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826 |
Irawati Y., Soedarman S., Arianti A., Widyasari A., Reksodiputro M.H. |
57201260313;57222867991;57201999421;57280734100;35090488800; |
Multiple approaches for managing complex ophthalmic blunt trauma: A case report |
2021 |
International Medical Case Reports Journal |
14 |
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205 |
210 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104124100&doi=10.2147%2fIMCRJ.S304193&partnerID=40&md5=1d5a9d9b836b19267fc2e128d84efc72 |
Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irawati, Y., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Soedarman, S., Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Arianti, A., Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Widyasari, A., JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Reksodiputro, M.H., Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Ophthalmic trauma is defined as injuries affecting the ocular structures, including the globe, eyelid, lacrimal system, and surrounding orbital walls. Blunt trauma acts as the leading cause of injury and it may affect both the anterior and posterior parts of the globe. Prompt diagnosis, early management, and sustained follow-up are mandatory for an optimal outcome. Purpose: This report presents a one-step surgery management process for an intricate case of blunt facial trauma with complex ophthalmic and nasal injury. Patients and Methods: A 45-year-old male with blunt force trauma of the left eye from a wooden block, suffered from naso-orbital-ethmoidal fractures, eyelid laceration with canalicular, close-globe injuries of traumatic cataract and vitreous hemorrhage with retinal detachment. A simultaneous one-step surgery was performed by a trauma team of ophthalmological and ENT surgeons during the height of the COVID-19 pandemic to lessen the risk of cross-transmission. After ruling out the possibility of open-globe rupture, traumatic cataract extraction, retinal detachment surgery, the repair of an eyelid laceration with canalicular involvement, and septorhinoplasty were performed on concomitantly. Results: Anatomical success was achieved for the repair of the nasoorbitoethmoidal (NOE) type II fracture and close-globe injuries, including the anatomical reattachment of the retina. However, the functional outcome remained unsatisfactory. Visual acuity failed to show further improvement at a later follow-up. Traumatic optic neuropathy was, at the final follow-up, considered to be the cause of the suboptimal visual acuity. Conclusion: A single-step multi-procedure for a complex ophthalmic blunt trauma, as demonstrated in this case, may be beneficial for reducing the complications that might arise due to treatment delay. The complex nature of the injury, however, creates the higher possibility for residual post-operative complications. Risks of residual functional impairment should be considered in such complex trauma prior to surgery, to determine the surgical prognostic value and provide appropriate consent to the patient. © 2021 Irawati et al. |
Blunt trauma; Canalicular laceration; Closed-globe injury; Facial injury; Nasal fracture; Ocular trauma |
adult; Article; blunt trauma; case report; cataract; clinical article; clinical examination; conjunctival hemorrhage; crackle; epistaxis; ethmoid bone; eye injury; eyelid closure; eyelid disease; eyelid reconstruction; face fracture; human; hyphema; Indonesia; laceration; lens implantation; male; middle aged; nasopharyngeal swab; nose injury; nose septum reconstruction; occupational accident; orbit fracture; postoperative care; retina detachment; ultrasound; visual acuity; vitrectomy; vitreous hemorrhage |
Dove Medical Press Ltd |
1179142X |
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Article |
Q4 |
198 |
19482 |
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827 |
Haryanto T., Suhartanto H., Arymurthy A.M., Kusmardi K. |
57193869197;16423632300;36815724000;56966625300; |
Conditional sliding windows: An approach for handling data limitation in colorectal histopathology image classification |
2021 |
Informatics in Medicine Unlocked |
23 |
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100565 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104075953&doi=10.1016%2fj.imu.2021.100565&partnerID=40&md5=dceb8084f0a81f31189f09578a878d62 |
Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Department of Computer Science, IPB University, Kampus IPB Dramaga, Bogor, 16680, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Kampus Universitas Indonesia, Jakarta, Indonesia |
