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402 |
van Crevel R., Avila-Pacheco J., Thuong N.T.T., Ganiem A.R., Imran D., Hamers R.L., Alisjahbana B., Dian S., Estiasari R., Tram T.T.B., Vinh D.N., Hai H.T., Donovan J., Ardiansyah E., Koeken V., Kumar V., Netea M.G., van Laarhoven A., Clish C., Thwaites G., The ULTIMATE consortium |
6603956378;57194750113;16551464800;35145741500;57203976849;23034345900;6506944516;55418398700;55240204000;56426109200;56562746100;57197774138;57203943392;57205617822;57194441324;57222877712;35378641700;55625910500;35460787900;57220045286; |
Improving host-directed therapy for tuberculous meningitis by linking clinical and multi-omics data |
2021 |
Tuberculosis |
128 |
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102085 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106295161&doi=10.1016%2fj.tube.2021.102085&partnerID=40&md5=4ce0f74084aad8c1c23b99ba0823c3f8 |
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman Oxford Clinical Research Unit, Jakarta, Indonesia |
van Crevel, R., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Avila-Pacheco, J., The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Thuong, N.T.T., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Ganiem, A.R., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Imran, D., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hamers, R.L., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Eijkman Oxford Clinical Research Unit, Jakarta, Indonesia; Alisjahbana, B., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Dian, S., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Estiasari, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tram, T.T.B., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Vinh, D.N., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Hai, H.T., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Donovan, J., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Ardiansyah, E., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Koeken, V., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Kumar, V., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Netea, M.G., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; van Laarhoven, A., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Clish, C., The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Thwaites, G., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; The ULTIMATE consortium |
There is a clear need to improve host-directed therapy for tuberculous meningitis (TBM), the most severe and deadly manifestation of tuberculosis. Corticosteroids represent the only host-directed therapy of proven benefit in TBM, yet their effect is modest, the mechanism by which they reduce mortality is unknown, and there is evidence for heterogeneity in their effect. Novel therapeutic approaches are therefore urgently needed. Cellular metabolism is critical for the function of immune cells; through unbiased metabolomics we recently found that high concentrations of cerebrospinal fluid (CSF) tryptophan are associated with increased mortality in Indonesian TBM patients, and that CSF tryptophan concentrations are under strong genetic regulation. Many questions remain. How exactly is tryptophan metabolism altered during TBM? How does it correlate with inflammation, immunopathology, and response to corticosteroids? How is tryptophan metabolism genetically regulated? What is the effect of HIV co-infection on tryptophan metabolism before and during TBM treatment? The ULTIMATE project addresses these questions by integrating data and specimens from large patient studies and clinical trials evaluating the effects of corticosteroids in Vietnam and Indonesia. Through its powerful and unbiased approach, ULTIMATE aims to identify which TBM patients benefit from corticosteroids and if novel therapeutic targets, such as the tryptophan pathway, could be targeted. © 2021 |
Cerebrospinal fluid; Genetics; Host-directed therapy; Meningitis; Metabolomics; Tryptophan; Tuberculosis |
corticosteroid; tryptophan; corticosteroid; tryptophan; tuberculostatic agent; Article; cerebrospinal fluid level; clinical trial (topic); coinfection; corticosteroid therapy; genetic regulation; host-directed therapy; human; Human immunodeficiency virus infection; multiomics; nonhuman; pathogenesis; priority journal; treatment response; tryptophan metabolism; tuberculous meningitis; cerebrospinal fluid; metabolomics; mortality; tuberculous meningitis; Adrenal Cortex Hormones; Antitubercular Agents; Humans; Metabolomics; Tryptophan; Tuberculosis, Meningeal |
Churchill Livingstone |
14729792 |
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34022506 |
Article |
Q2 |
977 |
4524 |
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403 |
Fuady A., Nuraini N., Sukandar K.K., Lestari B.W. |
37085331400;24605696400;57216947725;56589945500; |
Targeted vaccine allocation could increase the covid-19 vaccine benefits amidst its lack of availability: A mathematical modeling study in indonesia |
2021 |
Vaccines |
9 |
5 |
462 |
