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884 |
Pranata R., Lim M.A., Yonas E., Huang I., Nasution S.A., Setiati S., Alwi I., Kuswardhani R.A.T. |
57201973901;57216039756;57201987097;57208576645;57189373134;14325991900;15055173800;36863900500; |
Thrombocytopenia as a prognostic marker in COVID-19 patients: Diagnostic test accuracy meta-analysis |
2021 |
Epidemiology and Infection |
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11 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100393000&doi=10.1017%2fS0950268821000236&partnerID=40&md5=d8fa1ea1b15a19b5d451c4922b96ed06 |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Teaching Hospital, Denpasar-Bali, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Nasution, S.A., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Setiati, S., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Alwi, I., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Kuswardhani, R.A.T., Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Teaching Hospital, Denpasar-Bali, Indonesia |
This systematic review and meta-analysis aimed to evaluate thrombocytopenia as a prognostic biomarker in patients with COVID-19. We performed a systematic literature search using PubMed, Embase, and EuropePMC. The main outcome was composite poor outcome, a composite of mortality, severity, need for intensive care unit care, and invasive mechanical ventilation. There were 8963 patients from 23 studies. Thrombocytopenia occurred in 18% of the patients. Male gender (p=0.037) significantly reduce the incidence. Thrombocytopenia was associated with composite poor outcome (RR 1.90 [1.43, 2.52], p<0.001; I2: 92.3%). Subgroup analysis showed that thrombocytopenia was associated with mortality (RR 2.34 [1.23, 4.45], p<0.001; I2: 96.8%) and severity (RR 1.61 [1.33, 1.96], p<0.001; I2: 62.4%). Subgroup analysis for cut-off <100 × 109/L showed RR of 1.93 [1.37, 2.72], p<0.001; I2: 83.2%). Thrombocytopenia had a sensitivity of 0.26 (0.18, 0.36), specificity of 0.89 (0.84, 0.92), positive likelihood ratio of 2.3 (1.6, 3.2), negative likelihood ratio of 0.83 (0.75, 0.93), diagnostic odds ratio of 3 (2, 4), and area under curve of 0.70 (0.66 - 0.74) for composite poor outcome. Meta-regression analysis showed that the association between thrombocytopenia and poor outcome did not vary significantly with age, male, lymphocyte, d-dimer, hypertension, diabetes, and CKD. Fagan's nomogram showed that the posterior probability of poor outcome was 50% in patients with thrombocytopenia, and 26% in those without thrombocytopenia. The Deek's funnel plot was relatively symmetrical and the quantitative asymmetry test was non-significant (p = 0.14). This study indicates that thrombocytopenia was associated with poor outcome in patients with COVID-19. © 2021 Cambridge University Press. All rights reserved. |
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aged; artificial ventilation; diagnostic test; female; human; intensive care unit; male; meta analysis; middle aged; mortality; odds ratio; pathology; prognosis; sensitivity and specificity; severity of illness index; thrombocytopenia; Aged; COVID-19; Diagnostic Tests, Routine; Female; Humans; Intensive Care Units; Male; Middle Aged; Odds Ratio; Prognosis; Respiration, Artificial; SARS-CoV-2; Sensitivity and Specificity; Severity of Illness Index; Thrombocytopenia |
Cambridge University Press |
09502688 |
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33509306 |
Article |
Q2 |
992 |
4419 |
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885 |
Prayitno A., Supriyatno B., Munasir Z., Karuniawati A., Hadinegoro S.R.S., Prihartono J., Safari D., Sundoro J., Khoeri M.M. |
57193342301;37068046400;7801694370;54886816200;57226218772;6602605635;23493586700;49762130000;55994827400; |
Pneumococcal nasopharyngeal carriage in Indonesia infants and toddlers post-PCV13 vaccination in a 2+1 schedule: A prospective cohort study |
2021 |
PLoS ONE |
16 |
1 January |
e0245789 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100392996&doi=10.1371%2fjournal.pone.0245789&partnerID=40&md5=cb78eb658b86a8f3be7a35fe8b7fd3cc |
Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Microbiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Molecular Bacteriology, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia |
Prayitno, A., Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Supriyatno, B., Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Munasir, Z., Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Karuniawati, A., Department of Microbiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hadinegoro, S.R.S., Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prihartono, J., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Safari, D., Molecular Bacteriology, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sundoro, J., Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Khoeri, M.M., Molecular Bacteriology, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Background The PCV13 immunization demonstration program began in October 2017 in Indonesia. The aim of this study is to assess the dynamic changes of pneumococcal serotype before and after PCV13 administration, with two primary and one booster doses. Methods The prospective cohort study was conducted as a follow up study measuring the impact of PCV13 demonstration program by the Indonesian Ministry of Health in Lombok Island, West Nusa Tenggara, Indonesia, from March 2018 to June 2019. The subjects were two-month-old healthy infants who were brought to the primary care facility for routine vaccination and followed until 18 months of age. We use convenience sampling method. There were 115 infants in the control group and 118 infants in the vaccine group, and the PCV immunization was given on a 2+1 schedule. Nasopharyngeal (NP) swabs were collected four times during the vaccination periods by trained medical staff. Specimens were analyzed by culture methods to detect S. pneumonia colonization and multiplex polymerase chain reaction (mPCR) to determine serotype. The most frequently detected serotypes will be named as dominant serotypes. Descriptive analysis of demographic characteristics, the prevalence of overall and serotype colonization, and the distribution of serotypes were performed. The prevalence of both cohort groups were compared using chi-square test. Statistical significance was set at p < 0.05. Results Two hundred and thirty three infants age two months old were recruited, with 48.9% of the subjects were male and 51.1% of the subjects were female. Sociodemographic data in both cohort groups were relatively equal. Nasopharyngeal pneumococcal colonization before PCV13 administration occurred in 19.1% of the control and 22.9% of the vaccine group. The prevalence increased with increasing age in both groups. The prevalence of VT serotypes in control groups aged 2 months, 4 months, 12 months, and 18 months was 40.9%, 44.2%, 53.8%, and 54.3%, respectively, and in the vaccine group, 25.9%, 40.4%, 38.0%, and 22.6%, respectively. The most common VT serotypes in both groups were 6A/6B, 19F, 23F, and 14. The prevalence of VT serotypes decreased significantly compared to non-vaccine type serotypes after three doses of the PCV13 vaccine (p < 0.001). Another notable change was the decline in prevalence of serotype 6A/6B after PCV13 administration using the 2+1 schedule. Conclusions This study shows lower prevalence of VT and 6A/6B serotypes in the nasopharynx among children who were PCV13 vaccinated compared with those who were unvaccinated. The result from this study will be the beginning of future vaccine evaluation in larger population and longer period of study. © 2021 Prayitno et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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Pneumococcus vaccine; 13-valent pneumococcal vaccine; Pneumococcus vaccine; Article; bacterial colonization; bacterium carrier; cohort analysis; controlled study; demography; female; follow up; human; human experiment; Indonesia; infant; male; multiplex polymerase chain reaction; nasopharynx; normal human; population research; prevalence; primary medical care; serotype; sex ratio; social status; Streptococcus pneumoniae; toddler; trend study; vaccination; immunology; isolation and purification; microbiology; nose mucosa; pathogenicity; pneumococcal infection; preschool child; procedures; Streptococcus pneumoniae; Child, Preschool; Female; Humans; Indonesia; Infant; Male; Nasal Mucosa; Pneumococcal Infections; Pneumococcal Vaccines; Streptococcus pneumoniae; Vaccination |
Public Library of Science |
19326203 |
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33497405 |
Article |
Q1 |
990 |
4434 |
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886 |
Susanto A.D., Yusril N., Zaini J., Nuwidya F. |
57190425587;57221834981;57221833355;57221834238; |
Comparison of serum benzo(a)pyrene diol epoxide - Protein adducts level between kretek cigarette smokers and nonsmokers and the related factors |
2021 |
Journal of Natural Science, Biology and Medicine |
12 |
1 |
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52 |
