No records
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346 |
Irawati Y., Gondhowiardjo T.D., Soebono H. |
57201260313;7801650709;6508242918; |
Efficacy and safety of platinum chain and gold weight implants for paralytic lagophthalmos: A systematic review |
2021 |
Medical Journal of Indonesia |
30 |
2 |
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106 |
115 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110572321&doi=10.13181%2fmji.oa.214683&partnerID=40&md5=1e4455ed4f7b0f8707adf603031b37e0 |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Department of Dermatovenereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Central General Hospital, Yogyakarta, Indonesia |
Irawati, Y., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Gondhowiardjo, T.D., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Soebono, H., Department of Dermatovenereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Central General Hospital, Yogyakarta, Indonesia |
BACKGROUND Surgery has been proposed as a treatment of paralytic lagophthalmos. However, no consensus has been reached on the best treatment. This study was aimed to investigate the efficacy and safety between platinum chain and gold weight implants to treat paralytic lagophthalmos. METHODS This study used all randomized controlled trials or observational studies (prospective or retrospective) using platinum chain and gold weight implants for paralytic lagophthalmos surgery that were published from 1990 to 2020 in the PubMed, Cochrane, and Google Scholar databases. Efficacy was indicated by the reduction of ≥3 in lagophthalmos, and safety was measured based on complications after surgery. RESULTS The efficacy of platinum chain and gold weight implants were 60–100% and 10–93.6%, respectively. The complications of platinum chain implant were 0–2.9% of extrusion and 0–3.3% of migration. However, gold weight implant had 0–13.3% of migration. CONCLUSIONS Both platinum chain and gold weight implants have similar efficacy to treat paralytic lagophthalmos. However, gold weight implant has a higher rate of complication. © 2021 Authors. |
Paralytic lagophthalmus; Prostheses and implants; Surgical techniques |
acoustic neuroma; Article; drug efficacy; drug safety; human; lagophthalmos; lid loading technique; paralytic lagophthalmos; systematic review; visual acuity |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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347 |
Moegni F., Ocsilia Wengkang I.F. |
55450456100;57226112377; |
Correlation of levator ani muscle strength measurement between Modified Oxford Grading Scale and perineometer on pelvic organ prolapse patient |
2021 |
Urogynaecologia International Journal |
33 |
1 |
268 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110513972&doi=10.4081%2fUIJ.2021.268&partnerID=40&md5=f4aa2afc9d600b8716b8e0217ad613a6 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Moegni, F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ocsilia Wengkang, I.F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pelvic Organ Prolapse (POP) is a debilitating condition affecting about half of all women aged of more than 60 years globally. Reduced levator ani muscle strength in POP is associated with worse symptoms and prognosis. Measurement of levator ani muscle strength can be done with several tools such as perineometer and digital palpation. However, there is currently no study regarding conformity between tests. The aim of this study is to determine the correlation between tests in POP patients. An analytic observational study using cross sectional design was done to determine conformity between perineometer and digital examination using Modified Oxford Grading Scale (MOS) in Dr Cipto Mangunkusumo National General Hospital, Indonesia during the period of July, 2018 to June, 2020. Correlation between tests was determined using Spearman test. Cut-off of perineometer reading for each MOS score was also determined. A total of 110 subjects examined with both perineometer and digital palpation were recruited to the study. Positive correlation was observed between perineometer reading and Modified Oxford Grading Scale (r = 0.790, p < 0.001). According to the result, values between 0.01 – 9.64 cmH2O correspond to very weak pressure (MOS 1); 9.65 – 22.49 cmH2O represent weak pressure (MOS 2); 22.5 – 35.24 cmH2O represent moderate pressure (MOS 3); ≥ 35.25 cmH2O represent good pressure (MOS 4). There was a strong correlation between MOS and perineometer result for measuring levator ani strength in POP patients. Non ©Copyright: the Author(s), 2021 Licensee PAGEPress, Italy |
Levator ani muscle strength; Modified Oxford Grading Scale, pelvic organ prolapse; Perineometer |