Haryanto, T., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia, Department of Computer Science, IPB University, Kampus IPB Dramaga, Bogor, 16680, Indonesia; Suhartanto, H., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Arymurthy, A.M., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Kusmardi, K., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Kampus Universitas Indonesia, Jakarta, Indonesia |
Large amounts of data are required for the training process with a convolutional neural network (CNN) because small datasets with low variation will cause over-fitting, and the model cannot predict new data with high accuracy. Additionally, the non-availability of histopathological medical data presents an issue because without ethical permission, such data cannot be obtained easily. Therefore, this study proposes a conditional sliding window algorithm to obtain sub-sample data on images of histopathology. Two sets of original data were used, one from the Warwick dataset with dimensions of 775 × 522 pixels and the other from the Department of Pathology and Anatomy, Faculty of Medicine Universitas Indonesia. The algorithm used was inspired by the conventional sliding window method, but implemented with added conditions, such as sliding the window algorithm from the left on (x,y) pixel coordinates, thereby moving from left to right, then up to down until the entire image was covered. Consequently, the new image was produced with two dimensions: 200 × 200 and 300 × 300 pixels. However, to avoid loss of information, the 25 and 50 pixels overlap were used. In this study, CNN 7-5-7 was designed and proposed to perform the process. The conditional sliding window algorithm can produce various sub-samples depending on the image and window size. Furthermore, the images produced were used to develop a CNN and were proven to accurately predict benign and malignant tissues compared to the model from the original dataset. Moreover, the sensitivity values of the Warwick public dataset and the one generated in this study are above 0.80, which shows that the proposed CNN architecture is more stable compared to the existing methods such as AlexNet and DenseNet121. This study succeeded in solving the limitations of colorectal histopathological training data by developing a conditional sliding window algorithm. This algorithm can be applied to generate other histopathological data. Moreover, our proposed CNN 7-5-7 is the fastest architecture for training, comparable to state-of-the-art methodologies. Furthermore, the dataset was used to develop the model for colorectal cancer identification and integrated on the web-based application for further implementation. © 2021 The Authors |
Augmentation; Conditional sliding windows; Convolutional neural network; Histopathology |
Article; colorectal cancer; computer language; convolutional neural network; deep learning; diagnostic accuracy; entropy; feature extraction; histopathology; human; image processing; information processing; learning algorithm; sensitivity and specificity |
Elsevier Ltd |
23529148 |
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Article |
Q3 |
440 |
11223 |
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829 |
Azwar M.K., Setiati S. |
57202798959;14325991900; |
Modifiable Risk Factors for Dementia in Indonesia's Urban Population |
2021 |
Acta medica Indonesiana |
53 |
1 |
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31 |
41 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103993731&partnerID=40&md5=7f5fcb58c59d74fc45c0cac2c49add86 |
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Azwar, M.K., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Setiati, S. |
BACKGROUND: Indonesia is one of ten countries in the world with estimated number of dementia case exceeding a million. The number of elderly population living in Indonesian cities has exceeded the number in rural areas, but the country lacks data representing the urban population better related to modifiable risk factors for dementia, prevention of which is crucial. We aimed to identify the modifiable risk factors for dementia in Indonesia's urban population. METHODS: this case-control study used five-year data in Indonesia's national general hospital by tracing back medical record books of individuals aged 60 years and above in geriatric medicine outpatient clinic to the first hospital visit. Statistical analyses included bivariate and multivariate analyses to adjust for confounding factors appropriately. RESULTS: data from 345 patients suggested that the significant risk factors for dementia were history of smoking (adjusted OR 2.860, 95% CI 1.559-5.246), history of hearing loss (adjusted OR 7.962, 95% CI 3.534-17.941), history of depression (adjusted OR 12.473, 95% CI 2.533-61.417), hypertension (adjusted OR 1.751, 95% CI 1.006-3.048), and diabetes mellitus (adjusted OR 2.561, 95% CI 1.482-4.425). Dementia patients had longer median duration of diabetes mellitus (12 years) than elderly without dementia (9 years) before the diagnosis of dementia. Single point late-life underweight condition and low educational attainment were not associated with dementia in Indonesia's urban setting. The risk factors for vascular dementia were largely similar to those of dementia. CONCLUSION: in Indonesian urban population, history of smoking, hearing loss, depression, hypertension, and diabetes mellitus are associated with dementia. |
