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792 |
Marwali E.M., Caesa P., Purnama Y., Rayhan M., Budiwardhana N., Fitria L., Fakhri D., Portman M.A. |
36608535400;57204921746;57225291969;57219904946;56805196100;56500669600;8599513100;7004985824; |
Thiamine levels in Indonesian children with congenital heart diseases undergoing surgery using cardiopulmonary bypass machine |
2021 |
Asian Cardiovascular and Thoracic Annals |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107515265&doi=10.1177%2f02184923211024103&partnerID=40&md5=e04e32d473d0075386f8ced87f6df736 |
Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pediatric Cardiac Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiothoracic Surgery Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Marwali, E.M., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Caesa, P., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Purnama, Y., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Rayhan, M., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Budiwardhana, N., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Fitria, L., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Fakhri, D., Pediatric Cardiac Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Pediatric Cardiac Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Portman, M.A., Department of Cardiothoracic Surgery Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: This study evaluated thiamine levels in Indonesian children with congenital heart diseases before and after cardiopulmonary bypass and their relationship with clinical and surgical outcomes. Method: A prospective, single center cross-sectional study was conducted to evaluate thiamine levels in 25 children undergoing congenital heart diseases surgery with cardiopulmonary bypass procedure. Thiamine levels were quantified using a high-performance liquid chromatography method. Result: Preoperative thiamine deficiency was observed in one subject. Thiamine levels did not differ statistically between nutritional status and clinical outcomes categories. There were no significant changes in thiamine levels before and after cardiopulmonary bypass (median pre versus post (P25–75): 50 ng/mL (59.00–116.00) and 83.00 ng/mL (70.00–101.00), p = 0.84), although a significant reduction in thiamine levels were observed with longer cardiopulmonary bypass duration (p = 0.017, R = −0.472). Conclusion: Thiamine levels were not significantly impacted by cardiac surgery except in patients undergoing extremely long cardiopulmonary bypass duration. However, clinical outcome was not affected by thiamine levels. © The Author(s) 2021. |
cardiopulmonary bypass; congenital heart disease; malnutrition; Thiamine |
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SAGE Publications Inc. |
02184923 |
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Article |
Q3 |
203 |
19132 |
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795 |
Nadhif M.H., Irsyad M., Utomo M.S., Suhaeri M., Whulanza Y. |
57189057498;57220935587;56180933900;56183087500;36807053500; |
Computational Analysis of Soft Polymer Lattices for 3D Wound Dressing Materials |
2021 |
Journal of Mechanical Engineering |
18 |
2 |
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1 |
11 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107456696&partnerID=40&md5=fb3bc81a587f3564de3a190ebd6e1a72 |
Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Indonesia; Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Indonesia; Indonesia Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Department of Mechanical Engineering, Faculty of Engineering Universitas, Indonesia; Research Center on Biomedical Engineering (RCBE), Faculty of Engineering Universitas, Indonesia |
Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Irsyad, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Utomo, M.S., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Suhaeri, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia, Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Indonesia, Indonesia Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering Universitas, Indonesia, Research Center on Biomedical Engineering (RCBE), Faculty of Engineering Universitas, Indonesia |
One of the wound treatments was negative pressure wound therapy (NPWT), which used wound dressings on the wound bed to ameliorate the wound healing. Unfortunately, most wound dressings were two dimensional (2D), lacking the ability to cover severe wounds with a straightforward procedure. The sheets needed to be stacked following the wound curvature, which might be problematic since improper stacking could hinder the wound healing. Regarding the mentioned problems, our group develop 3D wound dressings, which are made using 3D printers. The wound dressings are made of polycaprolactone (PCL), polyurethane (PU), and polyvinyl alcohol (PVA). As the initial stage, the mechanical integrity of the soft polymers was investigated under uniaxial tensile and uniaxial compressive stress using computational methods. The polymers were defined as 3D lattices following the dimension of existing wound dressings. Based on the simulation results of displacement and von Mises stress, the three polymers are mechanically safe to be used as wound dressing materials. © 2021 College of Engineering, Universiti Teknologi MARA (UiTM), Malaysia. All Rights Reserved. |
