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273 |
Wibowo H., Harbuwono D.S., Tahapary D.L., Kartika R., Pradipta S., Larasati R.A. |
57217690943;36056341600;55944492500;57216548032;57212562643;57212549714; |
Impact of Sodium Butyrate Treatment in LPS-Stimulated Peripheral Blood Mononuclear Cells of Poorly Controlled Type 2 DM |
2021 |
Frontiers in Endocrinology |
12 |
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652942 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112435096&doi=10.3389%2ffendo.2021.652942&partnerID=40&md5=351393601155dbe575078ee467f93e21 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Metabolic Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biomedicines, Faculty of Medicine, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia |
Wibowo, H., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harbuwono, D.S., Division of Metabolic Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tahapary, D.L., Division of Metabolic Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kartika, R., Division of Metabolic Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pradipta, S., Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Larasati, R.A., Department of Biomedicines, Faculty of Medicine, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia |
Type 2 diabetes mellitus (T2DM) is associated with chronic low-grade inflammation, which is marked by the dysregulation of innate and adaptive immune responses. Therefore, reducing inflammation, possibly through an immunoregulatory agent, may play a role in T2DM treatment. Butyrate is the most potent short-chain fatty acid (SCFA), and it exerts anti-inflammatory properties by inhibiting histone deacetylase activity. As an immunoregulatory agent, sodium butyrate can inhibit nuclear factor kB (NF-kB) activation and reduce the production of pro-inflammatory cytokines in immune cells. The aim of the study was to measure the level of plasma butyrate in poorly controlled T2DM and normoglycemic participants and to compare the response of peripheral blood mononuclear cells (PBMCs) to sodium butyrate treatment between the groups by measuring production of the following cytokines: tumor necrosis factor (TNF)-α, interleukin (IL)-6, interferon (IFN)-γ, IL-13, and IL-10. The in vitro study examined the PBMCs of 15 participants with poorly controlled T2DM and 15 normoglycemic participants. PBMCs were cultured with the following stimulations for two days at a temperature of 37°C and 5% CO2: 100 ng/mL lipopolysaccharide (LPS), 1 mM sodium butyrate, or a combination of 100 ng/mL LPS and 1 mM sodium butyrate. Plasma butyrate was measured using gas chromatography-mass spectrometry, and cytokines from culture supernatant were analyzed using magnetic beads multiplex assay. Plasma butyrate levels in participants with poorly controlled T2DM did not significantly differ from those in normoglycemic participants (p = 0.105). Compared to treatment with an LPS-stimulated PBMC culture, treatment with 1 mM sodium butyrate reduced the levels of TNF-α (p < 0.039) and IFN-γ (p < 0.038) in normoglycemic participants. The same general trend was seen in PBMC from participants with poorly controlled T2DM, but higher variability appeared to preclude statistical significance. These data suggest that butyrate may modulate inflammatory cytokine production in human PBMCs, but more research is needed to determine if butyrate is anti-inflammatory in poorly controlled T2DM. © Copyright © 2021 Wibowo, Harbuwono, Tahapary, Kartika, Pradipta and Larasati. |
butyrate; inflammatory response; lipopolysaccharide (LPS); peripheral blood mononuclear cells; poorly controlled type 2 diabetes mellitus |
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Frontiers Media S.A. |
16642392 |
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Article |
Q1 |
1518 |
2233 |
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274 |
Andrijono, Prasetyo H., Gunardi E.R., Purwoto G., Winarto H. |
57192895639;57267560300;57192910998;14720170400;54080645300; |
The role of thrombocytosis as a prognostic factor for epithelial ovarian cancer [Peran Trombositosis sebagai Faktor Prognostik pada Kanker Ovarium Jenis Epitelial] |
2021 |
Indonesian Journal of Obstetrics and Gynecology |
9 |
3 |
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153 |