city; dementia; Indonesia; Jakarta; risk factor; urban |
adverse event; aged; case control study; complication; dementia; depression; diabetes mellitus; female; hearing impairment; human; hypertension; Indonesia; male; middle aged; multivariate analysis; risk factor; smoking; statistical model; urban population; very elderly; Aged; Aged, 80 and over; Case-Control Studies; Dementia; Depression; Diabetes Mellitus; Female; Hearing Loss; Humans; Hypertension; Indonesia; Logistic Models; Male; Middle Aged; Multivariate Analysis; Risk Factors; Smoking; Urban Population |
NLM (Medline) |
01259326 |
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33818405 |
Article |
Q3 |
321 |
14162 |
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830 |
Wicaksono I., Rahardjo H.E. |
57217251974;37762030000; |
Diagnostic Value of PCR compared to Urine Culture for Urinary Tuberculosis in Adult Women: An Evidence-Based Case Report |
2021 |
Acta medica Indonesiana |
53 |
1 |
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108 |
118 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103993519&partnerID=40&md5=7a612f7f41fa8ec9b31840cc9700f185 |
Department of Urology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Wicaksono, I., Department of Urology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Rahardjo, H.E. |
BACKGROUND: genitourinary tuberculosis (GUTB) refers to a Mycobacterium tuberculosis infection of the urinary tract with clinical manifestation masquerading as various urological diagnostic entities. With an incidence rate of 192-232 per 100,000 individuals, current diagnoses have fallen short in comparison to the total incidence. Combined with an atypical and non-specific manifestation, a high false negative rate of acid-fast bacilli (AFB) staining, and long AFB culture duration has made diagnosis difficult. We aim to gather current available evidence regarding the diagnostic performance of polymerase chain reaction (PCR) in the diagnosis of GUTB. METHODS: a literature search was conducted in four different, well-known databases using a predetermined PICO, keywords, and Boolean operators. All included articles will be subjected to rigorous appraisal according the University of Oxford's Centre for Evidence-Based Medicine (CEBM) Diagnostic Variability Criteria. Review and meta-analysis will be subjected to the QFAITH appraisal checklist to assess its quality. RESULTS: out of a total of 243 initial search results, 11 relevant studies were determined after title and abstract screening. Additionally, nine articles were excluded based on the predetermined criteria. Two fully appraised articles were included in the study: one systematic review article, revealing a heterogenous (I2 = unstated; p = unstated) result of sensitivity mean above 85% and specificity above 75%; and one cross-sectional diagnostic study that reported the use of two different PCR primers: IS6110-PCR and 16SrRNA-PCR primer with a sensitivity of 95.99% and 87.05% and specificity of 98.11% and 98.9%, respectively. CONCLUSION: current limited evidence showed that PCR could not be solely used for the diagnosis of GUTB, but its use is recommended to guide patient treatment and monitoring. |
acid-fast bacilli; diagnosis; genitourinary tuberculosis; polymerase chain reaction; urine culture |
adult; case report; comparative study; evidence based practice; female; genetics; human; isolation and purification; meta analysis; microbiology; Mycobacterium tuberculosis; polymerase chain reaction; sensitivity and specificity; urine; urogenital tuberculosis; Adult; Evidence-Based Practice; Female; Humans; Mycobacterium tuberculosis; Polymerase Chain Reaction; Sensitivity and Specificity; Tuberculosis, Urogenital; Urine |
NLM (Medline) |
01259326 |
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33818414 |
Article |
Q3 |
321 |
14162 |
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831 |
William W., Ascobat P., Instiaty I., Agustin H. |
57222750602;55795863600;55703138400;56135125000; |