Computational analysis; Lattice; Soft polymer; Wound dressing |
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UiTM Press |
18235514 |
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Article |
Q3 |
216 |
18402 |
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802 |
Lilihata G., Saputra C., Yaniarti D., Soerarso R. |
57223977510;57223988357;57223991240;57192913673; |
Hyperthyroidism in severe mitral regurgitation post mechanical mitral valve replacement: The effect on warfarin anticoagulation |
2021 |
Cardiovascular Endocrinology and Metabolism |
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146 |
148 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106612745&doi=10.1097%2fXCE.0000000000000233&partnerID=40&md5=01f9076c604667b3b97acb9eb9581c09 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Division of Clinical Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia |
Lilihata, G., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Saputra, C., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Yaniarti, D., Division of Clinical Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Soerarso, R., Division of Clinical Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia |
A 24-year-old male patient came to the emergency room with melena, gum bleeding and nosebleeds. This patient has a history of mechanical prosthetic mitral valve replacement for severe mitral regurgitation (MR) and consumed warfarin irregularly, but did not come back for regular check-up. Investigations showed greatly increased thyroid function and international normalised ratio (INR) was 15.8. Patients were diagnosed with thyroid storm and bleeding due to prolongation of INR. His hyperthyroid state might have caused increased rate of degradation of vitamin K-dependent clotting factor thereby increased sensitivity to warfarin. Concomitant acute decompensated heart failure, thrombocytopenia and hypoalbuminemia also contributed to his risk of bleeding. Treatment included anti-thyroid therapy as well as warfarin reversal therapy by stopping warfarin, low-dose intravenous vitamin K due to his mechanical prosthetic valve and fresh frozen plasma. In conclusion, hyperthyroidism could increase the response to warfarin so close monitoring is needed to balance the risk of bleeding and thromboembolism. © 2021 Lippincott Williams and Wilkins. All rights reserved. |
anticoagulation; bleeding; hyperthyroidism; mechanical valve; prosthetic valve; warfarin |
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Lippincott Williams and Wilkins |
25740954 |
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Article |
Q3 |
498 |
10107 |
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806 |
Adriztina I., Munir D., Sandra F., Ichwan M., Bashiruddin J., Putra I.B., Farhat, Sembiring R.J., Sartika C.R., Chouw A., Pratiwi E.D. |
56928394300;57039203600;56016164200;26040779000;56469338300;57194636376;57194721197;57038845000;57205297509;56431084200;57223858156; |
Differentiation capacity of dental pulp stem cell into inner ear hair cell using an in vitro assay: a preliminary step toward treating sensorineural hearing loss |
2021 |
European Archives of Oto-Rhino-Laryngology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106239040&doi=10.1007%2fs00405-021-06864-9&partnerID=40&md5=5a4ff939b0fff7361593d6d043015bd8 |
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No 5, Medan, Sumatera Utara 20155, Indonesia; Division of Oral Biology, Departement of Biochemistry and Molecular Biology, Faculty of Dentistry, Trisakti University, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Dermatovenerology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Prodia Stemcell Indonesia, Jl. Kramat VII No.11, Jakarta, Indonesia |
Adriztina, I., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No 5, Medan, Sumatera Utara 20155, Indonesia; Munir, D., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No 5, Medan, Sumatera Utara 20155, Indonesia; Sandra, F., Division of Oral Biology, Departement of Biochemistry and Molecular Biology, Faculty of Dentistry, Trisakti University, Jakarta, Indonesia; Ichwan, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Bashiruddin, J., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Putra, I.B., Department of Dermatovenerology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Farhat, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No 5, Medan, Sumatera Utara 20155, Indonesia; Sembiring, R.J., Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Sartika, C.R., Prodia Stemcell Indonesia, Jl. Kramat VII No.11, Jakarta, Indonesia; Chouw, A., Prodia Stemcell Indonesia, Jl. Kramat VII No.11, Jakarta, Indonesia; Pratiwi, E.D., Prodia Stemcell Indonesia, Jl. Kramat VII No.11, Jakarta, Indonesia |