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Page Press Publications |
20388314 |
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Article |
Q4 |
103 |
30394 |
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348 |
Djuardi Y., Lazarus G., Stefanie D., Fahmida U., Ariawan I., Supali T. |
6507800820;57214599425;57193121018;14420783500;8840573400;6602742029; |
Soil-transmitted helminth infection, anemia, and malnutrition among preschool-age children in nangapanda subdistrict, indonesia |
2021 |
PLoS Neglected Tropical Diseases |
15 |
6 |
e0009506 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110433985&doi=10.1371%2fjournal.pntd.0009506&partnerID=40&md5=acf6b372e3919f6422f75ae7d13a1c91 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON), Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Department of Biostatistics and Population Studies, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia |
Djuardi, Y., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stefanie, D., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fahmida, U., Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON), Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Ariawan, I., Department of Biostatistics and Population Studies, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Supali, T., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background Soil-transmitted helminth (STH) infections are still prevalent in Indonesia, with roughly one-third of infected population being preschool-age children (PSC), which are generally at higher risk of morbidity such as malnutrition and anemia. This study aimed to investigate the association of STH infections with nutritional status and anemia among PSC in Nangapanda subdistrict, Ende, East Nusa Tenggara. Methods A cross-sectional survey involving PSC ranging from 12 to 59 months old from Nangapanda subdistrict, Ende district, East Nusa Tenggara was performed. Socio-demographic, breastfeeding, and complementary feeding information was obtained from structured questionnaires, while nutritional and anemia status was determined from anthropometry and hemoglobin measurements, respectively. Anthropometric z-scores were calculated based on the World Health Organization 2006 standards and stool samples were examined using Kato-Katz method. Results A total of 393 PSC randomly selected from 22 villages were examined. The prevalence of underweight, stunting, wasting, and anemia were 33.1%, 40.2%, 17.1%, and 60.3%, respectively. STH infection, predominated by Ascaris lumbricoides, was found in 160 (58.8%) PSC. Single STH infection, but not multiple infection, was independently associated with a lower risk of anemia (odds ratio [OR] 0.320, 95% confidence interval [CI]: 0.126– 0.809, p = 0.016). Similar association with anemia was also found on mild STH infection (OR 0.318 [95% CI: 0.114–0.887], p = 0.029). On the other hand, younger children were found to have a higher risk of anemia and stunting. None of the examined variables were independently associated with underweight and wasting. Conclusion STH infection as well as anemia and malnutrition were prevalent in this region. However in this study, current STH infections seemed to have minimal negative impact on children’s nutritional status. © 2021 Djuardi et al. |
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edetic acid; hemoglobin; hemoglobin; anemia; anthropometry; antiretroviral therapy; Article; body mass; breast feeding; child; complementary feeding; controlled study; cross-sectional study; disorder of sex development; endoscopic retrograde cholangiopancreatography; feces analysis; female; flotation; food frequency questionnaire; food intake; helminthiasis; human; major clinical study; male; malnutrition; mass spectrometry; morbidity; nutritional status; obesity; preschool child; questionnaire; randomized controlled trial; risk factor; Strongyloides stercoralis; structured questionnaire; stunting; underweight; vitamin intake; vitamin supplementation; World Health Organization; anemia; animal; Ascaris lumbricoides; growth disorder; helminthiasis; Indonesia; infant; malnutrition; parasitolo |
Public Library of Science |
19352727 |
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34138863 |
Article |
Q1 |
1990 |
1322 |
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349 |
Shukla A., Shreshtha A., Mukund A., Bihari C., Eapen C.E., Han G., Deshmukh H., Cua I.H.Y., Lesmana C.R.A., Al Meshtab M., Kage M., Chaiteeraki R., Treeprasertsuk S., Giri S., Punamiya S., Paradis V., Qi X., Sugawara Y., Abbas Z., Sarin S.K. |
