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427 |
Setiati S., Soejono C.H., Harimurti K., Dwimartutie N., Aryana I.G.P.S., Sunarti S., Budiningsih F., Mulyana R., Dwipa L., Sudarso A., Rensa R., Istanti R., Azwar M.K., Marsigit J. |
14325991900;24472241900;23473513200;37067234900;37062993600;57215563311;56483278600;57203246879;55321762700;57223602321;6504343309;23496653300;57202798959;57218912589; |
Frailty and Its Associated Risk Factors: First Phase Analysis of Multicentre Indonesia Longitudinal Aging Study |
2021 |
Frontiers in Medicine |
8 |
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658580 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105939470&doi=10.3389%2ffmed.2021.658580&partnerID=40&md5=b2d32afefa94ab6754eec53482b82d31 |
Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Udayana, Bali, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Solo, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makasar, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Atma Jaya, Jakarta, Indonesia |
Setiati, S., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia, Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Soejono, C.H., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Harimurti, K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia, Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Dwimartutie, N., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Aryana, I.G.P.S., Department of Internal Medicine, Faculty of Medicine, Universitas Udayana, Bali, Indonesia; Sunarti, S., Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Budiningsih, F., Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Solo, Indonesia; Mulyana, R., Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Dwipa, L., Department of Internal Medicine, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Sudarso, A., Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makasar, Indonesia; Rensa, R., Department of Internal Medicine, Faculty of Medicine, Universitas Atma Jaya, Jakarta, Indonesia; Istanti, R., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Azwar, M.K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Marsigit, J., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: National long-term care development requires updated epidemiological data related to frailty. We aimed to find the prevalence of frailty and its associated factors among Indonesian elderly. Methods: We conducted first-phase cross-sectional analysis of Indonesia Longitudinal Aging Study (INALAS) data collected from community-dwelling outpatients aged 60 years and older without acute illness in nine geriatric service care centres. Descriptive, bivariate and multivariate analyses were conducted. Results: Among 908 elderly in this study, 15.10% were robust, 66.20% were pre-frail, and 18.70% were frail. Functional dependence was associated with frailty among Indonesian elderly (OR 5.97, 95% CI 4.04–8.80). Being depressed and at risk for malnutrition were also associated with frailty with OR 2.54, 95% CI 1.56–4.12, and OR 2.56, 95% CI 1.68–3.90, respectively. Prior history of fall (OR 1.77, 95% CI 1.16–2.72) and hospitalization (OR 1.46, 95% CI 0.97–2.20) in the previous 12 months were associated with frailty. There is also significant association between poly pharmacy and frailty (OR 2.42, 95% CI 1.50–3.91). Conclusion: Approximately one in five Indonesian community-dwelling elderly was frail. Frailty is associated with functional dependence, being at risk for malnutrition or being malnourished, depression, history of fall, history of hospitalization, and poly pharmacy. There may be bidirectional relationships between the risk factors and frailty. The development of long-term care in Indonesia should be considered, without forcing the elderly who need it. © Copyright © 2021 Setiati, Soejono, Harimurti, Dwimartutie, Aryana, Sunarti, Budiningsih, Mulyana, Dwipa, Sudarso, Rensa, Istanti, Azwar and Marsigit. |
community-dwelling elderly; frailty; Indonesia; long-term care; prevalence; risk factors |
adult; aged; aging; Article; community dwelling person; cross-sectional study; depression; falling; female; frailty; functional status; high risk population; hospitalization; human; Indonesian; longitudinal study; major clinical study; male; malnutrition; medical history; outpatient; polypharmacy; prevalence; risk factor |
Frontiers Media S.A. |
2296858X |
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Article |
Q1 |
1388 |
2608 |
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428 |
Soetisna T.W. |
57214887740; |
A new hope of cd133+ bone marrow stem cell for functional exercise capacity improvement in low ejection fraction coronary artery bypass graft patients: A clinical trial |
2021 |
Bali Medical Journal |
10 |
1 |
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229 |
233 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106002523&doi=10.15562%2fbmj.v10i1.2255&partnerID=40&md5=80046a217774aa6ef82836d9a524c4ff |
Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Soetisna, T.W., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Patients with low ejection fraction who are undergoing coronary artery bypass graft (CABG) only have an insignificant improvement in ejection fraction. This condition will make a little hope to achieve an improvement in physical performance. But now, from a view study, CD133+ stem cells offer new hope for this situation. This study evaluates CD133+ bone marrow stem cells’ role for functional exercise capacity improvement in low ejection fraction coronary artery bypass graft patients. Methods: Thirty patients with ischemic heart disease who had ejection fraction<35% at the National Cardiovascular Center were randomized into 2 groups. The treatment group undergoes the CABG + CD133+ procedure and the control group undergoes the CABG only. All research subjects underwent follow-up before and 6 months after the procedure. Fraction ejection, scar size, wall motion score index, ventricular dimensions, myocardial perfusion measured by cardiac MRI, 6 Minutes Walking Test (6MWT) and Minnesota Living with Heart Failure Questionnaire (MLHFQ) as an additional parameter for physical performance and quality of life. Data was analyzed using SPSS version 21 for Windows. Results: The results of the fraction ejection parameters showed a significant improvement in the treatment group, from 25.88±5.66% to 34.57%±11.31% compared to CABG only 30.18±3.85% to 31.61±7.89% (p=0.040), in the perfusion defect showed improvement but not significant, left ventricular end-systolic volume and left ventricular end-diastolic volume showed improvement with no significant result, scar size was found to be an improvement in the treatment group 10 persons (76.92%) compared to the control group 5 persons (38, 46%) (p=0.040), the wall motion score index and 6MWT showed a significant improvement in the treatment group (p=0.003 and p=0.03, respectively). The MLHFQ parameter showed improvement but not significant. Conclusion: CD 133+ stem cell implantation in patients with low ejection fraction who undergo CABG provides improved myocardial function and indirectly improves functional exercise capacity and patients’ quality of life. © 2021, Sanglah General Hospital. All rights reserved. |
CABG; CD133+ Stem cell; Functional exercise capacity |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
#N/A |
#N/A |
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429 |
Ocviyanti D., Putri R.A. |
57189661230;57226166006; |
Biopsychosocial aspect of pregnant women suspected brainstem death [Aspek Biopsikososial pada Perempuan Hamil dengan Kecurigaan Mati Batang Otak] |
2021 |
Indonesian Journal of Obstetrics and Gynecology |
9 |
2 |
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107 |
110 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115419653&doi=10.32771%2finajog.v9i2.1269&partnerID=40&md5=41a14ffbc68b4ced0cd44396ae92afad |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Ocviyanti, D., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Putri, R.A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objective: Diagnosis of brainstem death and the vital organ function support in the pregnant woman to prolong gestation to attain fetal viability is still controversial. The decision is influenced by ethical and legal issue in the country. Another consideration is the hospital cost and health insurance coverage. This article purpose is to report a case and discuss the biopsychosocial aspect of this issue, so the doctors know how to decide a similar case. Methods: We reported a suspected brainstem death in pregnant women and discussed the holistic approach. Case: This case is a-38-year-old women, third pregnancy, 22 weeks of gestation, referred from the secondary hospital in a comatose condition. She was diagnosed with brainstem dysfunction due to intracranial mass and cerebral oedema. She wasn't diagnosed with brainstem death due to the electrolyte imbalance that can cause this condition. We did the multidisciplinary management approach. We decided the termination of pregnancy would only be performed if the fetus reaches 28 weeks of gestational age (with survival rate on perinatology is 31%). From the husband point of view, since the attending doctors have not declared the mother to be dead, then the husband still want to keep the mother in full life support. The patient and the fetus died on the 8th day of hospitalization. The patient was fully paid for by Indonesian Health Insurance. Conclusions: Maternal brainstem dysfunction and brainstem death during pregnancy are rare. In Indonesia, ethical and legal consideration to keep both mother and fetus are appropriate with the general social, cultural, and religious values. However, we recommend managing every single case individually with an intensive multidisciplinary approach due to the possibility of the different personal value of the patient. © Creative Commons Atribuição-Não Comercial 4.0 Internacional |
Brain death; Brainstem dysfunction; Ethic; Fetal; Legal; Pregnancy |
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Indonesian Society of Obstetrics and Gynecology |
23386401 |
