57214141404; |
Snacks, nudges and asymmetric peer influence: Evidence from food choice experiments with children in Indonesia |
2021 |
Journal of Health Economics |
79 |
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102508 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111538660&doi=10.1016%2fj.jhealeco.2021.102508&partnerID=40&md5=652b5bd03857b33eba09516d04a40e6d |
The International Institute of Social Studies (ISS) of Erasmus University Rotterdam, Netherlands; Development Economics Group, Wageningen University, Netherlands; Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General HospitalJakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia |
Mecheva, M.D.V., The International Institute of Social Studies (ISS) of Erasmus University Rotterdam, Netherlands; Rieger, M., The International Institute of Social Studies (ISS) of Erasmus University Rotterdam, Netherlands; Sparrow, R., The International Institute of Social Studies (ISS) of Erasmus University Rotterdam, Netherlands, Development Economics Group, Wageningen University, Netherlands; Prafiantini, E., Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General HospitalJakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General HospitalJakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia |
Many children in low- and middle-income countries are growing up during a rapid nutrition transition. Experimental evidence on food choice in developing countries is scarce, while it is unclear to what extent evidence from high-income countries can be generalized. Children participated in a snack choice experiment. We expose some children to emoji labels encouraging healthy snacks, while others observe healthy or unhealthy snacking by peers. While emoji labels moderately promote healthy snacking, the adverse effect of observing a peer eating the unhealthy snack is very large. The effect associated with observing a healthy peer is insignificant. Additionally, cross-randomized blocks of children watched a nutrition video to study the interaction of information provision and nudging. The video independently improves healthy choices but does not aid the emoji nudge and cannot counter the strong negative peer effect. We compare our findings to studies conducted in developed countries and discuss policy implications. © 2021 The Author(s) |
Food choice; Indonesia; Nudges; Overweight; Peer effects |
body mass; child health; food policy; food preference; health expenditure; obesity; public health; adolescent; Article; child; child nutrition; controlled study; decision making; descriptive research; encouragement; fast food; female; human; human experiment; Indonesia; male; nutrition policy; obesity; peer pressure; pilot study; unhealthy diet; feeding behavior; food preference; nutritional status; Indonesia; Child; Feeding Behavior; Food Preferences; Humans; Indonesia; Nutritional Status; Peer Influence; Snacks |
Elsevier B.V. |
01676296 |
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34333202 |
Article |
Q1 |
2676 |
794 |
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222 |
Sirait B., Wiweko B., Jusuf A.A., Iftitah D., Muharam R. |
57222720264;43061741400;57192275719;57195199068;57191492732; |
Oocyte Competence Biomarkers Associated With Oocyte Maturation: A Review |
2021 |
Frontiers in Cell and Developmental Biology |
9 |
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710292 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114781833&doi=10.3389%2ffcell.2021.710292&partnerID=40&md5=0430c11851bd72e4085a2092ee2bfda4 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia; Morula IVF Jakarta Clinic, Jakarta, Indonesia; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Reproductive, Infertility, and Family Planning Research Cluster, Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sirait, B., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia, Morula IVF Jakarta Clinic, Jakarta, Indonesia; Wiweko, B., Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproductive, Infertility, and Family Planning Research Cluster, Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusuf, A.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iftitah, D., Human Reproductive, Infertility, and Family Planning Research Cluster, Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muharam, R., Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproductive, Infertility, and Family Planning Research Cluster, Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Oocyte developmental competence is one of the determining factors that influence the outcomes of an IVF cycle regarding the ability of a female gamete to reach maturation, be fertilized, and uphold an embryonic development up until the blastocyst stage. The current approach of assessing the competency of an oocyte is confined to an ambiguous and subjective oocyte morphological evaluation. Over the years, a myriad of biomarkers in the cumulus-oocyte-complex has been identified that could potentially function as molecular predictors for IVF program prognosis. This review aims to describe the predictive significance of several cumulus-oocyte complex (COC) biomarkers in evaluating oocyte developmental competence. A total of eight acclaimed cumulus biomarkers are examined in the study. RT-PCR and microarray analysis were extensively used to assess the significance of these biomarkers in foreseeing oocyte developmental competence. Notably, these biomarkers regulate vital processes associated with oocyte maturation and were found to be differentially expressed in COC encapsulating oocytes of different maturity. The biomarkers were reviewed according to the respective oocyte maturation events namely: nuclear maturation, apoptosis, and extracellular matrix remodeling, and steroid metabolism. Although substantial in vitro evidence was presented to justify the potential use of cumulus biomarkers in predicting oocyte competency and IVF outcomes, the feasibility of assessing these biomarkers as an add-on prognostic procedure in IVF is still restricted due to study challenges. © Copyright © 2021 Sirait, Wiweko, Jusuf, Iftitah and Muharam. |