36652088000;57225888142;15071187800;49860931800;7003684081;24741087200;7003527959;7801457234;8977683000;57225918379;57225886245;57225920095;57077082800;57221051314;23670642900;57195572516;35339923000;57197741618;35572268700;57220191468; |
Budd-Chiari syndrome: consensus guidance of the Asian Pacific Association for the study of the liver (APASL) |
2021 |
Hepatology International |
15 |
3 |
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531 |
567 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109622410&doi=10.1007%2fs12072-021-10189-4&partnerID=40&md5=727d2318980fa73306867439390cc762 |
Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Alka Hospital, Kathmandu, Nepal; Institute of Liver and Biliary Sciences, New Delhi, India; Christian Medical College, Vellore, India; Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, China; Dean and Head of Radiology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Institute of Digestive and Liver Diseases, St Lukes Medical Center, Global City, Philippines; Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Digestive Disease & GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh; Center for Innovative Cancer Therapy, Kurume University Research, 67 Asahi-machi, Kurume, 830-0011, Japan; Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Vascular and Interventional Radiology, Tan Tock Seng Hospital, Singapore, Singapore; Dpt dAnatomie Pathologique, Hôpital Beaujon, 100 bd du Gal Leclerc, Clichy, 92110, France; General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, China; Department of Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan; Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi, Pakistan |
Shukla, A., Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Shreshtha, A., Alka Hospital, Kathmandu, Nepal; Mukund, A., Institute of Liver and Biliary Sciences, New Delhi, India; Bihari, C., Institute of Liver and Biliary Sciences, New Delhi, India; Eapen, C.E., Christian Medical College, Vellore, India; Han, G., Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, China; Deshmukh, H., Dean and Head of Radiology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Cua, I.H.Y., Institute of Digestive and Liver Diseases, St Lukes Medical Center, Global City, Philippines; Lesmana, C.R.A., Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia, Digestive Disease & GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Al Meshtab, M., Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, Center for Innovative Cancer Therapy, Kurume University Research, 67 Asahi-machi, Kurume, 830-0011, Japan; Kage, M., Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Chaiteeraki, R., Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Treeprasertsuk, S., Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Giri, S., Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Punamiya, S., Vascular and Interventional Radiology, Tan Tock Seng Hospital, Singapore, Singapore; Paradis, V., Dpt dAnatomie Pathologique, Hôpital Beaujon, 100 bd du Gal Leclerc, Clichy, 92110, France; Qi, X., General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, China; Sugawara, Y., Department of Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan; Abbas, Z., Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi, Pakistan; Sarin, S.K., Institute of Liver and Biliary Sciences, New Delhi, India |
Budd Chiari syndrome (BCS) is a diverse disease with regard to the site of obstruction, the predisposing thrombophilic disorders and clinical presentation across the Asia-Pacific region. The hepatic vein ostial stenosis and short segment thrombosis are common in some parts of Asia-Pacific region, while membranous obstruction of the vena cava is common in some and complete thrombosis of hepatic veins in others. Prevalence of myeloproliferative neoplasms and other thrombophilic disorders in BCS varies from region to region and with different sites of obstruction. This heterogeneity also raises several issues and dilemmas in evaluation and approach to management of a patient with BCS. The opportunity to recanalize hepatic vein in patients with hepatic vein ostial stenosis or inferior vena cava stenting or pasty among those membranous obstruction of the vena cava is a unique opportunity in the Asia–Pacific region to restore hepatic outflow closely mimicking physiology. In order to address these issues arising out of the diversity as well as the unique features in the region, the Asia Pacific Association for Study of Liver has formulated these guidelines for clinicians. © 2021, Asian Pacific Association for the Study of the Liver. |
Ascites; Budd Chiari syndrome; Hepatic vein stenting; Hepatocellular carcinoma; HVOTO; Liver biopsy; Liver transplant; MOVC; Portal hypertension; TIPS |
