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261 |
Pravian D., Soesanto A.M., Ambari A.M., Kuncoro B.R.M.A.S., Dwiputra B., Muliawan H.S., Sukmawan R. |
57223935749;56374199000;57189576921;57223920990;57195383994;57203644653;8651025300; |
The effect of external counterpulsation on intrinsic myocardial function evaluated by speckle tracking echocardiography in refractory angina patients: a randomized controlled trial |
2021 |
International Journal of Cardiovascular Imaging |
37 |
8 |
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2483 |
2490 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106531230&doi=10.1007%2fs10554-021-02289-x&partnerID=40&md5=205259fb7afb6a50c7b9b375ac603918 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Pravian, D., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Soesanto, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Ambari, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Kuncoro, B.R.M.A.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Dwiputra, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Muliawan, H.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Sukmawan, R., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
External Counterpulsation (ECP) is one of the therapeutic options in patients with refractory angina inadequately controlled by medical, interventional, or surgical therapy. The 2D Speckle Tracking Echocardiography (2D-STE) method is considered superior in assessing clinical improvement. We would like to evaluate any improvement of myocardial intrinsic function using 2D-STE in patients underwent standard ECP protocol (35 sessions). We conducted a double-blind randomized controlled trial. Patients with refractory angina who could not be revascularized conventionally were randomized into two groups: (1) the ECP group (300 mmHg) and (2) the Sham/control group (75 mmHg). ECP standard therapy was given for 35 sessions (1 h/day/session). The 2D-STE data, including longitudinal strain and post systolic index (PSI) were obtained before and after therapy. 43 subjects were analyzed, with 22 subjects in ECP group and 21 control subjects (Sham group). A homogenous baseline strain was found either globally (12.42 ± 4.55 vs 12.00 ± 4.92 [− %]; P = 0.774) or segmentally/regionally (12.63 (0.01–25.16) vs 12.43 (0.01–27.20) [− %]; P = 0.570). There was no statistically significant improvement between groups in the left ventricle longitudinal strain globally (P = 0.535) and segmentally/regionally (P = 0.434). PSI parameters showed improvement in the ECP group (P = 0.049), and segments with PSI ≥ 20% seemed to improve longitudinal strains in the ECP group after therapy (P = 0.042). In conclusion, 35 ECP therapy sessions did not improve either global or segmental/regional left ventricular mechanical function in patients with refractory angina. However, the mechanical function of myocardial segments with PSS tends to improve after ECP therapy. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. |
2D speckle tracking echocardiography; External counterpulsation; Post systolic index; Refractory angina; Strain |
adult; aged; angina pectoris; Article; cardiovascular parameters; clinical article; clinical outcome; controlled study; counterpulsation; double blind procedure; female; follow up; heart function; heart left ventricle enddiastolic diameter; heart left ventricle endsystolic diameter; human; left ventricular global longitudinal strain; male; middle aged; post systolic index; post systolic shortening; randomized controlled trial; tricuspid annular plane systolic excursion; two dimensional speckle tracking echocardiography |
Springer Science and Business Media B.V. |
15695794 |
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34037889 |
Article |
Q2 |
726 |
6821 |
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262 |
Uchihara Y., Permata T.B.M., Sato H., Shibata A. |
57221723636;57197808751;55697961900;8323572900; |
Modulation of immune responses by DNA damage signaling |
2021 |
DNA Repair |
104 |
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103135 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106368761&doi=10.1016%2fj.dnarep.2021.103135&partnerID=40&md5=6d7c9e9634795d347738b7c970442465 |
Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Department of Radiation Oncology, Gunma University, Gunma, Japan |
Uchihara, Y., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan; Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Sato, H., Department of Radiation Oncology, Gunma University, Gunma, Japan; Shibata, A., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan |
An accumulation of evidence indicates the importance of DNA damage signaling in modulating immune responses. Indeed, understanding the mechanism that underlies signal transduction originating from DNA damage is vital to overcoming refractory cancer, particularly when cancer immune therapy is applied in combination with DNA damage-dependent radio/chemotherapy. In addition, immune-associated responses to such signals can aggravate the symptoms of infections, allergies, autoimmune disease, and aging. In this review, we discuss how cells transduce signals, triggered by DNA damage, from their origins to neighboring cells and how this affects immune and inflammatory responses. © 2021 Elsevier B.V. |
Cancer therapy; DNA damage signaling; Immune crosstalk; Immune-associated disease; Inflammation |
nucleic acid; DNA; Article; cancer immunotherapy; DNA damage response; down regulation; human; immune response; immunomodulation; immunopathology; immunoregulation; inflammation; priority journal; signal transduction; animal; DNA damage; DNA repair; immunity; immunology; metabolism; neoplasm; signal transduction; Animals; DNA Damage; DNA Repair; DNA, Neoplasm; Humans; Immunity; Inflammation; Neoplasms; Signal Transduction |
Elsevier B.V. |
15687864 |
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34029876 |
Article |
Q1 |
2359 |
1004 |
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263 |
Yunihastuti E., Lestari Agusin R., Sari V., Jhariah Hidayah A., Wulunggono W., Pramukti H., Shinta M., Shatri H., Harjono Karjadi T. |