Outcomes of Daily Dose versus Part-daily Dose Treatment for Lung Tuberculosis: A Real-World Database Study in an Indonesian Hospital |
2021 |
Acta medica Indonesiana |
53 |
1 |
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18 |
23 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103993218&partnerID=40&md5=8b5b59f2fda6442613cb3b59085dcbde |
1. Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Indonesia. 2. Department of Pharmacology, Faculty of Medicine, University of Christian Krida WacanaJakarta, Indonesia |
William, W., 1. Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Indonesia. 2. Department of Pharmacology, Faculty of Medicine, University of Christian Krida WacanaJakarta, Indonesia; Ascobat, P.; Instiaty, I.; Agustin, H. |
BACKGROUND: a meta-analysis of randomized control trials (RCTs) on category I pulmonary tuberculosis (PTB) treatments showed that either part-daily (2RHZE/4R3H3) or daily dose (2RHZE/4RH) had the same failure and recurrence rates. However, the World Health Organization (WHO) concluded that the part-daily dose had higher failure and recurrence rates. Therefore, this study was conducted to compare the treatment outcomes between both regimens, whether daily dose regimen has a better treatment outcome than part-daily dose regimen, and the adverse effects between both regimens. METHODS: this was an analytic cross-sectional study of patients at the Persahabatan General Hospital, over the period of January 2015-June 2018. Data were taken from medical records and supported by telephone interviews, each regimen group had 175 patients. RESULTS: there were no significant differences for success rates (p=0.470), lost to follow up rates (p=0.659), failure rates (p=1.000), death rates (p=1.000), and adverse effects in the continuation phase (p=0.324) between the groups. There were, however, significant differences in cure rates (p < 0.001) and complete treatment rates (p<0.001) between the groups. CONCLUSION: the cure rate and complete treatment rate were found to be better for the part-daily than the daily doses. The success rate of both regimens were the same as Indonesia's target (90%). In the continuation phase, there were no significant difference of adverse effects between both regimens. |
Adverse effects; dose regimen; pulmonary tuberculosis; treatment outcomes |
tuberculostatic agent; adolescent; adult; cross-sectional study; drug administration; female; follow up; human; Indonesia; lung tuberculosis; male; middle aged; recurrent disease; treatment outcome; young adult; Adolescent; Adult; Antitubercular Agents; Cross-Sectional Studies; Drug Administration Schedule; Female; Humans; Indonesia; Lost to Follow-Up; Male; Middle Aged; Recurrence; Treatment Outcome; Tuberculosis, Pulmonary; Young Adult |
NLM (Medline) |
01259326 |
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33818403 |
Article |
Q3 |
321 |
14162 |
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832 |
Shidiq K.M., Nelwan E.J., Yunihastuti E., Harimurti K., Pohan H.T. |
57222751395;14527452900;57221273925;23473513200;23474782900; |
Clinical Evaluation of HIV/AIDS Patients on Antiretroviral Therapy using HIV Symptoms Index: A reliability and Applicability Evaluation using Indonesian Language |
2021 |
Acta medica Indonesiana |
53 |
1 |
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52 |
59 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103992672&partnerID=40&md5=4dc758f0ec746e017c56b0c1bf8c2fdf |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Indonesia |
Shidiq, K.M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Indonesia; Nelwan, E.J.; Yunihastuti, E.; Harimurti, K.; Pohan, H.T. |
BACKGROUND: HIV/AIDS is a chronic, lifelong disease with a wide clinical spectrum which could decrease the quality of life. Objective symptoms measurement is important because it is correlated to treatment adherence and progressivity of the disease. Currently, there is no clinical tool available to evaluate symptoms of HIV infection and the treatment's side effect for the outpatient setting. This study aimed is to assess the reliability of the Indonesian version of HIV Symptom Index for measuring symptoms of HIV/AIDS patients, and use it for assessment of their symptom profile. METHODS: this is a cross sectional study in outpatient HIV/AIDS subjects (n=87) recruited in Cipto Mangunkusumo Hospital's HIV clinic from September-November 2018. The HIV Symptom Index consisted of 20 items evaluating somatic, psychologic, and the combination of both symptoms, and its' language adaptation to Indonesian was done with Beaton and Guillemin method. Reliability of the Indonesian version of HIV Symptom Index was tested by alpha cronbach's a coefficient analysis, and the internal validity was tested with multitrait scaling analysis before being used to profile the symptom pattern of HIV/AIDS patients. RESULTS: Indonesian version of HIV Symptom Index is reliable (cronbach alpha 0.76) and valid (multitrait correlation >0.4) for measuring symptoms of HIV/AIDS patients. The most common symptom is fatigue (55.7%), followed by insomnia (43.3%), dizziness and lightheadedness (42.3%), skin problems (42.3%), and pain, numbness, or tingling in the hands or feet (39.2%). CONCLUSION: Indonesian version of HIV symptom Index is reliable and valid to measure symptoms of HIV/AIDS patiens objectively. |