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9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105974918&doi=10.3390%2fvaccines9050462&partnerID=40&md5=4a9375c9281f8f4834500172552d5373 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10310, Indonesia; Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3015 GD, Netherlands; Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia; Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia; Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525 GA, Netherlands |
Fuady, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10310, Indonesia, Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3015 GD, Netherlands; Nuraini, N., Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia, Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia; Sukandar, K.K., Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia; Lestari, B.W., Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia, Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525 GA, Netherlands |
With a limited number of vaccines and healthcare capacity shortages, particularly in low-and middle-income countries, vaccination programs should seek the most efficient strategy to reduce the negative impact of the COVID-19 pandemics. This study aims at assessing several scenarios of delivering the vaccine to people in Indonesia. We develop a model for several scenarios of delivering vaccines: without vaccination, fair distribution, and targeted distribution to five and eight districts with the highest COVID-19 incidence in West Java, one of the most COVID-19-affected regions in Indonesia. We calculate the needs of vaccines and healthcare staff for the program, then simulate the model for the initial 4-month and one-year scenarios. A one-year vaccination program would require 232,000 inoculations per day by 4833 vaccinators. Targeted vaccine allocation based on the burden of COVID-19 cases could benefit the COVID-19 vaccination program by lowering at least 5000 active cases. The benefits would increase by improving the number of vaccines and healthcare staff. Amidst lacking available vaccines, targeted vaccine allocation based on the burden of COVID-19 cases could increase the benefit of the COVID-19 vaccination program but still requires progressive efforts to improve healthcare capacity and vaccine availability for optimal protection for people. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
COVID-19; Low-and middle-income countries; Modeling; Strategy; Vaccine |
SARS-CoV-2 vaccine; Article; coronavirus disease 2019; disease model; disease predisposition; disease transmission; drug bioavailability; drug efficacy; health care need; health care personnel; human; Indonesia; infection rate; mathematical model; mortality; quarantine; reinfection; resource allocation; SIQRD model; vaccination |
MDPI AG |
2076393X |
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Article |
Q1 |
1296 |
2913 |
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404 |
Harbuwono D.S., Sazli B.I., Kurniawan F., Darmowidjojo B., Koesnoe S., Tahapary D.L. |
36056341600;57223390172;57202309006;57210642934;26028015000;55944492500; |
The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus |
2021 |
Heliyon |
7 |
5 |
e06773 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105783321&doi=10.1016%2fj.heliyon.2021.e06773&partnerID=40&md5=2dd413b4d090b7268ec8e92f9121b6ce |
Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia |
Harbuwono, D.S., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Sazli, B.I., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Kurniawan, F., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Darmowidjojo, B., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Koesnoe, S., Division of Allergy and Immunology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Tahapary, D.L., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia |
Background/Aims: Ramadan fasting creates changes in lifestyle, causing biochemical alterations that affect glucose metabolism and insulin sensitivity. This study aims to assess the impact of Ramadan fasting on glycemic control and Fetuin-A, a glycoprotein that affects insulin resistance, in patients with type 2 diabetes mellitus (T2DM). Materials and methods: This was a prospective study done among 37 patients with T2DM from Internal Medicine Polyclinic in a hospital in Jakarta, Indonesia. Anthropometric data as well as Hemoglobin A1c (HbA1c), Fasting Blood Glucose (FBG), and Fetuin-A levels of the subjects were measured in three time points: before, during, and after Ramadan fasting. A bivariate analysis was done to see the effect of Ramadan fasting on those parameters. Results: Ramadan fasting reduced Fetuin-A levels [median (minimum–maximum), 5.35 (2.91–7.81) vs. 3.22 (2.35–5.60) mg/dl; p = 0.039] four weeks after the end of Ramadan compared to pre-Ramadan. After two weeks of Ramadan fasting, we found a significant reduction in body weight, BMI, FBG, and HbA1c levels which rebounded to baseline level after Ramadan. Conclusion: Ramadan fasting was associated with a significant decrease in Fetuin-A level post Ramadan. © 2021 The Authors |
Diabetes mellitus; Fetuin-A; Glycoprotein; Insulin resistance; Ramadan fasting |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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408 |
Prabowo Y., Saleh R.F. |
56682042400;57223172145; |
Pedicle screw system reconstruction in shoulder resection type IV-total scapulectomy: A case report and short term follow up |