57221273925;57223400304;57223400647;57223397657;57211629741;57223395589;57223397294;28767986500;57223406089; |
Prevalence and associated factors of depressive symptoms among people living with HIV on antiretroviral therapy in Jakarta, Indonesia |
2021 |
Tropical Medicine and International Health |
26 |
8 |
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908 |
915 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105775227&doi=10.1111%2ftmi.13597&partnerID=40&md5=56c4f01a1cfbf229aaa3658813422100 |
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; HIV Integrated Unit RSUPN Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Yunihastuti, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, HIV Integrated Unit RSUPN Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Lestari Agusin, R., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sari, V., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jhariah Hidayah, A., HIV Integrated Unit RSUPN Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wulunggono, W., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pramukti, H., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Shinta, M., HIV Integrated Unit RSUPN Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Shatri, H., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harjono Karjadi, T., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, HIV Integrated Unit RSUPN Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Objective: We aimed to investigate the prevalence of depressive symptoms among people living with HIV (PLHIV) on antiretroviral therapy (ART) in a large HIV treatment facility in Jakarta, Indonesia, and to assess associated factors. Methods: The Indonesian version of Beck Depression Inventory-II was used to assess depressive symptoms of 346 participants visiting the HIV Integrated Clinic Cipto Mangunkusumo hospital between June and November 2018. Results: Depressive symptoms (BDI-II score ≥14) were exhibited by 50.9% of participants, with prevalences of mild, moderate and severe depression of 30.4%, 15.6% and 4.9%, respectively. Poisson regression with robust variance analysis indicated that having lower income (aPR = 1.38, 95% CI 1.12–1.63), duration of ART for 1–5 years (aPR = 1.25, 95% CI 1.01–1.54) and same-sex partnership (aPR = 1.27, 95% CI 1.02–1.58) were positively associated with depressive symptoms. Age, sex and history of using intravenous drugs, and ART-based regimen were not associated with depressive symptoms. Conclusions: Depressive symptoms were common among our population despite long-term ART use and were associated with having low-income, ART for 1–5 years and same-sex partnership. © 2021 John Wiley & Sons Ltd |
antiretroviral therapy; depression; depressive symptoms; human immunodeficiency virus |
anti human immunodeficiency virus agent; disease prevalence; mental health; spatiotemporal analysis; symptom; variance analysis; adult; age; analysis of variance; antiretroviral therapy; Article; Beck Depression Inventory; confidence interval; controlled study; cross-sectional study; depression; disease association; disease severity; female; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; Indonesia; intravenous drug abuse; lowest income group; major clinical study; male; medical history; Poisson distribution; prevalence; sex; depression; highly active antiretroviral therapy; Indonesia; prevalence; psychology; psychometry; risk factor; Indonesia; Jakarta; Human immunodeficiency virus; Adult; Antiretroviral Therapy, Highly Active; Cross-Sectional |
John Wiley and Sons Inc |
13602276 |
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33930230 |
Article |
Q1 |
1056 |
4040 |
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265 |
Yuliwulandari R., Shin J.G., Kristin E., Suyatna F.D., Prahasto I.D., Prayuni K., Mahasirimongkol S., Cavallari L.H., Mitropoulou C., Patrinos G.P., Hao J., Williams M.S., Snyder S.R. |
23098874600;56031235700;6504458442;56039633100;57222660319;57190022456;14632559000;8396168500;37001846100;6603726539;57194283820;57203332674;7401687524; |
Cost-effectiveness analysis of genotyping for HLA-B*15:02 in Indonesian patients with epilepsy using a generic model |
2021 |
Pharmacogenomics Journal |
21 |
4 |
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476 |
483 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103643380&doi=10.1038%2fs41397-021-00225-9&partnerID=40&md5=927cb9a5fa739ff5a932d25eb4459bd0 |
Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta Pusat, Indonesia; Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea; Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Department of Pharmacology & Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Medical Genetics Section, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, United States; The Golden Helix Foundation, London, United Kingdom; Department of Pharmacy, University of Patras, Patras, Greece; Department of Pathology, United Arab Emirates University College of Medicine and Health Sciences, Al-Ain, United Arab Emirates; Department of Population Health Sciences, Geisinger, Danville, PA, United States; Genomic Medicine Institute, Geisinger, Danville, PA, United States; Health Policy & Behavioral Sciences, Georgia State University, Atlanta, GA, United States |
Yuliwulandari, R., Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta Pusat, Indonesia, Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Shin, J.G., Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea, Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea; Kristin, E., Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Suyatna, F.D., Department of Pharmacology & Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Prahasto, I.D., Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Prayuni, K., Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Mahasirimongkol, S., Medical Genetics Section, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; Cavallari, L.H., Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, United States; Mitropoulou, C., The Golden Helix Foundation, London, United Kingdom; Patrinos, G.P., Department of Pharmacy, University of Patras, Patras, Greece, Department of Pathology, United Arab Emirates University College of Medicine and Health Sciences, Al-Ain, United Arab Emirates; Hao, J., Department of Population Health Sciences, Geisinger, Danville, PA, United States; Williams, M.S., Genomic Medicine Institute, Geisinger, Danville, PA, United States; Snyder, S.R., Health Policy & Behavioral Sciences, Georgia State University, Atlanta, GA, United States |
