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6 |
Pranata R., Huang I., Lim M.A., Yonas E., Vania R., Lukito A.A., Nasution S.A., Siswanto B.B., Kuswardhani R.A.T. |
57201973901;57208576645;57216039756;57201987097;57208328436;57213835420;57189373134;14422648800;36863900500; |
Elevated De Ritis Ratio Is Associated With Poor Prognosis in COVID-19: A Systematic Review and Meta-Analysis |
2021 |
Frontiers in Medicine |
8 |
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676581 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122327729&doi=10.3389%2ffmed.2021.676581&partnerID=40&md5=254957cc5c17b448a803a88e33741d8f |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Lukito, A.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Nasution, S.A., Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Kuswardhani, R.A.T., Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia |
Objective: This meta-analysis aims to assess whether elevated De Ritis ratio is associated with poor prognosis in patients with coronavirus 2019 (COVID-19). Methods: A systematic literature search was performed using PubMed, Embase, and EuropePMC databases up until September 17, 2021. De Ritis ratio is also known as Aspartate aminotransferase/alanine transaminase (AST/ALT) ratio. The main outcome was poor prognosis, a composite of mortality, severity, the need for ICU care, and intubation. The effect measure was odds ratios (ORs) and mean differences. We generated sensitivity and specificity, negative and positive likelihood ratio (NLR and PLR), diagnostic odds ratio (DOR), and area under curve (AUC). Results: There were eight studies with 4,606 patients. De Ritis ratio was elevated in 44% of the patients. Patients with poor prognosis have higher De Ritis ratio [mean difference 0.41 (0.31, 0.50), p < 0.001; I2: 81.0%] and subgroup analysis showed that non-survivors also have higher De Ritis Ratio [mean difference 0.47 (0.46, 0.48), p < 0.001; I2: 0%]. Elevated De Ritis ratio was associated with poor prognosis [OR 3.28 (2.39, 4.52), p < 0.001; I2: 35.8%]. It has a sensitivity of 55% (36–73), specificity of 71% (52–85), PLR 1.9, NLR.63, DOR of 3 (2–4), and AUC of.67 (0.63–0.71). The posterior probability of poor prognosis was 38% if De Ritis is elevated, while 17% if De Ritis is not elevated. Conclusion: Elevated De Ritis ratio is associated with poor prognosis in patients with COVID-19. Systematic Review Registration: PROSPERO ID: CRD42020216634. Copyright © 2021 Pranata, Huang, Lim, Yonas, Vania, Lukito, Nasution, Siswanto and Kuswardhani. |
coronavirus—COVID-19; De Ritis ratio; liver enzyme; SARS-CoV-2; transaminase |
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Frontiers Media S.A. |
2296858X |
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Review |
Q1 |
1388 |
2608 |
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18 |
Firdaus R., Theresia S., Austin R., Tiara R. |
57423039300;57222095380;57422434500;57422587800; |
Propofol effects in rodent models of traumatic brain injury: A systematic review |
2021 |
Asian Biomedicine |
15 |
6 |
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253 |
265 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123275403&doi=10.2478%2fabm-2021-0032&partnerID=40&md5=fdc2eb2da5eaacf73d60546fd4a9fc72 |
Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Firdaus, R., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Theresia, S., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Austin, R., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Tiara, R., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Background: Traumatic brain injury (TBI) causes high mortality and disability worldwide. Animal models have been developed to explore the complex processes in TBI. Propofol is used to manage head injuries during surgical intervention and mechanical ventilation in patients with TBI. Many studies have investigated the neuroprotective effect of propofol on TBI. However, other studies have shown neurotoxic effects. Objectives: To review systematically the literature regarding the neuroprotective and neurotoxic effects of propofol in rodent models of TBI. Methods: Data from rodents as models of TBI with propofol as one of the intervention agents, and/or comparing the neuroprotective effects of propofol with the other substances in rodent models of TBI, were obtained from PubMed, EBSCO Host, and ProQuest databases. The PRISMA 2020 statement recommendations were followed and research questions were developed based on PICOS guidelines. Data was extracted from the literature using a standardized Cochrane method. Results: We analyzed data from 12 articles on physiological changes of experimental animals before and after trauma, the effects of propofol administration, and the observed neurotoxic effects. The effects of propofol administration were observed in terms of changes in traumatic lesion volume, the release of antioxidants and inflammatory factors, and the neurological function of rodent models of TBI. Conclusion: Propofol has neuroprotective and neurotoxic effects via several mechanisms, and various doses have been used in research to determine its effects. The timing of administration, the dose administered, and the duration of administration contribute to determine the effect of propofol in rodent models of TBI. However, the doses that produce neuroprotective and neurotoxic effects are not yet clear and further research is needed to determine them. © 2021 Riyadh Firdaus et al., published by Sciendo. |