2021 |
International Journal of Surgery Case Reports |
82 |
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105899 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105046123&doi=10.1016%2fj.ijscr.2021.105899&partnerID=40&md5=8ea9fee43652fb219badfae749ce4703 |
Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Prabowo, Y., Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Saleh, R.F., Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Introduction: Shoulder resection remains a challenging procedure after scapulectomy for tumour resection. The results have various functional outcome, wound coverage, and cosmetic aspect. In this case report, we reported the outcome of pedicle screw application after scapulectomy procedure within 1 month follow up after surgical tumour excision. Case presentation: A 74-year-old female presented with a painful lump on the left shoulder since nine months before admission. We performed physical examination, radiological evaluation using x-ray and MRI. We performed limb salvage surgery with shoulder girdle resection of tumour procedure using Malawer technique type IVB and applied pedicle and screw in proximal end clavicula and proximal end of humerus. We performed histopathological examination to ensure the tumour. We evaluated the patient one month after surgery using DASH score. Discussion: MRI examination revealed that there was a solid mass with malignant characteristic destructing left scapular bone with the acromioclavicular and glenohumeral joint involvement. We used pedicle and screw to reconstruct the patient with efficient cost spending consideration. Clinical valuation showed there was no pain left and hand-free movement except the limitation of shoulder abduction. DASH score evaluation pre operative and post operative showed improvement from 70.8 to 45.0. Conclusion: Limb salvage procedure using pedicle screw system may be one of treatment of choice for treating tumour of the shoulder affecting glenohumeral joint with excellent result of evaluation both clinical and functional outcome. © 2021 |
DASH score; Pedicle screw; Scapulectomy; Shoulder tumour |
acromioclavicular joint; aged; Article; case report; clavicle; clinical article; Disabilities of the Arm, Shoulder and Hand (score); elbow; evaluation study; female; follow up; hand function; histopathology; human; limb salvage; nuclear magnetic resonance imaging; physical examination; practice guideline; priority journal; proximal humerus; radiodiagnosis; range of motion; shoulder girdle; shoulder surgery; solid malignant neoplasm; treatment outcome; tumor volume; X ray |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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409 |
Elhidsi M., Rasmin M., Prasenohadi |
57203157152;15754578700;55758911100; |
In-hospital mortality of pulmonary tuberculosis with acute respiratory failure and related clinical risk factors |
2021 |
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
23 |
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100236 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104769874&doi=10.1016%2fj.jctube.2021.100236&partnerID=40&md5=9a5aabc171edcb9f93c20e1128bf350e |
Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia – Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Elhidsi, M., Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia – Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Rasmin, M., Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia – Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Prasenohadi, Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia – Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Background/objective: Data on acute respiratory failure (ARF) in pulmonary tuberculosis (PTB) patients is limited. This study aims to investigate in-hospital mortality, its clinical risk factors and the accuracy of the existing scoring system in predicting in-hospital mortality. Methods: An observational prospective cohort study involving PTB patients with ARF in tertiary hospital, between January 2017 and December 2018, was conducted. The in-hospital mortality was predicted using the National Early Warning Score 2 (NEWS2), quick Sequential Organ Failure Assessment (qSOFA) and CRB-65. Regression models were run to analyze the clinical risk factors for in-hospital Mortality. Sensitivity and specificity of scoring systems were calculated using a Wilson score interval. Results: A total of 111 subjects were included. Most of subjects were hypoxemic type respiratory failure (68.5%), advanced lesions (62.2%), new cases (70.3%) and pneumonia co-infection (72.1%) patients. Invasive mechanical ventilation was utilized for 29.73% of cases. There were 53 (47.75%) in-hospital mortality cases and its risk factors were intensive phase treatment (3.34 OR; CI95% 1.27–8.78), P/F ratio < 100 (OR 4.30; CI 95% 1.75–10.59) and renal insufficiency (4.09 OR; CI95% 1.46–11.49). The sensitivity and specificity of NEWS2 ≥ 6, qSOFA ≥ 2 and CRB-65 ≥ 2 were 62.26% and 67.24%; 60.38% and 72.41%; 41.51% and 84.48% respectively. Conclusions: Most of PTB with ARF were new cases, advanced lesion and hypoxemic type respiratory failure. Intensive phase treatment, severe hypoxemia and renal insufficiency are independent predictors of in-hospital mortality in PTB patients with ARF. NEWS2, qSOFA and CRB-65 scores were poor to predict the in-hospital mortality. © 2021 The Author(s) |