calreticulin; low molecular weight heparin; acute liver failure; acute on chronic liver failure; angioplasty; anticoagulant therapy; Article; Asia; blood clot lysis; blood clotting; Budd Chiari syndrome; cancer chemotherapy; chemoembolization; clinical feature; computer assisted tomography; Doppler flowmetry; female fertility; follow up; groups by age; hepatocellular adenoma; human; hyperhomocysteinemia; incidence; inferior cava vein; liver adenoma; liver cell carcinoma; liver nodule; liver transplantation; liver vein; nodular hyperplasia; nuclear magnetic resonance imaging; pathogenesis; postoperative complication; practice guideline; pregnancy; preoperative evaluation; prognosis; recanalization; risk factor; stent thrombosis; survival factor; thrombophilia; transjugular intrahepatic port |
Springer |
19360533 |
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34240318 |
Article |
Q2 |
1304 |
2874 |
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350 |
Herawati F., Jaelani A.K., Wijono H., Rahem A., Setiasih, Yulia R., Andrajati R., Soemantri D. |
57194722742;57372559200;57222260570;57204655643;57209025002;56768083700;9940247700;36640659100; |
Antibiotic stewardship knowledge and belief differences among healthcare professionals in hospitals: A survey study |
2021 |
Heliyon |
7 |
6 |
e07377 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109492428&doi=10.1016%2fj.heliyon.2021.e07377&partnerID=40&md5=5c399c28320a996c1e4e405a6c2d8169 |
Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Pharmacy, RSUD Bangil, Pasuruan, 67153, Indonesia; Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Community Pharmacy Department, Faculty of Pharmacy, Airlangga University, Surabaya, 60115, Indonesia; Laboratory for Developmental Psychology, Faculty of Psychology, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Herawati, F., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Jaelani, A.K., Department of Pharmacy, RSUD Bangil, Pasuruan, 67153, Indonesia; Wijono, H., Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Rahem, A., Community Pharmacy Department, Faculty of Pharmacy, Airlangga University, Surabaya, 60115, Indonesia; Setiasih, Laboratory for Developmental Psychology, Faculty of Psychology, Universitas Surabaya, Surabaya, 60293, Indonesia; Yulia, R., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Andrajati, R., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Soemantri, D., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Background: Collaborative practice in healthcare has been recommended to improve the quality of antimicrobial stewardship interventions, a behavioral change in antimicrobial use. Insufficient knowledge regarding antibiotic resistance, the fear of complications from infections, and how providers perceive antibiotic use and resistance are likely to influence prescribing behavior. This study's objective was to identify the knowledge and belief healthcare professionals' differences about antibiotic stewardship. Methods: This cross-sectional survey study of three hospitals in the East Java province, Indonesia utilized a 43-item questionnaire to assess antimicrobial stewardship knowledge and belief. There were 12 knowledge questions (total possible score: 12) and 31 belief questions (total possible score: 155). The Kuder Richardson 20 (KR-20) and Cronbach alpha values of the questionnaire were 0.54 and 0.92, respectively. Results: Out of the 257 respondents, 19% (48/257) had a low scores of knowledge, and 39% (101/257) had low scores on belief about antibiotic stewardship (101/257). Most midwives had a low scores on knowledge (25/61) and low scores on belief (46/61). Respondents with high scores on belief were 17% (10/59) physicians, 15% (4/27) pharmacists, 8% (5/65) nurses, and 3% (2/61) midwives. Conclusion: Among healthcare professionals, knowledge and belief differences concerning antibiotic stewardship vary widely. These differences will affect their capability, behavior, and contribution to the healthcare team collaboration and performance. Further studies are needed to evaluate the correlation between the level of inter-professional collaboration and the quality of the antibiotic stewardship implementation. © 2021 The Author(s) |
Antibiotic stewardship; Belief; Knowledge |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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351 |
Wijaya A.N., Margiana R., Kusumaningtyas S., Furqonita D. |
57225105688;56685900600;57193925307;57191057597; |
Comparison of decomposition rate of hind limbs of preserved mice with ethanol-glycerin and formaldehyde of advanced fixative solution |
2021 |
Anatomy and Cell Biology |
54 |
2 |
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225 |