Carbamazepine (CBZ)-induced Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are strongly associated with the HLA-B*15:02 allele. Screening HLA-B*15:02 before CBZ administration might prevent CBZ-induced SJS/TEN by enabling clinicians to prescribe alternative therapy for positive patients. Similar to other Southeastern Asian countries, HLA-B*15:02 is highly prevalent in Indonesia. Therefore, we assessed the economic value of HLA-B*15:02 screening before CBZ prescription to patients with epilepsy in Indonesia. A generic cost-effectiveness model and decision support tool, developed to enable users to perform an initial cost-effectiveness analysis from a healthcare provider/payer perspective, were used to assess the value of HLA-B*15:02 genotyping. The incremental cost-effectiveness ratio of adopting universal HLA-B*15:02 screening was 656,444,671 Indonesian Rupiah (IDR)/quality-adjusted life year (QALY) gained for patients compared with 2,634,975,574 IDR/QALY gained for providing valproic acid (alternative drug) without screening. Thus, neither HLA-B*15:02 screening nor substitution with VPA meets the Indonesian threshold for cost effectiveness. However, the improved outcomes with this test in other Asian countries may inform the desirability of implementation in Indonesia even with suboptimal cost-effectiveness. © 2021, The Author(s), under exclusive licence to Springer Nature Limited. |
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anticonvulsive agent; carbamazepine; HLA B antigen; valproic acid; anticonvulsive agent; carbamazepine; HLA B15 antigen; aged; Article; cost effectiveness analysis; epilepsy; epileptic patient; female; genotyping; human; Indonesian; Javanese (people); major clinical study; male; predictive value; prevalence; quality adjusted life year; sensitivity analysis; sensitivity and specificity; Stevens Johnson syndrome; Sundanese (people); toxic epidermal necrolysis; adult; allele; Asian; cost benefit analysis; epilepsy; genetic predisposition; genetic screening; genetics; genotype; Indonesia; procedures; risk factor; Adult; Alleles; Anticonvulsants; Asians; Carbamazepine; Cost-Benefit Analysis; Epilepsy; Female; Genetic Predisposition to Disease; Genetic Testing; Genotype; HLA-B15 Antigen; Humans; |
Springer Nature |
1470269X |
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33824430 |
Article |
Q2 |
804 |
6015 |
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266 |
Akada J., Tshibangu-Kabamba E., Tuan V.P., Kurogi S., Matsuo Y., Ansari S., Doohan D., Phuc B.H., Subsomwong P., Waskito L.A., Binh T.T., Nguyen L.T., Khien V.V., Dung H.D.Q., Miftahussurur M., Syam A.F., Tshering L., Vilaichone R.-K., Mahachai V., Ratanachu-ek T., Shrestha P.K., Yee T.T., Htet K., Aftab H., Matsuhisa T., Uchida T., Okimoto T., Mizukami K., Kodama M., Murakami K., Takahashi N., Yamaoka Y. |
6506986959;57218760439;57195367045;57195277760;55567953900;55523204000;57204644036;57222165127;57113712700;57192177367;55415987700;35285702000;6507745643;56681908900;56323903000;8443384400;57211294242;6701788898;7003739875;6507122700;8099897200;57211455497;57241639000;55359226800;7005493709;35286123100;7005300232;7005239531;35285903900;57214336895;7403938865;55183784100; |
Serum Helicobacter pylori antibody reactivity in seven Asian countries using an automated latex aggregation turbidity assay |
2021 |
Journal of Gastroenterology and Hepatology (Australia) |
36 |
8 |
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2198 |
2209 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102320750&doi=10.1111%2fjgh.15467&partnerID=40&md5=71760e350adacfbf3a65094e953e8182 |
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Clinical Laboratory Center, Oita University Hospital, Yufu, Japan; Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh City, Viet Nam; Department of Hepatogastroenterology, 108 Military Central Hospital, Hanoi, Viet Nam; Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Airlangga University, Surabaya, Indonesia; Division of Gastroenterology, Department of Intestinal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Surgery, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan; Gastroenterology Unit, Digestive Diseases Research Center, Thammasat University Hospital, Khlong Luang, Thailand; Department of Medicine, Chulabhorn International College of Medicine, Thammasat University Hospital, Khlong Luang, Thailand; GI and Liver Center, Bangkok Medical Center, Bangkok, Thailand; Department of Surgery, Rajavithi Hospital, Bangkok, Thailand; Department of Gastroenterology, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Kathmandu, Nepal; Department of GI and HBP Surgery, No (2) Defense Service General Hospital, Nay Pyi Taw, Myanmar; Department of GI and HBP Surgery, No (1) Defense Service General Hospital, Mingaladon, Myanmar; Department of Gastroenterology, Dhaka Medical Collage and Hospital, Dhaka, Bangladesh; Department of Gastroenterology, Tama-Nagayama University Hospital, Nippon Medical School, Tama, Japan; Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu, Japan; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan; Faculty of Welfare and Health Science, Oita University, Yufu, Japan; Global Oita Medical Advanced Research Center for Health, Oita University, Yufu, Japan; Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, United States |
