No records
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441 |
Sukmawati D., Junaidi H., Syaidah R. |
55615650900;57202926303;55418885900; |
Human platelet-rich plasma as a biological stimulant for proliferation and differentiation of mesenchymal stem cells |
2021 |
Biomedicine (India) |
41 |
2 |
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168 |
173 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117427828&doi=10.51248%2f.v41i2.777&partnerID=40&md5=08fabc44956a1de6990d42feb38813ba |
Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia |
Sukmawati, D., Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Junaidi, H., Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Syaidah, R., Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia |
Platelet is one of the cells within the blood that have potential in regenerative therapy. Recently platelet-related products got special attention due to the abundance of growth factors and easy availability and processing. With the robust in cell-based therapy, platelet-rich plasma (PRP) has been intensively studied for its potential to substitute the fetal bovine serum (FBS) as the supplement in cell culture. Our study aimed to investigate the use of human PRP in mesenchymal stem cells (MSC) culture and its related effect on stem cell biology. We searched in vitro studies that used human PRP as a supplementing factor on human MSCs culture. From the initial 172 studies, 14 studies fulfilled the selection criteria and were analysed. The results showed that the sources of MSCs were varied, including adipose tissue, bone marrow, and dental tissue. The PRP concentration showing the best effects was ranged from 10 to 20%. In addition, most of the studies demonstrated the superiority of PRP to FBS in promoting the proliferation and differentiation of MSCs in vitro. Therefore, PRP could be an alternative to FBS in supporting a xeno-free culture system. Studies are needed to reveal the mechanism of PRP in maintaining the physiology of MSCs. © 2021, Indian Association of Biomedical Scientists. All rights reserved. |
Cell culture; Differentiation; Mesenchymal stem cells; Platelet-rich plasma; Proliferation; Xeno-free |
adipose tissue; Article; bone marrow; cell differentiation; cell proliferation; controlled study; human; human cell; in vitro study; mesenchymal stem cell; thrombocyte rich plasma; tooth tissue; xeno-free culture |
Indian Association of Biomedical Scientists |
09702067 |
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Article |
Q4 |
106 |
29384 |
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442 |
Legiawati L., Raissa, Santoso I.D., Lubis F.F. |
57202804484;57240272100;57219513443;57239954700; |
Comparison between clinical diagnosis with and without dermoscopy in the assessment of hair disorders |
2021 |
Journal of Pakistan Association of Dermatologists |
31 |
2 |
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201 |
205 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113937212&partnerID=40&md5=c56b73079d0a2b354502f693b7d4fa6e |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Tarumanegara, Jakarta, Indonesia |
Legiawati, L., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Raissa, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Santoso, I.D., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Tarumanegara, Jakarta, Indonesia; Lubis, F.F., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Background: Hair dermoscopy or trichoscopy is a tool used to find hair abnormalities more clearly. Morphologic feature of skin and hair abnormalities becomes more visible under this tool compared with naked eye. It helps to diagnose hair disorders faster and can be used for follow up treatment in patients. The purpose of this study is to compare superiority between clinical diagnosis alone and with addition of dermoscopy tool in the assessment of hair disease. Methods: Research was conducted in October 2018 in a boarding school in West Java, Indonesia. This was a cross-sectional descriptive study. Statistical analysis was done using SPSS Statistics 20.0. Data were collected from 127 subjects through anamnesis, general physical examination and dermatological findings, pull test, dermoscopy, and photographs of scalp and hair lesions. Results: The highest incidence of hair disorder in this study