56 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100352390&doi=10.4103%2fjnsbm.JNSBM_100_20&partnerID=40&md5=b1c54ebf4ef8452d480f9da52582dabe |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Susanto, A.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Yusril, N., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Zaini, J., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Nuwidya, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Benzopyrene is a carcinogenic agent found in cigarette smoke. Benzo(a)pyrene diol epoxide (BPDE) is one of the benzopyrene metabolites. In this study, we investigated the level of serum BPDE in kretek cigarette smokers compared to non-smokers. Methods: A cross-sectional study which involved 32 "healthy" kretek cigarette smokers and 32 "healthy" nonsmokers were conducted. We collected the blood sample and the serum BPDE level was assayed using enzyme-linked immunosorbent assay kit. The BPDE serum level in kretek cigarette smokers was compared to the level in nonsmokers. Results: A total of 32 kretek smokers and 32 controls underwent an examination of the BPDE-protein adducts level. In the kretek smokers group, 59.4% were aged over 45 years and 56.3% have a high educational background, while in the control group, 87.5% were aged under 45 years and 75% have high educational backgrounds. The level of BPDE-protein adducts in the kretek smokers subject was 12.15 (8.87-33.55) ng/ml and the levels in the control group were 11.4 (3.87-13.27) ng/ml, P = 0.004. The factors which influence the levels BDPE-protein adducts in smokers cigarettes, as determined by multivariate analysis, were sucking pattern (P = 0.002) and the degree of addiction (P = 0.047). Conclusion: The serum BPDE-protein adducts level was higher in smokers compared to nonsmokers, and the sucking pattern and degree of addiction are the influencing factors. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Benzo(a)pyrene diol epoxide-protein adducts; nonsmokers; smokers |
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Wolters Kluwer Medknow Publications |
09769668 |
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Article |
Q3 |
236 |
17374 |
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887 |
Arliny Y., Yunus F., Burhan E., Andarini S., Jusman S.W.A., Yunir E., Kekalih A., Soeroton A.Y., Nurwidya F. |
57221832635;57194486277;36058554600;8716259500;36518792100;36520254800;55633562200;57221832157;55221773800; |
Diagnostic predictors of active tuberculosis infection in diabetic patients with latent tuberculosis: A review on cathelicidin and 1,25-dihydroxyvitamin d3 |
2021 |
Journal of Natural Science, Biology and Medicine |
12 |
1 |
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117 |
123 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100332647&doi=10.4103%2fjnsbm.JNSBM_26_20&partnerID=40&md5=bcbc06659ad7db8063dc7a77d40a3bd0 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Syiah Kuala, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia; Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Respirology and Critical Illness, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia |
Arliny, Y., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Syiah Kuala, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Yunus, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Syiah Kuala, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Andarini, S., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia; Yunir, E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kekalih, A., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soeroton, A.Y., Division of Respirology and Critical Illness, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia; Nurwidya, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia |
Background: Diabetes Mellitus has been identified as one of factors causing increased risks of latent TB infection. The roles of cathelicidin LL-37, 1.25(OH)2D3 as well as their correlation with specific IFN-γ in latent TB has not been extensively identified. Aims and Objectives: Our study was aimed to identify proportion of latent TB infection in patients with DM and to identify the role of cathelicidin, 1.25(OH)2D3, vitamin D and other clinical factors as predictors for active TB infection in diabetic patients with latent TB. Methods: Our study was conducted in 2 stages. The first-stage study was a cross-sectional study to identify the proportion of latent TB infection in patients with DM without any history of TB, which was continued with a case-control study to identify the roles of predictive biomarkers (cathelicidin LL-37, 25(OH) D3, 1.25(OH)2D3 and IFN-γ) as well as clinical predictive factors for active TB infection in diabetic patients with latent TB. Results: Out of 242 diabetic patients without any history of TB