anesthetics; brain injuries, traumatic; neuroprotection; propofol; Rodentia |
calpain; carbon dioxide; catalase; citicoline; diazepam; erythropoietin; fentanyl; glucose; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 6; isoflurane; ketamine; malonaldehyde; mitogen activated protein kinase p38; morphine; nitric oxide; oxygen; pentobarbital; propofol; semaphorin; superoxide dismutase; tumor necrosis factor; xanthine oxidase; adult; antiinflammatory activity; antioxidant activity; arterial carbon dioxide tension; arterial oxygen tension; blood pH; brain edema; brain injury; Cochrane Library; combination drug therapy; controlled study; core temperature; diffuse brain injury; dose response; drug megadose; female; glucose blood level; head injury; heart rate; hematocrit; lesion volume; lipid peroxidation; low drug dose; male; mean arterial pressur |
Sciendo |
19057415 |
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Review |
Q4 |
178 |
20816 |
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39 |
Marofi F., Kozlitina I.A., Margiana R., Bahramali M., Suksatan W., Abdelbasset W.K., Chupradit S., Nasimi M., Maashi M.S. |
57199650994;57428645300;56685900600;57365531600;57219950613;57208873763;57211329338;57189347372;57220613490; |
MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy |
2021 |
Stem Cell Research and Therapy |
12 |
1 |
597 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120732728&doi=10.1186%2fs13287-021-02662-6&partnerID=40&md5=1bb65103a59b38f350d6be8213b4dad8 |
Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Sechenov First Moscow State Medical University, Moscow, Russian Federation; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biotechnology Department, University of Tehran, Tehran, Iran; Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Tehran University of Medical Sciences, Tehran, Iran; Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia |
Marofi, F., Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Kozlitina, I.A., Sechenov First Moscow State Medical University, Moscow, Russian Federation; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bahramali, M., Biotechnology Department, University of Tehran, Tehran, Iran; Suksatan, W., Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Chupradit, S., Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Nasimi, M., Tehran University of Medical Sciences, Tehran, Iran; Maashi, M.S., Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia |
Currently, mesenchymal stem/stromal stem cell (MSC) therapy has become a promising option for accelerating cutaneous wound healing. In vivo reports have outlined the robust competences of MSCs to offer a solid milieu by inhibition of inflammatory reactions, which in turn, enables skin regeneration. Further, due to their great potential to stimulate angiogenesis and also facilitate matrix remodeling, MSCs hold substantial potential as future therapeutic strategies in this context. The MSCs-induced wound healing is thought to mainly rely on the secretion of a myriad of paracrine factors in addition to their direct differentiation to skin-resident cells. Besides, MSCs-derived exosomes as nanoscale and closed membrane vesicles have recently been suggested as an effective and cell-free approach to support skin regeneration, circumventing the concerns respecting direct application of MSCs. The MSCs-derived exosomes comprise molecular components including lipid, proteins, DNA, microRNA, and also mRNA, which target molecular pathways and also biological activities in recipient cells (e.g., endothelial cell, keratinocyte, and fibroblast). The secreted exosome modifies macrophage activation, stimulates angiogenesis, and instigates keratinocytes and dermal fibroblast proliferations as well as migrations concurrently regulate inherent potential of myofibroblast for adjustment of turnover of the ECM. In the present review, we will focus on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports. © 2021, The Author(s). |
Cutaneous wounds; Differentiation; Exosome; Mesenchymal stem/stromal stem cell (MSC); Paracrine factors |