Akada, J., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Tshibangu-Kabamba, E., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Tuan, V.P., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan, Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh City, Viet Nam; Kurogi, S., Clinical Laboratory Center, Oita University Hospital, Yufu, Japan, Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu, Japan; Matsuo, Y., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Ansari, S., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Doohan, D., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia; Phuc, B.H., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Subsomwong, P., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Waskito, L.A., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia; Binh, T.T., Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh City, Viet Nam; Nguyen, L.T., Department of Hepatogastroenterology, 108 Military Central Hospital, Hanoi, Viet Nam; Khien, V.V., Department of Hepatogastroenterology, 108 Military Central Hospital, Hanoi, Viet Nam; Dung, H.D.Q., Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh City, Viet Nam; Miftahussurur, M., Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia, Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Airlangga University, Surabaya, Indonesia; Syam, A.F., Division of Gastroenterology, Department of Intestinal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Tshering, L., Department of Surgery, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan; Vilaichone, R.-K., Gastroenterology Unit, Digestive Diseases Research Center, Thammasat University Hospital, Khlong Luang, Thailand, Department of Medicine, Chulabhorn International College of Medicine, Thammasat University Hospital, Khlong Luang, Thailand; Mahachai, V., GI and Liver Center, Bangkok Medical Center, Bangkok, Thailand; Ratanachu-ek, T., Department of Surgery, Rajavithi Hospital, Bangkok, Thailand; Shrestha, P.K., Department of Gastroenterology, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Kathmandu, Nepal; Yee, T.T., Department of GI and HBP Surgery, No (2) Defense Service General Hospital, Nay Pyi Taw, Myanmar; Htet, K., Department of GI and HBP Surgery, No (1) Defense Service General Hospital, Mingaladon, Myanmar; Aftab, H., Department of Gastroenterology, Dhaka Medical Collage and Hospital, Dhaka, Bangladesh; Matsuhisa, T., Department of Gastroenterology, Tama-Nagayama University Hospital, Nippon Medical School, Tama, Japan; Uchida, T., Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu, Japan; Okimoto, T., Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan; Mizukami, K., Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan; Kodama, M., Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan, Faculty of Welfare and Health Science, Oita University, Yufu, Japan; Murakami, K., Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan; Takahashi, N., Clinical Laboratory Center, Oita University Hospital, Yufu, Japan; Yamaoka, Y., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan, Global Oita Medical Advanced Research Center for Health, Oita University, Yufu, Japan, Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, United States |
Background and Aim: To determine the application range of diagnostic kits utilizing anti-Helicobacter pylori antibody, we tested a newly developed latex aggregation turbidity assay (latex) and a conventional enzyme-linked immunosorbent assay (E-plate), both containing Japanese H. pylori protein lysates as antigens, using sera from seven Asian countries. Methods: Serum samples (1797) were obtained, and standard H. pylori infection status and atrophy status were determined by culture and histology (immunohistochemistry) using gastric biopsy samples from the same individuals. The two tests (enzyme-linked immunosorbent assay and latex) were applied, and receiver operating characteristics analysis was performed. Results: Area under the curve (AUC) from the receiver operating characteristic of E-plate and latex curves were almost the same and the highest in Vietnam. The latex AUC was slightly lower than the E-plate AUC in other countries, and the difference became statistically significant in Myanmar and then Bangladesh as the lowest. To consider past infection cases, atrophy was additionally evaluated. Most of the AUCs decreased using this atrophy-evaluated status; however, the difference between the two kits was not significant in each country, but the latex AUC was better using all samples. Practical cut-off values were 3.0 U/mL in the E-test and 3.5 U/mL in the latex test, to avoid missing gastric cancer patients to the greatest extent possible. Conclusions: The kits were applicable in all countries, but new kits using regional H. pylori strains are recommended for Myanmar and Bangladesh. Use of a cut-off value lower than the best cut-off value is essential for screening gastric cancer patients. © 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd |
Asia; ELISA; Helicobacter pylori; Latex aggregation turbidity assay; Serum antibody |
antigen; bacterium antibody; immunoglobulin G; protein hydrolysate; bacterium antibody; adult; antibody blood level; Article; Asia; bacterial strain; bacterium culture; Bangladesh; Bhutan; cancer patient; cancer screening; controlled study; diagnostic accuracy; diagnostic test; evaluation study; female; Helicobacter infection; Helicobacter pylori; histopathology; human; human tissue; immunohistochemistry; Indonesia; infection rate; Japan; latex aggregation turbidity assay; major clinical study; male; marginal zone lymphoma; middle aged; Myanmar; Nepal; nonhuman; plate ELISA; predictive value; receiver operating characteristic; reference value; sensitivity and specificity; serum; statistical significance; stomach atrophy; stomach biopsy; stomach cancer; Viet Nam; aged; atrophy; biopsy; bloo |
John Wiley and Sons Inc |
08159319 |
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33609333 |
Article |
Q1 |
1214 |
3242 |
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267 |
Quek S.X.Z., Loo E.X.L., Demutska A., Chua C.E., Kew G.S., Wong S., Lau H.X., Low E.X.S., Loh T.L., Lung O.S., Hung E.C.W., Rahman M.M., Ghoshal U.C., Wong S.H., Cheung C.K.Y., Syam A.F., Tan N., Xiao Y., Liu J.-S., Lu F., Chen C.-L., Lee Y.Y., Maralit R.M., Kim Y.-S., Oshima T., Miwa H., Pang J., Siah K.T.H. |
