No records
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366 |
Moegni F., Quzwain S., Rustamadji P. |
55450456100;57224084579;55321572200; |
Transverse vaginal septum managed by simple flap surgery technique: A case report |
2021 |
International Journal of Surgery Case Reports |
83 |
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105990 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106902483&doi=10.1016%2fj.ijscr.2021.105990&partnerID=40&md5=4b34257622117eec368834315e672694 |
Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Moegni, F., Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Quzwain, S., Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rustamadji, P., Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Transverse Vaginal Septum (TVS) is a rare congenital abnormality, classified as the Mullerian duct anomaly development.1,2 TVS incidence range from 1:2.000 to 1:72.000. Management of TVS may only requirement local excision with a simple end to end anastomosis of the vagina, and use of skin grafts, but this technique has been reported has common complications of secondary tissue contracture, which often lead to stenosis of the vagina.3 In this case we managed TVS with simple flap technique to avoid such postoperative complications and maintain caliber of vagina. Case: A 11 years old girl complained cyclical abdominal pain since a year ago without history of menstrual blood. Patient already had vaginal surgery for removing menstrual blood, but after vaginal surgery the menstrual blood cannot be removed, then referred to our hospital. Ultrasound examination revealed hematometra and hemocolpos. The septum location was 3,38 cm proximal distance from vaginal introitus with the thickness of 8.1 mm. We performed simple excision of the septum with formerly performed distal vaginal septum mucosa preparation creating lateral flaps, then approximating the flaps to the edge of the proximal vaginal mucosa with interrupted suture continued with hymenorraphy. The patient has no complaint 6 months after surgery with vaginal length 8 cm, and had regular menstrual cycle. Conclusion: A simple flap surgery technique can be done in transverse vaginal septum, with no complication such as tissue contracture, vaginal stenosis, or insightly scarring. This is a simple technique and can be done with hymenorraphy to restore normal anatomy of hymen. © 2021 The Author(s) |
Simple flap vaginal technique; Surgery management; Transverse vaginal septum |
abdominal pain; abdominal ultrasound; Article; case report; child; clinical article; congenital disorder; echography; excision; female; follow up; hematocolpos; hematometra; histopathology; human; human tissue; menstrual cycle; priority journal; school child; spinal anesthesia; tissue flap; transperineal ultrasound; transrectal ultrasonography; transverse vaginal septum; vagina disease; vagina mucosa |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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367 |
Lestari D.A., Rahadiani N., Syaiful R.A. |
57223975816;16426455700;57214818481; |
Isolated spleen tuberculosis in an immunocompetent patient, a rare case report |
2021 |
International Journal of Surgery Case Reports |
83 |
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105966 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106577439&doi=10.1016%2fj.ijscr.2021.105966&partnerID=40&md5=f05086fe8ba1008071d740065a24ddd6 |
Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat, 10430, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat, 10430, Indonesia |
Lestari, D.A., Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat, 10430, Indonesia; Rahadiani, N., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat, 10430, Indonesia; Syaiful, R.A., Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat, 10430, Indonesia |
Introduction: Tuberculosis (TB), as a major public health concern, is affecting almost 10 million people globally. At present, diagnostic and screening efforts mainly focus on positive smear results. Therefore, the number of extra pulmonary and negative sputum TB is rising and hampering the diagnosis and treatment process due to the large number of false negatives. Rare cases such as solitary splenic TB are usually seen in patients with splenic abnormalities, spleen trauma, immunosuppression, sickle cell disease, pyogenic infections, etc. Presentation of case: A 40-year-old female with no comorbidity came with chief complaint of early satiety every mealtime and epigastric pain in the last 6 months prior to admission. There was no significant positive examination except for positive IGRA test and enlargement of spleen with multiple cystic lesions on abdominal CT. We performed laparotomy with splenectomy followed by a histopathology examination which showed features of primary tubercular abscess. Discussion: In the immunocompromised patient, the visceral abdomen is usually involved and a part of miliary TB. However, this case revealed the rare possibility of a healthy person with primary isolated tubercular splenic abscess while being immunocompetent and lacking any comorbidity. Conclusion: Splenic TB diagnosis is difficult in patients lacking pulmonary involvement and without specific symptoms. Thorough examinations and clinical expertise are needed to provide accurate diagnosis and treat uncommon forms of TB and cases with negative smear results in consideration of rising prevalence and difficult disease control. © 2021 The Authors |