found by clinical examination and dermoscopy was pediculosis capitis, with a total of 86 subjects (67.7%). From the comparison between clinical examination and dermoscopy, we found that dermoscopy was superior for diagnosis. As much as 43 cases of hair disorders which were not detected on clinical examination screening were found by dermoscopy. Out of 127 children, there were 49 subjects with hair disorders found in clinical examination and 92 subjects found by dermoscopy. Conclusion: Dermoscopy as a non-invasive tool which plays an important role in determining the diagnosis of hair disorder. © 2021 Pakistan Association of Dermatologists. All rights reserved. |
Dermoscopy; Diagnosis; Hair disease; Lice infestations; Pediculosis capitis |
adolescent; alopecia; Article; child; clinical examination; controlled study; cross-sectional study; descriptive research; epiluminescence microscopy; female; hair; hair disease; human; Indonesia; major clinical study; male; pediculosis capitis; scar; sebaceous nevus; seborrheic dermatitis |
Pakistan Association of Dermatologists |
15609014 |
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Article |
Q4 |
129 |
25503 |
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444 |
Wardoyo E.Y., Nainggolan G., Hustrini N.M., Setiati S. |
57219411333;23498775400;57200424892;14325991900; |
Factors Associated with Arterial Stiffness in Chronic Hemodialysis Patients in Jakarta: The Role of Hemodialysis Frequency and Pentraxin 3 |
2021 |
Acta medica Indonesiana |
53 |
2 |
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177 |
183 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111583410&partnerID=40&md5=48c271443cfc8fc3a9b8370bf863e403 |
Department of Internal Medicine, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Wardoyo, E.Y., Department of Internal Medicine, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Nainggolan, G.; Hustrini, N.M.; Setiati, S. |
BACKGROUND: arterial stiffness is a mortality predictor in hemodialysis patients, hemodialysis induces inflammation, marked by an intradialysis increase in the inflammatory marker pentraxin 3 (PTX3). Arterial stiffness in twice-weekly hemodialysis patients in Indonesia is lower than has been found in studies of thrice-weekly patients. This study therefore aims to determine the factors associated with arterial stiffness, focusing on the role of hemodialysis frequency and PTX3. METHODS: a cross-sectional study was conducted at Cipto Mangunkusumo Hospital, Fatmawati Hospital, and Medistra Hospital involving patients with twice- and thrice-weekly hemodialysis. Arterial stiffness was measured by carotid-femoral pulse wave velocity after hemodialysis, and blood samples for PTX3 testing were taken before hemodialysis. Bivariate and multivariate analyses were performed using chi-squared tests and logistic regression. RESULTS: out of 122 subjects, 82 underwent twice-weekly hemodialysis. There was no difference in arterial stiffness between patients with twice- and thrice-weekly hemodialysis. In bivariate analysis, PTX3, cardiovascular disease, dialysis vintage had p values of <0.05, while the subsequent multivariate analysis showed that PTX3>2.3 ng/ml was associated with arterial stiffness (adjusted OR 5.18; 95% CI 1.07-24.91), as well as cardiovascular disease (adjusted OR 3.67; 95% CI 1.40-10.55), LDL (adjusted OR 3.10; 95% CI 1.04-9.24), and dialysis vintage (adjusted OR 2.72; 95% CI 1.001-7.38). CONCLUSION: predialysis PTX3 levels above 2.3 ng/ml were associated with arterial stiffness. There was no difference in arterial stiffness between patients with twice- and thrice-weekly hemodialysis. |
arterial stiffness; hemodialysis frequency; pentraxin 3; pulse wave velocity |
biological marker; C reactive protein; pentraxin 3; serum amyloid P; adult; aged; arterial stiffness; blood; blood flow velocity; chronic kidney failure; clinical trial; cross-sectional study; female; hemodialysis; human; Indonesia; male; metabolism; middle aged; multicenter study; multivariate analysis; physiology; pulse wave; statistical model; Adult; Aged; Biomarkers; Blood Flow Velocity; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Indonesia; Kidney Failure, Chronic; Logistic Models; Male; Middle Aged; Multivariate Analysis; Pulse Wave Analysis; Renal Dialysis; Serum Amyloid P-Component; Vascular Stiffness |