biomarker; cumulus-oocyte complex (COC); in-vitro fertilization; oocyte competence; oocyte maturation |
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Frontiers Media S.A. |
2296634X |
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Review |
Q1 |
2452 |
946 |
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228 |
Reksodiputro M.H., Harahap A.R., Setiawan L., Yosia M. |
35090488800;6507325543;57053036100;57204933098; |
A Modified Preparation Method of Ideal Platelet-Rich Fibrin Matrix From Whole Blood |
2021 |
Frontiers in Medicine |
8 |
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724488 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114628863&doi=10.3389%2ffmed.2021.724488&partnerID=40&md5=2a784dc8d442d97efac9d34d1c6769cc |
Division of Facial Plastic & Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Rumah Sakit Dharmais Pusat Kanker Nasional, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Reksodiputro, M.H., Division of Facial Plastic & Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap, A.R., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Setiawan, L., Department of Clinical Pathology, Rumah Sakit Dharmais Pusat Kanker Nasional, Jakarta, Indonesia; Yosia, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
One bioproduct that is widely used in the wound healing process is platelet-rich plasma (PRP). PRP is a liquid solution with high autologous platelet concentration, making it a good source of growth factors to accelerate wound healing. Recent development in PRP had created a new product called platelet-rich fibrin matrix (PRFM), which has a denser and more flexible structure. PRFM is the newest generation of platelet concentrate with a fibrin matrix that holds platelet in it. The key concept in creating PRFM from PRP is the addition of CaCl2 followed by centrifugation, which converts fibrinogen to fibrin, and the fibrin cross-links to form a matrix that contains viable platelets. There are many commercially available kits to create PRFM, but they are often expensive and uneconomical. This research will test a modified method of making ideal PRFM from PRP without any commercial kits. The modified method will include determining the minimum level of CaCl2 used, the type of centrifuge, and the speed and duration of centrifugation. By performing a modified preparation method on five samples of whole blood, it was found that the ideal PRFM could be made by mixing PRP with 25 mM CaCl2 and centrifuging it at a speed of 2,264 × g for 25 min at room temperature. The PRP and PRFM platelet counts of this method tend to be lower than the platelet counts found in other studies. Although visually comparable, further study is needed to compare the performance of PRFMs made with this method and PRFMs made with commercial kits. © Copyright © 2021 Reksodiputro, Harahap, Setiawan and Yosia. |
CaCl2; centrifugation; fibrin matrix; platelet concentrate; platelet rich fibrin matrix; platelet rich plasma |
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Frontiers Media S.A. |
2296858X |
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Article |
Q1 |
1388 |
2608 |
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260 |
Saharman Y.R., Karuniawati A., Sedono R., Aditianingsih D., Qi H., Verbrugh H.A., Severin J.A. |
55980934300;54886816200;56660590500;56312263600;57200516838;7103296623;8700385500; |
Multimodal intervention to reduce acquisition of carbapenem-non-susceptible Gram-negative bacteria in intensive care units in the National Referral Hospital of Indonesia: An interrupted time series study |
2021 |
Journal of Critical Care |
64 |
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237 |
244 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107783916&doi=10.1016%2fj.jcrc.2021.04.016&partnerID=40&md5=5958a3646b6b7e60f517ca3456c7f72a |
Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Critical Care Division, Department of Anesthesia and Intensive Care, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Biostatistics, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands |
Saharman, Y.R., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Karuniawati, A., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sedono, R., Critical Care Division, Department of Anesthesia and Intensive Care, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Aditianingsih, D., Critical Care Division, Department of Anesthesia and Intensive Care, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Qi, H., Department of Biostatistics, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Verbrugh, H.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Severin, J.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands |
Purpose: To evaluate a low-cost multimodal intervention on the acquisition of carbapenem-non-susceptible Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa by patients in low-resource intensive care units. Materials and methods: We performed a quasi-experimental study in a referral hospital in Jakarta, Indonesia: pre-intervention phase 1 (2013–2014), intervention phase 2 (2014–2015) and post-intervention phase 3 (2015–2016). The intervention was hand hygiene promotion and environmental cleaning and disinfection combined with patient disinfection and cohorting. The primary outcome was acquisition of resistant bacteria per 100 patient-days at risk, which was assessed by active microbiological surveillance and analysed with a multilevel Poisson segmented regression model. Results: In phase 1 (387 patients), the acquisition rate was 4.3/100 days for carbapenem-non-susceptible A. baumannii versus 1.1/100 days for both K. pneumoniae and P. aeruginosa. There was a significant step change from phase 1 to phase 3 (361 patients) in the acquisition of carbapenem-non-susceptible strains, the incidence rate ratio (IRR) was 0.343 (99%CI: 0.164–0.717). This significant change was mainly due to reduced acquisitions of resistant A. baumannii (IRR 0.4, 99%CI: 0.181–1.061). Negative confounding was observed. Conclusion: A multimodal intervention to prevent acquisition of resistant pathogens is feasible and may be effective in ICUs in lower-middle income countries. © 2021 The Authors |
Acinetobacter baumannii-calcoaceticus complex; Acquisition rate; Carbapenem-non-susceptible; ICU; Indonesia; Klebsiella pneumoniae; Multimodal interventions; Pseudomonas aeruginosa |
carbapenem; antiinfective agent; carbapenem derivative; Acinetobacter baumannii; Acinetobacter calcoaceticus-baumannii complex; adult; aged; antibiotic sensitivity; Article; artificial ventilation; bacterium isolation; cleaning; controlled study; disease surveillance; disinfection; emergency ward; female; human; hygiene; incidence; infection control; information processing; intensive care unit; Klebsiella pneumoniae; length of stay; major clinical study; male; multidrug resistance; outcome assessment; phase 1 clinical trial; phase 2 clinical trial; phase 3 clinical trial; Pseudomonas aeruginosa; quasi experimental study; remission; Sequential Organ Failure Assessment Score; systemic inflammatory response syndrome; time series analysis; cross infection; Gram negative bacterium; hospital; In |
W.B. Saunders |
08839441 |
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34044188 |
Article |
Q1 |
1149 |
3541 |
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261 |
Pravian D., Soesanto A.M., Ambari A.M., Kuncoro B.R.M.A.S., Dwiputra B., Muliawan H.S., Sukmawan R. |
57223935749;56374199000;57189576921;57223920990;57195383994;57203644653;8651025300; |
The effect of external counterpulsation on intrinsic myocardial function evaluated by speckle tracking echocardiography in refractory angina patients: a randomized controlled trial |
2021 |
International Journal of Cardiovascular Imaging |
37 |
8 |
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2483 |
2490 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106531230&doi=10.1007%2fs10554-021-02289-x&partnerID=40&md5=205259fb7afb6a50c7b9b375ac603918 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Pravian, D., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Soesanto, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Ambari, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Kuncoro, B.R.M.A.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Dwiputra, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Muliawan, H.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Sukmawan, R., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
External Counterpulsation (ECP) is one of the therapeutic options in patients with refractory angina inadequately controlled by medical, interventional, or surgical therapy. The 2D Speckle Tracking Echocardiography (2D-STE) method is considered superior in assessing clinical improvement. We would like to evaluate any improvement of myocardial intrinsic function using 2D-STE in patients underwent standard ECP protocol (35 sessions). We conducted a double-blind randomized controlled trial. Patients with refractory angina who could not be revascularized conventionally were randomized into two groups: (1) the ECP group (300 mmHg) and (2) the Sham/control group (75 mmHg). ECP standard therapy was given for 35 sessions (1 h/day/session). The 2D-STE data, including longitudinal strain and post systolic index (PSI) were obtained before and after therapy. 43 subjects were analyzed, with 22 subjects in ECP group and 21 control subjects (Sham group). A homogenous baseline strain was found either globally (12.42 ± 4.55 vs 12.00 ± 4.92 [− %]; P = 0.774) or segmentally/regionally (12.63 (0.01–25.16) vs 12.43 (0.01–27.20) [− %]; P = 0.570). There was no statistically significant improvement between groups in the left ventricle longitudinal strain globally (P = 0.535) and segmentally/regionally (P = 0.434). PSI parameters showed improvement in the ECP group (P = 0.049), and segments with PSI ≥ 20% seemed to improve longitudinal strains in the ECP group after therapy (P = 0.042). In conclusion, 35 ECP therapy sessions did not improve either global or segmental/regional left ventricular mechanical function in patients with refractory angina. However, the mechanical function of myocardial segments with PSS tends to improve after ECP therapy. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. |
2D speckle tracking echocardiography; External counterpulsation; Post systolic index; Refractory angina; Strain |
adult; aged; angina pectoris; Article; cardiovascular parameters; clinical article; clinical outcome; controlled study; counterpulsation; double blind procedure; female; follow up; heart function; heart left ventricle enddiastolic diameter; heart left ventricle endsystolic diameter; human; left ventricular global longitudinal strain; male; middle aged; post systolic index; post systolic shortening; randomized controlled trial; tricuspid annular plane systolic excursion; two dimensional speckle tracking echocardiography |