156 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115438818&doi=10.32771%2finajog.v9i3.1275&partnerID=40&md5=154dc76298f51380a153d1c86748bdf7 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Andrijono, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Prasetyo, H., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Gunardi, E.R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Purwoto, G., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Winarto, H., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objective: To determine whether thrombocytosis is a prognostic factor for epithelial ovarian cancer and its relationship with 3-year overall survival in epithelial ovarian cancer patients. Methods: This study is a retrospective cohort study using medical record of patients with epithelial ovarian cancer registered in cancer registry of Oncology Division in Obstetrics and Gynecology Department, Dr. Cipto Mangunkusumo National General Hospital from January 2014 - July 2016. Data were collected when subjects were first until diseases outcomes identified in 3 years. Result: Out of 220 subjects, 132 (60%) were patients with advanced stage epithelial ovarian cancer (stage II/III/IV). 94 (42.7%) subjects had thrombocytosis. Patients with advanced stage of disease had higher risk of having thrombocytosis than the ones with earlier stage (p=0.005; OR=2.329). Correlation between thrombocytosis and 3-year overall survival was known to be insignificant (p=0.555). There was shorter mean time survival between patients with thrombocytosis and the ones without but the there was no significant difference in hazard ratio between the two groups (p = 0.399). Conclusions: Thrombocytosis is not a prognostic factor in patients with epithelial ovarian cancer. There is also no significant difference of 3-year overall survival between patients with or without thrombocytosis. © 2021 Indonesian Journal of Obstetrics and Gynecology. All rights reserved. |
Epithelial ovarian carcinoma; Prognosis; Thrombocytosis |
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Indonesian Society of Obstetrics and Gynecology |
23386401 |
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Article |
#N/A |
#N/A |
#N/A |
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275 |
Ocviyanti D., Sari J.M., Meutia Y. |
57189661230;57192922757;57268400900; |
Analysis of antenatal care quality in cases of referred pregnant women in emergency rooms based on MCH book records [Analisis Kualitas Asuhan Antenatal Berbasis Telaah Buku KIA pada Kasus Rujukan Ibu Hamil di Unit Gawat Darurat] |
2021 |
Indonesian Journal of Obstetrics and Gynecology |
9 |
3 |
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121 |
125 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115437292&doi=10.32771%2finajog.v9i3.1339&partnerID=40&md5=3f7ec96ae8c1dbf252ee97414e16bec7 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Ocviyanti, D., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sari, J.M., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Meutia, Y., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: To determine the quality of antenatal care received by pregnant women, and perceptions of pregnant women and antenatal care providers regarding antenatal care. Methods: A quantitative and qualitative study of cases of referred pregnant women in the Emergency Room (ER) of Dr. Cipto Mangunkusumo Hospital (RSCM) from 2017-2018 was conducted. Quantitative data was obtained by assessing the overall completeness of filling in the Maternal Child Health (MCH) book used to report the antenatal care received by the subjects. The completeness of antenatal care in the health facility was obtained using a checklist. Qualitative data was obtained by interviewing pregnant women and antenatal care providers in health facilities. Result: There were 1.442 cases of referred pregnant women in RSCM's ER for the year 2017-2018, of whom 820 possessed and could show their MCH Book. Pregnancy in adolescence below 20 years (9.1%) and pregnancy after age 35 (19.5%) were reported. Most pregnant women were well educated (74.3%), referred from hospital or clinic (57.6%), received antenatal care in a public health center (38.7%), were in labor (32%), and were in the third trimester of pregnancy (92%). All subjects presented an incomplete MCH book. Almost half had inadequate antenatal frequency (46%). The completeness of antenatal care components in health care was 90-100%. Qualitatively, the perceptions of mothers and antenatal care providers regarding quality of antenatal care, was inadequate. Conclusions: The quality of antenatal care in the case of referred pregnant women at the RSCM's ER based on MCH Book records did not meet the required standard. © Creative Commons Atribuição-Não Comercial 4.0 Internacional |
Antenatal care quality; MCH book |