NLM (Medline) |
01259326 |
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34251346 |
Article |
Q3 |
321 |
14162 |
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445 |
Pramono L.A., Yunir E., Tarigan T.J.E., Nusanti S., Aman R.A., Suroyo I. |
37063602400;36520254800;36057746500;57189727162;57226434769;57204106272; |
Giant Recurrence Pituitary Adenoma After Three Times Transphenoidal Removal Surgery, One Craniotomy Procedure, and 30 Doses of External Radiotherapy |
2021 |
Acta medica Indonesiana |
53 |
2 |
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221 |
224 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111572434&partnerID=40&md5=3fbf4691ce27b57e71d3a91134445173 |
1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Indonesia. 2. Department of Public Health and Nutrition, School of Medicine and Health Sciences Universitas Katolik Indonesia Atma Jaya - Department of Internal Medicine St Carolus HospitalJakarta, Indonesia |
Pramono, L.A., 1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Indonesia. 2. Department of Public Health and Nutrition, School of Medicine and Health Sciences Universitas Katolik Indonesia Atma Jaya - Department of Internal Medicine St Carolus HospitalJakarta, Indonesia; Yunir, E.; Tarigan, T.J.E.; Nusanti, S.; Aman, R.A.; Suroyo, I. |
This is a case of 42nd year-old woman with history of sight loss in her both eyes. She experienced headache and visual field decrease gradually since 2014. After several laboratory and imaging examinations, from her dynamic pituitary magnetic resonance imaging (MRI), it is concluded that she had a giant adenoma of the pituitary gland which compressed to her optic chiasm. From her pituitary laboratory hormone panel, it is revealed that the tumor is a non-functioning pituitary adenoma. From the neuro-ophthalmology (campimetry) examinations, she had papillae atrophy in her both eyes and also bilateral temporal hemianopia. |
Giant Recurrence Pituitary Adenoma; Radiotherapy; Transphenoidal Removal Surgery |
adenoma; adult; case report; craniotomy; female; hemianopia; human; hypophysis tumor; nuclear magnetic resonance imaging; optic nerve; pathology; tumor recurrence; Adenoma; Adult; Craniotomy; Female; Hemianopsia; Humans; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Optic Nerve; Pituitary Neoplasms |
NLM (Medline) |
01259326 |
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34251352 |
Article |
Q3 |
321 |
14162 |
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447 |
Nugroho P., Lydia A., Suhardjono S., Harimurti K. |
55987056300;8451287200;57218776121;23473513200; |
Association of BsmI Polymorphisms in the Vitamin D Receptor Gene Among Indonesian Population with Diabetic Kidney Disease |
2021 |
Acta medica Indonesiana |
53 |
2 |
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149 |
155 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111468637&partnerID=40&md5=791ec67dac5f5065a522a04484329da4 |
Division of Nephrology and Hypertension, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo HospitalJakarta, Indonesia |
Nugroho, P., Division of Nephrology and Hypertension, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo HospitalJakarta, Indonesia; Lydia, A.; Suhardjono, S.; Harimurti, K. |
BACKGROUND: Diabetic kidney disease (DKD), as a common cause of end-stage renal disease (ESRD), is a chronic complication of diabetes mellitus (DM). It has been established that vitamin D deficiency is one of DKD risk factors, which may be related to vitamin D receptor (VDR) polymorphisms. This study aimed to analyze the association between VDR polymorphisms and DKD in Indonesian population, also risk factors that influence it. METHODS: a cross-sectional study was conducted in Type 2 DM patients who visited internal medicine outpatient clinic at Dr. Cipto Mangunkusumo Hospital, Jakarta, from November 2014 until March 2015. Data collection includes characteristics of subjects and laboratory examination, including BsmI polymorphisms in the vitamin D receptor gene. Patients with acute and severe disease were excluded from the study. Bivariate and multivariate analyses were done. RESULTS: of 93 DM subjects, 42 (45.2%) subjects were without DKD and 51 (54.8%) subjects had DKD. Most of the subjects had the Bb genotype (89.2%), with no subject having the BB genotype. The proportions of the B and b alleles were 44.6% and 55.4%, respectively. There is no association between BsmI polymorphisms in the vitamin D receptor gene and DKD (OR = 1.243; CI 95% 0.334-4.621; p value = 0.751). CONCLUSION: the profile of BsmI polymorphisms in the vitamin D receptor gene in the Indonesian population were genotypes Bb (89.2%) and bb (10.8%). There was no association between BsmI polymorphisms in the vitamin D receptor gene and DKD. Duration of DM more than five years influenced the association between those variables. |