Purpose: Sensorineural hearing loss (SNHL) is commonly caused by the death or dysfunction of cochlear cell types as a result of their lack of regenerative capacity. However, regenerative medicine, such as stem cell therapy, has become a promising tool to cure many diseases, including hearing loss. In this study, we determined whether DPSCs could differentiate into cochlear hair cell in vitro. Methods: DPSCs derived from human third molar dental pulp were induced into NSCs using a medium containing basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) for 7 days, and then into cochlear hair cell using a medium containing EGF and IGF-1 for the next 14 days. We used the neuroepithelial protein marker nestin and cochlear hair cell marker myosin VIIa as the markers for cells differentiation. Cells expressing the positive markers under the microscope were confirmed to have differentiated into cochlear hair cell. Results: DPSCs were successfully induced to differentiate into NSCs, with mean 24% nestin-positive cells. We found that DPSC-derived NSCs have a great capacity in differentiating into inner ear hair cell-like cells with an average of 81% cells presenting myosin VIIa. Thus, DPSCs have high potential to serve as a good resource for SNHL treatment. Conclusion: We found the high potential of DPSCs to differentiate into NSC. The ability of DPSCs in differentiating into neural lineage cell made them a good candidate for regenerative therapy in neural diseases, such as SNHL © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
Cochlear hair cell; Dental pulp stem cells; Sensorineural hearing loss |
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Springer Science and Business Media Deutschland GmbH |
09374477 |
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34008035 |
Article |
Q1 |
849 |
5560 |
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813 |
Azmi L., Rukmana A., Sjatha F. |
57223235228;35491487100;55372815000; |
Cloning of the pe11 (LipX, Rv1169c) gene of a mycobacterium tuberculosis beijing strain into the pcDNA3.1 plasmid vector |
2021 |
Makara Journal of Science |
25 |
1 |
6 |
35 |
42 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105345058&doi=10.7454%2fmss.v25i1.1206&partnerID=40&md5=15f89692c545a91386310b30b135be6b |
Biomedical Student, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Departement of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
Azmi, L., Biomedical Student, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Rukmana, A., Departement of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Sjatha, F., Departement of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. It is a persistent global health problem with a high mortality rate. Currently, TB is controlled by administering the Bacillus Calmette-Guerin (BCG) vaccine, but the effectiveness of its protection varies among individuals in a population. The pe/ppe gene family comprises a typical group of genes that play a role in avoiding the host immune response and inducing persistent TB infection. Based on in silico analysis, the pe11 gene has estimated immunogenicity and potential as a TB seed vaccine candidate. The pe11 gene from an Indonesian isolate of an M. tuberculosis Beijing strain was amplified by polymerase chain reaction (PCR) and inserted into the mammalian expression vector pcDNA3.1. The recombinant vector pcDNA3.1-pe11 was used to transform Top10 competent Escherichia coli. Clones from the transformation were subjected to colony PCR to confirm the direction of the insert. Sequencing was performed to confirm the correctness of the insert sequence. In this study, the pe11 gene was successfully cloned into the pcDNA3.1 vector in the correct direction to assure PE11 expression. No mutations were found in the pe11 gene insert, compared with the M. tuberculosis H37Rv sequence as the standard. A pcDNA3.1 vector contain-ing the pe11 gene derived from an M. tuberculosis Beijing strain was successfully constructed. © 2021, Universitas Indonesia. All rights reserved. |
M. tuberculosis; PcDNA3.1; Pe11; Tuberculosis |
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Universitas Indonesia |
23391995 |
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Article |
#N/A |
#N/A |
#N/A |
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817 |
Kusumawardani A., Yanfaunnas A.M., Supandi D.P., Inggita R.A.M., Andayani N.G.A.A.P.T., Louisa M., Soetikno V., Burhan E. |
57223083920;57223095441;57222624055;57223087394;57223088955;41461551400;36769252100;36058554600; |
The use of Urinary Lipoarabinomannan (LAM) as a Rapid Diagnostic Test for Adult Pulmonary Tuberculosis in HIV-Positive Patients: An Evidence-based Case Report |
2021 |
Journal of International Dental and Medical Research |
14 |
1 |
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461 |
466 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104790784&partnerID=40&md5=012c79128a2fc69230627fe766651487 |
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia/Persahabatan Hospital, Jakarta, Indonesia |
Kusumawardani, A., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Yanfaunnas, A.M., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Supandi, D.P., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Inggita, R.A.M., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Andayani, N.G.A.A.P.T., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia/Persahabatan Hospital, Jakarta, Indonesia |