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Article |
#N/A |
#N/A |
#N/A |
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430 |
Mariati N.M.A.S., Sugiarto A., Endriani E., Lestari R., Anindita K. |
57223228784;57189612291;57222314378;57223220725;57192903786; |
High flow nasal cannula to prevent intubation in obese patient with COVID-19 induced ARDS: a case report |
2021 |
Anaesthesia, Pain and Intensive Care |
25 |
2 |
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212 |
216 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105281913&doi=10.35975%2fAPIC.V25I2.1473&partnerID=40&md5=2108db369e86e24a12b1ed89d9a0970b |
Department of Anesthesiology & Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anesthesiology & Intensive Care, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Pulmonology Department, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Department of Internal Medicine, Siloam Hospitals Mataram, Jl. Majapahit, Pagesangan, Kec. Mataram, Kota Mataram, Nusa Tenggara Bar, 83115, Indonesia |
Mariati, N.M.A.S., Department of Anesthesiology & Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiarto, A., Department of Anesthesiology & Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Endriani, E., Department of Anesthesiology & Intensive Care, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Lestari, R., Pulmonology Department, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Anindita, K., Department of Internal Medicine, Siloam Hospitals Mataram, Jl. Majapahit, Pagesangan, Kec. Mataram, Kota Mataram, Nusa Tenggara Bar, 83115, Indonesia |
Obese patients have been identified to have a poor prognosis and a higher risk of death from coronavirus disease-2019 (COVID-19). We present reports of two obese patients infected with COVID-19 with acute respiratory distress syndrome (ARDS) who showed improvement with high flow nasal cannula (HFNC). HFNC is a noninvasive oxygen delivery device which is capable of delivering a high concentration of oxygen that can reduce the requirement for tracheal intubation. HFNC is convenient to use, can reduce dyspnea without effecting the length of stay in ICU in these cases; and has a high merit to be used in selected patients requiring oxygen before attempting intubation and mechanical ventilation. © the authors. |
ARDS; COVID-19; HFNC; High flow nasal cannula; Obese |
alanine aminotransferase; antiarrhythmic agent; ascorbic acid; aspartate aminotransferase; azithromycin; C reactive protein; chloroquine; dexamethasone; famotidine; heparin; hypertensive factor; levofloxacin; low molecular weight heparin; methylprednisolone; micafungin; oseltamivir; remdesivir; SARS-CoV-2 convalescent plasma; vancomycin; adult; adult respiratory distress syndrome; ageusia; alanine aminotransferase blood level; anosmia; Article; artificial ventilation; aspartate aminotransferase blood level; case report; clinical article; coronavirus disease 2019; coughing; COVID-19 testing; crackle; diarrhea; drug withdrawal; dyspnea; endotracheal intubation; fever; heart arrhythmia; high flow nasal cannula therapy; hospital admission; human; hypotension; hypoxemia; intensive care unit; le |
Faculty of Anaesthesia, Pain and Intensive Care, AFMS |
16078322 |
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Article |
Q3 |
170 |
21404 |
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431 |
Marzuki N.S., Idris F.P., Kartapradja H., Renata S., Harahap A., Latief Batubara J.R. |
37111053300;57224096699;6504373157;57224098534;6507325543;57224097014; |
Accuracy of urinary etiocholanolone/androsterone ratio as alternative to serum testosterone/dihydrotestosterone ratio for diagnosis of 5 alpha-reductase type 2 deficiency patients and carriers in Indonesia |
2021 |
International Journal of Endocrinology and Metabolism |
19 |
2 |
e109510 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106858176&doi=10.5812%2fIJEM.109510&partnerID=40&md5=262ad88d94d397f7bc55e0ace31050be |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Marzuki, N.S., Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Idris, F.P., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Kartapradja, H., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Renata, S., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Harahap, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Latief Batubara, J.R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The 5 Alpha-reductase type 2 deficiency (5ARD2) is an inherited condition, which clinically presents as variable degrees of under virilization in affected 46,XY individuals. In the diagnostic pathway of 5ARD2, the testosterone/dihydrotestosterone (T/DHT) ratio is broadly employed before molecular analysis of the SRD5A2 gene. However, due to cost-benefit considerations, the DHT test in our country is routinely lacking in clinical settings; therefore, we considered applying the urinary etiocholanolone/androsterone (Et/An) ratio as an alternative test. Objectives: We aimed to determine the diagnostic value of the urinary Et/An ratio versus the T/DHT ratio in diagnosing 5ARD2 patients and carriers. Methods: Sixty-six