BsmI; diabetic kidney disease; Indonesia-Malay race; polymorphisms; vitamin D receptor (VDR) gene |
calcitriol receptor; VDR protein, human; aged; blood; case control study; complication; cross-sectional study; diabetic nephropathy; female; genetic polymorphism; genetics; genotype; human; Indonesia; male; middle aged; non insulin dependent diabetes mellitus; risk factor; very elderly; Aged; Aged, 80 and over; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Genotype; Humans; Indonesia; Male; Middle Aged; Polymorphism, Genetic; Receptors, Calcitriol; Risk Factors |
NLM (Medline) |
01259326 |
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34251342 |
Article |
Q3 |
321 |
14162 |
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448 |
Syam A.F., Pitoyo C.W., Suhendro S., Zulkarnain B., Indrasari N.D., Aditianingsih D., Irawan C., Susilo A., Rumende C.M., Wijaya I.P., Ibrahim F., Rasmin M., Alwi I., Makmun D. |
8443384400;26022606900;8443626100;57226403717;6506289872;56312263600;28767651600;57217867079;14325966300;57221504958;57226400046;15754578700;15055173800;16638046900; |
Tocilizumab as a Treatment for 'Cytokine Storm Syndrome' in COVID-19: A Case Report |
2021 |
Acta medica Indonesiana |
53 |
2 |
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194 |
201 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111460182&partnerID=40&md5=9fddc7ae8a7dbf93ea0a07158c0ab2b2 |
Fellow of the American College of Physicians; Division of Gastroenterology, Dept. of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Syam, A.F., Fellow of the American College of Physicians; Division of Gastroenterology, Dept. of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pitoyo, C.W.; Suhendro, S.; Zulkarnain, B.; Indrasari, N.D.; Aditianingsih, D.; Irawan, C.; Susilo, A.; Rumende, C.M.; Wijaya, I.P.; Ibrahim, F.; Rasmin, M.; Alwi, I.; Makmun, D. |
Coronavirus disease 19 (COVID-19) which is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been a problem worldwide, particularly due to the high rate of transmission and wide range of clinical manifestations. Acute respiratory distress syndrome (ARDS) and multiorgan failure are the most common events observed in severe cases and can be fatal. Cytokine storm syndrome emerges as one of the possibilities for the development of ARDS and multiorgan failure in severe cases of COVID-19. This case report describes a case of a 53-year-old male patient who has been diagnosed with COVID-19. Further evaluation in this patient showed that there was a marked increase in IL-6 level in blood accompanied with hyperferritinemia, which was in accordance with the characteristic of cytokine storm syndrome. Patient was treated with tocilizumab, a monoclonal antibody and is an antagonist to IL-6 receptor. The binding between tocilizumab and IL-6 receptors effectively inhibit and manage cytokine storm syndrome. Although this case report reported the efficacy of tocilizumab in managing cytokine storm syndrome, tocilizumab has several adverse effects requiring close monitoring. Further clinical randomized control trial is required to evaluate the efficacy and safety of tocilizumab administration in participants with various clinical characteristics and greater number of subjects. |
acute respiratory distress syndrome (ARDS); COVID-19; SARS-CoV-2; Tocilizumab |
biological marker; interleukin 6; monoclonal antibody; tocilizumab; blood; case report; complication; cytokine release syndrome; human; male; middle aged; Antibodies, Monoclonal, Humanized; Biomarkers; COVID-19; Cytokine Release Syndrome; Humans; Interleukin-6; Male; Middle Aged; SARS-CoV-2 |
NLM (Medline) |
01259326 |
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34251348 |
Article |
Q3 |
321 |
14162 |
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450 |