231 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109181614&doi=10.5115%2facb.20.314&partnerID=40&md5=b084cc2abbf0ad3096da22401b79fe9b |
Undergraduate Program of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Wijaya, A.N., Undergraduate Program of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusumaningtyas, S., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Furqonita, D., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Learning anatomy in medical school is still closely based on the use of cadavers. The burial of preserved cadaver poses a problem, specifically, it contaminates the soil with formalin. Many studies have been conducted to find an alternative fixative to update or modify formalin usage. One of them is ethanol-glycerin (EG), which suggests promising results. Despite that fact, there has yet to be any research comparing the decomposition rate between EG and formalin. This study is conducted to compare the rate of decomposition between the two fixative solutions, EG and 4% formalin on the hind limb of mice. The mice were first preserved using a standard primary fixative solution which is 10% formalin, following that procedure is preservation using advanced fixative solution, EG or 4% formalin. Upon completing the preservation steps, the mice were buried for 6 weeks and observed weekly. The stages of decomposition were assessed semi-quantitatively depending on its appearance. The hind limbs of mice that were fixed with EG solution managed to reach the last stage of decomposition, dry & remains, while the 4% formalin group of mice still remained in the previous stage, advanced decay. It is concluded that the mice hind limbs that have been previously preserved with EG advanced fixative solution has a faster decomposition rate compared to 4% formalin. Copyright © 2021. Anatomy & Cell Biology |
Burial; Glycerol; Mice; Preservation |
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Korean Association of Anatomists |
20933665 |
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Article |
Q2 |
366 |
12934 |
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352 |
Kristin E., Endarti D., Khoe L.C., Taroeno-Hariadi K.W., Trijayanti C., Armansyah A., Sastroasmoro S. |
6504458442;56626162000;56586245200;37012289000;57203727260;57225098604;6507794136; |
Economic Evaluation of Adding Bevacizumab to Chemotherapy for Metastatic Colorectal Cancer (mCRC) Patients in Indonesia |
2021 |
Asian Pacific Journal of Cancer Prevention |
22 |
6 |
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1921 |
1926 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109162811&doi=10.31557%2fAPJCP.2021.22.6.1921&partnerID=40&md5=8b230f77f7dbd1e3652b63db9226b4c0 |
Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Respira Hospital, Yogyakarta, Indonesia; Center of Financing and Health Insurance, Ministry of Health, Government of Indonesia, Indonesia; Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kristin, E., Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Endarti, D., Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia; Khoe, L.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Taroeno-Hariadi, K.W., Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Trijayanti, C., Respira Hospital, Yogyakarta, Indonesia; Armansyah, A., Center of Financing and Health Insurance, Ministry of Health, Government of Indonesia, Indonesia; Sastroasmoro, S., Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: Since 2016, bevacizumab has been widely used to treat metastatic colorectal cancer (mCRC) in Indonesia. Nevertheless, the high cost of bevacizumab has raised the question of whether the therapy is considered cost-effective and should be included in the national health insurance system. This study aimed to assess the cost-effectiveness of bevacizumab plus chemotherapy versus chemotherapy alone for the treatment of mCRC patients. Methods: A Markov model was applied using the perspective of the Indonesian healthcare system to assess cost-effectiveness. The health outcomes were expressed in terms of quality-adjusted life years (QALY) using the validated EuroQoL-5D-5L instrument. Data for medical costs were collected from hospital billings in four hospitals located in three different cities in Indonesia. Meanwhile, data for utility were obtained from interviewing 90 patients who came to the hospital. We compared those mCRC patients who received chemotherapy alone either with FOLFOX or FOLFIRI, versus patients who received the addition of bevacizumab. Results: With the perspective of societal, the incremental cost-effectiveness ratio (ICER) of adding bevacizumab was USD 49,312 per QALY gained using secondary data and USD 28,446 per QALY using real world data. Conclusion: Using either a healthcare or societal perspective, the addition of bevacizumab for mCRC treatment was considered not cost-effective. © 2021. All Rights Reserved. |