suspected 5ARD2 46,XY disorders of sex development (DSD) individuals and 95 family members were recruited in the study. Their clinical manifestations, T/DHT and urinary Et/An ratios, and SRD5A2 genes were analyzed. Using molecular analysis of the SRD5A2 gene as the gold standard, we compared the accuracy of both ratios in diagnosing 5ARD2 patients and carriers with receiver operating characteristic (ROC) curve analysis. Results: Thirty-seven patients were confirmed molecularly to have 5ARD2, and the rest (n = 29) were assessed as normal controls, while in the carrier group, 53 were molecularly confirmed as carriers and 42 as controls. The AUCs (areas under the curve) of the T/DHT and urinary Et/An ratios were 57.7% (95% CI 43.0 - 72.4%, P > 0.05) and 79.7% (95% CI 69.0 - 90.4%, P < 0.001), respectively, in diagnosing 5ARD2 patients and 54.1% (95% CI 42.4 - 65.8%, P > 0.05) and 75.1% (95% CI 65.1 - 85.1%, P < 0.001), respectively, in diagnosing carriers. The cutoff value of the urinary Et/An ratio was set at ≥ 0.95 for detecting 5ARD2 patients and ≥ 0.99 for detecting carriers. Conclusions: The testosterone/DHT ratio was inaccurate in diagnosing 5ARD2 patients. When molecular analysis for the SRD5A2 gene is lacking, the urinary Et/An ratio may be a useful test to diagnose 5ARD2 patients and carriers. Copyright © 2021, International Journal of Endocrinology and Metabolism. |
46; 5 Alpha-reductase 2 deficiency; Androsterone; Dihydrotestosterone; Etiocholanolone; SRD5A2; Testosterone; XY DSD |
androstanolone; androsterone; chorionic gonadotropin; etiocholanolone; genomic DNA; steroid; steroid 5alpha reductase 2; testosterone; 5 alpha reductase deficiency; adolescent; adult; analytical parameters; area under the curve; Article; child; clinical article; clinical assessment; clinical feature; competitive ELISA; controlled study; cost benefit analysis; diagnostic accuracy; diagnostic value; disorder of sex development; female; genetic analysis; hormone urine level; human; human tissue; Indonesia; infant; male; molecular biology; neutrophil lymphocyte ratio; newborn; receiver operating characteristic; serum testosterone dihydrotestosterone ratio; testosterone blood level; urinary etiocholanolone androsterone ratio |
Kowsar Medical Institute |
1726913X |
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Article |
Q3 |
652 |
7699 |
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432 |
Aitken R.J., Curry B.J., Shokri S., Pujianto D.A., Gavriliouk D., Gibb Z., Whiting S., Connaughton H.S., Nixon B., Salamonsen L.A., Baker M.A. |
7201959888;56908506100;8856710600;8745734300;56926729700;36650800200;55363694400;55488741500;34571659200;7005800278;57201355280; |
Evidence that extrapancreatic insulin production is involved in the mediation of sperm survival |
2021 |
Molecular and Cellular Endocrinology |
526 |
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111193 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101239641&doi=10.1016%2fj.mce.2021.111193&partnerID=40&md5=dd3268ec7434c8487b5f42a0d81d0e4a |
Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Family Fertility Centre, Ashford Specialist CentreSA 5035, Australia; Hudson Institute of Medical Research, Centre for Reproductive Health, Monash UniversityVIC 3168, Australia |
Aitken, R.J., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Curry, B.J., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Shokri, S., Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Pujianto, D.A., Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Gavriliouk, D., Family Fertility Centre, Ashford Specialist CentreSA 5035, Australia; Gibb, Z., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Whiting, S., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Connaughton, H.S., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Nixon, B., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Salamonsen, L.A., Hudson Institute of Medical Research, Centre for Reproductive Health, Monash UniversityVIC 3168, Australia; Baker, M.A., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia |
Evidence is presented for expression of the insulin receptor on the surface of mammalian spermatozoa as well as transcripts for the receptor substrate adaptor proteins (IRS1-4) needed to mediate insulin action. Exposure to this hormone resulted in insulin receptor phosphorylation (pTyr972), activation of AKT (pSer473) and the stimulation of sperm motility. Intriguingly, the male germ line is also shown to be capable of generating insulin, possessing the relevant mRNA transcript and expressing strong immunocytochemical signals for both insulin and C-peptide. Insulin could be released from the spermatozoa by sonication in a concentration-dependent manner but was not secreted in response to glucose, fructose or stimulation with progesterone. However, insulin release could be induced by factors present in human uterine lavages. Furthermore, the endometrium was also shown to possess the machinery for insulin production and action (mRNA, insulin, C-peptide, proprotein convertase and insulin receptor), releasing insulin into the uterine lumen prior to ovulation. These studies emphasize the fundamental importance of extra-pancreatic insulin in regulating the reproductive process, particularly in the support of spermatozoa on their perilous voyage to the site of fertilization. © 2021 Elsevier B.V. |