who underwent screening test for latent TB, there were 78 (33.2%) subjects with a diagnosis of latent TB and 1 subject was diagnosed with active TB. There was significant association on the level of cathelicidin LL-37 in DM patient with latent TB, active TB and without TB infection (23.49 ng/mL vs. 49.6 ng/mL vs. 10.46 ng/mL, P < 0,005). Almost all of subjects with DM showed low levels of vitamin D, most in subject with active TB (97%). There was no significant association between 1.25(OH)2D3 and 25(OH)D3 in DM patients with latent TB, active TB and without TB infection. There was a significant association on the levels of IFN-γ ((TB1 1.4 IU/mL vs. 0.03 IU/mL P < 0.005; TB2 1.4 IU/mL vs. 0.04 IU/mL P < 0.005) in DM subjects with latent TB and those without TB infection; however, no significant association was found in DM subjects with latent TB and active TB. History of smoking, HbA1C > 9.5% and cathelicidin LL-37 levels of > 30 ng/mL were predictors for latent TB into active TB in DM patients. Conclusion: Cathelicidin LL-37 can serve as a biomarker of latent TB progressiveness in patients with DM. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
1,25 (OH)2D3; cathelicidin; diabetes; latent tuberculosis infection; Vitamin D |
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Wolters Kluwer Medknow Publications |
09769668 |
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Article |
Q3 |
236 |
17374 |
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888 |
Subekti I., Kartiko G.J., Suhardi Z.F., Muhadi, Wisnu W. |
24336854300;57221818935;57221814580;57189615533;57200425452; |
Serum TSH level as predictor of Graves' disease recurrence following antithyroid drug withdrawal: A systematic review |
2021 |
PLoS ONE |
16 |
1 January |
e0245978 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100298149&doi=10.1371%2fjournal.pone.0245978&partnerID=40&md5=68971152ed2933aff2d374d62012a231 |
Faculty of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Subekti, I., Faculty of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Kartiko, G.J., Faculty of Medicine, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Suhardi, Z.F., Faculty of Medicine, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Muhadi, Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Wisnu, W., Faculty of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Graves' disease (GD) has a high recurrence rate despite various and adequate treatment. Numerous studies have been performed to identify the predictor of disease recurrence. This report aims to investigate the role of thyroid stimulating hormone (TSH) level as a thyrotropin in predicting the recurrence of Graves' disease within 1 to 2 years following antithyroid drug (ATD) withdrawal. Literature searching was conducted on PubMed, Scopus, Cochrane, Proquest, EBSCO in August 2019 and Google Scholar in October 2020. The study criteria include the study that evaluates TSH level 4 weeks following ATD withdrawal, with subjects ≥18 years old who are retrospectively or prospectively followed up after 1 to 2 years following ATD withdrawal. Four eligible studies were selected based on inclusion/exclusion criteria, all of which measured TSH level at 4 weeks following ATD withdrawal. All studies had 1 to 2 years follow up. One study was an RCT, two studies were done in prospective cohort and another in retrospective cohort. All studies had comparable validity and applicability. Three out of four studies suggested that low TSH level measured 4 weeks following treatment withdrawal was associated with higher risk of disease recurrence. In conclusion, low TSH level obtained 4 weeks after ATD withdrawal was associated with higher rate of recurrence rate in GD. Copyright: © 2021 Subekti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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antithyroid agent; thyrotropin; antithyroid agent; thyrotropin; Article; clinical evaluation; clinical outcome; disease association; drug withdrawal; follow up; Graves disease; human; prospective study; recurrence risk; recurrent disease; risk factor; systematic review; thyrotropin blood level; blood; Graves disease; recurrent disease; treatment withdrawal; Antithyroid Agents; Graves Disease; Humans; Recurrence; Thyrotropin; Withholding Treatment |
Public Library of Science |
19326203 |
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33513181 |
Article |
Q1 |
990 |
4434 |
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889 |
Irdam G.A., Sutojo B., Raharja P.A.R. |
57194729795;57218247988;57201013616; |
Risk Factors of Ureteral Stenosis in Kidney Transplant Recipients: A Retrospective Study in National Referral Hospital in Indonesia |