Pujianto D., Oktarina M., Sharma Sharaswati I., Yulhasri Y. |
8745734300;57225172840;57225177505;57225180520; |
Hydrogen peroxide has adverse effects on human sperm quality parameters, induces apoptosis, and reduces survival |
2021 |
Journal of Human Reproductive Sciences |
14 |
2 |
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121 |
128 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109421886&doi=10.4103%2fjhrs.jhrs_241_20&partnerID=40&md5=b51e205fbcc1300b22e8e8898e7a1c02 |
Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pujianto, D., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktarina, M., Master Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sharma Sharaswati, I., Master Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: One of the causes of male fertility disorders is the exposure of oxidative stress on the human sperm. Understanding the mechanism of disturbance is important to develop a better treatment for infertile or subfertile patients. Aims: The aim of this study was to analyze the effects of hydrogen peroxide (H2O2) on human sperm quality parameters and cell survival. Settings and Design: This study used an experimental design. Materials and Methods: Sperm cells from 15 donors were washed in a Percoll gradient and dissolved in Biggers, Whitter, and Whittingham medium. Cells were incubated with H2O2at various concentrations from 0 to 250 μM for 2 h. Sperm viability was examined by eosin assay, sperm kinetic by computer-assisted sperm analyzer, sperm penetration by cervical mucus penetration assay, and membrane integrity by hypo-osmotic swelling test. Sperm capacitation, apoptosis, and cell survival were analyzed using western immunoblotting. Statistical Analysis Used: One-way ANOVA on SPSS 21 combined with post hoc LSD test was used to analyze differences among the groups. A P < 0.05 was considered significant. Results: Sperm viability and kinetic were significantly reduced at H2O2concentrations of 200 and 250 μM. H2O2reduced sperm capability to penetrate cervical mucus and also damage cell membrane integrity at all concentrations used. H2O2significantly inhibited sperm capacitation, indicated by reduced total tyrosine phosphorylation. H2O2exposure stimulated activation of caspase 3 and significantly reduced phosphorylated AKT at all concentrations used. Conclusions: H2O2comprehensively inhibits sperm qualities related to the capacity to fertilize oocyte, stimulates caspase activity, and inhibits cell survival. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
AKT; capacitation; caspase; hydrogen peroxide; sperm |
caspase 3; hydrogen peroxide; malonaldehyde; protein kinase B; adverse event; analysis of variance; apoptosis; Article; cell survival; clinical article; densitometry; human; human cell; immunoblotting; kinetics; lipid peroxidation; male; male infertility; oxidative stress; post hoc analysis; protein phosphorylation; sperm capacitation; sperm preparation; sperm quality; sperm viability; spermatozoon penetration; uterine cervix mucus |
Wolters Kluwer Medknow Publications |
09741208 |
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Article |
Q3 |
484 |
10359 |
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451 |
Christian, Puruhita N., Himawan A., Muis S.F., Fasitasari M., Pangarsa E.A., Panigoro S.S., Sutandyo N. |
57224896360;57224902090;57224910728;57193264578;57192872474;57204907532;56790104300;26028099200; |
Fat intake in Javanese breast cancer patients: Any difference? |
2021 |
Bali Medical Journal |
10 |
1 |
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320 |
324 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108565233&doi=10.15562%2fbmj.v10i1.2173&partnerID=40&md5=7840397cf684896b0d8d5929cbb1e87c |
Resident of Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Clinical Nutrition Department, SMC Telogorejo Hospital, Semarang, Indonesia; Faculty of Medicine, Universitas Islam Sultan Agung-Sultan Agung Islamic Hospital Semarang, Indonesia; Hematology-Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Oncology Surgery Division, Surgery Department, Faculty of Medicine, Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Hematology-Oncology Division, Internal Medicine Department, Dharmais National Cancer Centre Hospital, Jakarta, Indonesia |