angiopoietin 1; angiopoietin 2; biomaterial; chemokine receptor CCR2; chemokine receptor CCR3; chemokine receptor CXCR1; chemokine receptor CXCR4; collagen type 1; collagen type 3; elastin; fibroblast growth factor 2; gelatinase B; immunoglobulin enhancer binding protein; interleukin 1; interleukin 6; microRNA; microRNA 21 5p; mitogen activated protein kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; platelet derived growth factor beta receptor; platelet endothelial cell adhesion molecule 1; stromal cell derived factor 1; toll like receptor 4; tumor necrosis factor; unclassified drug; vasculotropin; vasculotropin C; angiogenesis; biogenesis; cell differentiation; cell migration; cell proliferation; diabetic foot; endothelium cell; exosome; extracellular matrix; fibroblast; h |
BioMed Central Ltd |
17576512 |
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34863308 |
Review |
Q1 |
1599 |
2021 |
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57 |
Diptyanusa A., Sari I.P. |
57205340891;57197543698; |
Treatment of human intestinal cryptosporidiosis: A review of published clinical trials |
2021 |
International Journal for Parasitology: Drugs and Drug Resistance |
17 |
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128 |
138 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115755098&doi=10.1016%2fj.ijpddr.2021.09.001&partnerID=40&md5=e7d5494025a277d99586bf5f73027625 |
Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia; Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia |
Diptyanusa, A., Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia, Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia |
The global burden of diarrhea caused by Cryptosporidium parasite is underestimated. In immunocompromised hosts, chronic and severe presentation of intestinal cryptosporidiosis can result in long-term morbidity and high illness costs. The evidence of effective treatments for cryptosporidiosis has been lacking. We reviewed the published clinical trials to bring forward the feasible therapeutic options of human cryptosporidiosis in various populations and settings according to clinical improvement and parasite clearance rates. A total of 42 studies consisting of the use of nitazoxanide, paromomycin, macrolides, somatostatin analogues, letrazuril, albendazole, rifaximin, miltefosine, clofazimine, and colostrum were included in the review. The trials were mostly conducted in small number of individuals infected with human immunodeficiency virus (HIV), and there is inadequate data of controlled trials to suggest the use of these treatment modalities. Nitazoxanide was reported to be highly efficacious only in immunocompetent hosts and was found to be superior to paromomycin in the same group of patients. Macrolides showed no effective results in both clinical and parasitological improvement. Human bovine colostrum should possibly be administered as one of complementary therapeutic modalities along with other antimicrobials to reach optimal parasite eradication. Other trials of therapeutic modalities were terminated due to futility. Currently, available data is intended to aid the development of strategies for improving access to treatments in different clinical settings, as well as to help guide further studies on treatments of human intestinal cryptosporidiosis. © 2021 |
Clearance; Clinical trial; Cryptosporidiosis; Cryptosporidium; Drug; Treatment |
acetylspiramycin; albendazole; alkaline phosphatase; antiparasitic agent; azithromycin; clofazimine; erythromycin; garlicin; immunoglobulin; letrazuril; macrolide; miltefosine; nitazoxanide; octreotide; paromomycin; placebo; probiotic agent; rifaximin; roxithromycin; somatostatin derivative; spiramycin; unclassified drug; vapreotide; antiprotozoal agent; paromomycin; abdominal pain; adolescent; adult; aged; alkaline phosphatase level; alternative medicine; anorexia; antiparasitic therapy; child; cholecystitis; clinical trial (topic); colostrum; constipation; cryptosporidiosis; diarrhea; dizziness; drowsiness; drug efficacy; fatigue; fever; headache; health care access; human; Human immunodeficiency virus infection; hypertransaminasemia; infant; injection site pain; intestine obstruction; k |
Elsevier Ltd |
22113207 |
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34562754 |
Review |
Q1 |
1071 |
3953 |
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59 |
Adriansyah I.A., Afriansyah A., Siregar M.A.R., Purnomo N., Mirza H., Seno D.H. |
57255172900;57190688768;57255058200;57255293100;57208513330;57255640300; |
Efficacy of holmium laser enucleation of the prostate in patients with detrusor underactivity: systematic review and meta-analysis |
2021 |
African Journal of Urology |
27 |
1 |
128 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114753119&doi=10.1186%2fs12301-021-00230-1&partnerID=40&md5=a5780c3ae26d7da14412977dd81e01f7 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Salemba, Jakarta Pusat, Jakarta, DKI Jakarta 10430, Indonesia; Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia |
Adriansyah, I.A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Salemba, Jakarta Pusat, Jakarta, DKI Jakarta 10430, Indonesia; Afriansyah, A., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Siregar, M.A.R., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Purnomo, N., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Mirza, H., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Seno, D.H., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia |
Background: Benign prostatic hyperplasia (BPH) is commonly found in the aging male. Treatment of BPH can be in form of conservative or surgical intervention. Transurethral resection of the prostate (TURP) is the gold-standard treatment for BPH according to the guideline. However, there is no evidence that there is a benefit for TURP in patients with detrusor underactivity (DUA). Holmium laser enucleation (HoLEP) is theorized to have a better outcome due to its property of complete prostate enucleation. Therefore, this meta-analysis aims to determine the benefit of HoLEP for BPH patients with DUA. Main body: We performed systematic literature searching from five databases including PubMed, Scopus, Embase, Science Direct, and Web of Science for articles up to 31 December 2020 for relevant studies. A total of five articles are eligible for this meta-analysis. A total of 2.180 subjects participated in all of the studies included. Two studies comparing patients with and without DUA that was treated with HoLEP, two studies comparing HoLEP with other surgical approaches for BPH, and one study comparing both parameters. IPSS score reduction is significantly higher in the patients with DUA (Mean Difference = 3.28, 95% CI 1.91 to 4.64, p < 0.01). Qmax and PVR are not significantly different between both groups. HoLEP also showed better improvement in IPSS and Qmax compared to TURP (IPSS: Mean Difference = -4.80, 95% CI − 7.83 to − 1.77, p = 0.002; Qmax: Mean Difference = 4.20, 95% CI 0.58 to 7.82, p = 0.02) and PVP (IPSS: Mean Difference = − 2.47, 95% CI − 4.47 to − 0.47, p = 0.02; Qmax: Mean Difference = 2.31, 95% CI 0.34 to 4.28, p = 0.02). Conclusion: HoLEP showed better improvement in IPSS scores in patients with DUA. HoLEP can be considered to be performed in the BPH patients with DUA for better outcomes for the patients. © 2021, The Author(s). |
Benign prostatic hyperplasia; Detrusor underactivity; HoLEP; Laser enucleation; Surgical outcome |
clinical effectiveness; Embase; enucleation; human; hypotonic bladder; information retrieval; intermethod comparison; International Prostate Symptom Score; laser surgery; male; measurement; Medline; meta analysis; Newcastle-Ottawa scale; postvoid residual urine volume; prostate hypertrophy; prostate surgery; randomized controlled trial (topic); Review; ScienceDirect; Scopus; surgical approach; systematic review; transurethral resection; Web of Science |
Springer Science and Business Media Deutschland GmbH |
11105704 |
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Review |
Q4 |
174 |
21103 |
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78 |
Laurentius A., Mendel B., Prakoso R. |
57213147353;57221914088;57192893243; |
Clinical outcome of renin-angiotensin-aldosterone system blockers in treatment of hypertensive patients with COVID-19: a systematic review and meta-analysis |
2021 |
Egyptian Heart Journal |
73 |
1 |
13 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100576309&doi=10.1186%2fs43044-021-00135-y&partnerID=40&md5=09d9e73f520074123305d8d901cd705f |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pediatric Cardiology and Congenital Heart Defect Division, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Laurentius, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mendel, B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prakoso, R., Pediatric Cardiology and Congenital Heart Defect Division, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Background: Novel coronavirus disease 2019 has been stated as global disease pandemic due to its rapid spread worldwide. Up to 30% of coronavirus disease 2019 patients with hypertension are more susceptible to death. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have been used as primary line of medication for hypertension; nonetheless, conflicting data arises as numerous studies showed contradictory results. Main body: Aiming to show clinical outcome of renin-angiotensin-aldosterone system blockers in hospital treatment of hypertensive patients with coronavirus disease 2019, systematically searched literatures through five databases were intensively appraised using The Grading of Recommendations Assessment, Development and Evaluation checklists for cohort studies. Based on the result evaluation from retrospective cohorts involving more than 15,000 patients across Asia and other regions of the world, ten encompassed studies divided into two subgroups in this meta-review showed that in-hospital hypertensive coronavirus disease 2019 patients receiving antihypertensive drugs were associated with overall risk reduction in subgroup 1 (hazard ratio, HR = 0.96, 95% CI = 0.82–1.12) to no outcome association of all-cause mortalities in subgroup 2 (HR = 0.26, 95% CI = 0.19–0.34). All appraised studies in synergism showed that mortality outcomes were not augmented with the employment of either ACE inhibitor or ARB in subjects. Conclusion: Therefore, the results support recommendation by the American Heart Association not to discontinue angiotensin-converting enzyme inhibitor or angiotensin receptor blocker regimens in coronavirus disease 2019 patients with hypertension. © 2021, The Author(s). |