Tuberculosis is a major health concerns around the world as it is causing morbidity and mortality, especially in HIV infected patients. Detection of lipoarabinomannan (LAM) on urine is a non-sputum-based diagnostic test for TB that could accelerate TB case detection in HIV-positive patients. This evidence-based case report was aimed to evaluate the diagnostic value of urinary Lipoarabinomannan (LAM) test in diagnosing pulmonary tuberculosis in HIV-positive patients as compared to sputum culture. Structured literature searching was done on cross-sectional or systematic reviews of diagnostic studies of lipoarabinomannan versus sputum culture in adult HIV-positive patients suspected with pulmonary TB. There were 9 articles that meet the eligibility criteria; 1 systematic review and 8 cross-sectional studies. Two out of nine articles were deemed as not valid due to not using sputum on all samples and the index test and reference test were not carried out on all samples. There were contradictory results regarding the sensitivity, positive predictive values and negative predictive values, meanwhile the specificity showed good results. We conclude that urinary LAM can be used to diagnose pulmonary TB in HIV-positive patients due to its high specificity. However, it could not be used as a stand-alone test, due to its suboptimal sensitivity. © 2021 |
Sputum culture; TB-HIV; tuberculosis; urinary lipoarabinomannan |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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818 |
Sahar N., Birowo P., Kusmardi, Kristianty D., Rahmaningrum K., Miranda A.V., Rasyad A., Prasasty V.D. |
57212464367;6504153311;56966625300;57223024424;57223023016;57222664687;57223027205;56019989700; |
Mucin-1 expression in endometrial tissue of Macaca nemestrina during mid-luteal phase after controlled-ovarian hyperstimulation |
2021 |
Biodiversitas |
22 |
4 |
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1927 |
1933 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104548199&doi=10.13057%2fbiodiv%2fd220440&partnerID=40&md5=436be5fa1fbe0e2157ca68a386731018 |
Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Departement Urology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Faculty of Biotechnology, Universita Katolik Atma Jaya Indonesia, Jl. Jend. Sudirman No. 51, Jakarta Selatan, Jakarta, 12930, Indonesia |
Sahar, N., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Birowo, P., Departement Urology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Kusmardi, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Kristianty, D., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Rahmaningrum, K., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Miranda, A.V., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Rasyad, A., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Prasasty, V.D., Faculty of Biotechnology, Universita Katolik Atma Jaya Indonesia, Jl. Jend. Sudirman No. 51, Jakarta Selatan, Jakarta, 12930, Indonesia |
Endometrial receptivity is one of the factors for successful implantation in pregnancy. Controlled ovarian hyperstimulation (COH) is a required step of in vitro fertilization (IVF), one of the standard procedures to overcome infertility. Exogenous gonadotropin hormones from COH provoke the secretion of estrogen and progesterone from the ovaries in higher amounts. The supraphysiological environment could impact the endometrial receptivity of the implantation process. Mucin-1 (MUC1) can be used as a marker to indicate alterations in the endometrial tissue. Therefore, this study aimed to investigate the alteration of mucin-1 expression in endometrial tissue of Macaca nemestrina after COH protocol. This study used endometrium tissue of M. nemestrina embedded with paraffin as tissue blocks. The subjects were 15 female macaques in reproductive age (8-10 years old) with a history of producing offspring. These macaques were classified into four groups based on the COH protocols, which consist of administering gonadotropin-releasing hormone (GnRH) agonist and recombinant FSH (r-FSH) with dosages of 30 IU, 50 IU, 70 IU (intervention groups), and no r-FSH (control group). The stimulations were administered for 14 days during the mid-luteal phase. Moreover, tissue staining was done by using immunohistochemistry. Mucin-1 expression was analyzed manually for glandular and luminal compartments and automatically for the stromal compartment by Red Green Blue (RGB) measure plugin as a color image from ImageJ software. The expression of mucin-1 was counted semi-quantitatively as H-score. Mucin-1 expression differences in endometrial tissue were assessed by one-way ANOVA with a significant difference found in the glandular part and insignificant results found in luminal and stromal parts. Pearson correlation test was also performed to determine the relationship of steroidal hormones and mucin-1 expression in glandular and luminal compartments. Both correlations were statistically insignificant. However, a positive correlation was found with the glandular compartment and a negative correlation with luminal compartment. As the subject species, M. nemestrina is limited for research utilization in our country, small number of subjects becomes a limitation of this study. Further studies need to be conducted to deepen the understanding of the regulation of mucin-1 expression, particularly by the altered concentrations of steroidal hormones as a consequence of COH. © 2021, Society for Indonesian Biodiversity. All rights reserved. |
Controlled ovarian hyperstimulation; Endometrial receptivity; In vitro fertilization; Mucin-1 |
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Society for Indonesian Biodiversity |
1412033X |
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Article |
Q3 |
257 |
16376 |
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819 |
Putri A.S., Soedarsono N., Nehemia B., Atmadja D.S., Ubelaker D.H. |
57223021361;14049161500;57204102056;6507824506;7003416830; |
Age estimation of individuals aged 5–23 years based on dental development of the Indonesian population |