Christian, Resident of Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Puruhita, N., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia, Clinical Nutrition Department, SMC Telogorejo Hospital, Semarang, Indonesia; Himawan, A., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia, Clinical Nutrition Department, SMC Telogorejo Hospital, Semarang, Indonesia; Muis, S.F., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Fasitasari, M., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia, Faculty of Medicine, Universitas Islam Sultan Agung-Sultan Agung Islamic Hospital Semarang, Indonesia; Pangarsa, E.A., Hematology-Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Panigoro, S.S., Oncology Surgery Division, Surgery Department, Faculty of Medicine, Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Sutandyo, N., Hematology-Oncology Division, Internal Medicine Department, Dharmais National Cancer Centre Hospital, Jakarta, Indonesia |
Background: Breast cancer is the second most prevalent women’s malignancy in Central Java. The risk of breast cancer incidence drops by 2.5 times for breast cancer if fat consumption is reduced by 50%, although not all types of fat intake increase the risk of breast cancer incidence. Fat consumption in Indonesia increased by 11% in the last 7 years. The study aims to analyze the differences in fat intake between breast cancer subjects and healthy subjects. Methods: This study is a cross-sectional study. We invited 45 outpatients diagnosed with breast cancer in Kariadi Hospital from January to August 2019 as well as 45 healthy subjects who are relatives or friends of the patients who met the inclusion criteria to participate in this study. Various types of fat intake were measured with quantitative food frequency questionnaires. The statistical analysis employed a chi-square test and Mann-Whitney test for non-parametric tests and an independent t-test for parametric data. Results: There was a significant difference in polyunsaturated fatty acid (PUFA) intake between breast cancer patients and healthy subjects (p=0.022). This study found no significant differences in total fat intake (p=0.677), saturated fatty acid (SFA) (p=0.368), monounsaturated fatty acid (MUFA) (p=0.593), omega 3 (p=0.095), omega 6 (p=0.092), and TFA (p=0.669) between breast cancer patients and healthy subjects. Conclusion: There is a significant difference in PUFA intake, but not in the other types of fat between breast cancer patients and healthy subjects. For further study, more precise and objective fat intake measurements may be achieved in studies with animal models. © 2021, Sanglah General Hospital. All rights reserved. |
Breast cancer; Fat; Intake; Nutrition |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
#N/A |
#N/A |
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452 |
Jusuf A.A., Viventius Y., Djaali W. |
57192275719;57223088537;57212479564; |
Comparison between the effectiveness of manual acupuncture and laser acupuncture at ex-b3 weiwanxiashu in a rat model of type 2 diabetes |
2021 |
JAMS Journal of Acupuncture and Meridian Studies |
14 |
2 |
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75 |
81 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107546334&doi=10.51507%2fj.jams.2021.14.2.75&partnerID=40&md5=e5fc6b12ab3bd259eeccdf3c7d1658af |
Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Acupuncture, RSUPN Dr. CiptoMangunkusumo, Jakarta, Indonesia; Universitas Negeri Jakarta, Jakarta, Indonesia |
Jusuf, A.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Viventius, Y., Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Acupuncture, RSUPN Dr. CiptoMangunkusumo, Jakarta, Indonesia; Djaali, W., Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Negeri Jakarta, Jakarta, Indonesia |