Angiotensin receptor blockers; Angiotensin-converting enzyme inhibitors; COVID-19; Hypertension; Outcome |
angiotensin receptor antagonist; dipeptidyl carboxypeptidase inhibitor; adult; aged; all cause mortality; clinical outcome; confidence interval; coronavirus disease 2019; data base; female; hazard ratio; human; hypertension; hypertensive patient; male; medical society; meta analysis; mortality; renin angiotensin aldosterone system; Review; risk reduction; systematic review |
Springer Science and Business Media Deutschland GmbH |
11102608 |
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Review |
Q3 |
212 |
18617 |
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79 |
Saharman Y.R., Karuniawati A., Severin J.A., Verbrugh H.A. |
55980934300;54886816200;8700385500;7103296623; |
Infections and antimicrobial resistance in intensive care units in lower-middle income countries: a scoping review |
2021 |
Antimicrobial Resistance and Infection Control |
10 |
1 |
22 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100075262&doi=10.1186%2fs13756-020-00871-x&partnerID=40&md5=137569c4bc3b7584a1b51042515f7130 |
Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, Netherlands |
Saharman, Y.R., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, Netherlands; Karuniawati, A., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Severin, J.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, Netherlands; Verbrugh, H.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, Netherlands |
Background: Intensive care units (ICUs) in lower-middle income countries (LMICs) are suspected to constitute a special risk for patients of acquiring infection due to multiple antibiotic resistant organisms. The aim of this systematic scoping review was to present the data published on ICU-acquired infections and on antimicrobial resistance observed in ICUs in LMICs over a 13-year period. A systematic scoping review was conducted according to the PRISMA extension guideline for scoping reviews and registered in the Open Science Framework. Main body of the abstract: Articles were sought that reported on ICU-acquired infection in LMICs between 2005 and 2018. Two reviewers parallelly reviewed 1961 titles and abstracts retrieved from five data banks, found 274 eligible and finally included 51. Most LMICs had not produced reports in Q1 or Q2 journals in this period, constituting a large gap in knowledge. However, from the reported evidence it is clear that the rate of ICU-acquired infections was comparable, albeit approximately 10% higher, in LMICs compared to high income countries. In contrast, ICU mortality was much higher in LMICs (33.6%) than in high income countries (< 20%). Multidrug-resistant Gram-negative species, especially Acinetobacter baumannii and Pseudomonas aeruginosa, and Klebsiella pneumoniae played a much more dominant role in LMIC ICUs than in those in high income countries. However, interventions to improve this situation have been shown to be feasible and effective, even cost-effective. Conclusions: Compared to high income countries the burden of ICU-acquired infection is higher in LMICs, as is the level of antimicrobial resistance; the pathogen distribution is also different. However, there is evidence that interventions are feasible and may be quite effective in these settings. Protocol Registration The protocol was registered with Open Science Framework (https://osf.io/c8vjk) © 2021, The Author(s). |
Acinetobacter; Bacterial drug resistance; Cross infection; Infection control; Intensive care units |
antibiotic agent; Acinetobacter baumannii; adult; antibiotic resistance; bacterial infection; cross infection; female; high income country; hospital mortality; human; infection control; intensive care unit; Klebsiella pneumoniae; major clinical study; male; middle income country; multidrug resistance; nonhuman; priority journal; Pseudomonas aeruginosa; Review; bacterial infection; cross infection; developing country; Acinetobacter baumannii; Adult; Bacterial Infections; Cross Infection; Developing Countries; Drug Resistance, Bacterial; Humans; Intensive Care Units; Klebsiella pneumoniae; Pseudomonas aeruginosa |
BioMed Central Ltd |
20472994 |
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33514432 |
Review |
Q1 |
1456 |
2381 |
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81 |
Raharja A., Tamara A., Kok L.T. |