57222222782;50162082500;36136970000;56816437200;56611839100;57222223736;57218857855;57201335892;57222224359;57222226377;7004256338;57216556340;7005966711;55451145400;8714367400;8443384400;56417185400;23500436000;57196288418;36120914800;23495616400;56191149300;57202206761;57196171210;7401663152;56921458500;57224357479;35757936600; |
Impact of the coronavirus disease 2019 pandemic on irritable bowel syndrome |
2021 |
Journal of Gastroenterology and Hepatology (Australia) |
36 |
8 |
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2187 |
2197 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101935332&doi=10.1111%2fjgh.15466&partnerID=40&md5=4f7271b5d9e13c1b4bdea5a3463fd019 |
Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Department of Clinical Psychology, James Cook University, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore; Department of Medicine, Ng Teng Fong General Hospital, Singapore; Department of Otorhinolarygology, Head and Neck Surgery, Universiti Putra Malaysia, Seri Kembangan, Malaysia; Department of Anaesthesiology, Columbia Asia Hospital, Miri, Sarawak, Malaysia; Cambridge Paediatrics, Shatin, Hong Kong; Department of Gastroenterology, Sheikh Russel National Gastroliver Institute and Hospital, Dhaka, Bangladesh; Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute Medical Science, Lucknow, India; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong; Department of Medicine, The University of Hong Kong, Hong Kong; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Departments of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Department of Gastroenterology, Wuhan Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei, China; Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Department of Medicine, Buddhist Tzu Chi Hospital and University School of Medicine, Hualien, Taiwan; St George and Sutherland Clinical School, University of New South Wales, Sydney, NSW, Australia; Gut Research Group, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; The Medical City, Metro Manila, Philippines; Wonkwang Digestive Disease Research Institute, Gut and Food Healthcare, Wonkwang University School of Medicine, Iksan, South Korea; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore; Centre for Infectious Disease Epidemiology and Research, National University of Singapore, Singapore |
Quek, S.X.Z., Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, Singapore; Loo, E.X.L., Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Demutska, A., Department of Clinical Psychology, James Cook University, Singapore; Chua, C.E., Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, Singapore; Kew, G.S., Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, Singapore, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore; Wong, S., Department of Medicine, Ng Teng Fong General Hospital, Singapore; Lau, H.X., Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Low, E.X.S., Department of Medicine, Ng Teng Fong General Hospital, Singapore; Loh, T.L., Department of Otorhinolarygology, Head and Neck Surgery, Universiti Putra Malaysia, Seri Kembangan, Malaysia; Lung, O.S., Department of Anaesthesiology, Columbia Asia Hospital, Miri, Sarawak, Malaysia; Hung, E.C.W., Cambridge Paediatrics, Shatin, Hong Kong; Rahman, M.M., Department of Gastroenterology, Sheikh Russel National Gastroliver Institute and Hospital, Dhaka, Bangladesh; Ghoshal, U.C., Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute Medical Science, Lucknow, India; Wong, S.H., Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; Cheung, C.K.Y., State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, Department of Medicine, The University of Hong Kong, Hong Kong; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tan, N., Departments of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Xiao, Y., Departments of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Liu, J.-S., Department of Gastroenterology, Wuhan Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei, China; Lu, F., Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Chen, C.-L., Department of Medicine, Buddhist Tzu Chi Hospital and University School of Medicine, Hualien, Taiwan; Lee, Y.Y., St George and Sutherland Clinical School, University of New South Wales, Sydney, NSW, Australia, Gut Research Group, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; Maralit, R.M., The Medical City, Metro Manila, Philippines; Kim, Y.-S., Wonkwang Digestive Disease Research Institute, Gut and Food Healthcare, Wonkwang University School of Medicine, Iksan, South Korea; Oshima, T., Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; Miwa, H., Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore; Pang, J., Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Centre for Infectious Disease Epidemiology and Research, National University of Singapore, Singapore; Siah, K.T.H., Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, Singapore, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore |
Background and Aim: Gastrointestinal manifestations of the coronavirus disease 2019 (COVID-19) pandemic may mimic irritable bowel syndrome (IBS), and social distancing measures may affect IBS patients negatively. We aimed to study the impact of COVID-19 on respondents with self-reported IBS. Methods: We conducted an anonymized survey from May to June 2020 in 33 countries. Knowledge, attitudes, and practices on personal hygiene and social distancing as well as psychological impact of COVID-19 were assessed. Statistical analysis was performed to determine differences in well-being and compliance to social distancing measures between respondents with and without self-reported IBS. Factors associated with improvement or worsening of IBS symptoms were evaluated. Results: Out of 2704 respondents, 2024 (74.9%) did not have IBS, 305 (11.3%) had self-reported IBS, and 374 (13.8%) did not know what IBS was. Self-reported IBS respondents reported significantly worse emotional, social, and psychological well-being compared with non-IBS respondents and were less compliant to social distancing measures (28.2% vs 35.3%, P = 0.029); 61.6% reported no change, 26.6% reported improvement, and 11.8% reported worsening IBS symptoms. Higher proportion of respondents with no change in IBS symptoms were willing to practice social distancing indefinitely versus those who deteriorated (74.9% vs 51.4%, P = 0.016). In multivariate analysis, willingness to continue social distancing for another 2–3 weeks (vs longer period) was significantly associated with higher odds of worsening IBS. Conclusion: Our study showed that self-reported IBS respondents had worse well-being and compliance to social distancing measures than non-IBS respondents. Future research will focus on occupational stress and dietary changes during COVID-19 that may influence IBS. © 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd |
COVID-19; IBS; Social distancing |
adult; Article; attitude to health; clinical assessment; clinical evaluation; clinical practice; comparative study; controlled study; coronavirus disease 2019; disease severity; emotion regulation; female; general condition deterioration; health survey; human; irritable colon; major clinical study; male; pandemic; personal hygiene; psychological aspect; psychological well-being; risk factor; self report; social distancing; symptom; clinical trial; cross-sectional study; irritable colon; multicenter study; pandemic; patient compliance; questionnaire; retrospective study; self report; Singapore; Adult; COVID-19; Cross-Sectional Studies; Female; Humans; Irritable Bowel Syndrome; Male; Pandemics; Patient Compliance; Retrospective Studies; SARS-CoV-2; Self Report; Singapore; Surveys and Questio |
John Wiley and Sons Inc |
08159319 |
|
33615534 |
Article |
Q1 |
1214 |
3242 |
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268 |
Findyartini A., Ramani S., McKimm J., Fornari A. |
56543777300;56186462600;26433565200;6701517660; |
Collaborative writing for clinical educators: recommendations from a community of scholars |
2021 |
Clinical Teacher |
18 |
4 |
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330 |
335 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101865035&doi=10.1111%2ftct.13329&partnerID=40&md5=c416c9d2916367a128e14dacb48e7fc6 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States; Swansea University Medical School, United Kingdom; Donald and Barbara Zucker SOM at Hofstra/Northwell, Hempstead, NY, United States |
Findyartini, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ramani, S., Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States; McKimm, J., Swansea University Medical School, United Kingdom; Fornari, A., Donald and Barbara Zucker SOM at Hofstra/Northwell, Hempstead, NY, United States |
Clinical educators who wish to engage in scholarship in health professions’ education (HPE), are ideally poised at the intersection of educational theories and their application to educational practice. However, the burden of clinical practice does not often allow the time and space for scholarly writing. Being part of a collaborative writing team, incorporating members with varying levels of expertise, from different health care professions, and at different stages of their career, can provide valuable opportunities for clinicians to contribute to scholarship. Such collaborations can also bridge the gap between scholarship and educational practice in clinical settings. In this paper, we emphasise the benefits of collaborative writing, describe challenges for clinical educators in starting writing projects, and identify potential solutions. We outline a systematic approach to collaborative writing grounded in literature and our own experiences. Three key concepts underpin the provided recommendations: types and standards for scholarship, leadership and followership and communities of practice. Psychological safety, mentoring and a growth mindset are emphasised as integral to successful team projects. Finally, we argue that collaborative writing groups in clinical education can be powerful communities of practice where the overall contribution to the field can be greater than the sum of its parts. © 2021 John Wiley & Sons Ltd and The Association for the Study of Medical Education |
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article; clinical education; human; human experiment; leadership; mentoring; psychological safety; writing; medical education; mentor; Fellowships and Scholarships; Humans; Leadership; Mentors; Writing |
John Wiley and Sons Inc |
17434971 |
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33655649 |
Article |
Q3 |
354 |
13257 |
|
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270 |
Smith O.J., Wicaksana A., Davidson D., Spratt D., Mosahebi A. |
54881691700;57211445559;55553306500;7004394482;55985666400; |
An evaluation of the bacteriostatic effect of platelet-rich plasma |
2021 |
International Wound Journal |
18 |
4 |
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448 |
456 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100215304&doi=10.1111%2fiwj.13545&partnerID=40&md5=1f9c16fc126205b4735c175e68af0b2e |
Department of Plastic Surgery, Royal Free Hospital, London, United Kingdom; Division of Surgery and Interventional Science, University College London, London, United Kingdom; Division of Plastic Surgery, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Microbial Diseases, Eastman Dental Institute, Faculty of Medical Sciences, University College London, London, United Kingdom |
Smith, O.J., Department of Plastic Surgery, Royal Free Hospital, London, United Kingdom, Division of Surgery and Interventional Science, University College London, London, United Kingdom; Wicaksana, A., Division of Surgery and Interventional Science, University College London, London, United Kingdom, Division of Plastic Surgery, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Davidson, D., Microbial Diseases, Eastman Dental Institute, Faculty of Medical Sciences, University College London, London, United Kingdom; Spratt, D., Microbial Diseases, Eastman Dental Institute, Faculty of Medical Sciences, University College London, London, United Kingdom; Mosahebi, A., Department of Plastic Surgery, Royal Free Hospital, London, United Kingdom, Division of Surgery and Interventional Science, University College London, London, United Kingdom |