2021 |
Advances in Urology |
2021 |
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2410951 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100218047&doi=10.1155%2f2021%2f2410951&partnerID=40&md5=8c80f4380c17c32aba39dc8572cc7807 |
Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Irdam, G.A., Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Sutojo, B., Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Raharja, P.A.R., Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Ureteral stenosis is one of the most common urological complications following kidney transplantations. It is occurred in 2-10% of patients and poses a significant problem to the patients as it may lead to permanent damage to renal damage. Identification of risk factors is important to prevent the incidence of ureteral stenosis. Thus, we aim to determine the risk factors of ureteral stenosis in the Indonesian population. This is a retrospective analysis of 487 kidney transplant patients performed in Cipto Mangunkusumo Hospital between 2014 and 2018. We collected and compared donor and recipient demography data in recipients who developed ureteral stenosis and recipients who did not develop ureteral stenosis. Ureteral stenosis was defined as the presence of hydronephrosis from ultrasound and increased number of serum creatinine. The overall incidence of ureteral stenosis post-kidney transplantation in our center is 6.6% (32 from 487 patients) from January 2014 until June 2018. We found that older donor and recipient age more frequent in developing ureteral stenosis post-kidney transplantation (p < 0.001). We also found that donors with number of arteries more than 2 (p < 0.001) and prolonged warm ischemic time (p < 0.05) are more frequently to develop ureteral stenosis post-kidney transplantation. There is no association between type II diabetes mellitus and hypertension with ureteral stenosis in this study. Donor age, recipient age, donor number of arteries more than 2, and prolonged warm ischemia time are associated with ureteral stenosis after kidney transplantation. © 2021 Gampo A. Irdam et al. |
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creatinine; adolescent; adult; age; aged; allograft; Article; child; creatinine blood level; disease association; female; graft recipient; human; hydronephrosis; hypertension; Indonesia; ischemia time; kidney donor; kidney graft; kidney transplantation; major clinical study; male; medical history; neurogenic bladder; non insulin dependent diabetes mellitus; postoperative period; retrospective study; risk factor; ureter obstruction; warm ischemia time |
Hindawi Limited |
16876369 |
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Article |
Q1 |
1180 |
3392 |
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890 |
Elliyanti A., Rustam R., Tofrizal T., Yenita Y., Susanto Y.D.B. |
57217097313;57210705603;57219663511;57221789235;57197866044; |
Evaluating the natrium iodide symporter expressions in thyroid tumors |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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18 |
23 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100161267&doi=10.3889%2foamjms.2021.5534&partnerID=40&md5=f5dd69104ea66dab03a6a98ac2928162 |
Department of Medical Physics, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Division of Nuclear Medicine, Department of Radiology, Dr. M.Djamil Hospital, Padang, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Elliyanti, A., Department of Medical Physics, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Division of Nuclear Medicine, Department of Radiology, Dr. M.Djamil Hospital, Padang, Indonesia; Rustam, R., Department of Surgery, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Tofrizal, T., Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Yenita, Y., Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Susanto, Y.D.B., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Decreased Natrium iodide symporter (NIS) expression levels or diminished NIS targeting thyroid cancer cells’ plasma membrane leads to radioiodine-refractory disease. AIM: The aim of this study was to analyze the NIS expression in thyroid tumors. MATERIALS AND METHODS: The samples were thyroid tissues of patients who underwent surgery for a thyroid tumor. The tissues were processed for NIS protein expressions by immunohistochemistry (IHC) and Western blot (WB). Graves’ disease samples were used as positive controls. The samples were incubated without the primary antibody, and they were used as negative controls for IHC examination. Na+/K+ ATPase was a