Background: Diabetes mellitus (DM) is a chronic metabolic disease characterized by increased blood sugar levels. The current management of DM to date has a target of controlling blood glucose, but the therapy cannot be separated from long-term drug side effects. Acupuncture can be an option as an adjunct therapy for DM. Objectives: The purpose of this study was to compare the effectiveness between manual acupuncture and laser acupuncture. Methods: This study was a randomized control experimental study with a pretest and posttest design using 24 male Sprague-Dawley rats divided into 4 groups: A normal group, a diabetes group, an acupuncture group, and a laser group. Manual acupuncture and laser acupuncture were performed 6 times in two weeks. Fasting blood glucose (FBG) levels, the cell density of Langerhans islets, and side effects were assessed and compared among the 4 groups. Results: The highest mean cell density of Langerhans islets was found in the laser and acupuncture group, and the lowest was found in the diabetes group. In the post hoc analysis, the normal, acupuncture, and the laser groups had a significantly higher mean cell density than the diabetes group. The lowest mean FBG level was in the laser group, followed by the acupuncture group, and the highest was in the diabetes group, but this difference was not significant. There were no serious side effects from the use of manual acupuncture or laser acupuncture. Conclusion: Both manual acupuncture and laser acupuncture can improve the histological findings of Langerhans islets in type 2 diabetic rats, and both are safe to use. © 2021 Korean Pharmacopuncture Institute. All rights reserved. |
EX-B3; Laser acupuncture; Manual acupuncture; Type 2 diabetes |
glucose; acupuncture; acupuncture point; animal experiment; animal model; Article; cell density; comparative effectiveness; controlled study; erythema; fasting; glucose blood level; laser therapy; male; meichong acupoint; non insulin dependent diabetes mellitus; nonhuman; pancreas islet; post hoc analysis; rat; streptozotocin-induced diabetes mellitus |
Medical Association of pharmacopuncture Institute |
20052901 |
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Article |
Q2 |
374 |
12741 |
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453 |
Yani A., Dorothy D., Amaliah R. |
57215433374;57224003330;57224001785; |
Influence of Intestinal Strangulation Release on Ischemiareperfusion Injury in Sprague Dawley Rats |
2021 |
Annals of African Surgery |
18 |
2 |
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90 |
95 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106736281&doi=10.4314%2fAAS.V18I2.6&partnerID=40&md5=611bcf09b29bda5c9a4b2e09279bdd15 |
Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Yani, A., Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Dorothy, D., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Amaliah, R., Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: In intestinal ischemia, reperfusion towards the injured intestine can cause further injury to the intestine itself and to remote organs. This research aimed to evaluate the influence of intestinal strangulation release (SR) before resection on the intestine outside margin of the strangulated intestine compared with subjects without intestinal strangulation release (WSR). Methods: Fourteen male Sprague Dawley rats were subjected to strangulation of one loop of the distal ileum for 4 h. In the SR group, the strangulated intestine was released for 5 min and then resected for necrotic parts. In the WSR group, the strangulated intestine was immediately resected WSR. The control group received a sham laparotomy. Four hours after the second laparotomy, the animals were sacrificed, and intestinal samples were taken for histomorphological analysis and measurement of intestinal malondialdehyde (MDA) level. Results: The injury on the histomorphological intestinal mucosa and intestinal MDA level were insignificantly higher in the SR group than in the WSR group (p>0.05). Conclusion: Intestinal SR before resection causes more tissue injury and oxidative stress on the intestine outside the strangulation section, but the difference is not statistically significant. © 2021 Surgical Society of Kenya. All rights reserved. |
Intestinal ischemia; Intestinal strangulation release; Intestine injury; Ischemia-reperfusion injury; Malondialdehyde |
ketamine; malonaldehyde; xylazine; animal experiment; animal model; animal tissue; Article; controlled study; histopathology; ileum; intestinal strangulation; intestine injury; intestine ischemia; intestine necrosis; laparotomy; male; nonhuman; oxidative stress; rat; reperfusion injury; sham procedure; small intestine obstruction; small intestine resection; Sprague Dawley rat |
Surgical Society of Kenya |
19999674 |
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Article |
Q4 |
114 |
27851 |
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