Case report; Immunocompetent; Infection; Spleen; Tuberculosis |
gamma interferon; tuberculostatic agent; vaccine; adult; antibiotic therapy; Article; case report; clinical article; clinical feature; diagnostic imaging; epigastric pain; female; granulomatous inflammation; histopathology; hospital admission; human; human cell; human tissue; immunocompromised patient; infection risk; interferon gamma release assay; Langhans giant cell; laparotomy; leukocytosis; lymph node biopsy; lymphadenopathy; operative blood loss; pancreas cyst; priority journal; rare disease; risk reduction; satiety; spleen abscess; spleen cyst; splenectomy; splenic tuberculosis; splenomegaly; thrombocytosis; tissue necrosis; vaccination; x-ray computed tomography |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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369 |
Yugo D., Lo L.-W., Wu Y.-H., Chung F.-P., Lin Y.-J., Chang S.-L., Hu Y.-F., Chao T.-F., Liao J.-N., Chang T.-Y., Lin C.-Y., Tuan T.-C., Kuo L., Wu C.-I., Liu C.-M., Liu S.-H., Cheng W.-H., Lugtu I.C., Jain A., Chen S.-A. |
57215499689;25224685100;57150405500;40560956700;56512618600;57154909400;57219519883;35335897300;55179923000;56763173800;56469967500;7005704090;57193883698;56320807100;57202736753;57191375309;26025932500;57212467736;57216788165;57211727582; |
Case series on stereotactic body radiation therapy in non-ischemic cardiomyopathy patients with recurrent ventricular tachycardia |
2021 |
PACE - Pacing and Clinical Electrophysiology |
44 |
6 |
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1085 |
1093 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105961876&doi=10.1111%2fpace.14254&partnerID=40&md5=d3ccf6f5cafcbd0b6064e6a5a180d5ce |
Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Cardiology and Vascular Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Arrhythmia Division, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia; Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Heart Institute, Chinese General Hospital and Medical Center, Metro Manila, Philippines; Department of Cardiology, Vardhman Mahavir Medical College, New Delhi, India; Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan |
Yugo, D., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Cardiology and Vascular Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia, Arrhythmia Division, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia; Lo, L.-W., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Wu, Y.-H., Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Chung, F.-P., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Lin, Y.-J., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Chang, S.-L., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Hu, Y.-F., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Chao, T.-F., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Liao, J.-N., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Chang, T.-Y., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Lin, C.-Y., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Tuan, T.-C., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Kuo, L., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Wu, C.-I., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Liu, C.-M., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Liu, S.-H., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Cheng, W.-H., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Lugtu, I.C., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Heart Institute, Chinese General Hospital and Medical Center, Metro Manila, Philippines; Jain, A., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Cardiology, Vardhman Mahavir Medical College, New Delhi, India; Chen, S.-A., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan |
Introduction: The efficacy of stereotactic body radiation therapy (SBRT) as an alternative treatment for recurrent ventricular tachycardia (VT) is still unclear. This study aimed to report the outcome of SBRT in VT patients with nonischemic cardiomyopathy (NICM). Methods: The determination of the target substrate for radiation was based on the combination of CMR results and electroanatomical mapping merged with the real-time CT scan image. Radiation therapy was performed by Flattening-filter-free (Truebeam) system, and afterward, patients were followed up for 13.5 ± 2.8 months. We analyzed the outcome of death, incidence of recurrent VT, ICD shocks, anti-tachycardia pacing (ATP) sequences, and possible irradiation side-effects. Results: A total of three cases of NICM patients with anteroseptal scar detected by CMR. SBRT was successfully performed in all patients. During the follow-up, we found that VT recurrences occurred in all patients. In one patient, it happened during a 6-week blanking period, while the others happened afterward. Re-hospitalization due to VT only appeared in one patient. Through ICD interrogation, we found that all patients have reduced VT burden and ATP therapies. All of the patients died during the follow-up period. Radiotherapy-related adverse events did not occur in all patients. Conclusions: SBRT therapy reduces the number of VT burden and ATP sequence therapy in NICM patients with VT, which had a failed previous catheter ablation. However, the efficacy and safety aspects, especially in NICM cases, remained unclear. © 2021 Wiley Periodicals LLC |
radio-ablation; stereotactic; ventricular tachycardia |
aged; Article; cardiovascular magnetic resonance; case report; clinical article; clinical effectiveness; clinical outcome; computer assisted tomography; death; disease burden; female; follow up; heart pacing; heart ventricle tachycardia; hospital readmission; human; incidence; male; nonischemic cardiomyopathy; recurrent disease; stereotactic body radiation therapy; very elderly; cardiomyopathy; diagnostic imaging; epicardium mapping; heart ventricle tachycardia; procedures; radiosurgery; radiotherapy dosage; scar; x-ray computed tomography; Aged; Aged, 80 and over; Cardiomyopathies; Cicatrix; Epicardial Mapping; Female; Humans; Male; Radiosurgery; Radiotherapy Dosage; Tachycardia, Ventricular; Tomography, X-Ray Computed |
John Wiley and Sons Inc |
01478389 |
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33932305 |
Article |
Q2 |
686 |
7284 |
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370 |
Purbadi S., Rustamadji P., Purwoto G., Kusuma F., Putra A.D., Scovani L., Sianturi E.T. |
6505677307;55321572200;14720170400;57192911548;57208996180;57223440213;57223430479; |
Skin metastases originated from cervical cancer: A rare case report |
2021 |
Annals of Medicine and Surgery |
66 |
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102363 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105852603&doi=10.1016%2fj.amsu.2021.102363&partnerID=40&md5=6edeeefd66a3289a6bb1540f0adc31fe |
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo National Referral Hospital, Indonesia |
Purbadi, S., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rustamadji, P., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo National Referral Hospital, Indonesia; Purwoto, G., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kusuma, F., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putra, A.D., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Scovani, L., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sianturi, E.T., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Metastases in cervical cancer could be spread through direct local invasion, lymphatic dissemination, or hematogenous dissemination. The most common sites of distant metastases are lungs, bone, and liver. Skin metastases from cervical cancer are categorized as a rare occurrence of metastases. This rarity of the cases has led us to report it. Case description: A 66-year-old multiparous woman diagnosed with stage IIA cervical cancer seven years ago, then she came into our outpatient clinic complained about a brownish white color mass on the left side of the neck that keeps getting bigger over time came from a skin lesion. The lesion was first treated with topical steroid but there was no improvement. Biopsy was done and the result showed a carcinoma metastasis that led to adenosquamous carcinoma or cervical adenocarcinoma. The patient went through chemoradiation with biosensitizer paclitaxel 120 mg/m2 for six cycles, which began in August 2019 until October 2019. The treatment progress showed a promising result. We observed the patient during treatment until two months after finishing the treatment. At the last visit, the patient came to our outpatient clinic, the mass size decreased significantly, and the skin showed an excellent regeneration sign. Conclusion: The physicians should always consider the patient's history and pay more attention to skin lesions in patients with a history of cervical cancer. The physicians should also perform a thorough physical examination and biopsy to confirm the diagnosis. © 2021 The Author(s) |
Cervical cancer; Skin lesion; Skin metastasis |
paclitaxel; adenocarcinoma; adenosquamous carcinoma; aged; anemia; Article; attention; body weight; brain metastasis; cancer patient; case report; chemoradiotherapy; clinical article; cutaneous leishmaniasis; distant metastasis; drug industry; female; histopathology; human; human tissue; hysterectomy; laparotomy; mammography; metastasis; multipara; ovariectomy; physical examination; physician; regeneration; sexual behavior; skin defect; skin metastasis; thrombocytopenia; uterine cervix adenocarcinoma; uterine cervix cancer; vaginal secretion |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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371 |