57192080346;57205305387;57219901696; |
Association Between Ethnicity and Severe COVID-19 Disease: a Systematic Review and Meta-analysis |
2021 |
Journal of Racial and Ethnic Health Disparities |
8 |
6 |
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1563 |
1572 |
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8 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096023866&doi=10.1007%2fs40615-020-00921-5&partnerID=40&md5=139e8ff070e1e792a6383269e01b7342 |
Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Raharja, A., Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; Tamara, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kok, L.T., Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom |
Objectives: This article evaluates if ethnicity is an independent poor prognostic factor in COVID-19 disease. Methods: MEDLINE, EMBASE, Cochrane, WHO COVID-19 databases from inception to 15/06/2020 and medRxiv. No language restriction. Newcastle-Ottawa Scale (NOS) and GRADE framework were utilised to assess the risk of bias and certainty of evidence. PROSPERO CRD42020188421. Results: Seventy-two articles (59 cohort studies with 17,950,989 participants, 13 ecological studies; 54 US-based, 15 UK-based; 41 peer-reviewed) were included for systematic review and 45 for meta-analyses. Risk of bias was low: median NOS 7 of 9 (interquartile range 6–8). Compared to White ethnicity, unadjusted all-cause mortality was similar in Black (RR: 0.96 [95% CI: 0.83–1.08]) and Asian (RR: 0.99 [0.85–1.16]) but reduced in Hispanic ethnicity (RR: 0.69 [0.57–0.84]). Age- and sex-adjusted risks were significantly elevated for Black (HR: 1.38 [1.09–1.75]) and Asian (HR: 1.42 [1.15–1.75]), but not for Hispanic (RR: 1.14 [0.93–1.40]). Further adjusting for comorbidities attenuated these associations to non-significance: Black (HR: 0.95 [0.72–1.25]); Asian (HR: 1.17 [0.84–1.63]); Hispanic (HR: 0.94 [0.63–1.44]). Subgroup analyses showed a trend towards greater disparity in outcomes for UK ethnic minorities, especially hospitalisation risk. Conclusions: This review could not confirm a certain ethnicity as an independent poor prognostic factor for COVID-19. Racial disparities in COVID-19 outcomes may be partially attributed to higher comorbidity rates in certain ethnicity. © 2020, W. Montague Cobb-NMA Health Institute. |
Acute kidney injury; COVID-19; Ethnicity; Hospitalisation; Intubation; Mortality |
ethnicity; ethnology; human; meta analysis; patient acuity; prognosis; risk factor; therapy; COVID-19; Ethnicity; Humans; Patient Acuity; Prognosis; Risk Factors |
Springer Science and Business Media Deutschland GmbH |
21973792 |
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33180278 |
Review |
Q1 |
644 |
7820 |
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88 |
Lokeswara A.W., Hiksas R., Irwinda R., Wibowo N. |
57200937543;57226152029;57205713130;15049026900; |
Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition |
2021 |
Frontiers in Cell and Developmental Biology |
9 |
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726513 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119532670&doi=10.3389%2ffcell.2021.726513&partnerID=40&md5=38456382efeb541572619e5bed470318 |
Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia |
Lokeswara, A.W., Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia |
Preeclampsia is one of the most common obstetrical complications worldwide. The pathomechanism of this disease begins with abnormal placentation in early pregnancy, which is associated with inappropriate decidualization, vasculogenesis, angiogenesis, and spiral artery remodeling, leading to endothelial dysfunction. In these processes, appropriate cellular deaths have been proposed to play a pivotal role, including apoptosis and autophagy. The proper functioning of these physiological cell deaths for placentation depends on the wellbeing of the trophoblasts, affected by the structural and functional integrity of each cellular component including the cell membrane, mitochondria, endoplasmic reticulum, genetics, and epigenetics. This cellular wellness, which includes optimal cellular integrity and function, is heavily influenced by nutritional adequacy. In contrast, nutritional deficiencies may result in the alteration of plasma membrane, mitochondrial dysfunction, endoplasmic reticulum stress, and changes in gene expression, DNA methylation, and miRNA expression, as well as weakened defense against environmental contaminants, hence inducing a series of inappropriate cellular deaths such as abnormal apoptosis and necrosis, and autophagy dysfunction and resulting in abnormal trophoblast invasion. Despite their inherent connection, the currently available studies examined the functions of each organelle, the cellular death mechanisms and the nutrition involved, both physiologically in the placenta and in preeclampsia, separately. Therefore, this review aims to comprehensively discuss the relationship between each organelle in maintaining the physiological cell death mechanisms and the nutrition involved, and the interconnection between the disruptions in the cellular organelles and inappropriate cell death mechanisms, resulting in poor trophoblast invasion and differentiation, as seen in preeclampsia. Copyright © 2021 Lokeswara, Hiksas, Irwinda and Wibowo. |