plasma membrane protein marker in the WB procedure. RESULTS: Twenty-nine samples were assessed for NIS protein. All of them showed the expression in the cytoplasm with intensity 1+ to 3+ with Allred score 3-8. Fourteen out of 29 cases (48.2%) showed NIS cytoplasm staining intensity ≥2+ consist of 10 papillary thyroid cancer (PTC), three follicular thyroid cancer, and one adenoma. Membrane staining was found in 2 samples of PTC (6.9%). Six samples (adenoma 1 sample, PTC 5 samples) showed NIS expression at membrane very weak (1+); they were considered as negative. NIS protein has several bands of ~ 80 kDa, ~ 62 kDa, and ~ 49 kDa. CONCLUSION: NIS expression in thyroid cancer mostly expresses in the cytoplasm instead of the membrane. NIS will play a functional role in the membrane to bring iodine across the membrane against the concentration. It can be the main reason for the lack of response of radioiodine in some differentiated thyroid cancers. © 2021 Aisyah Elliyanti, Rony Rustam, Tofrizal Tofrizal, Yenita Yenita, Susanto YDB. |
Follicular thyroid cancer; Immunohistochemistry; Membrane staining; Papillary thyroid cancer; Western blot |
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Open Access Macedonian Journal of Medical Sciences |
18579655 |
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Article |
Q3 |
288 |
15252 |
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891 |
Soetisna T.W., Buana A.C., Tirta E.S., Ardiyan A., Aligheri D., Herlambang B., Tjubandi A., Hanafy D.A., Sugisman S. |
57214887740;57221743134;57221753958;57212102199;57221752393;36468390900;57211055979;57220157579;57221747222; |
A 48-year-old man at low risk for SARS-CoV-2 infection who underwent planned elective triple-vessel coronary artery bypass graft surgery at a national heart center in indonesia followed by a fatal case of COVID-19 |
2021 |
American Journal of Case Reports |
22 |
1 |
e928900 |
1 |
5 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100047943&doi=10.12659%2fAJCR.928900&partnerID=40&md5=a033f16e0dbe64b1b4c3e7d6f2d25ab7 |
Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, University Syiah Kuala, Banda Aceh, Indonesia; Department of Surgery, Faculty of Medicine, University Krida Wacana, Jakarta, Indonesia; Department of Anesthesiologist and Intensive Therapy, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Anesthesiologist and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Soetisna, T.W., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Buana, A.C., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University Syiah Kuala, Banda Aceh, Indonesia; Tirta, E.S., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University Krida Wacana, Jakarta, Indonesia; Ardiyan, A., Department of Anesthesiologist and Intensive Therapy, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Anesthesiologist and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Aligheri, D., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Herlambang, B., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Tjubandi, A., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hanafy, D.A., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sugisman, S., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Patient: Male, 48-year-old Final Diagnosis: Chronic kidney disease • coronary artery disease • COVID-19 Symptoms: Chest pain • fever • shorthness of breath Medication: — Clinical Procedure: Coronary artery bypass graft surgery Specialty: Cardiac surgery Objective: Background: Case Report: Conclusions: Rare co-existance of disease or pathology This is of the first fatal case of coronavirus disease 2019 (COVID-19) pneumonia at a National Heart Center in Indonesia following planned elective triple-vessel coronary artery bypass graft (CABG) who was considered to be at low risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection when admitted for surgery. A 48-year-old man was diagnosed with coronary artery disease (CAD) in 3 vessels (3VD) with an ejection fraction (EF) of 61% and chronic kidney disease (CKD) with routine hemodialysis. The patient was scheduled for a coronary artery bypass graft (CABG) surgery. He underwent surgery after COVID-19 screening using a checklist provided by the hospital. The patient’s condition worsened on the 3rd postoperative day in the ward, and he was transferred back to the Intensive Care Unit (ICU), reintubated, and tested for COVID-19 with a real time-polymerase chain reaction (PCR) test. Because of the COVID-19 pandemic, we excluded the other possible pneumonia causes (e.g., influenza). An RT-PCR test performed after surgery revealed that the patient was positive for COVID-19. COVID-19 tracing was performed for all health care providers and relatives; all results were negative except for 1 family member. The patient was treated for 4 days in the isolation ICU but died due to complications of the infection. This report shows the importance of testing patients for SARS-CoV-2 infection before hospital admission for elective surgery and during the hospital stay, and the importance of developing rapid and accurate testing methods that can be used in countries and centers with limited health resources. © Am J Case Rep, 2021;. |
