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825 |
Wardoyo S., Pardede J.P.P., Asari H.A. |
57211106608;57222900416;57222898312; |
Patients’ characteristics following reoperation after modified blalock-taussig shunt (Mbts) in cardiac centre national general hospital cipto mangunkusumo from 2018-2020 |
2021 |
Bali Medical Journal |
10 |
1 |
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103 |
107 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104181375&doi=10.15562%2fbmj.v10i1.2124&partnerID=40&md5=71f0e48c1ff1cce6ec58341517f2fb6a |
Thoracic, Cardiac, and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Wardoyo, S., Thoracic, Cardiac, and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pardede, J.P.P., Thoracic, Cardiac, and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Asari, H.A., Thoracic, Cardiac, and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Background: Modified Blalock-Taussig shunt (MBTS) is a common palliative procedure for congenital heart defect to connect the systemic to the pulmonary circulation via a synthetic shunt from a subclavian artery to a pulmonary artery. However, certain postoperative complications do exist, such as blockage. Early identification of modifiable risk factors is important to prompt early intervention for better outcomes. Material: This article is a descriptive narrative retrospective study. We gather data from the Cipto Mangunkusumo Hospital Cardiovascular Center medical report of 8 patients having undergone reoperation post-MBTS surgery as their first operation between January 2018 and October 2020. Data were analyzed using SPSS version 20 for Windows. Results: The patient’s age ranged from 3 months to 30 years old. Seven of them suffered from shunt occlusion complications, while the other suffered from the bleeding problem. The laboratory results showed that preoperative hemoglobin (18.9±4.1 g/dL vs. 16.90 (10.80-19.20) g/dL), hematocrit (58.8±12.40% vs. 42.9±14.30%), platelet counts (284.487±147.003 vs. 210.625±104.688) 103/uL, and oxygen saturation (86.00 (75.00-89.00) vs. 70.00±17.00) levels were higher than the pre-reoperative. The coagulation markers showed that PT value has increasing trend (1.10 (0.90-2.30) vs. 1.30±0.20) while aPTT (5.90 (2.90-6.30) vs. 2.30 (1.60-5.30)) seconds and activated clotting time (ACT) (205.00±86.00 vs. 165.00 (114.00-255.00)) showed the opposite. Conclusion: MBTS remains the first-choice bridging palliation surgery to increase the pulmonary blood flow in congenital heart defects. The cause of shunt failure remains inconclusive in this study. Other studies suggest that graft material choice, S/PA ratio, S/W ratio, operative approach, thrombus formation, and aPTT value contribute to shunt failure, thus needing a reoperation. © 2021, Sanglah General Hospital. All rights reserved. |
Characteristic; Modified Blalock-Taussig Shunt; Re-operation |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
#N/A |
#N/A |
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845 |
Aggarwal B., Jones P.W., Yunus F., Lan L.T.T., Boonsawat W., Ismaila A., Ascioglu S. |
23007797900;26121204500;57194486277;55570089700;35608231000;15127439100;57222578443; |
Direct healthcare costs associated with management of asthma: comparison of two treatment regimens in Indonesia, Thailand and Vietnam |
2021 |
Journal of Asthma |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103248190&doi=10.1080%2f02770903.2021.1903915&partnerID=40&md5=24168d049c94d08b0ab06a00763e2d22 |
Regional Respiratory Medical Affairs, GSK, Singapore, Singapore; Global Specialty & Primary Care, GSK, Brentford, Middlesex, United Kingdom; Institute for Infection and Immunity, St George’s University of London, London, United Kingdom; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia-Persahabatan National Respiratory Center Hospital, Jakarta, Indonesia; Faculty of Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam; Division of Respiratory System, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Value Evidence and Outcomes, GSK, Collegeville, PA, United States; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Clinical Sciences R&D, GSK, Singapore, Singapore |
Aggarwal, B., Regional Respiratory Medical Affairs, GSK, Singapore, Singapore; Jones, P.W., Global Specialty & Primary Care, GSK, Brentford, Middlesex, United Kingdom, Institute for Infection and Immunity, St George’s University of London, London, United Kingdom; Yunus, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia-Persahabatan National Respiratory Center Hospital, Jakarta, Indonesia; Lan, L.T.T., Faculty of Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam; Boonsawat, W., Division of Respiratory System, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Ismaila, A., Value Evidence and Outcomes, GSK, Collegeville, PA, United States, Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Ascioglu, S., Clinical Sciences R&D, GSK, Singapore, Singapore |