Metastatic colorectal cancer- bevacizumab- chemotherapy |
antineoplastic agent; bevacizumab; camptothecin; fluorouracil; folinic acid; platinum complex; colorectal tumor; cost benefit analysis; economics; human; Indonesia; Markov chain; metastasis; pathology; quality adjusted life year; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Cost-Benefit Analysis; Fluorouracil; Humans; Indonesia; Leucovorin; Markov Chains; Neoplasm Metastasis; Organoplatinum Compounds; Quality-Adjusted Life Years |
Asian Pacific Organization for Cancer Prevention |
15137368 |
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34181352 |
Article |
Q2 |
512 |
9866 |
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353 |
Auer S., Haelterman N.A., Weissgerber T.L., Erlich J.C., Susilaradeya D., Julkowska M., Gazda M.A., Schwessinger B., Jadavji N.M., Abitua A., Niraulu A., Shahb A., Clyburne-Sherinb A., Guiquel B., Alicea B., Lamanna C., Ganguly D., Perkins E., Jambor H., Li I.M.H., Tsang J., Kamens J., Teytelman L., Paul M., Cronin M., Schmelling N., Crisp P., Kutum R., Phuyal S., Sarabipour S., Roy S., Bachle S.M., Tran T., Ford T., Steeves V., Ilangovan V., Baburamani A., Bachle S. |
57224755481;43961196400;6506688349;54396932600;57208325289;54787902500;57194268384;24438486300;8866064800;57224999223;57224994032;57224999963;57224992543;57224993799;51563211500;57225409050;56514870300;57224997775;25421754600;57224994090;57224992895;57224995287;57205247619;57216221631;57224995069;57193626389;36933973000;56871221600;55388614600;16053538000;57224999908;55516154900;57224994106;57224992308;57092624000;57216037751;26867552100;55516154900; |
Science forum: A community-led initiative for training in reproducible research |
2021 |
eLife |
10 |
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e64719 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108881951&doi=10.7554%2feLife.64719&partnerID=40&md5=86ee0e85a4e402a7d89730773f6396b8 |
Department of Plant Physiology, Institute of Botany, Faculty of Biology, TU Dresden, Dresden, Germany; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States; Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center, Berlin, Germany; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China; Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Boyce Thompson Institute, United States; CIBO/InBIOO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Portio, Campus Agrário de Vairão, Porto, Portugal; Departamento de Biologia, Faculdade de Ciências, Universidade do Portio, Porto, Portugal; Research School of Biology, Australian National University, Canberra, Australia; Department of Biomedical Science, Midwestern University, Glendale, United States; Addgene, Boston, United States; Neuroscience Graduate Program, Ohio State UniversityOH, United States; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States; Reproducibility for EveryoneNY, United States; Addgene, London, United Kingdom; Orthogonal Research and Education Laboratory, Champaign, United States; Research School of Biology, Australian National University, Canberra, Australia; Centre for Regenerative Therapies Dresden, Dresden, Germany; Massachusetts General Hospital, Harvard University, Boston, United States; Protocols.io, San Francisco, United States; Psychology of Language Group, University of Gottingen, Gottingen, Germany; Institute for Synthetic Microbiology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany; Institute of Basic Medical Science, University of Oslo, Oslo, Norway; Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; Plant Biotechnology, Tennessee State University, Nashville, United States; School of Mechanical & Aerospace Engineering, Nanyang Technological University, Nanyang, Singapore; Picture as Portal, San Francisco, United States; Research Data Management and Reproducibility, New York UniversityNY, United States; Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany; Centre for the Development of Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom; Department of Neuroscience, Carleton University, Ottawa, Canada |