Acute respiratory failure; In-hospital mortality; Pulmonary tuberculosis; Tuberculosis |
steroid; tuberculostatic agent; acute respiratory failure; adult; aged; Article; cohort analysis; coinfection; confidence interval; controlled study; CRB-65 score; diagnostic test accuracy study; female; human; in-hospital mortality; invasive ventilation; kidney failure; lung tuberculosis; major clinical study; male; National Early Warning Score 2; observational study; odds ratio; pneumonia; prospective study; quick Sequential Organ Failure Assessment Score; regression analysis; risk assessment; risk factor; scoring system; sensitivity and specificity; tertiary care center |
Elsevier Ltd |
24055794 |
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Article |
Q3 |
585 |
8643 |
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410 |
Solichin I., Sandjaya G., Prabowo I., Dwi Putra N.H., Rhatomy S. |
57202813479;57223086553;57221098612;57223086083;57204509883; |
The lateral curved osteotomy for cubitus varus deformity in children: A case report and literature review |
2021 |
Annals of Medicine and Surgery |
65 |
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102315 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104767442&doi=10.1016%2fj.amsu.2021.102315&partnerID=40&md5=d2cf2846c9fa539b567bea0b5a8e358f |
Orthopaedic Hospital Purwokerto, Network Hospital of Department Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Indonesia; Soedarso Hospital Pontianak, Network Hospital of Department Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Indonesia; Department of Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sport and Adult Reconstruction Division, Department of Orthopedics and Traumatology, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia; Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Solichin, I., Orthopaedic Hospital Purwokerto, Network Hospital of Department Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Indonesia; Sandjaya, G., Soedarso Hospital Pontianak, Network Hospital of Department Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Indonesia; Prabowo, I., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Dwi Putra, N.H., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rhatomy, S., Sport and Adult Reconstruction Division, Department of Orthopedics and Traumatology, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Introduction: Cubitus varus deformity after malunited supracondylar humerus fracture has various surgical techniques, implant configurations, and approaches. We describe a combination of French and Dome osteotomy and novel internal fixation technique to deliver an easy, safe, fast and reproducible result based on the current best evidence. Presentation of case: Two cases of malunited supracondylar humerus are described. The first case involves a 3-year-old girl who presented with outstretched and supinated left arm after falling during bike riding 3 weeks earlier. We found no abnormality in radial and median nerve function, but the left arm radiographs showed a callus formation and the early stages of a malunited fracture of the supracondylar humerus. We waited two months for further radiographic evaluation and the radiographs showed the malunited supracondylar humerus with elbow flexion of only 105° and elbow hyperextension of 20°. The cubitus varus was recorded with clinical carrying angle of varus 10°. We used a combination of original French and Dome osteotomy, lateral approach, and our novel fixation technique with excellent results. The second case involved a 8-year-old boy with malunited right elbow and the surgery was done in the same manner, with the result of restoration to normal elbow range of motion. We also assessed the pain score and disabilities of the arm, shoulder and hand (DASH) score and recorded satisfactory results. Conclusions: The combination of French and Dome osteotomy for treatment of cubitus varus deformity can provide an easy, safe, and reproducible result. © 2021 The Author(s) |
Cubitus varus deformity; Dome osteotomy; French osteotomy; Malunited supracondylar humerus |
Article; callus; case report; cerclage; child; clinical article; Disabilities of the Arm, Shoulder and Hand (score); disability; elbow flexion; elbow radiography; female; follow up; human; humeral supracondylar fracture; iatrogenic disease; male; nerve function; open reduction (procedure); osteotomy; pain; pain assessment; preschool child; range of motion; school child; varus deformity |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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412 |
Pulungan A., Andarie A.A., Soesanti F., Yassien M.R., De Bruin C., Wijaya A., Firmansyah A., Wit J.M. |
57192905981;57195935134;37068080600;57223039155;57028043300;57225459566;6602915502;7101895972; |
Anthropometric, biochemical and hormonal profiles of the partially admixed pygmoid group in Rampasasa (Flores, Indonesia) |
2021 |
Journal of Pediatric Endocrinology and Metabolism |
34 |
5 |
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547 |