AKT-1; Apoptosis; Insulin; Motility; Spermatozoa |
C peptide; fructose; glucose; insulin; insulin receptor; messenger RNA; progesterone; proprotein convertase 1; proprotein convertase 3; protein kinase B; serine proteinase; unclassified drug; C peptide; insulin; insulin receptor; insulin receptor substrate; isoprotein; adult; animal tissue; Article; controlled study; enzyme activation; female; fertilization; human; immunocytochemistry; insulin release; male; mouse; nested polymerase chain reaction; nonhuman; ovulation; protein function; protein phosphorylation; protein RNA binding; real time polymerase chain reaction; spermatozoon motility; animal; biosynthesis; cell survival; cytology; endometrium; epithelium; germ cell; mammal; metabolism; pancreas; rat; spermatozoon; uterus; Animals; C-Peptide; Cell Survival; Endometrium; Epithelium; Fe |
Elsevier Ireland Ltd |
03037207 |
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33610643 |
Article |
Q1 |
1296 |
2909 |
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433 |
Jiamsakul A., Azwa I., Zhang F., Yunihastuti E., Ditangco R., Kumarasamy N., Ng O.T., Chan Y.-J., Ly P.S., Choi J.Y., Lee M.-P., Pujari S., Kiertiburanakul S., Chaiwarith R., Merati T.P., Sangle S., Khusuwan S., Sim B.L.H., Avihingsanon A., Do C.D., Tanuma J., Ross J., Law M., the TREAT Asia HIV Observational Database of IeDEA Asia-Pacific |
55285745500;55553159100;55503803800;57221273925;55406840800;7003549856;57203665233;33667461800;9743902800;48761023600;56143671100;57205894660;6506539792;57203665049;57203678680;6602877716;56166613100;9242778900;57200282477;56658396600;57208428839;57193109926;57222965808; |
Treatment modification after second-line failure among people living with HIV in Asia-Pacific |
2021 |
Antiviral Therapy |
25 |
7 |
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377 |
387 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106544855&doi=10.3851%2fIMP3388&partnerID=40&md5=485e6ef464b90e2346135f1d92ba9394 |
The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia; University of Malaya Medical Centre, Kuala Lumpur, Malaysia; Beijing Ditan Hospital, Capital Medical University, Beijing, China; Working Group on AIDS, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Research Institute for Tropical Medicine, Manila, Philippines; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), The Voluntary Health Services (VHS), Chennai, India; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; Taipei Veterans General Hospital, Taipei, Taiwan; National Center for HIV/AIDS, Dermatology and STDs, University of Health Sciences, Phnom Penh, Cambodia; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, South Korea; Queen Elizabeth Hospital, Yau Ma Tei, Hong Kong; Institute of Infectious Diseases, Pune, India; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Research Institute for Health Sciences, Chiang Mai, Thailand; Faculty of Medicine, Udayana University, Sanglah Hospital, Bali, Indonesia; BJ Government Medical College, Sassoon General Hospital, Pune, India; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Hospital Sungai Buloh, Sungai Buloh, Malaysia; HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Bach Mai Hospital, Hanoi, Viet Nam; National Center for Global Health and Medicine, Tokyo, Japan; TREAT Asia, AmfAR, The Foundation for AIDS Research, Bangkok, Thailand |
Jiamsakul, A., The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia; Azwa, I., University of Malaya Medical Centre, Kuala Lumpur, Malaysia; Zhang, F., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Yunihastuti, E., Working Group on AIDS, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ditangco, R., Research Institute for Tropical Medicine, Manila, Philippines; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), The Voluntary Health Services (VHS), Chennai, India; Ng, O.T., Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; Chan, Y.-J., Taipei Veterans General Hospital, Taipei, Taiwan; Ly, P.S., National Center for HIV/AIDS, Dermatology and STDs, University of Health Sciences, Phnom Penh, Cambodia; Choi, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, South Korea; Lee, M.-P., Queen Elizabeth Hospital, Yau Ma Tei, Hong Kong; Pujari, S., Institute of Infectious Diseases, Pune, India; Kiertiburanakul, S., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chaiwarith, R., Research Institute for Health Sciences, Chiang Mai, Thailand; Merati, T.P., Faculty of Medicine, Udayana University, Sanglah Hospital, Bali, Indonesia; Sangle, S., BJ Government Medical College, Sassoon General Hospital, Pune, India; Khusuwan, S., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Sim, B.L.H., Hospital Sungai Buloh, Sungai Buloh, Malaysia; Avihingsanon, A., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Do, C.D., Bach Mai Hospital, Hanoi, Viet Nam; Tanuma, J., National Center for Global Health and Medicine, Tokyo, Japan; Ross, J., TREAT Asia, AmfAR, The Foundation for AIDS Research, Bangkok, Thailand; Law, M., The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia; the TREAT Asia HIV Observational Database of IeDEA Asia-Pacific |