Solichin I., Prabowo I., Laras S., Putra N.H.D., Rhatomy S. |
57202813479;57221098612;57221107761;57223369199;57204509883; |
Early ambulatory Duchenne muscular dystrophy: First symptomatic stage of ambulation - A case report |
2021 |
International Journal of Surgery Open |
33 |
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100349 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105724819&doi=10.1016%2fj.ijso.2021.100349&partnerID=40&md5=63b5fb970c994ebc6ab98bdfa879fb05 |
Department of Orthopaedics and Traumatology, Purwokerto Orthopaedics Hospital, Purwokerto, Central Java, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sport and Adult Reconstruction Division, Department of Orthopaedics and Traumatology, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia; Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Solichin, I., Department of Orthopaedics and Traumatology, Purwokerto Orthopaedics Hospital, Purwokerto, Central Java, Indonesia; Prabowo, I., Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Laras, S., Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putra, N.H.D., Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rhatomy, S., Sport and Adult Reconstruction Division, Department of Orthopaedics and Traumatology, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Introduction and importance: Duchenne muscular dystrophy (DMD) is a rare neuromuscular disease, affected male at young age, progressive and deteriorating symptoms followed the age and usually died in age 20. The early sign of DMD or early ambulatory DMD appeared lately after walking age, and progressively deteriorated by the time of aging. Case presentation: A 9 years old boy with symptoms of waddling gait, toe walking and difficulty to climb the stairs came to our center to seek medical help. He initially walked with assistance at 18 months, but always fell down when he tried to walk for distance. No family history of developmental delay. He still has the ability to stand up after sitting on the floor and run even with the difficulty. Behavioral problem or academic achievement was according to his age. The way he did to get down the stairs, he had to sit down and the get back up when he finished. His parents’ status of economic and education is low, which brought them difficult to understand their child is in suffer. Clinical discussion: The diagnosis and staging of DMD are quite challenging. A consistency and knowledge to gathered all the information related to history, symptoms, and signs provided the qualified data to overcome the complexity of the case, and to managed the spectrum of the disease appropriately, thus avoid the unnecessary treatment. The symptomatic stage of DMD is distinguished by the spectrum of ambulation. The effective and efficacy of the treatment are depending on good clinical assessment of neuromuscular function. Multidisciplinary team to diagnose and manage the case was needed to create to solve the problem became easier. Conclusion: The early ambulatory DMD is the first symptomatic early warning signs to treat DMD. The oral corticosteroids believed could mainstay the functional outcome the upper limb, avoid severe scoliosis, and maintain the respiratory function as normal as possible. Occupational and physical therapies were proposed to maintain the good quality of life. © 2021 The Author(s) |
Duchenne muscular dystrophy; Early ambulatory; Waddling gait |
methylprednisolone; academic achievement; Article; case report; child; clinical article; clinical assessment; daily life activity; Duchenne muscular dystrophy; gestational age; human; male; mobilization; multidisciplinary team; neuromuscular function; physical examination; physiotherapist; physiotherapy; priority journal; problem behavior; running; school child; waddling gait; walking |
Elsevier Ltd |
24058572 |
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Article |
Q4 |
187 |
20224 |
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372 |
Reksodiputro M.H., Harahap A.R., Siregar N.C., Malik S.G., Bashirudin J., Boesoirie M.T.S., Widodo D.W., Iljanto S., Sajuthi D., Sukrisman L., Yosia M. |
35090488800;6507325543;6508087790;7402973374;57223288901;57223301168;56644646600;57223273746;6603075144;8661764000;57204933098; |
Comparison between PRP and PRFM on FTSG healing profile: Macroscopic, microscopic and ELISA evaluation |
2021 |
Annals of Medicine and Surgery |
66 |
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102350 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105502675&doi=10.1016%2fj.amsu.2021.102350&partnerID=40&md5=632e6c1f802e9603336c9a0770ecc410 |