557 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104614948&doi=10.1515%2fjpem-2020-0526&partnerID=40&md5=64730b2ca3a487374a34509077be3f0d |
Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands; Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia |
Pulungan, A., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Andarie, A.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soesanti, F., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yassien, M.R., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; De Bruin, C., Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands; Wijaya, A., Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia; Firmansyah, A., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wit, J.M., Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands |
Objectives: We performed a cross-sectional study on anthropometric and laboratory characteristics of inhabitants of Rampasasa (Flores, Indonesia). Adults were categorised according to ancestry into three groups: pygmoid (P/P, offspring of pygmoid parents, n=8), mixed pygmoid (P/N, offspring of pygmoid and non-pygmoid parents, n=12) and non-pygmoid (N/N, n=10). Children (n=28) were P/N. Methods: Measurements included height, weight, sitting height, arm span, head circumference, haematological analysis and serum albumin, calcium, vitamin D, insulinlike growth factor-I (IGF-I) and IGF binding protein 3 (IGFBP-3). Pubertal stage and bone age was assessed in children. Anthropometric data were expressed as standard deviation score (SDS) for age. IGF-I, IGFBP-3 and IGF-I/ IGFBP-3 ratio were expressed as SDS for age, bone age and pubertal stage. Results: Mean height SDS showed a gradient from P/P (-4.0) via P/N (-3.2) to N/N (-2.3) (-3.4, -3.1 and -2.2 adjusted for age-associated shrinking). Sitting height and head circumference showed similar gradients. Serum IGF-I SDS was similar among groups (approximately -1 SDS). IGFBP-3 SDS tended toward a gradient from P/P (-1.9) via P/N (-1.5) to N/N (-1.1), but IGF-I/IGFBP-3 ratio was normal in all groups. In P/P and P/N, mean head circumference SDS was >2 SD greater than mean height SDS. Children showed a progressive growth failure and bone age delay, delayed female pubertal onset and an initial low serum IGF-I, normal IGFBP-3 and low IGF-I/IGFBP-3 ratio. Conclusions: P/P showed proportionate short stature with relative macrocephaly and relatively low IGFBP-3; P/N presented an intermediate pattern. P/N children were progressively short, showed delayed skeletal maturation, delayed puberty in girls and low IGF-I and IGF-I/IGFBP-3. © 2021 De Gruyter. All rights reserved. |
Growth; Head circumference; IGF-I; IGFBP-3; Negritos; Pygmies; Short stature; Vitamin D deficiency |
albumin; calcium; somatomedin binding protein 3; somatomedin C receptor; vitamin D; IGFBP3 protein, human; somatomedin binding protein 3; somatomedin C; adult; albumin blood level; analytical parameters; anthropology; anthropometry; Article; biochemistry; blood analysis; bone age; calcium blood level; child; controlled study; cross-sectional study; crossover procedure; female; head circumference; hormone determination; human; Indonesia; macrocephaly; male; molecular dynamics; population research; protein blood level; puberty; pygmy; scoring system; vitamin blood level; anthropometry; blood; body mass; body weight; bone disease; ethnic group; follow up; growth disorder; infant; metabolism; middle aged; newborn; pathology; preschool child; prognosis; Adult; Anthropometry; Body Mass Index; Bo |
De Gruyter Open Ltd |
0334018X |
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33851527 |
Article |
Q2 |
502 |
10041 |
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413 |
Basuki A., Song A., Yovita N.V., Suryadinata K.L., Sagala A.E. |
57201667022;57222711862;57222712061;57222712562;57222714377; |
The treatment challenges and limitation in high-voltage pediatric electrical burn at rural area: A case report |
2021 |
International Journal of Surgery Case Reports |
82 |
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105857 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103792595&doi=10.1016%2fj.ijscr.2021.105857&partnerID=40&md5=3f77d2991bbaae35b0c106d482e306f2 |
Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine, Universitas Indonesia, Indonesia; S. K. Lerik Public General Hospital, Kupang City, East Nusa Tenggara, Indonesia; Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Hasan Sadikin General Hospital/Faculty of Medicine, Universitas Padjajaran, Indonesia; Department of Physical Medicine and Rehabilitation, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine, Universitas Indonesia, Indonesia |
Basuki, A., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine, Universitas Indonesia, Indonesia; Song, A., S. K. Lerik Public General Hospital, Kupang City, East Nusa Tenggara, Indonesia; Yovita, N.V., Department of Physical Medicine and Rehabilitation, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine, Universitas Indonesia, Indonesia; Suryadinata, K.L., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Hasan Sadikin General Hospital/Faculty of Medicine, Universitas Padjajaran, Indonesia; Sagala, A.E., S. K. Lerik Public General Hospital, Kupang City, East Nusa Tenggara, Indonesia |