clinical evaluation; HIV/AIDS; symptom |
antiretrovirus agent; acquired immune deficiency syndrome; adult; cross-sectional study; female; human; Human immunodeficiency virus infection; Indonesia; language; male; middle aged; quality of life; questionnaire; reproducibility; severity of illness index; Acquired Immunodeficiency Syndrome; Adult; Anti-Retroviral Agents; Cross-Sectional Studies; Female; HIV Infections; Humans; Indonesia; Language; Male; Middle Aged; Quality of Life; Reproducibility of Results; Severity of Illness Index; Surveys and Questionnaires |
NLM (Medline) |
01259326 |
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33818407 |
Article |
Q3 |
321 |
14162 |
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833 |
Kaligis F., Ismail R.I., Wiguna T., Prasetyo S., Indriatmi W., Gunardi H., Pandia V., Magdalena C.C. |
36604651700;55996895500;24367785700;56879108300;57189888041;56510252700;57208206604;57222744289; |
Mental health problems and needs among transitional-age youth in Indonesia |
2021 |
International Journal of Environmental Research and Public Health |
18 |
8 |
4046 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103933053&doi=10.3390%2fijerph18084046&partnerID=40&md5=5f79eeea8b723a621bb8c21de80ea384 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Faculty of Public Health, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Dermatovenereology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Psychiatry, Faculty of Medicine, Universitas Padjajaran, Bandung, West Java, 40115, Indonesia |
Kaligis, F., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Wiguna, T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Prasetyo, S., Faculty of Public Health, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Indriatmi, W., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Dermatovenereology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Gunardi, H., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Pandia, V., Department of Psychiatry, Faculty of Medicine, Universitas Padjajaran, Bandung, West Java, 40115, Indonesia; Magdalena, C.C., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
“Transitional-age youth” describes those whose ages range from 16–24 years old. In this phase, the youth face new challenges and new experiences which may increase the risk for having mental health problems, yet not very many seek help from mental health professionals. In Indone-sia, no data are available about mental health problems and the needs of transitional-age youth. This study explores common mental health problems experienced during this stage and assesses how they cope with problems and their expectations from health services. This was a cross-sectional study involving 393 Indonesians aged 16–24 years in May 2020. More than 90% of students had financial and academic difficulties and felt lonely. The most prevalent mental health problem among students was anxiety (95.4%). Most of the students, ranging from 90% to 96.4%, had positive coping strategies. However, around 50% of respondents reported self-harming and having suicidal thoughts. The results of subcategories analysis between ages and faculties were similar. Their most important expectations from mental health services included confidentiality (99.2%) and being wel-coming and friendly (99.2%). In conclusion, this study highlighted the most common problems tran-sitional-age youth experience in Indonesia. While some of them already knew how to deal with their problems, not all the participants had good coping mechanisms. Their healthcare expectations were also explored, thereby providing a useful background to revise and amend the current condi-tions. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Adolescence; Coping mechanisms; Health service expectation; Mental health needs; Mental health problems; Transitional-age youth |