Coronary artery bypass; Coronary artery disease; COVID-19 |
bicarbonate; carbon dioxide; creatine kinase MB; creatinine; oxygen; urea; adult; anemia; angina pectoris; Article; bicarbonate blood level; blood carbon dioxide tension; blood oxygen tension; body mass; cardiomegaly; case report; cerebrovascular accident; chronic kidney failure; clinical article; comorbidity; contact examination; continuous renal replacement therapy; coronary angiography; coronary artery bypass graft; coronary artery disease; coronavirus disease 2019; creatine kinase blood level; creatinine blood level; deterioration; disease exacerbation; dyslipidemia; dyspnea; elective surgery; emergency surgery; emergency ward; fatality; fever; health care personnel; heart center; heart ejection fraction; hemodialysis; high risk patient; hospital admission; human; Indonesia; infection |
International Scientific Information, Inc. |
19415923 |
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33487629 |
Article |
Q3 |
247 |
16822 |
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892 |
Dwinata M., Putera D.D., Hasan I., Raharjo M. |
57209231012;57210288025;12776850800;57212400550; |
SGLT2 inhibitors for improving hepatic fibrosis and steatosis in non-alcoholic fatty liver disease complicated with type 2 diabetes mellitus: a systematic review |
2021 |
Clinical and Experimental Hepatology |
6 |
4 |
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339 |
346 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099931230&doi=10.5114%2fceh.2020.102173&partnerID=40&md5=628a477d8f6d02f9de989db2ce816c8c |
Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Dwinata, M., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Putera, D.D., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hasan, I., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Raharjo, M., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Aim of the study: To evaluate the efficacy of sodium/glucose cotransporter-2 inhibitors (SGLT2i) in improving hepatic fibrosis and steatosis of non-alcoholic fatty liver disease (NAFLD) patients with type 2 diabetes mellitus (T2DM). Material and methods: We searched CENTRAL, MEDLINE, and EMBASE and included any clinical trials involving patients with NAFLD and T2DM aged ≥ 18 years comparing efficacy of SGLT2i and other antidiabetic drugs in improving fibrosis and steatosis, irrespective of publication status, year of publication, and language. Results: Five clinical trials were included. One study reported significant improvements in the controlled attenuation parameter 314.6 ±61.0 dB/m to 290.3 ±72.7 dB/m (p = 0.04) in the SGLT2i group measured by transient elastography. In patients with significant fibrosis, dapagliflozin treatment significantly decreased the liver stiffness measurement from 14.7 ±5.7 kPa at baseline to 11.0 ±7.3 kPa after 24 weeks (p = 0.02). One study reported a significant decrease in liver fat content 16.2% to 11.3% (p < 0.001) in the SGLT2i group compared to the control (p < 0.001). Three studies reported significant improvement in the liver-to-spleen ratio in the SGLT2i group after treatment 0.96 (0.86-1.07) to 1.07 (0.98-1.14), p < 0.01, 0.80 ±0.24 to 1.00 ±0.18, p < 0.001, and 0.91 (0.64-1.04) to 1.03 (0.80-1.20), p < 0.001 respectively. All studies reported a significant decrease in alanine aminotransferase with SGLT2i. Conclusions: SGLT2i is associated with positive effects on hepatic steatosis measured by non-invasive modalities. Further studies are needed to confirm the impact of SGLT2i on hepatic fibrosis and steatosis. © 2020 Termedia Publishing House Ltd.. All rights reserved. |
Diabetes mellitus; Fibrosis; NAFLD; SGLT2 inhibitor; Steatosis |
alanine aminotransferase; dapagliflozin; empagliflozin; ipragliflozin; luseogliflozin; metformin; pioglitazone; sodium glucose cotransporter 2 inhibitor; adult; aged; alanine aminotransferase blood level; Article; comparative effectiveness; controlled study; diabetic patient; drug efficacy; elastography; female; human; liver fibrosis; liver stiffness; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; quasi experimental study; randomized controlled trial; systematic review; transient elastography; treatment outcome |