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Indonesian Society of Obstetrics and Gynecology |
23386401 |
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Article |
#N/A |
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#N/A |
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276 |
Situmorang H., Surya R., Hellyanti T. |
57195939562;56986345100;57217993236; |
Role of ambulatory laparoscopy in diagnosis of ascites with unknown etiology [Peran Laparoskopi dalam Mendiagnosis Asites akibat Etiologi yang tidak Diketahui] |
2021 |
Indonesian Journal of Obstetrics and Gynecology |
9 |
3 |
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162 |
168 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115358024&doi=10.32771%2finajog.v9i3.1362&partnerID=40&md5=5d4551247278e44c4fa03e7e3b9b12a3 |
Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital Jakarta, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Situmorang, H., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital Jakarta, Indonesia; Surya, R., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital Jakarta, Indonesia; Hellyanti, T., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objective: To determine the evidence about timing and role of laparoscopy in ascites work-up. Methods: : Case report Case: A-26-year-old P2 woman went to our hospital with a history of vaginal delivery 22 days before admission. She also presented with massive ascites. No obstetric complication was found. Transvaginal ultrasound revealed normal postpartum uterus and ovaries, surrounded with ascites. Both the liver and kidneys were found normal on ultrasound. Abdominal CT scan with contrast showed massive ascites with thickened omentum. Ascites ADA (adenosine deaminase) was 36 IU/L. Diagnostic laparoscopy was performed, we found massive yellowish ascites, miliary whitish lesions and hyperaemic tubal enlargement with thickening of the peritoneum. Biopsy was taken, pathology examination showed the appearance of chronic salpingitis and granulomatous peritonitis, in accordance with tuberculosis peritonitis. Conclusions: Laparoscopy should be the method of choice in diagnosing ascites with unknown etiology after inconclusive results of laboratory and radiological examination. Better visualization, typical appearance in peritoneal TB, chance to perform direct biopsy with lower risk of morbidity are the hallmarks of laparoscopy to be the method of choice to rule out the etiology of ascites. © 2021 Indonesian Journal of Obstetrics and Gynecology. All rights reserved. |
Ascites; Laparoscopy; Peritoneal tuberculosis |
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Indonesian Society of Obstetrics and Gynecology |
23386401 |
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Article |
#N/A |
#N/A |
#N/A |
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277 |
Sigit F.S., Trompet S., Tahapary D.L., Sartono E., Willems van Dijk K., Yazdanbakhsh M., Supali T., Smit J.W.A., Rosendaal F.R., de Mutsert R. |
57213595986;22954837300;55944492500;6701506022;57202571815;7006269286;6602742029;24577861400;7004174530;16042051400; |
The associations of leptin and adiponectin with the metabolic syndrome in an Indonesian and a Dutch population |
2021 |
Nutrition, Metabolism and Cardiovascular Diseases |
31 |
8 |
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2426 |
2435 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108275064&doi=10.1016%2fj.numecd.2021.05.012&partnerID=40&md5=b98f561673afb80c486c693b20480984 |
Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Internal Medicine, Section of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Parasitology, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands |
Sigit, F.S., Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands, Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Trompet, S., Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Tahapary, D.L., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Sartono, E., Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Willems van Dijk, K., Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands, Department of Internal Medicine, Section of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Yazdanbakhsh, M., Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Supali, T., Department of Parasitology, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Smit, J.W.A., Department of Internal Medicine, Section of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands; Rosendaal, F.R., Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; de Mutsert, R., Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands |
Background and aims: At the same BMI, Asian populations develop cardiometabolic complications earlier than Western populations. We hypothesized that a different secretion of the adipocyte-derived hormones leptin and adiponectin plays a role and investigated the associations of the two hormones with the metabolic syndrome (MetS) in an Indonesian and a Dutch population. Methods and results: We performed cross-sectional analyses of the Netherlands Epidemiology of Obesity Study (n = 6602) and the SUGAR Scientific Programme Indonesia–Netherlands Study (n = 1461). We examined sex-stratified associations of leptin and adiponectin with MetS, using multivariate logistic regression including adjustment for total body fat. The mean (SD) leptin (mcg/L) were 4.7 (6.0) in Indonesian men, 18.6 (12.0) in Indonesian women, 9.1 (7.7) in Dutch men, and 23.4 (17.4) in Dutch women. The mean (SD) adiponectin (mg/L) were 5.7 (5.4), 7.5 (7.1), 6.6 (3.3), and 11.3 (4.9), respectively. Within the same BMI category, leptin concentrations were similar in the two populations, whereas adiponectin was lower in the Indonesian population. Per SD of leptin, adjusted prevalence odds ratios (ORs, 95%CI) of MetS were 0.9 (0.6–1.2) in Indonesian men, 1.1 (0.9–1.4) in Indonesian women, 2.2 (1.6–2.8) in Dutch men, and 1.2 (1.0–1.5) in Dutch women. Per SD of adiponectin, the ORs were 0.9 (0.7–1.2), 0.8 (0.7–1.0), 0.6 (0.6–0.8), and 0.4 (0.4–0.5), respectively. Conclusions: Despite lower adiponectin levels, adiponectin was not related to the MetS in the Indonesian population and can not explain their increased cardiometabolic risk at the same BMI. © 2021 The Author(s) |
Adiponectin; Asian; Leptin; The metabolic syndrome (MetS); Total body fat; Western |
adiponectin; ADIPOQ protein, human; biological marker; LEP protein, human; leptin; adolescent; adult; aged; blood; body mass; clinical trial; comparative study; cross-sectional study; female; human; Indonesia; male; metabolic syndrome X; middle aged; multicenter study; Netherlands; obesity; prevalence; randomized controlled trial (topic); risk assessment; sex factor; very elderly; young adult; Adiponectin; Adiposity; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Body Mass Index; Cardiometabolic Risk Factors; Cross-Sectional Studies; Female; Humans; Indonesia; Leptin; Male; Metabolic Syndrome; Middle Aged; Netherlands; Prevalence; Randomized Controlled Trials as Topic; Risk Assessment; Sex Factors; Young Adult |
Elsevier B.V. |
09394753 |
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34154890 |
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Q1 |
1127 |
3665 |
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278 |
Saroyo Y.B., Harzif A.K., Anisa B.M., Charilda F.E. |
57164888400;57191493435;57195936232;57222329284; |
Thyroid storm in the second stage of labour: A case report |
2021 |
BMJ Case Reports |
14 |
7 |
e243159 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111078258&doi=10.1136%2fbcr-2021-243159&partnerID=40&md5=e3ec18b255c13bcad0e9401bfa44b499 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia |
Saroyo, Y.B., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia; Harzif, A.K., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia; Anisa, B.M., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia; Charilda, F.E., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia |
A thyroid storm (or thyroid crisis) is an emergency in endocrinology. It is a form of complication of hyperthyroidism that can be life-threatening. Inadequate control of hyperthyroidism in pregnancy could develop into thyroid storm, especially in the peripartum period. We present a woman came in the second stage of labour, with thyroid storm, superimposed pre-eclampsia, acute lung oedema and impending respiratory failure. Treatment for thyroid storm, pre-eclampsia protocol and corticosteroid was delivered. The baby was born uneventfully, while the mother was discharged after 5 days of hospitalisation. Delivery is an important precipitant in the development of thyroid storm in uncontrolled hyperthyroidism in pregnancy. Although very rare, it can cause severe consequences. Diagnosis and treatment guidelines for thyroid storm were available and should be done aggressively and immediately. Uncontrolled hyperthyroidism should be prevented by adequate control in thyroid hormone levels, especially before the peripartum period. © |
endocrinology; obstetrics and gynaecology; thyroid disease |