academic performance; coping strategy; finance; health services; mental health; student; young population; adolescent; adult; age; anxiety; Article; automutilation; confidentiality; coping behavior; cross-sectional study; female; financial stress; health care access; health care need; health care quality; human; Indonesia; juvenile; loneliness; male; mental health; mental health service; prevalence; risk factor; school stress; suicidal ideation; transitional age youth; young adult; epidemiology; mental health service; Indonesia; Adolescent; Adult; Cross-Sectional Studies; Humans; Indonesia; Mental Health; Mental Health Services; Suicidal Ideation; Young Adult |
MDPI AG |
16617827 |
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33921344 |
Article |
Q2 |
747 |
6560 |
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834 |
Ibrahim F., Natasha A., Saharman Y.R., Yasmon A., Fithriyah F., Karuniawati A., Ganiesa S., Sudarmono P. |
54886001500;57211428938;55980934300;41462004500;57210142453;54886816200;57222740114;6507855437; |
Consideration of the Cycle Threshold Values from Real-Time RT-PCR SARS-CoV-2 Interpretation for the Clinicians: Analysis of 339 Positive Cases from a Referral Laboratory in Jakarta, Indonesia |
2021 |
Acta medica Indonesiana |
53 |
1 |
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13 |
17 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921764&partnerID=40&md5=34f56312ba1b549b121d030e28212342 |
Clinical Microbiology Department, faculty of medicine, University of Indonesia |
Ibrahim, F., Clinical Microbiology Department, faculty of medicine, University of Indonesia; Natasha, A.; Saharman, Y.R.; Yasmon, A.; Fithriyah, F.; Karuniawati, A.; Ganiesa, S.; Sudarmono, P. |
BACKGROUND: real-time RT-PCR was recommended by WHO for COVID-19 diagnosis. The cycle threshold (Ct) values were expected to have an association with clinical manifestation. However, the diagnostic modalities such as quantitative molecular detection and virus isolation were not yet available for the routine test. This study has been conducted to analyze the relationship between the Ct values of qualitative rRT-PCR and the clinical manifestation and to describe the factors determining the result. METHODS: from March to April 2020, specimens were sent to our laboratory from different healthcare centers in Jakarta. The patient's characteristic and clinical manifestation were extracted from the specimen's epidemiology forms. The specimens extracted and tested using rRT-PCR, and the Ct value were collected. The data were analyzed using the appropriate statistic test. RESULTS: from 339 positive results, the mild to moderate case was 176 (52%) and the severe cases was 163 (48%). Female was dominant in the mild to moderate cases (58%), while the male was prevalent in the severe cases (60%). The median age for mild to moderate case was 35 years old and severe cases was 49 years old. Statistical analysis found relationship between both group with gender (p = 0.001) and age (p < 0.001), but not with the Ct value. CONCLUSION: many variables in specimen sampling and processing could affect the Ct value result. In addition, the disease's severity was depended with the host immune response, regardless the number of virus. There was suggested no significant difference between the Ct values of mild-moderate and severe COVID-19, and thus should not be loosely interpreted. |
clinical interpretation; Cycle Threshold; rRT-PCR; SARS-Cov-2 |
adult; age; diagnosis; epidemiology; female; human; Indonesia; isolation and purification; male; middle aged; observer variation; pathophysiology; physiology; procedures; real time polymerase chain reaction; reproducibility; severity of illness index; sex factor; symptom assessment; virus load; Adult; Age Factors; Correlation of Data; COVID-19; COVID-19 Nucleic Acid Testing; Female; Humans; Indonesia; Male; Middle Aged; Observer Variation; Real-Time Polymerase Chain Reaction; Reproducibility of Results; SARS-CoV-2; Severity of Illness Index; Sex Factors; Symptom Assessment; Viral Load |
NLM (Medline) |
01259326 |
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33818402 |
Article |
Q3 |
321 |
14162 |
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835 |
Loho T., Widodo D. |
55624513300;8231822900; |
Rapid Antigen Detection Test for Severe Acute Respiratory Syndrome Coronavirus 2: How to Use It Properly? |
2021 |
Acta medica Indonesiana |
53 |
1 |
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119 |
131 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921511&partnerID=40&md5=d85899546f23d6d70bd458483c6c9ac1 |
Department of Clinical Pathology, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Loho, T., Department of Clinical Pathology, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Widodo, D. |