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Padjajaran, Hasan Sadikin Hospital, Bandung, Indonesia; Faculty of Public Health, Centre for Health Administration, Management and Policy, Universitas Indonesia, Jakarta, Indonesia; Department of Clinics, Reproduction, and Pathology, Faculty of Veterinary Medicine, Institute Pertanian Bogor, Bogor, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Reksodiputro, M.H., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap, A.R., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Siregar, N.C., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Malik, S.G., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Bashirudin, J., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Boesoirie, M.T.S., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Padjajaran, Hasan Sadikin Hospital, Bandung, Indonesia; Widodo, D.W., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Iljanto, S., Faculty of Public Health, Centre for Health Administration, Management and Policy, Universitas Indonesia, Jakarta, Indonesia; Sajuthi, D., Department of Clinics, Reproduction, and Pathology, Faculty of Veterinary Medicine, Institute Pertanian Bogor, Bogor, Indonesia; Sukrisman, L., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yosia, M., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Studies had shown the benefit of PRFM and PRP in wound healing but their use in skin graft healing was rarely studied. This study aims to compare the use of PRP and PRFM in accelerating wound healing process of skin full-thickness skin graft (FTSG). Materials and methods: Five pigs were used to look at the wound healing effect of PRP and PRFM usage prior to FTSG implantation. Subsequent punch biopsies were then conducted on the 1st, 3rd, 7th, 14th, and 30th day to obtain samples for macroscopic (skin color), extracellular matrix (collagen), microscopic (PMN, macrophage, and fibroblast), and ELISA (TGFβ1 and PDGF) analysis to determine the level of wound healing activity. ImageJ software was used to photograph for macroscopic and extracellular matrix analysis. Results: Macroscopic, extracellular matrix, and ELISA evaluation show no significant difference in FTSG survival rates for all treatment groups. Microscopic examination showed an increase in PMN, macrophage, and fibroblast levels with PRFM application showing higher increases in all observed microscopic variables compared to PRP and control. Conclusion: This study observed that both PRFM and PRP as autologous platelet preparation accelerate wound healing in FTSG, with PRFM being superior due to the higher number of PMN, macrophage, and fibroblast. © 2021 The Authors |
FTSG; PRFM; PRP; Wound healing |
atropine; collagen; collagen type 1; hemoglobin; isoflurane; ketamine; lidocaine; platelet derived growth factor; platelet-rich fibrin; transforming growth factor beta1; xylazine; animal experiment; animal model; animal tissue; Article; enzyme linked immunosorbent assay; exosome; extracellular matrix; female; fibroblast; full thickness skin graft; glomerulus filtration rate; graft survival; histology; macrophage; male; microscopy; neutrophil; nonhuman; platelet-rich plasma cell; punch biopsy; scientific literature; skin injury; survival rate; thrombocyte; wound healing |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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373 |
Dewi R., Kaswandani N., Karyanti M.R., Setyanto D.B., Pudjiadi A.H., Hendarto A., Djer M.M., Prayitno A., Yuniar I., Indawati W., Prawira Y., Handryastuti S., Sjakti H.A., Hidayati E.L., Muktiarti D., Soebadi A., Puspaningtyas N.W., Muhaimin R., Rahmadhany A., Octavius G.S., Puspitasari H.A., Jasin M.R., Tartila T., Putri N.D. |
57190859324;57195941745;56290680800;57203009929;18435202300;57204142249;12771087900;57193342301;57222295046;57190171077;55455747000;18434003700;57195720458;57200542624;57189047743;56986580800;57223288515;57223307995;57223290366;57221016506;57214119502;57223292665;57223304533;57200573842; |
Mortality in children with positive SARS-CoV-2 polymerase chain reaction test: Lessons learned from a tertiary referral hospital in Indonesia |
2021 |
International Journal of Infectious Diseases |
107 |
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78 |
85 |
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9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105478543&doi=10.1016%2fj.ijid.2021.04.019&partnerID=40&md5=6ef75a9ece8a84ed984ec94cf9c3f923 |
Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Dewi, R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kaswandani, N., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Karyanti, M.R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyanto, D.B., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pudjiadi, A.H., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hendarto, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Djer, M.M., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prayitno, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yuniar, I., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Indawati, W., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prawira, Y., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handryastuti, S., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sjakti, H.A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hidayati, E.L., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muktiarti, D., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soebadi, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspaningtyas, N.W., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muhaimin, R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmadhany, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Octavius, G.S., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspitasari, H.A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jasin, M.R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tartila, T., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putri, N.D., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The incidence of coronavirus disease 2019 (COVID-19) is still increasing rapidly, but little is known about the prevalence and characteristics of fatal cases in children in Indonesia. This study aimed to describe the characteristics of children with COVID-19 with fatal outcomes in a tertiary referral hospital in Indonesia. Methods: This cross-sectional study used data collected from the medical records of patients with COVID-19 admitted to Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia from March to October 2020. Results: During the study period, 490 patients were admitted and diagnosed with suspected and probable COVID-19. Of these patients, 50 (10.2%) were confirmed to have COVID-19, and 20 (40%) had a fatal outcome. The fatality rate was higher in patients aged ≥10 years, categorized with severe disease upon admission, PaO2/FiO2 ratio ≤300 mmHg and chronic underlying diseases. The most common clinical manifestations were generalized symptoms, while acute respiratory distress syndrome (8/20) and septic shock (7/20) were the two most common causes of death. Increased procalcitonin, D-dimer, lactate dehydrogenase and presepsin levels were found in all fatal cases. One patient met the criteria of multisystem inflammatory syndrome in children. Conclusion: Our work highlights the high mortality rate in paediatric patients with positive SARS-CoV-2 polymerase chain reaction test. These findings might be related to or co-incided with COVID-19 infection. Further studies are needed to improve understanding of the role of severe acute respiratory syndrome coronavirus-2 in elaborating the mechanisms leading to death in children with comorbidities. © 2021 The Author(s) |
Children; COVID-19; Indonesia; Outcome; SARS-CoV-2 |
antibiotic agent; biological marker; D dimer; dobutamine; dopamine; enoxaparin; epinephrine; hydrocortisone; immunoglobulin; lactate dehydrogenase; lopinavir; noradrenalin; presepsin; procalcitonin; ritonavir; steroid; unclassified drug; adolescent; adult; adult respiratory distress syndrome; age; Article; artificial ventilation; cause of death; child; childhood mortality; clinical feature; coronavirus disease 2019; cross-sectional study; disease severity; fatality; female; Horowitz index; hospital admission; human; Indonesia; infant; major clinical study; male; mortality rate; newborn; pediatric multisystem inflammatory syndrome; polymerase chain reaction; preschool child; real time polymerase chain reaction; school child; septic shock; tertiary care center; complication; mortality; Adole |
Elsevier B.V. |
12019712 |
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33857609 |
Article |
Q1 |
1278 |
2980 |
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374 |
Prasasty V.D., Hutagalung R.A., Gunadi R., Sofia D.Y., Rosmalena R., Yazid F., Sinaga E. |
56019989700;57196436040;57223239895;57223238377;56891769500;57207890516;6503946360; |
Prediction of human-Streptococcus pneumoniae protein-protein interactions using logistic regression |
2021 |
Computational Biology and Chemistry |
92 |
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107492 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105320211&doi=10.1016%2fj.compbiolchem.2021.107492&partnerID=40&md5=5e13061470115aaa99774510455cd385 |
Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Department of Biology, Faculty of Life Sciences, Universitas Surya, Tangerang, Banten 15143, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Faculty of Biology, Universitas Nasional, Jakarta, 12520, Indonesia |
Prasasty, V.D., Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Hutagalung, R.A., Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Gunadi, R., Department of Biology, Faculty of Life Sciences, Universitas Surya, Tangerang, Banten 15143, Indonesia; Sofia, D.Y., Department of Biology, Faculty of Life Sciences, Universitas Surya, Tangerang, Banten 15143, Indonesia; Rosmalena, R., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Yazid, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Sinaga, E., Faculty of Biology, Universitas Nasional, Jakarta, 12520, Indonesia |