2021 |
Forensic Sciences Research |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104502186&doi=10.1080%2f20961790.2021.1886648&partnerID=40&md5=b3c0a614893fe57774dae608436d737a |
Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Department of Dento-Maxillofacial Radiology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Department of Forensic Medicine and Medico-legal, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC, United States |
Putri, A.S., Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Soedarsono, N., Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Nehemia, B., Department of Dento-Maxillofacial Radiology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Atmadja, D.S., Department of Forensic Medicine and Medico-legal, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ubelaker, D.H., Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC, United States |
Dental development can be used to estimate age for forensic purposes. However, most of the currently available methods are less reliable for the Indonesian population due to population variability. This study presents a new method and evaluates other methods that utilize dental development to estimate the age of Indonesian people. Panoramic radiographs of 304 young Indonesian people aged 5–23 years old were analysed for deciduous tooth root resorption, permanent tooth calcification, and eruption. The extent of tooth root resorption was determined based on AlQahtani’s modified Moorrees et al. method. Tooth calcification was classified based on a modified Demirjian et al. method. Tooth eruption was evaluated based on AlQahtani’s modified Bengston system. The sequence of tooth root resorption, and permanent tooth calcification and eruption were grouped into 19 age categories (from 5–23 years old) in an atlas. The differences between males and females, between maxillary and mandibular teeth, and between right and left teeth were also analysed. There were minimal significant differences of tooth development between males and females, and between the right and left teeth (P > 0.05), while the maxillary and mandibular dental development was significantly different (P < 0.05). The newly developed atlas showed the development of the right side of maxillary and mandibular tooth of combined sex of Indonesian population. Another 34 panoramic radiographs of known-age and sex individuals from Indonesia were assessed using the newly developed Atlas of Dental Development in the Indonesian Population, Ubelaker’s Dental Development Chart, The London Atlas of Human Tooth Development and Eruption by AlQahtani, and the Age Estimation Guide-Modern Australia population by Blenkin-Taylor. Accuracy was assessed by comparing estimated age to actual chronological age using the Bland-Altmand test. Results show that the smallest range of error was found in the Atlas of Dental Development in the Indonesian Population (−0.969 to 1.210 years), followed by The London Atlas of Human Tooth Development and Eruption by AlQahtani (−2.013 to 1.990 years), the Age Estimation Guide-Modern Australia population by Blenkin-Taylor (−2.495 to 2.598 years), the Dental Development Chart by Ubelaker (−2.960 to 3.289 years). These findings show that the Atlas of Dental Development constructed in this study performs better than the other three methods and presents greater accuracy of age estimation in the Indonesian population. Key points •Dental development such as deciduous tooth root resorption, permanent tooth calcification, and tooth eruption can be used to estimate age for forensic purposes. •The development of the teeth are influenced by genetic, ethnicity, and sex, therefore an age estimation method must be constructed based on the same population. •There were minimal significant differences in tooth development between male and female, and between right and left teeth, but there was significant difference between maxillary and mandibular teeth. •The Atlas of Dental Development in the Indonesian Population constructed in this study allowed more accurate age estimation of the Indonesian sample than the other methods tested. Supplemental data for this article is available online at https://doi.org/10.1080/20961790.2021.1886648. © 2021 The Author(s). Published by Taylor & Francis Group on behalf of the Academy of Forensic Science. |
age estimation; forensic odontology; Forensic sciences; root resorption; tooth calcification; tooth eruption |
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Taylor and Francis Ltd. |
20961790 |
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Article |
Q1 |
729 |
6779 |
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820 |
Rini I.S., Gunardi A.J., Yashinta, Kevin J., Marsaulina R.P., Aryandono T., Dachlan I., Dwiprahasto I. |
57189690245;57215216664;57223006688;57223012633;57220026579;23495038400;57210391374;6506398126; |
Quality of Life in Palliative Post-mastectomy Reconstruction: Keystone versus Rotational Flap |
2021 |
Plastic and Reconstructive Surgery - Global Open |
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e3457 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104488039&doi=10.1097%2fGOX.0000000000003457&partnerID=40&md5=4e95d37965469db84b820afb28853499 |