Background: The World Health Organization recommends continuation with the failing second-line regimen if third-line option is not available. We investigated treatment outcomes among people living with HIV in Asia who continued with failing second-line regimens compared with those who had treatment modifications after failure. Methods: Treatment modification was defined as a change of two antiretrovirals, a drug class change or treatment interruption (TI), all for >14 days. We assessed factors associated with CD4 changes and undetectable viral load (UVL <1,000 copies/ml) at 1 year after second-line failure using linear and logistic regression, respectively. Survival time was analysed using competing risk regression. Results: Of the 328 patients who failed second-line ART in our cohorts, 208 (63%) had a subsequent treatment modification. Compared with those who continued the failing regimen, the average CD4 cell increase was higher in patients who had a modification without TI (difference =77.5, 95% CI 35.3, 119.7) while no difference was observed among those with TI (difference =-5.3, 95% CI -67.3, 56.8). Compared with those who continued the failing regimen, the odds of achieving UVL was lower in patients with TI (OR=0.18, 95% CI 0.06, 0.60) and similar among those who had a modification without TI (OR=1.97, 95% CI 0.95, 4.10), with proportions of UVL 60%, 22% and 75%, respectively. Survival time was not affected by treatment modifications. Conclusions: CD4 cell improvements were observed in those who had treatment modification without TI compared with those on the failing regimen. When no other options are available, maintaining the same failing ART combination provided better VL control than interrupting treatment. © 2020 International Medical Press |
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Human immunodeficiency virus proteinase inhibitor; nonnucleoside reverse transcriptase inhibitor; RNA directed DNA polymerase inhibitor; adult; antiretroviral therapy; Article; Asia; CD4 lymphocyte count; clinical outcome; cohort analysis; confidence interval; controlled study; female; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; linear regression analysis; logistic regression analysis; major clinical study; male; odds ratio; survival time; treatment duration; treatment modification; undetectable virus load; virus load |
International Medical Press Ltd |
13596535 |
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33843656 |
Article |
Q2 |
747 |
6553 |
|
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438 |
Hadi I.A.N., Ekaputri M., Baskoro J.C., Winarsih N.S. |
57345259600;57242005600;57242005500;57211183552; |
Association between duration of untreated psychosis and executive function in early-onset psychosis |
2021 |
Journal of Affective Disorders Reports |
4 |
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100068 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125606448&doi=10.1016%2fj.jadr.2020.100068&partnerID=40&md5=fa88cf50f43a9cc6eaaa94d1676fa411 |
Medical Doctor Graduate, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Psychiatry Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hopsital, Jakarta, Indonesia |
Hadi, I.A.N., Medical Doctor Graduate, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ekaputri, M., Medical Doctor Graduate, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Baskoro, J.C., Medical Doctor Graduate, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Winarsih, N.S., Department of Psychiatry Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hopsital, Jakarta, Indonesia |
Introduction: Psychosis is a severe mental illness that causes impaired executive function (EF). The prolonged duration of untreated psychosis (DUP) is one of the negative factors in the course of psychosis. However, the results of previous studies remain inconsistent. The aim of this study is to find out the association between DUP and all the components of EF, i.e. behavioral regulation and metacognition with all their subdomains. Method: This was a cross-sectional study involving patients with early onset-psychosis aged 5–18 years old. DUP were collected from medical records, whereas sociodemographic data were collected by interview and EF was measured using the Behavior Rating Inventory of Executive Function-Parent Indonesian Version questionnaire. Results: Total 50 subjects were included in the study. The median age of subjects was 15.9 ± 1.9 years old with schizophrenia as majority of diagnosis (58%). Median DUP was 2 (0; 84) months. Subjects were divided into short DUP (≤2 months) and long DUP (>2 months) group. A significant association was found between long DUP (>2 months) and higher Global Executive Composite (GEC) score indicating poorer function, which consisted of Behavioral Regulation Index (BRI) and Metacognition Index (MI) (p = 0.001, p = 0.007, p = 0.001, respectively). All subdomains of BRI and MI, except material organization, showed significant associations with DUP. Conclusion: There was a significant association between long DUP (>2 months) and poorer EF in early-onset psychosis. © 2021 The Author(s) |