Streptococcus pneumoniae is a major cause of mortality in children under five years old. In recent years, the emergence of antibiotic-resistant strains of S. pneumoniae increases the threat level of this pathogen. For that reason, the exploration of S. pneumoniae protein virulence factors should be considered in developing new drugs or vaccines, for instance by the analysis of host-pathogen protein-protein interactions (HP-PPIs). In this research, prediction of protein-protein interactions was performed with a logistic regression model with the number of protein domain occurrences as features. By utilizing HP-PPIs of three different pathogens as training data, the model achieved 57–77 % precision, 64–75 % recall, and 96–98 % specificity. Prediction of human-S. pneumoniae protein-protein interactions using the model yielded 5823 interactions involving thirty S. pneumoniae proteins and 324 human proteins. Pathway enrichment analysis showed that most of the pathways involved in the predicted interactions are immune system pathways. Network topology analysis revealed β-galactosidase (BgaA) as the most central among the S. pneumoniae proteins in the predicted HP-PPI networks, with a degree centrality of 1.0 and a betweenness centrality of 0.451853. Further experimental studies are required to validate the predicted interactions and examine their roles in S. pneumoniae infection. © 2021 Elsevier Ltd |
Host-pathogen protein-protein interactions; Logistic regression; Network centrality; Pathway enrichment; Streptococcus pneumoniae |
Forecasting; Logistic regression; Betweenness centrality; Degree centrality; Logistic Regression modeling; Network topology analysis; Protein-protein interactions; Resistant strains; Streptococcus pneumoniae; Virulence factors; Proteins; protein; protein binding; chemistry; host pathogen interaction; human; statistical model; Streptococcus pneumoniae; Host-Pathogen Interactions; Humans; Logistic Models; Protein Binding; Proteins; Streptococcus pneumoniae |
Elsevier Ltd |
14769271 |
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33964803 |
Article |
Q3 |
416 |
11737 |
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375 |
Djusad S., Sari Y.M., Tjahjadi H. |
57192276788;57217020003;57210953454; |
Deep (aggressive) angiomyxoma of the vagina misdiagnosed as Gartner cyst: A case report |
2021 |
International Journal of Surgery Case Reports |
83 |
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105948 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105312488&doi=10.1016%2fj.ijscr.2021.105948&partnerID=40&md5=b18f961bc2c3f8c96cac7a019b1ba409 |
Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Anatomic Pathology Department, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Djusad, S., Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sari, Y.M., Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tjahjadi, H., Anatomic Pathology Department, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Aggressive angiomyxoma is a rare soft tissue tumor. Aggressive angiomyxoma is a slow-growing vulvovaginal mesenchymal neoplasm with a marked tendency for local recurrence, but with a low tendency to metastasize. As it has a predilection for the pelvic and perineal regions, Aggressive angiomyxoma is often misdiagnosed. This case report documented rare case of misdiagnosed Aggressive Angiomyxoma as Gartner duct cyst. Presentation of case: This article report a case of 31 year old women who complained mass came out from vagina without any urinary symptom and trauma. Physical examination and ultrasound finding suggested that the mass was Gartner Duct cyst. Management in this case was excision of the vaginal cyst. Histopathology examination revealed Deep (aggressive) angiomyxoma. Discussion: The rarity of Deep (Aggressive) Angiomyxoma makes the preoperative diagnosis fairly difficult. Aggressive angiomyxoma is often misdiagnosed as it may have similar clinical presentation to common lesions such as Bartholin cyst or prolapse vaginal wall, Gartner cyst or levator hernia. Aggressive Angiomyxoma should be considered as differential diagnosis in patient with vaginal cyst. Conclusion: Aggressive Angiomyxoma is rare condition. Preoperative diagnosis and management are challenging. Long term follow op and evaluation should be done due to high rate of recurrence. © 2021 The Author(s) |
Case report; Deep (aggressive) angiomyxoma of the vagina; Misdiagnosed Gartner cyst; Misdiagnosis of vaginal tumor; Rare case |
desmin; estrogen receptor; progesterone receptor; smooth muscle actin; adult; Article; case report; clinical article; diagnostic error; differential diagnosis; excision; female; Gartner cyst; histopathology; human; human tissue; physical examination; priority journal; translabial ultrasound; vagina aggressive angiomyxoma; vagina mucosa; vagina tumor; vaginal cyst |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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376 |