alanine aminotransferase; aspartate aminotransferase; bicarbonate; corticosteroid; creatinine; dexamethasone; lactate dehydrogenase; lugol; magnesium sulfate; nifedipine; propranolol; propylthiouracil; thyroid hormone; thyrotropin; thyroxine; adult; alanine aminotransferase blood level; ambient air; amnion fluid; Apgar score; Article; aspartate aminotransferase blood level; auscultation; birth length; birth weight; bleeding; blood carbon dioxide tension; blood gas analysis; blood pressure; body temperature; breathing rate; case report; clinical article; clinical examination; clinical feature; consciousness level; continuous positive airway pressure; coronavirus disease 2019; creatinine blood level; diagnostic procedure; disease course; disease duration; disease severity; electrography; epi |
BMJ Publishing Group |
1757790X |
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34290023 |
Article |
Q4 |
231 |
17583 |
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279 |
Mesiano T., Kurniawan M., Saputri K.M., Hidayat R., Permana A.P., Rasyid A., Harris S. |
57204830976;57196001182;57226439255;57225289998;57218558566;56703146700;55325116600; |
Endovascular Treatment in Acute Ischemic Stroke Adoption and Practice: A Single-Center Indonesian Experience |
2021 |
Cerebrovascular Diseases Extra |
11 |
2 |
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72 |
76 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111589407&doi=10.1159%2f000517183&partnerID=40&md5=aa029d4460bd9e0c30ddd00eef1a7bfd |
Division of Neurovascular and Neurosonology, Department of Neurology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Vascular, Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Mesiano, T., Division of Neurovascular and Neurosonology, Department of Neurology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kurniawan, M., Division of Neurovascular and Neurosonology, Department of Neurology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Saputri, K.M., Division of Neurovascular and Neurosonology, Department of Neurology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hidayat, R., Division of Neurovascular and Neurosonology, Department of Neurology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Permana, A.P., Division of Vascular, Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rasyid, A., Division of Neurovascular and Neurosonology, Department of Neurology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harris, S., Division of Neurovascular and Neurosonology, Department of Neurology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Indonesia is facing increasing stroke prevalence in the past 5 years. Ischemic stroke imposes economic and productivity burden if it is not addressed properly. Endovascular treatment studies are conducted in developed countries where facilities and cost do not count in therapy consideration if it is indicated. Developing countries like Indonesia should work hard to provide the best hyperacute stroke care with protocol deviation and limitation. This is the first review on endovascular treatment practice in a top single-center hospital in Indonesia. Further improvement is needed to catch up with state-of-the-art hyperacute ischemic stroke treatment. © 2021 |
Acute ischemic stroke; Developing countries; Endovascular treatment; Indonesia; Intravenous thrombolysis |
alteplase; glucose; fibrinolytic agent; acute ischemic stroke; adult; aged; Article; clinical article; clinical practice; controlled study; coronary artery disease; disease burden; endovascular surgery; female; glucose blood level; health care; heart failure; human; Indonesian; internal carotid artery; male; mechanical thrombectomy; middle cerebral artery; National Institutes of Health Stroke Scale; personal experience; recanalization; smoking; adverse event; brain ischemia; developing country; fibrinolytic therapy; Indonesia; intravenous drug administration; middle aged; prevalence; retrospective study; thrombectomy; time factor; treatment outcome; very elderly; Adult; Aged; Aged, 80 and over; Developing Countries; Endovascular Procedures; Female; Fibrinolytic Agents; Humans; Indonesia; I |
S. Karger AG |
16645456 |
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34284377 |
Article |
Q1 |
1015 |
4300 |
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283 |
Meilia P.D.I., Zeegers M.P., Herkutanto, Freeman M.D. |
57204065074;7003691618;57204069374;34769701500; |
Medicolegal causation investigation of bacterial endocarditis associated with an oral surgery practice using the INFERENCE approach |
2021 |
International Journal of Environmental Research and Public Health |
18 |
14 |
7530 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110118162&doi=10.3390%2fijerph18147530&partnerID=40&md5=c18a2f743bdf484bc116e962d9bb593b |
Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands; Department of Forensic Medicine and Medicolegal Studies, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 4, Salemba, Jakarta Pusat, 10430, Indonesia |
Meilia, P.D.I., Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands; Zeegers, M.P., Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands; Herkutanto, Department of Forensic Medicine and Medicolegal Studies, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 4, Salemba, Jakarta Pusat, 10430, Indonesia; Freeman, M.D., Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands |
Investigating causation is a primary goal in forensic/legal medicine, aiming to establish the connection between an unlawful/negligent act and an adverse outcome. In malpractice litigation involving a healthcare-associated infection due to a failure of infection prevention and control prac-tices, the medicolegal causal analysis needs to quantify the individual causal probabilities to meet the evidentiary requirements of the court. In this paper, we present the investigation of the most probable cause of bacterial endocarditis in a patient who underwent an invasive procedure at a dental/oral surgical practice where an outbreak of bacterial endocarditis had already been identified by the state Department of Health. We assessed the probability that the patient’s endocarditis was part of the outbreak versus that it was an unrelated sporadic infection using the INFERENCE (Integration of Forensic Epidemiology and the Rigorous Evaluation of Causation Elements) approach to medicolegal causation analysis. This paper describes the step-by-step application of the INFERENCE approach to demonstrate its utility in quantifying the probability of causation. The use of INFERENCE provides the court with an evidence-based, transparent, and reliable guide to determine liability, causation, and damages. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Bacterial endocarditis; Infection prevention and control practices; INFERENCE approach; Malpractice litigation; Medicolegal causal analysis; Quantification of causation |
bacterium; disease control; forensic science; health care; infectious disease; medicine; oral health; quantitative analysis; adult; aged; aortic regurgitation; Article; bacteremia; bacterial endocarditis; cardiomegaly; dizziness; dyspnea; electrocardiography; emergency ward; Enterococcus faecalis; female; fever; follow up; hospitalization; human; infection prevention; legal epidemiology; lumpectomy; male; malpractice; night sweat; nuclear magnetic resonance imaging; oral surgery; public health; transesophageal echocardiography; bacterial endocarditis; causality; forensic medicine; malpractice; Bacteria (microorganisms); Causality; Endocarditis, Bacterial; Forensic Medicine; Humans; Malpractice; Oral Surgical Procedures |
MDPI |
16617827 |
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34299979 |
Article |
Q2 |
747 |
6560 |
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284 |
Rustamadji P., Takbir M., Wuyung P.E., Kusmardi K., Wiyarta E. |
55321572200;57318063000;57192889605;56966625300;57221521342; |
Correlation between CD 34 and CD 68 expression in placental malaria with maternal anemia |
2021 |
Tropical Parasitology |
11 |
2 |
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92 |
96 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118308075&doi=10.4103%2ftp.TP_108_20&partnerID=40&md5=a57c3187c0926ddc2e00415c87f7f7bb |
Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Labuha Hospital, North Maluku, South Halmahera, Indonesia |
Rustamadji, P., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Takbir, M., Department of Anatomical Pathology, Labuha Hospital, North Maluku, South Halmahera, Indonesia; Wuyung, P.E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyarta, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Malaria is the second most life-threatening infectious disease in Indonesia, causing approximately 1-3 million deaths annually. Histopathologic studies assessing CD 68 and CD 34 protein expression in placental malaria and its association with maternal anemia are essential to determine the prognosis of malaria in pregnancy. Materials and Methods: This cross-sectional study was carried out in 2017. Thirty biopsy samples of human placental tissue were obtained from Timika and Sumba, and ten normal biopsy samples were taken from the Pathological Anatomy Department of Cipto Mangunkusumo General Hospital as comparisons. CD 34 and CD 68 protein expressions were