Auer, S., Department of Plant Physiology, Institute of Botany, Faculty of Biology, TU Dresden, Dresden, Germany; Haelterman, N.A., Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States; Weissgerber, T.L., Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center, Berlin, Germany; Erlich, J.C., NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China; Susilaradeya, D., Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Julkowska, M., Boyce Thompson Institute, United States; Gazda, M.A., CIBO/InBIOO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Portio, Campus Agrário de Vairão, Porto, Portugal, Departamento de Biologia, Faculdade de Ciências, Universidade do Portio, Porto, Portugal; Schwessinger, B., Research School of Biology, Australian National University, Canberra, Australia; Jadavji, N.M., Department of Biomedical Science, Midwestern University, Glendale, United States, Department of Neuroscience, Carleton University, Ottawa, Canada; Abitua, A., Addgene, Boston, United States; Niraulu, A., Neuroscience Graduate Program, Ohio State UniversityOH, United States; Shahb, A., The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States; Clyburne-Sherinb, A., Reproducibility for EveryoneNY, United States; Guiquel, B., Addgene, London, United Kingdom; Alicea, B., Orthogonal Research and Education Laboratory, Champaign, United States; Lamanna, C., Addgene, Boston, United States; Ganguly, D., Research School of Biology, Australian National University, Canberra, Australia; Perkins, E., Addgene, Boston, United States; Jambor, H., Centre for Regenerative Therapies Dresden, Dresden, Germany; Li, I.M.H., Massachusetts General Hospital, Harvard University, Boston, United States; Tsang, J., Addgene, Boston, United States; Kamens, J., Addgene, Boston, United States; Teytelman, L., Protocols.io, San Francisco, United States; Paul, M., Psychology of Language Group, University of Gottingen, Gottingen, Germany; Cronin, M., Addgene, Boston, United States; Schmelling, N., Institute for Synthetic Microbiology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany; Crisp, P., Research School of Biology, Australian National University, Canberra, Australia; Kutum, R., Institute of Basic Medical Science, University of Oslo, Oslo, Norway; Phuyal, S., Institute of Basic Medical Science, University of Oslo, Oslo, Norway; Sarabipour, S., Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; Roy, S., Plant Biotechnology, Tennessee State University, Nashville, United States; Bachle, S.M., Addgene, Boston, United States, Addgene, Boston, United States; Tran, T., School of Mechanical & Aerospace Engineering, Nanyang Technological University, Nanyang, Singapore; Ford, T., Picture as Portal, San Francisco, United States; Steeves, V., Research Data Management and Reproducibility, New York UniversityNY, United States; Ilangovan, V., Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany; Baburamani, A., Centre for the Development of Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom; Bachle, S., Addgene, Boston, United States, Addgene, Boston, United States |
Open and reproducible research practices increase the reusability and impact of scientific research. The reproducibility of research results is influenced by many factors, most of which can be addressed by improved education and training. Here we describe how workshops developed by the Reproducibility for Everyone (R4E) initiative can be customized to provide researchers at all career stages and across most disciplines levels and across disciplines with education and training in reproducible research practices. The R4E initiative, which is led by volunteers, has reached more than 2000 researchers worldwide to date, and all workshop materials, including accompanying resources, are available under a CC-BY 4.0 license at www.repro4everyone.org. © 2021, eLife Sciences Publications Ltd. All rights reserved. |
Accessible protocols; FAIR data; Reproducibility; Rigor; Transparency; Transparent data processing |
biomaterial; Article; bioinformatics; FAIR principles; reproducibility; software; training; education; human; medical research; methodology; personnel; procedures; reproducibility; Biomedical Research; Humans; Reproducibility of Results; Research Design; Research Personnel |
eLife Sciences Publications Ltd |
2050084X |
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34151774 |
Article |
Q1 |
5879 |
219 |
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354 |
Wangsaputra V.K., Syarinta S., Louisa M. |
57215576000;57224977663;41461551400; |
Alpha-mangostin Reduces Cell Viability in Sorafenib-surviving Cells by Modulating Multiple Drug Transporters in Hepg2 Hepatocellular Carcinoma Cells |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
6 |
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105 |
110 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108813859&doi=10.7324%2fJAPS.2021.110612&partnerID=40&md5=eec4655af84852758d672bc24d8bc83b |
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Wangsaputra, V.K., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Syarinta, S., Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