Dewiasty E., Setiati S., Agustina R., Roosheroe A.G., Abdullah M., Istanti R., de Groot L.C. |
55257705500;14325991900;57214141404;28767975000;7103393434;23496653300;57213769769; |
Prevalence of lactose intolerance and nutrients intake in an older population regarded as lactase non-persistent |
2021 |
Clinical Nutrition ESPEN |
43 |
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317 |
321 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104952533&doi=10.1016%2fj.clnesp.2021.03.033&partnerID=40&md5=afacacb3695eb5029eae5ee3bb8270ab |
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia; Division of Human Nutrition and Health, Wageningen University and Research, P.O. Box 176700, Wageningen, AA, Netherlands; Center of Clinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta Indonesia, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Jl., Salemba Raya No. 6, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, DKI Jakarta 10430, Indonesia |
Dewiasty, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia, Division of Human Nutrition and Health, Wageningen University and Research, P.O. Box 176700, Wageningen, AA, Netherlands; Setiati, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia, Center of Clinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta Indonesia, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Jl., Salemba Raya No. 6, Jakarta Pusat, DKI Jakarta 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Roosheroe, A.G., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia; Abdullah, M., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia; Istanti, R., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia; de Groot, L.C., Division of Human Nutrition and Health, Wageningen University and Research, P.O. Box 176700, Wageningen, AA, Netherlands |
Background and aims: Energy and nutrient intakes of community-dwelling older adults in Indonesia are inadequate whereby milk consumption is among the lowest in the world. Lactose intolerance is probably one of the reasons for such low milk consumption, but information on the burden of this problem and its consequences for dietary intake is lacking. We obtained data on the prevalence of lactose intolerance and dietary intakes in Indonesian older outpatients, thereby comparing dairy users and non-dairy users. Methods: A cross-sectional study was conducted in 2019 involving 103 community-dwelling older adults in the outpatient geriatric clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta. A structured questionnaire was used to categorize participants as dairy- or non-dairy users. Food records were collected to assess nutrients intake from the diet. The prevalence of lactose intolerance (LI) was estimated based on the results of the hydrogen breath test (HBT) and on symptoms of lactose malabsorption. The difference in LI prevalence between dairy- and non-dairy user group was presented as a prevalence ratio (with 95% confidence interval). Chi-square tests, t-test, and Mann–Whitney tests were used to evaluate differences in demographic and clinical characteristics, as well as in nutrient intake profiles between dairy and non-dairy users. Results: The prevalence of lactose intolerance amounted to 66% (57–75%), 54% (37–70%), and 73% (61–84%) in the total population, dairy- and non-dairy users, respectively. Lactose intolerance tended to be higher among non-dairy users (PR 1.36 95% CI 0.99–1.89). On the other hand, we found no pronounced differences in symptoms of lactose intolerance between dairy and non-dairy users. The overall mean protein, calcium, vitamin D, and vitamin B12 intakes of the older adults were low. Intakes of protein, calcium, vitamin D and vitamin B12 were higher among dairy than among non-dairy users. Conclusions: This study uncovered the large size of the lactose intolerance problem in Indonesian older adults. Especially in non-dairy users, the intakes of proteins and some micronutrients are a concern. Strategies to tackle lactose intolerance are most relevant as to open the door for more nutrient-dense foods in the diet of Indonesian older adults. © 2021 European Society for Clinical Nutrition and Metabolism |
Indonesia; Lactase non-persistent; Lactose intolerance; Nutrients intake; Older adults |
calcium; cyanocobalamin; lactase; vitamin D; adult; aged; Article; cross-sectional study; dietary intake; female; human; hydrogen breath test; lactose intolerance; male; middle aged; Mini-Nutritional Assessment; nutrient intake; nutritional assessment; nutritional status; prevalence; structured questionnaire; vitamin intake |
Elsevier Ltd |
24054577 |
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34024534 |
Article |
Q2 |
659 |
7601 |
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