Cases of coronavirus disease 2019 (COVID-19) in Indonesia are still increasing and even higher in the last few weeks. Contact tracing and surveillance are important to locate cases in the community, including asymptomatic individuals. Diagnosis of COVID-19 depends on the detection of viral RNA, viral antigen, or indirectly, viral antibodies. Molecular diagnosis, using real time, reverse transcriptase polymerase chain reaction (RT-PCR), is the common standard method; however, it is not widely available in Indonesia and requires a high standard laboratory. Rapid, point-of-care antibody testing has been widely used as an alternative; however, interpretation of the results is not simple and now it is no longer used by the Indonesian government as a screening test for people travelling between locations. Thus, the rapid antigen detection test (Ag-RDT) is used by the Indonesian government as a screening test for travellers. As a result, many people buy the kit online and perform self-Ag-RDT at home. This raises the question of how safe and accurate it is to perform self-Ag-RDT at home. Before a test is applied, it is suggested to research its sensitivity and specificity, as compared to gold standard, and its limitations. In this article, laboratory diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is discussed, with an emphasis on Ag-RDT and the recommendation to use it properly in daily practice. |
antigen testing; COVID-19; SARS-CoV-2 |
virus antibody; virus RNA; diagnosis; epidemiology; human; immunology; isolation and purification; physiology; prevention and control; procedures; reproducibility; sensitivity and specificity; Antibodies, Viral; COVID-19; COVID-19 Nucleic Acid Testing; COVID-19 Serological Testing; Humans; Reproducibility of Results; RNA, Viral; SARS-CoV-2; Sensitivity and Specificity |
NLM (Medline) |
01259326 |
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33818415 |
Article |
Q3 |
321 |
14162 |
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836 |
Nelwan E.J., Tunjungputri R.N., Tunjung N., Widodo D. |
14527452900;56342194400;57208446370;8231822900; |
Hospital-acquired Skin and Skin-structure Infection in COVID-19 Infected Patient with Prolonged Hospitalization |
2021 |
Acta medica Indonesiana |
53 |
1 |
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105 |
107 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921503&partnerID=40&md5=23cf0f1fefa15f3ad7ca5a2fea78cdeb |
Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Nelwan, E.J., Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Tunjungputri, R.N.; Tunjung, N.; Widodo, D. |
Acute bacterial skin and skin-structure infections (ABSSSI) is defined in 2013 by the US Food and Drug Administration as a bacterial cellulitis/erysipelas, major skin abscesses, and wound infections. The Infectious Diseases Society of America (IDSA) in 2014 classifies skin and soft-tissue infection (SSTI) as either non-purulent (which includes cellulitis, erysipelas, and necrotizing infection) or purulent (including furuncle, carbuncle, and abscess). Among hospitalized patients with SSTI, healthcare-associated infections account for 73.5% of all cases. Notably, skin and skin-structure infections caused by Pseudomonas aeruginosa, a common hospital pathogen, was reported to cause higher total cost and longer hospital length of stay compared to non-P. aeruginosa cases, despite causing only approximately 5.7% of all healthcare-associated SSTIs. Infection with P. aeruginosa should always be considered in non-healing skin infections in patients with prolonged hospitalization and antibiotic exposure. Tissue culture, preferably taken by surgical debridement, should be promptly performed; and when hospital-infection is suspected, appropriate antibiotics should be started along with removal of all devitalized tissue and to promote skin and soft tissue healing. Expedited discharge should be considered when possible, with adequate antibiotic treatment and follow up for definitive wound treatment. |
COVID-19; Hospital-acquired skin; prolonged hospitalization; skin-structure infection |
antiinfective agent; linezolid; case report; complication; debridement; female; hospitalization; human; iatrogenic disease; isolation and purification; microbiology; middle aged; pathology; pathophysiology; procedures; skin; skin infection; treatment outcome; Anti-Bacterial Agents; COVID-19; Debridement; Female; Hospitalization; Humans; Iatrogenic Disease; Linezolid; Middle Aged; SARS-CoV-2; Skin; Skin Diseases, Infectious; Treatment Outcome |
NLM (Medline) |
01259326 |
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33818413 |
Article |
Q3 |
321 |
14162 |
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