Termedia Publishing House Ltd. |
23921099 |
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Article |
Q4 |
394 |
12273 |
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893 |
Alkaff F.F., Illavi F., Salamah S., Setiyawati W., Ramadhani R., Purwantini E., Tahapary D.L. |
57208781930;57221732812;57217109015;57221720254;57219870814;57221736394;55944492500; |
The Impact of the Indonesian Chronic Disease Management Program (PROLANIS) on Metabolic Control and Renal Function of Type 2 Diabetes Mellitus Patients in Primary Care Setting |
2021 |
Journal of Primary Care and Community Health |
12 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099918670&doi=10.1177%2f2150132720984409&partnerID=40&md5=6ba221c547d10bfc27fa5120aa56a223 |
Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Department of Internal Medicine, Dr.Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Central Jakarta, Jakarta, Indonesia; Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Politeknik Elektronika Negeri Surabaya, Surabaya, East Java, Indonesia; Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Central Jakarta, Jakarta, Indonesia |
Alkaff, F.F., Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Illavi, F., Department of Internal Medicine, Dr.Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Central Jakarta, Jakarta, Indonesia; Salamah, S., Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Setiyawati, W., Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Ramadhani, R., Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Purwantini, E., Politeknik Elektronika Negeri Surabaya, Surabaya, East Java, Indonesia; Tahapary, D.L., Department of Internal Medicine, Dr.Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Central Jakarta, Jakarta, Indonesia, Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Central Jakarta, Jakarta, Indonesia |
Background: Indonesia through its government National Health Insurance System has launched a non-communicable and chronic disease management program named Indonesian Chronic Disease Management Program (PROLANIS), with Type 2 Diabetes Mellitus (T2DM) and hypertension as the main focus. However, study that evaluates the clinical impact of PROLANIS in patients with T2DM is still scarce to this date. This study aims to evaluate the metabolic control and renal function of PROLANIS participants with T2DM every six month within the first 18-months of implementation. Methods: This study was a retrospective cohort study conducted at Wates sub-district, East Java using secondary data from PROLANIS group report from April 2018 to October 2019. The study population was T2DM patients who voluntarily joined the PROLANIS group in April 2018. The six-month-evaluation included metabolic parameters [body mass index (BMI), blood pressure, hemoglobin A1C, total cholesterol, high-density lipid, low-density lipid, and triglyceride (TG)] and renal parameters [blood urea nitrogen (BUN), creatinine serum, and urinary microalbumin]. Paired t-test and wilcoxon signed-rank test was used for the analysis, and the P-value was adjusted using Bonferroni correction. A P-value <.0015 was considered statistically significant, while a P-value between.0015 and.003 was considered as marginally significant. Results: A total of 30 participants were included in the analysis. Following the PROLANIS implementation, the only parameter of metabolic control that showed significant improvement was TG serum level (P <.001). Despite the worsening status of other metabolic parameters, the changes were not statistically significant except for BMI that was marginally significant (P =.002). From renal function, only BUN serum level was significantly deteriorated (P <.001), while the others did not significantly change. Conclusion: PROLANIS implementation in our study population seems to be ineffective. Future study with more primary healthcare centers needs to be done to scrutinize the clinical impact of this program nationwide. © The Author(s) 2021. |
government program; Indonesia; primary healthcare; PROLANIS; type 2 diabetes mellitus |
glycosylated hemoglobin; disease management; human; Indonesia; non insulin dependent diabetes mellitus; primary health care; retrospective study; Diabetes Mellitus, Type 2; Disease Management; Glycated Hemoglobin A; Humans; Indonesia; Primary Health Care; Retrospective Studies |
SAGE Publications Inc. |
21501319 |
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33472499 |
Article |
Q2 |
550 |
9179 |
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