determined using immunohistochemistry, and the resulting data were analyzed using SPSS. Results: Average hemoglobin (Hb) level was 9.5 mg/dL, 11.5 mg/dL, and 9.9 mg/dL in acute infection, chronic infection, and latent infection, respectively. A positive correlation was found between CD 68 protein expression and maternal Hb level. No correlation was found between CD34 expression and maternal anemia. Conclusions: CD 68 expression in placental tissue biopsy from Timika and Sumba residents with placental malaria was shown to be positively correlated with maternal anemia. Immunohistochemical examination of CD 68 may play a role in the early diagnosis of malaria. © 2021 Tropical Parasitology | Published by Wolters Kluwer - Medknow. |
CD 34; CD 68; Maternal anemia; Placental malaria |
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Wolters Kluwer Medknow Publications |
22295070 |
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Article |
Q3 |
418 |
11707 |
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285 |
MANSYUR A.S., WIDYAHENING I.S., SUDARSONO N.C. |
57312107800;54893154400;57201862518; |
Incidence of musculoskeletal injuries among Indonesian volleyball athletes during a national training and championship |
2021 |
Gazzetta Medica Italiana Archivio per le Scienze Mediche |
180 |
7-8 |
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374 |
379 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117904317&doi=10.23736%2fS0393-3660.20.04382-X&partnerID=40&md5=706fa0522bf3dbc8cae2b23a407d416b |
Sports Medicine Study Program, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Family Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Sports Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
MANSYUR, A.S., Sports Medicine Study Program, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; WIDYAHENING, I.S., Division of Family Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; SUDARSONO, N.C., Division of Sports Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: This study aimed to find out the incidence and characteristics of musculoskeletal injuries among Indonesian volleyball athletes during a national volleyball training and championship. METHODS: A prospective cohort study involving 34 Indonesian volleyball national team athletes (18 male and 16 female) during one volleyball national training and championship in July-September 2019 was conducted. All athletes were observed for 11 weeks and the incidence and the characteristics (duration, pain level, severity in loss time, nature, recurrence, anatomical location and types) of the injuries were documented. Some etiological factors of the injuries such as the court zone (back, front/net, and un-specified) time of injury (practice, competition or both), injury mechanism (ball contact, player contact, surface contact, non-contact or overuse), biomechanics (bending, compression, repetitive or traction) and movements (blocking, digging, passing, serving, spiking, or not specific) were also recorded. Incidence of injuries was presented in 1000 player hours. RESULTS: The incidence of injuries was 20.4/1000 player hours. Only one out of the 34 athletes did not have injury. Injuries occurred most frequently in the knee (36%), followed by the ankle (18%) and waist (16%). The most common type of injuries was sprain (21%) and tendinitis (21%) followed by low back pain (13%). The overuse and recurrence type of injuries were much more dominant to the acute one. CONCLUSIONS: Musculoskeletal injuries were common among Indonesian volleyball athletes. This adds information to the limited available evidence concerning the incidence, prevalence and etiology of volleyball-specific injuries which were needed to prevent its occurrence. © 2021 Edizioni Minerva Medica. All rights reserved. |
Athletes; Cumulative trauma disorders; Sports medicine; Volleyball |
adult; ankle; Article; athlete; beep test; biomechanics; body mass; bursitis; cardiopulmonary endurance; clinical article; cohort analysis; compression; concussion; court; elbow; female; hand-grip strength test; head; human; incidence; Indonesian; knee; low back pain; male; maximal oxygen uptake; muscle exercise; muscle strength; musculoskeletal injury; nuclear magnetic resonance imaging; patellofemoral pain syndrome; physical examination; prospective study; shoulder; shuttle run test; situp test; sprain; tendinitis; training; volleyball; x-ray computed tomography |
Edizioni Minerva Medica |
03933660 |
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Article |
Q4 |
114 |
27889 |
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