Introduction: Although rare, electrical injury in pediatrics is potentially life threatening and has significant and long-term impact in life. It is challenging to manage such cases in rural areas. Presentation of case: A fully conscious 13-year-old boy was admitted to the emergency room after being electrocuted by high-voltage power cable, with superficial partial thickness burn over right arm, trunk, and left leg (26 % of total body surface area). Tachycardia and non-specific ST depression was found on ECG examination and was diagnosed with high-voltage electrical injury. Treatments were based on ANZBA algorithm with several modifications, i.e., administering lower concentration of oxygen with nasal cannula instead of non-rebreathing mask as well as Ketorolac and Antrain® for analgesic instead of morphine. Discussion: Different choices of treatments were given due to limited resources. Despite possible cardiac and renal complication, further tests could not be done. Fortunately, after strict monitoring, no signs of abnormality were found. We used silver sulfadiazine, Sofratulle® and dry sterile gauze as a dressing of choice following immediate surgical debridement. The patient was observed daily through 7 days of hospitalization and followed-up for 1 year, achieving normal physiologic function of the affected area but unsatisfactory esthetic result. Conclusion: Lack of infrastructure, drugs, and trained personnel are some of the challenges that still exist in most rural areas. Thus, implementation of available standardized guidelines such as ANZBA, and giving similar training to personnel as well as providing feasible equipment followed by strict monitoring for the patient are needed to achieve maximum results. © 2021 |
Case report; Electrical burn; Pediatric; Rural area |
alanine aminotransferase; analgesic agent; antrain; aspartate aminotransferase; ceftriaxone; dipyrone; framycetin; ketorolac; olive oil; oxygen; Ringer lactate solution; sulfadiazine silver; adolescent; alanine aminotransferase blood level; analgesia; antibiotic prophylaxis; arm; Article; aspartate aminotransferase blood level; blood examination; burn; case report; clinical article; depression; drug substitution; drug withdrawal; electric accident; electric burn; electrocardiogram; electrocardiography; electrocution; emergency treatment; emergency ward; epithelization; fluid resuscitation; follow up; general anesthesia; granulation tissue; human; hypokalemia; leg; leukocytosis; male; outpatient care; oxygen saturation; patient monitoring; pediatric patient; priority journal; pulse oximetry |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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414 |
Rasyid N., Nainggolan H.J., Jonardi P.A., Raharja P.A.R., Wiweko B., Atmoko W., Birowo P. |
56245069300;57222668459;57222670069;57201013616;43061741400;57193125664;6504153311; |
Early-onset complete spontaneous migration of contraceptive intrauterine device to the bladder in a post C-section patient: A case report |
2021 |
International Journal of Surgery Case Reports |
82 |
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105850 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103712294&doi=10.1016%2fj.ijscr.2021.105850&partnerID=40&md5=098c129a6d385c5e68c5b79c45fb304a |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jalan Diponegoro No. 71, Jakarta, 10430, Indonesia; Division of Reproductive Endocrinology and Infertility, Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jalan Diponegoro No. 71, Jakarta, 10430, Indonesia |
Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jalan Diponegoro No. 71, Jakarta, 10430, Indonesia; Nainggolan, H.J., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jalan Diponegoro No. 71, Jakarta, 10430, Indonesia; Jonardi, P.A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jalan Diponegoro No. 71, Jakarta, 10430, Indonesia; Raharja, P.A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jalan Diponegoro No. 71, Jakarta, 10430, Indonesia; Wiweko, B., Division of Reproductive Endocrinology and Infertility, Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jalan Diponegoro No. 71, Jakarta, 10430, Indonesia; Atmoko, W., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jalan Diponegoro No. 71, Jakarta, 10430, Indonesia; Birowo, P., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jalan Diponegoro No. 71, Jakarta, 10430, Indonesia |
Introduction and importance: Spontaneous migration of a contraceptive intrauterine device (IUD) to the bladder is very rare. It usually takes years for the IUD to migrate completely from the uterine cavity to the bladder. We report a case of early-onset complete spontaneous migration of contraceptive IUD to the bladder in a post C-section patient. Case presentation: A 30-year-old woman presented with suprapubic pain and dysuria three weeks prior to hospitalization. She had C-section three months prior and underwent copper IUD insertion two months after the surgery. One week after IUD insertion, radiography showed that the IUD remained in the uterus, but the patient felt suprapubic pain and dysuria. Computed tomography (CT) three weeks after IUD insertions showed IUD migration to the bladder with its tips embedded in the uterine