Objective: Daily inhaled corticosteroid (ICS) and long-acting beta-2-agonist (LABA) combinations comprising either regular maintenance therapy with ICS/LABA plus as-needed short-acting beta-2-agonist (SABA) or ICS-formoterol combinations used as maintenance and reliever therapy (MART) are recommended for moderate asthma. This analysis compares the direct costs of twice-daily fluticasone propionate/salmeterol (FP/salm) and budesonide/formoterol MART in three Southeast Asian countries. Methods: A literature review identified three randomized trials in patients with asthma (≥ 12 years) comparing regular twice-daily FP/salm with as-needed SABA versus MART in moderate asthma: AHEAD (NCT00242775/17 countries/2309 patients), COMPASS (AstraZeneca study SD-039-0735/16 countries/3335 patients), and COSMOS (AstraZeneca study SD-039-0691/16 countries/2143 patients). Economic analyses, conducted from a healthcare sector perspective (medication costs + healthcare utilization costs), applied unit costs from countries where healthcare costs are publicly available: Indonesia, Thailand and Vietnam. Results are expressed in British pound sterling (GBP/patient/year). Results: Annual exacerbation rates were low and differences between treatment strategies were small (range, FP/salm: 0.31–0.38, MART: 0.24–0.25) although statistically significant in favor of MART. Total average (minimum-maximum) direct costs (in GBP/patient/year) across the three studies were £187 (£137–£284), £158 (£125–£190), and £151 (£141–£164) for those who used FP/salm, and £242 (£217–£267), £284 (£237–£340) and £266 (£224–£315) for MART in Indonesia, Thailand and Vietnam, respectively. On average, total direct costs/patient/year with FP/salm were 22.8%, 44.6% and 43.0% lower than with MART for Indonesia, Thailand and Vietnam, respectively. Conclusions: In the three countries evaluated, total treatment costs with regular twice-daily FP/salm were consistently lower than with budesonide/formoterol MART due to lower direct healthcare costs. © 2021 GlaxoSmithKline. Published with license by Taylor & Francis Group, LLC. |
healthcare utilization; ICS/LABA; maintenance therapy; medication; Southeast Asia |
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Taylor and Francis Ltd. |
02770903 |
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Article |
Q2 |
687 |
7267 |
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850 |
Prasetyono T.O.H. |
26646993900; |
Indonesian plastic surgeons’ attitude during early period of the covid-19 pandemic |
2021 |
Archives of Craniofacial Surgery |
22 |
1 |
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17 |
25 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102865686&doi=10.7181%2facfs.2020.00451&partnerID=40&md5=a8e6d8b196710b9f9880783cbcb51fba |
Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Prasetyono, T.O.H., Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: This study aims to report how the practice of plastic surgeons and their attitude was during the first measure period of coronavirus disease 2019 (COVID-19) pandemic. Methods: A survey study was held among members of the Indonesian Association of Plastic Re-constructive and Aesthetic Surgeons during week 5 after the first report of COVID-19. A 10 multi-ple-choice questions (MCQs) and 1 essay covered key questions on the area of surgery and operating room, clinics, internal meeting, and consultation. The only open-ended question relates to the last MCQ addresses a future “flipped” medical practice. Results: Response rate was 45.6% among 228 members, with 89.4% did no practice or limited their service to emergency and urgent cases only. Only 1.9% kept their official meeting as usual, while the majority modified it. The practice in the operating theatre and clinic were also altered to comply with the measures; with 21.2% from the total respondents only allowed patients with ex-posure to come for visit after taking 14 days of self-quarantine. Teleconsultation was practiced by 50% of the respondents, while 41.3% agreed and 10.6% disagreed upon the future “flipped” medical practice. Conclusion: In general plastic surgeons have made supportive actions during the pandemic. Surgery was performed with all precautions at the utmost as a reflection of high alert of viral infec-tion. Teleconsultation has been embraced via existing social media. Agreement upon the future “flipped” medical practice is reasonable. All in all, the actions were considered as most relevant. © 2021 Korean Cleft Palate-Craniofacial Association. |