A previous study showed that alpha-mangostin (AM) showed benefit when given to sorafenib (SOR)-surviving cells. However, the mechanism was not fully understood. The present study aimed to understand the effect of AM on SOR-surviving cells and its agent concerning drug transporters. SOR-surviving cells were treated with SOR 10 μM. Surviving cells were divided into four groups of treatment, namely, vehicle only dimethyl sulfoxide (DMSO), SOR 10 μM, AM 20 μM, or combination of SOR 10 μM-AM 20 μM. As controls, HepG2 naïve cells were treated with DMSO only or AM 20 μM. Cell viability was counted using trypan blue exclusion assay. Simultaneously, the mRNA expressions of P-glycoprotein (P-gp), ABCG2, MRP2, MRP3, OCT1, and OATP1B3 drug transporters were examined with quantitative reverse transcriptase-polymerase chain reaction. Decreased mRNA expression of P-gp was found in SOR-surviving cells treated with SOR. In contrast, AM alone or SOR's combination caused a significant increase in both efflux and influx transporters, no difference in fold increase of all transporters evaluated in AM versus SOR-AM combinations. Generally, AM treatment increased the mRNA expression of all the drug transporters. © 2021 Vincent Kharisma Wangsaputra et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). |
Alpha-mangostin; drug transporters; OCT1; P-glycoprotein; sorafenib resistance |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
Q2 |
286 |
15310 |
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355 |
Purwoningsih E., Pawitan J.A. |
57224985986;6508348067; |
Mesenchymal stem cells: Potential application in covid-19 patients with acute respiratory distress syndrome (ards) |
2021 |
International Medical Journal |
28 |
3 |
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303 |
306 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108812441&partnerID=40&md5=0feffaf110f53271a8fb3d884ed44c7c |
Biomedical Science, Faculty of Medicine, Universitas Indonesia, Indonesia; Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia |
Purwoningsih, E., Biomedical Science, Faculty of Medicine, Universitas Indonesia, Indonesia, Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia |
Objective: To highlight the potential of mesenchymal stem cells (MSCs) as an adjuvant therapy for severe COVID-19 patient. Materials and Methods: We searched Pubmed and Google Scholar, using keywords: 'MSC AND lung injury', 'MSC AND ARDS', 'MSC AND COVID-19', 'Stem cell AND Lung injury' and 'Stem cell AND ARDS', on 19 Mei and 19 July 2020. Results and Discussions: Severe manifestations in COVID-19 patients are due to immune system response. MSCs have immunomodulatory and anti-inflammatory effect and therefore may be beneficial to alleviate acute respiratory distress syndrome (ARDS). A small published study showed that MSCs had beneficial effect on COVID-19 patients, who showed clinical symptom improvements. Further, application of MSCs from several sources such as bone marrow, menstrual blood, and umbilical cord-derived MSCs, which were used in patients suffering from lung injury/ARDS due to conditions other than COVID-19, showed that a dose of up to 1.0 x 107 cells/kg body weight was well tolerated. Conclusion: administration of MSCs to COVID-19 patients showed improvement in clinical symptoms, and a dose up to 1.0 x 107 cells/kg body weight showed tolerance in ARDS patients with moderate to severe conditions. However, the results came from studies with small number of patients, so the results need to be interpreted with caution, and more well design studies with a larger number of patients are needed. © 2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation. |
Coronavirus; COVID-19; Mesenchymal stem cell; Stem cells |
alpha interferon; angiopoietin; angiotensin converting enzyme 2; beta interferon; bradykinin; C reactive protein; cytokine; gamma interferon inducible protein 10; granulocyte colony stimulating factor; interferon; interleukin 1; interleukin 10; interleukin 13; interleukin 1beta; interleukin 2 receptor; interleukin 4; interleukin 6; keratinocyte growth factor; monocyte chemotactic protein 1; receptor binding domain; toll like receptor; transmembrane protease serine 2; tumor necrosis factor; unclassified drug; vasculotropin; viral protein; virus spike protein; adjuvant therapy; adult respiratory distress syndrome; angiogenesis; Article; B lymphocyte; CD8+ T lymphocyte; cell differentiation; coronavirus disease 2019; cytokine storm; dendritic cell; exosome; genetic transcription; human; immun |
Japan International Cultural Exchange Foundation |
13412051 |
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Article |
Q4 |
183 |
20490 |
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