wall. Cystoscopy was performed one week later and the IUD was completely inside the bladder. By then, the IUD was removed completely via forceps with no complication. Clinical discussion: The exact pathophysiology of spontaneous IUD migration is unknown, but migration always starts with uterine perforation. In our case, uterine perforation was probably caused by immediate traumatic perforation. CT is the preferred radiological examination. IUD removal was performed one month after IUD insertion showing complete migration of the IUD, though CT one week prior suggested that the tips of the IUD remained embedded. Conclusion: In cases of early-onset complete spontaneous migration of contraceptive IUD to the bladder, CT is the preferred radiological examination, and delaying removal procedure may be beneficial. © 2021 The Author(s) |
Bladder; Case report; Cystoscopy; Intrauterine device; Spontaneous migration |
nonsteroid antiinflammatory agent; adult; Article; case report; clinical article; cystoscopy; dysuria; female; human; hysterography; hysteroscopy; intrauterine device migration; priority journal |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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416 |
Irawati Y., Fitri M.A.R., Natalia M.E.R., Atmodiwirjo P., Ramadan M.R., Triatmoko S.E. |
57201260313;57222671166;57222668119;57222670453;57222667572;57222671805; |
A case report of reconstruction of ocular and complete upper eyelid avulsion with severe facial soft tissue injuries using anterolateral thigh free flap |
2021 |
International Journal of Surgery Case Reports |
82 |
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105856 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103698401&doi=10.1016%2fj.ijscr.2021.105856&partnerID=40&md5=af73a4517bc594c3298dc3cd1272efe3 |
Plastic Reconstructive Surgery Division, Ophthalmology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Ophthalmology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Reconstructive Microsurgery Section, Division of Plastic Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Irawati, Y., Plastic Reconstructive Surgery Division, Ophthalmology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Fitri, M.A.R., Ophthalmology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Natalia, M.E.R., Ophthalmology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Atmodiwirjo, P., Reconstructive Microsurgery Section, Division of Plastic Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Ramadan, M.R., Reconstructive Microsurgery Section, Division of Plastic Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Triatmoko, S.E., Reconstructive Microsurgery Section, Division of Plastic Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Introduction and importance: Ocular injury is second mostly caused by motor vehicle accident (MVA) and often leads to severe ocular injury even to visual loss and various aesthetic problems. The outcome is determined by the magnitude of the initial damage and treatment availability. Treating ocular and facial injury due to MVA is challenging given the scope of the damage and may result in various outcomes. Case presentation: This case presented a 22-years old woman with a history of car accident assessed with total upper eyelid avulsion with corneal perforation and involvement of multiple facial fractures on the left side. The visual function is irreparable due to the extensive corneal defect from exposure and secondary infection, and possible optic nerve damage. Clinical discussion: This case presented a complete upper eyelid avulsion with severe facial tissue injury. Therefore, the reconstructive procedure main objectives are to maintain appropriate prosthetic position and to improve cosmetic function. This case used anterolateral thigh free flap as the reconstructive surgery method because it is convenient for large defects and the donor scar is not visible. After completing the surgery and several follow-up procedures, the patient recovered without any significant complications. Conclusion: Despite visual loss due to the extent damage of the eye, it is important to restore the facial damages. Visual function is as crucial as cosmetic function in determining the patient's quality of life. © 2021 |
Anterolateral thigh free flap; Case report; Ocular injury; Surgical intervention; Upper eyelid avulsion |
abscess; adult; anterolateral thigh flap; Article; avulsion injury; bulbar conjunctiva; canthopexy; case report; chemosis; clinical article; collaborative care team; computer assisted tomography; conjunctival hyperemia; convalescence; cornea perforation; corneal abscess; ectropion; esthetic surgery; esthetics; eye evisceration; eye examination; eye injury; eye surgery; eyelid disease; eyelid reconstruction; face fracture; face injury; female; hair transplantation; horizontal palpebral fissure; human; injury severity; keratitis; lagophthalmos; liposuction; multiple fracture; palpebral fissure; patient referral; patient safety; patient satisfaction; plastic surgeon; priority journal; pus; socialization; soft tissue injury; suture technique; three-dimensional imaging; tissue necrosis; total q |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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