apoptosis; autophagy; cell death; cellular wellness; nutrition; preeclampsia |
aneuploidy; cell death; cell differentiation; cell invasion; cell membrane; cell organelle; endoplasmic reticulum; endoplasmic reticulum stress; environmental factor; epigenetics; gene expression; human; mitochondrion; nonhuman; nutrition; preeclampsia; pregnancy; Review; trophoblast; vascular remodeling |
Frontiers Media S.A. |
2296634X |
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Review |
Q1 |
2452 |
946 |
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92 |
Habiburrahman M., Ariq H., Handayani R.R.D. |
57204537114;57252668400;57394104600; |
Combining LAMP and Au-Nanoprobe to detect INH-RIF resistance accurately in tuberculosis: An evidence-based review |
2021 |
Journal of Infection in Developing Countries |
15 |
11 |
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1555 |
1568 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122149394&doi=10.3855%2fJIDC.15188&partnerID=40&md5=6f29dbd01464318f481e0062398c92a4 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; National Respiratory Center Persahabatan Hospital, Jakarta, Indonesia |
Habiburrahman, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ariq, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handayani, R.R.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, National Respiratory Center Persahabatan Hospital, Jakarta, Indonesia |
Approximately 1.41 million people die annually due to tuberculosis. One of the main problems in Tuberculosis eradication is the development of resistance to various antibiotics. However, current efforts to detect resistances face challenges such as limited equipment, budget, and time. This evidence-based review investigated loop-mediated isothermal amplification, an alternative molecular diagnostic tool with promising performance and applicability in developing countries, and its use combined with Au-Nanoprobe to detect antibiotic resistance in tuberculosis. The literature search was conducted through four databases (Proquest, EBSCOhost, Scopus, and Pubmed) for useful articles on loop-mediated isothermal amplification and Au-Nanoprobe in detecting tuberculosis and tuberculosis resistance. After filtering the result with inclusion and exclusion criteria, the search produced three papers that best answer the clinical question. Loop-mediated isothermal amplification amplifies a target sequence, and Au-Nanoprobe responds to the DNA specific to the target mutant, producing an observable color change. Loop-mediated isothermal amplification and Au-Nanoprobe showed 100% sensitivity and specificity in detecting rifampicin and isoniazid resistance. Another study investigated its viability to detect tuberculosis and found 98.2% sensitivity and 88.2% specificity. Combining loop-mediated isothermal amplification and Au-Nanoprobe had a shorter time to get results and should also be relatively cheaper because it does not need a high temperature to work and requires less equipment. In conclusion, loop-mediated isothermal amplification and Au-Nanoprobe can be used as an efficient and accurate method to detect isoniazid and rifampicin-resistant tuberculosis strains. The new technology is promising for developing countries due to their high disease burden but facing several healthcare barriers. Copyright © 2021 Habiburrahman et al. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Au-Nanoprobes; Diagnosis; Isoniazid; Loop-mediated isothermal amplification; Multidrug-resistant tuberculosis; Rifampicin |
aflatoxin B1; antibiotic agent; betaine; catalase; gold; gold nanoparticle; isoniazid; isoniazid plus rifampicin; penicillin derivative; rifampicin; rifapentine; bacterial DNA; isoniazid; rifampicin; tuberculostatic agent; antibiotic resistance; blood culture; cost effectiveness analysis; developing country; disease burden; DNA extraction; filtration; gene amplification; genotype; high temperature; human; loop mediated isothermal amplification; Medline; molecular diagnosis; multiplex polymerase chain reaction; Mycobacterium tuberculosis; nonhuman; nucleotide sequence; polymerase chain reaction; Review; rifampicin resistance; Scopus; sputum cytodiagnosis; sputum smear; Streptococcus pneumoniae; surface plasmon resonance; systematic review; temperature; tuberculosis; multidrug resistant tube |
Journal of Infection in Developing Countries |
20366590 |
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34898479 |
Review |
Q3 |
322 |
14136 |
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