Behavioral regulation; Duration of untreated psychosis; Early-onset psychosis; Executive function; Metacognition |
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Elsevier B.V. |
26669153 |
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Article |
#N/A |
#N/A |
#N/A |
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439 |
Restuti R., Sriyana A., Priyono H., Saleh R. |
55261428300;57203022550;57201550021;57391850200; |
Postauricular Cutaneous Mastoid Fistula Closure with Combination of Bilobed Flap and Fibro-Muscular-Periosteal Flap: A Case Series |
2021 |
Indian Journal of Otology |
27 |
2 |
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116 |
119 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122022487&doi=10.4103%2findianjotol.indianjotol_10_21&partnerID=40&md5=dfd65407309ade3f15f32833b03bb0ef |
Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia |
Restuti, R., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Sriyana, A., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Priyono, H., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Saleh, R., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia |
Chronic suppurative otitis media (CSOM) with cholesteatoma can present with intratemporal complications such as postauricular subperiosteal abscess with or without fistula. In some postauricular cutaneous mastoid fistula cases, direct closure of the wound is not possible due to skin tension, leading to skin necrosis and postoperative recurrent cutaneous fistula. Here, we describe a surgical technique using a combination of a bilobed flap and a fibro-muscular-periosteal flap for fistula closure on a 31-year-old and a 35-year-old female with postauricular cutaneous mastoid fistula due to CSOM. All patients were successfully managed with no fistula recurrence. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Bilobed flap; cholesteatoma; chronic suppurative otitis media; postauricular cutaneous mastoid fistula |
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Wolters Kluwer Medknow Publications |
09717749 |
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Article |
Q4 |
174 |
21127 |
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440 |
Rinaldhy K., Yani A., Tamba R.P. |
57325189500;57215433374;47761736600; |
Papaverine for the prevention of anastomosis leakage after intussusception management in rat model |
2021 |
Surgical Chronicles |
26 |
2 |
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162 |
164 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118534016&partnerID=40&md5=b67121e208a15e9402e0b83764f168b7 |
Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia |
Rinaldhy, K., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia; Yani, A., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia; Tamba, R.P., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia |
Background. The most common complication of surgical management for intussusception is anastomosis leakage. Warm normal saline application, especially on the bowel with a doubtful viability, is thought to cause vasodilation and subsequently reduce the resected bowel requirement. This research compared the effect of topical warm normal saline and papaverine on collagen grading and incidence of anastomosis leakage of the intussusception model in rats. Methods. Ileo-ileal intussusception was created on 21 Sprague-Dawley rats. Groups included control group, normal saline group, and papaverine group. Intussusceptions were then reduced and given topical warm normal saline or papaverine according to each group. Afterward, each bowel was resected, and an end-to-end anastomosis was created. After five days, laparotomy was performed to assess anastomosis leakages. Moreover, a collagen grading assessment was performed on the anastomosis. Results. The papaverine group had the highest collagen grade and no anastomosis leakage. There was no significant association between treatments and the incidence of anastomosis leakage (p=0.174), but treatments were significantly associated with collagen grade (p=0.014). Collagen grade was significantly associated with anastomosis leakage (p=0.01). Conclusion. Findings suggested that the topical application of papaverine is associated with an increase in collagen grading and higher collagen grade is associated with a decrease of anastomosis leakage. © 2021 Surgical Society of Northern Greece. All rights reserved. |
Anastomosis leakage; Collagen; Intussusception; Normal saline; Papaverine. |
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Surgical Society of Northern Greece |
11085002 |
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Article |
Q4 |
102 |
30883 |
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