Chronic wounds are a considerable health burden with high morbidity and poor rates of healing. Colonisation of chronic wounds by bacteria can be a significant factor in their poor healing rate. These bacteria can develop antibiotic resistance over time and can lead to wound infections, systemic illness, and occasionally amputation. When a large number of micro-organisms colonise wounds, they can lead to biofilm formation, which are self-perpetuating colonies of bacteria closed within an extracellular matrix, which are poorly penetrated by antibiotics. Platelet-rich plasma (PRP) is an autologous blood product rich in growth factors and cytokines that are involved in an inflammatory response. PRP can be injected or applied to a wound as a topical gel, and there is some interest regarding its antimicrobial properties and whether this can improve wound healing. This study aimed to evaluate the in vitro bacteriostatic effect of PRP. PRP was collected from healthy volunteers and processed into two preparations: activated PRP—activated with calcium chloride and ethanol; inactivated PRP. The activity of each preparation against Staphylococcus aureus and Staphylococcus epidermis was evaluated against a control by three experiments: bacterial kill assay to assess planktonic bacterial growth; plate colony assay to assess bacterial colony growth; and colony biofilm assay to assess biofilm growth. Compared with control, both preparations of PRP significantly inhibited growth of planktonic S aureus and S epidermis. Activated PRP reduced planktonic bacterial concentration more than inactivated PRP in both bacteria. Both PRP preparations significantly reduced bacterial colony counts for both bacteria when compared with control; however, there was no difference between the two. There was no difference found between biofilm growth in either PRP against control or against the other preparation. This study demonstrates that PRP does have an inhibitory effect on the growth of common wound pathogens. Activation may be an important factor in increasing the antimicrobial effect of PRP. However, we did not find evidence of an effect against more complex bacterial colonies. © 2021 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd. |
antimicrobial therapy; chronic wounds; platelet-rich plasma |
alcohol; calcium chloride; antiinfective agent; Article; bacterial count; bacterial growth; bacterial strain; bacteriostatic activity; bacterium colony; biofilm; controlled study; extracellular matrix; in vitro study; nonhuman; Staphylococcus aureus; Staphylococcus epidermidis; thrombocyte activation; thrombocyte rich plasma; human; Staphylococcus infection; wound healing; wound infection; Anti-Bacterial Agents; Humans; Platelet-Rich Plasma; Staphylococcal Infections; Wound Healing; Wound Infection |
John Wiley and Sons Inc |
17424801 |
|
33476481 |
Article |
Q1 |
867 |
5385 |
|
|
271 |
Yonas E., Alwi I., Pranata R., Huang I., Lim M.A., Gutierrez E.J., Yamin M., Siswanto B.B., Virani S.S. |
57201987097;15055173800;57201973901;57208576645;57216039756;57200435964;23475706300;14422648800;6701757915; |
Effect of heart failure on the outcome of COVID-19 — A meta analysis and systematic review |
2021 |
American Journal of Emergency Medicine |
46 |
|
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204 |
211 |
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43 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090893264&doi=10.1016%2fj.ajem.2020.07.009&partnerID=40&md5=08c8139ca7f811f915c445cf5c2e3f1c |
Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Critical Care Medicine, Baptist Medical Center, Jacksonville, FL, United States; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Michael E. DeBakey Veterans Affairs Medical Center & Baylor College of Medicine, Houston, TX, United States; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Alwi, I., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Gutierrez, E.J., Department of Critical Care Medicine, Baptist Medical Center, Jacksonville, FL, United States; Yamin, M., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Virani, S.S., Michael E. DeBakey Veterans Affairs Medical Center & Baylor College of Medicine, Houston, TX, United States |
Background: Several comorbidities have been associated with an increased risk of severity and mortality in coronavirus disease 2019 (COVID-19), including hypertension, diabetes, cerebrovascular disease, chronic kidney disease, and chronic obstructive pulmonary disease. Purpose: In this systematic review and meta-analysis, we attempted to investigate the association between heart failure (HF) and poor outcome in patients with COVID-19. Methods: We performed a systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and medRxiv with the search terms, “Heart failure” and “COVID-19”. The outcome of interest was mortality and poor prognosis (defined by incidence of severe COVID-19 infection, admission to ICU, and use of ventilator) in patients with preexisting heart failure with coronavirus disease. Results: We identified 204 potential articles from our search, and 22 duplicates were removed. After screening of the titles and abstracts of the remaining 182 articles we identified 92 potentially relevant articles. We excluded 74 studies due to the following reasons: four studies were systematic reviews, two studies were meta-analyses, three articles were literature reviews, and 65 articles did not report on the outcome of interest. Finally, we included the remaining 18 studies in our qualitative synthesis and meta-analysis. There were 21,640 patients from 18 studies. HF was associated with hospitalization in COVID19 HR was 2.37 [1.48, 3.79; p < 0.001], high heterogeneity [I2, 82%; p < 0.001]. HF was associated with a poor outcome demonstrated by an OR of 2.86 [2.07; 3.95; p < 0.001] high heterogeneity [I2, 80%; p < 0.001]. Patient with preexisting HF was associated with higher mortality OR of 3.46 [2.52, 4.75; p < 0.001] moderately high heterogeneity [I2, 77%; p < 0.001]. Conclusion: Patients with heart failure are at increased risk for hospitalization, poor outcome, and death from COVID-19. A significant difference in mortality between patients with and without heart failure was observed, patients with heart failure having a higher mortality. © 2020 Elsevier Inc. |