Springer Science and Business Media B.V. |
15695794 |
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34037889 |
Article |
Q2 |
726 |
6821 |
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265 |
Yuliwulandari R., Shin J.G., Kristin E., Suyatna F.D., Prahasto I.D., Prayuni K., Mahasirimongkol S., Cavallari L.H., Mitropoulou C., Patrinos G.P., Hao J., Williams M.S., Snyder S.R. |
23098874600;56031235700;6504458442;56039633100;57222660319;57190022456;14632559000;8396168500;37001846100;6603726539;57194283820;57203332674;7401687524; |
Cost-effectiveness analysis of genotyping for HLA-B*15:02 in Indonesian patients with epilepsy using a generic model |
2021 |
Pharmacogenomics Journal |
21 |
4 |
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476 |
483 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103643380&doi=10.1038%2fs41397-021-00225-9&partnerID=40&md5=927cb9a5fa739ff5a932d25eb4459bd0 |
Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta Pusat, Indonesia; Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea; Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Department of Pharmacology & Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Medical Genetics Section, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, United States; The Golden Helix Foundation, London, United Kingdom; Department of Pharmacy, University of Patras, Patras, Greece; Department of Pathology, United Arab Emirates University College of Medicine and Health Sciences, Al-Ain, United Arab Emirates; Department of Population Health Sciences, Geisinger, Danville, PA, United States; Genomic Medicine Institute, Geisinger, Danville, PA, United States; Health Policy & Behavioral Sciences, Georgia State University, Atlanta, GA, United States |
Yuliwulandari, R., Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta Pusat, Indonesia, Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Shin, J.G., Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea, Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea; Kristin, E., Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Suyatna, F.D., Department of Pharmacology & Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Prahasto, I.D., Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Prayuni, K., Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Mahasirimongkol, S., Medical Genetics Section, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; Cavallari, L.H., Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, United States; Mitropoulou, C., The Golden Helix Foundation, London, United Kingdom; Patrinos, G.P., Department of Pharmacy, University of Patras, Patras, Greece, Department of Pathology, United Arab Emirates University College of Medicine and Health Sciences, Al-Ain, United Arab Emirates; Hao, J., Department of Population Health Sciences, Geisinger, Danville, PA, United States; Williams, M.S., Genomic Medicine Institute, Geisinger, Danville, PA, United States; Snyder, S.R., Health Policy & Behavioral Sciences, Georgia State University, Atlanta, GA, United States |
Carbamazepine (CBZ)-induced Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are strongly associated with the HLA-B*15:02 allele. Screening HLA-B*15:02 before CBZ administration might prevent CBZ-induced SJS/TEN by enabling clinicians to prescribe alternative therapy for positive patients. Similar to other Southeastern Asian countries, HLA-B*15:02 is highly prevalent in Indonesia. Therefore, we assessed the economic value of HLA-B*15:02 screening before CBZ prescription to patients with epilepsy in Indonesia. A generic cost-effectiveness model and decision support tool, developed to enable users to perform an initial cost-effectiveness analysis from a healthcare provider/payer perspective, were used to assess the value of HLA-B*15:02 genotyping. The incremental cost-effectiveness ratio of adopting universal HLA-B*15:02 screening was 656,444,671 Indonesian Rupiah (IDR)/quality-adjusted life year (QALY) gained for patients compared with 2,634,975,574 IDR/QALY gained for providing valproic acid (alternative drug) without screening. Thus, neither HLA-B*15:02 screening nor substitution with VPA meets the Indonesian threshold for cost effectiveness. However, the improved outcomes with this test in other Asian countries may inform the desirability of implementation in Indonesia even with suboptimal cost-effectiveness. © 2021, The Author(s), under exclusive licence to Springer Nature Limited. |
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anticonvulsive agent; carbamazepine; HLA B antigen; valproic acid; anticonvulsive agent; carbamazepine; HLA B15 antigen; aged; Article; cost effectiveness analysis; epilepsy; epileptic patient; female; genotyping; human; Indonesian; Javanese (people); major clinical study; male; predictive value; prevalence; quality adjusted life year; sensitivity analysis; sensitivity and specificity; Stevens Johnson syndrome; Sundanese (people); toxic epidermal necrolysis; adult; allele; Asian; cost benefit analysis; epilepsy; genetic predisposition; genetic screening; genetics; genotype; Indonesia; procedures; risk factor; Adult; Alleles; Anticonvulsants; Asians; Carbamazepine; Cost-Benefit Analysis; Epilepsy; Female; Genetic Predisposition to Disease; Genetic Testing; Genotype; HLA-B15 Antigen; Humans; |
Springer Nature |
1470269X |
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33824430 |
Article |
Q2 |
804 |
6015 |
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