Department of Plastic Surgery, Dharmais Cancer Hospital, Jalan Letjen Jend. S. Parman No. 84-86, West Jakarta, DKI Jakarta, 11420, Indonesia; Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Faculty of Medicine, Universitas Kristen Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia |
Rini, I.S., Department of Plastic Surgery, Dharmais Cancer Hospital, Jalan Letjen Jend. S. Parman No. 84-86, West Jakarta, DKI Jakarta, 11420, Indonesia; Gunardi, A.J., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Yashinta, Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Kevin, J., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Marsaulina, R.P., Faculty of Medicine, Universitas Kristen Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Aryandono, T., Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Dachlan, I., Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Dwiprahasto, I., Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia |
Background: Late stage breast cancer presents with malignant wound causing skin infiltration, pain, bleeding, and malodour, which affect quality of life (QoL). Palliative mastectomy aims to eliminate wound symptoms and requires prolonged wound care to improve QoL. This study aimed to prospectively investigate QoL differences in 2 alternative reconstructive methods: keystone flap and rotational flap. Methods: Twenty-four late stage breast cancer patients with symptoms of cancer wounds were included in this study. They were divided into 2 groups: keystone flap and rotational flap. Each patient's QoL was evaluated using EORTC QLQ-C30 and QLQ-BR23 before and 3 weeks after surgery. Results: Global health post-surgery was significantly improved compared with pre-surgery in all patients (P < 0.001), across both the keystone (P = 0.018) and rotational groups (P = 0.007). Breast symptoms post-surgery were also improved compared with pre-surgery in all patients (P = 0.035). However, when analyzed per group, breast symptoms were only improved significantly in the keystone group (P = 0.013) but not in the rotational group (P = 0.575). When compared between 2 groups, future perspective post-surgery in the keystone group [100 (0-100)] was better than the rotational group [66.7 (0-100)], (P = 0.020). Conclusions: Reconstructive surgery after mastectomy improves QoL in late stage breast cancer patients. The keystone flap is superior to the rotational flap in improving global health and breast symptoms. © 2021 Georg Thieme Verlag. All rights reserved. |
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Lippincott Williams and Wilkins |
21697574 |
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Article |
Q2 |
759 |
6437 |
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824 |
Agung N.P., Nadhif M.H., Irdam G.A., Mochtar C.A. |
57222963984;57189057498;57194729795;6506558321; |
The Role of 3D-Printed Phantoms and Devices for Organ-specified Appliances in Urology |
2021 |
International Journal of Bioprinting |
7 |
2 |
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1 |
14 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104261313&doi=10.18063%2fIJB.V7I2.333&partnerID=40&md5=0bbeefb808ac4fbf51023802ccfa25db |
Department of Urology, Universitas Indonesia, Faculty of Medicine/Ciptomangunkusumo Central Hospital, Jakarta, Indonesia; Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Technology Cluster, Indonesian Medical Education and Research Institute, Jakarta, Indonesia |
Agung, N.P., Department of Urology, Universitas Indonesia, Faculty of Medicine/Ciptomangunkusumo Central Hospital, Jakarta, Indonesia; Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Medical Technology Cluster, Indonesian Medical Education and Research Institute, Jakarta, Indonesia; Irdam, G.A., Department of Urology, Universitas Indonesia, Faculty of Medicine/Ciptomangunkusumo Central Hospital, Jakarta, Indonesia; Mochtar, C.A., Department of Urology, Universitas Indonesia, Faculty of Medicine/Ciptomangunkusumo Central Hospital, Jakarta, Indonesia |
Urology is one of the fields that are always at the frontline of bringing scientific advancements into clinical practice, including 3D printing (3DP). This study aims to discuss and presents the current role of 3D-printed phantoms and devices for organ-specified applications in urology. The discussion started with a literature search regarding the two mentioned topics within PubMed, Embase, Scopus, and EBSCOhost databases. 3D-printed urological organ phantoms are reported for providing residents new insight regarding anatomical characteristics of organs, either normal or diseased, in a tangible manner. Furthermore, 3D-printed organ phantoms also helped urologists to prepare a pre-surgical planning strategy with detailed anatomical models of the diseased organs. In some centers, 3DP technology also contributed to developing specified devices for disease management. To date, urologists have been benefitted by 3D-printed phantoms and devices in the education and disease management of organs of in the genitourinary system, including kidney, bladder, prostate, ureter, urethra, penis, and adrenal. It is safe to say that 3DP technology can bring remarkable changes to daily urological practices. © 2021 Agung, et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
3D printing; Devices; Phantoms; Urology |
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Whioce Publishing Pte. Ltd. |
24248002 |
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Article |
Q1 |
1014 |
4306 |
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