Coronavirus disease 2019; Heart failure; Poor outcomes |
apnea hypopnea index; Article; artificial ventilation; coronavirus disease 2019; heart failure; hospitalization; human; incidence; meta analysis; mortality; outcome assessment; prevalence; prognosis; questionnaire; risk factor; systematic review; comorbidity; global health; heart failure; pandemic; procedures; risk assessment; survival rate; Comorbidity; COVID-19; Global Health; Heart Failure; Humans; Pandemics; Risk Assessment; Risk Factors; SARS-CoV-2; Survival Rate |
W.B. Saunders |
07356757 |
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33071085 |
Article |
Q1 |
725 |
6828 |
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272 |
Rozaliyani A., Sedono R., Sjam R., Tugiran M., Adawiyah R., Setianingrum F., Jusuf A., Sungkar S., Hagen F., Meis J.F., Wahyuningsih R. |
57203065912;56660590500;23398458200;57218291154;57208658742;57203061705;57205710194;57016857300;8050973500;55941779900;6507268400; |
Molecular typing and antifungal susceptibility study of Aspergillus spp. In intensive care unit (ICU) patients in Indonesia |
2021 |
Journal of Infection in Developing Countries |
15 |
7 |
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1014 |
1020 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112486692&doi=10.3855%2fjidc.13135&partnerID=40&md5=1a4e201e605dd6b5e4f597b467372d29 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anesthesiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan Hospital, Jakarta, Indonesia; Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital (CWZ), Nijmegen, Netherlands; Department of Medical Mycology, Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands; Centre of Expertise in Mycology, Radboudumc/CWZ, Nijmegen, Netherlands; Department of Parasitology, Faculty of Medicine, Universitas Kristen, Jakarta, Indonesia |
Rozaliyani, A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sedono, R., Department of Anesthesiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sjam, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tugiran, M., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Adawiyah, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setianingrum, F., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusuf, A., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan Hospital, Jakarta, Indonesia; Sungkar, S., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hagen, F., Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital (CWZ), Nijmegen, Netherlands, Department of Medical Mycology, Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands; Meis, J.F., Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital (CWZ), Nijmegen, Netherlands, Centre of Expertise in Mycology, Radboudumc/CWZ, Nijmegen, Netherlands; Wahyuningsih, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Kristen, Jakarta, Indonesia |
Introduction: Aspergillus exhibits a wide variation of susceptibility against antifungals according to genetic and environmental factors. Identification to the species level is necessary for appropriate treatment. Our objective was to determine the Aspergillus species involved in invasive pulmonary aspergillosis (IPA) among ICU patients in Jakarta, Indonesia. Methodology: The incidence of IPA in ICU patients at six hospitals in Jakarta from October 2012 - January 2015 was investigated. It involved a collection of endotracheal aspirates (ETA), nasal swabs and environmental samples around the hospitals, phenotypic screening, molecular characterization, and antifungal susceptibility testing. Results: Of the 405 patients investigated, 31 patients (7.7%) were diagnosed with putative IPA, from whom 45 Aspergillus isolates were collected. Aspergillus isolates were identified from pulmonary secretions in 24 patients, from nasal swabs in 7 patients and from both pulmonary secretions and nasal swabs in 7 patients. The phenotypic method showed 33 isolates of Aspergillus flavus (73.4%), nine Aspergillus fumigatus (20%), two Aspergillus niger (4.4%), and one Aspergillus nidulans (2.2%) isolate. Molecular identification showed 27 isolates of A. flavus (60.0%), eight isolates of A. fumigatus (17.8%), two isolates of A. niger (4.4%) and one isolate of A. nidulans (2.2%), while seven isolates (15.6%) were cryptic species or mixed isolates. Conclusions: Susceptibility testing showed all isolates were susceptible to amphotericin B, azoles and micafungin. Aspergillus flavus was the main causative organism in IPA cases in Jakarta, followed by A. fumigatus. © 2021 Journal of Infection in Developing Countries. All rights reserved. |
Aspergillus; Molecular typing; Susceptibility |
amphotericin B; internal transcribed spacer; isavuconazole; itraconazole; micafungin; microsatellite DNA; posaconazole; pyrrole; voriconazole; antifungal agent; microsatellite DNA; antifungal susceptibility; Article; Aspergillus; Aspergillus flavus; Aspergillus nidulans; Aspergillus niger; Aspergillus tamarii; cohort analysis; controlled study; fungus identification; human; incidence; Indonesia; intensive care unit; invasive aspergillosis; major clinical study; minimum effective concentration; minimum inhibitory concentration; multicenter study; nonhuman; Penicillium citrinum; phenotype; prospective study; Aspergillus; classification; clinical trial; drug effect; environmental microbiology; genetics; Indonesia; invasive aspergillosis; isolation and purification; microbiology; nose mucosa; |
Journal of Infection in Developing Countries |
20366590 |
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34343127 |
Article |
Q3 |
322 |
14136 |
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