Pandemics; Surgery, plastic; Surveys and questionnaires; Viruses |
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Korean Cleft Palate-Craniofacial Association |
22871152 |
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Article |
Q4 |
192 |
19848 |
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854 |
Kirana A.N., Prafiantini E., Hardiany N.S. |
57222361321;57193088368;57192910605; |
Protein intake and loss of proteostasis in the eldery |
2021 |
Ukrainian Biochemical Journal |
93 |
1 |
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30 |
39 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102434761&doi=10.15407%2fubj93.01.030&partnerID=40&md5=e09be01091937944ac8ad3197ad54b2c |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Indonesia |
Kirana, A.N., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Prafiantini, E., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Indonesia |
Ageing is a process of declining bodily function and a major risk factor of chronic diseases. The declining bodily function in ageing can cause loss of proteostasis (protein homeostasis), which is a balance between protein synthesis, folding, modification and degradation. For the elderly, adequate protein intake is necessary to prevent sarcopenia, frailty, fracture and osteoporosis as well as reduced resistance to infection. However, increasing the protein intake can enhance the risk of oxidized protein formation, loss of proteostasis and degenerative disorder occurrence. On the other hand, several studies show that protein restriction would increase longevity. The aim of this review was to explain the importance of determining the right amount and composition of protein intake for the elderly. Oxidative stress and molecular mechanism of proteostasis loss in ageing cells as well as its suppression pathway by protein restriction are discussed in this review. © 2021 Kirana A. N. et al. |
Ageing; Dietary proteins; MTOR; Oxidative stress; Proteostasis loss |
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Palladin Institute of Biochemistry of the NASU |
24094943 |
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Article |
Q4 |
173 |
21241 |
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859 |
Gunardi W.D., Karuniawati A., Umbas R., Bardosono S., Lydia A., Soebandrio A., Safari D. |
57222314683;54886816200;6602634832;21933841000;8451287200;8602893200;23493586700; |
Biofilm-Producing Bacteria and Risk Factors (Gender and Duration of Catheterization) Characterized as Catheter-Associated Biofilm Formation |
2021 |
International Journal of Microbiology |
2021 |
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8869275 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102259916&doi=10.1155%2f2021%2f8869275&partnerID=40&md5=2173f2f0a162e1277f45979d11bf433c |
Department of Clinical Microbiology, Faculty of Medicine, Krida Wacana Christian University, Jakarta, 1151, Indonesia; Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Urology, FMUI-CMH, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, 10430, Indonesia |
Gunardi, W.D., Department of Clinical Microbiology, Faculty of Medicine, Krida Wacana Christian University, Jakarta, 1151, Indonesia; Karuniawati, A., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Umbas, R., Department of Urology, FMUI-CMH, Jakarta, 10430, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Lydia, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, 10430, Indonesia; Safari, D., Eijkman Institute for Molecular Biology, Jakarta, 10430, Indonesia |
Background. A catheter-associated urinary tract infection (CA-UTI) is preceded by biofilm formation, which is related to several risk factors such as gender, age, diabetic status, duration of catheterization, bacteriuria before catheterization, virulence gene factor, and antibiotic usage. Aims. This study aims to identify the microbial composition of catheter samples, including its corresponding comparison with urine samples, to determine the most important risk factors of biofilm formation and characterize the virulence gene factors that correlate with biofilm formation. Methods. A longitudinal cross-sectional study was conducted on 109 catheterized patients from September 2017 to January 2018. The risk factors were obtained from the patients' medical records. All catheter and urine samples were cultured after removal, followed by biomass quantification. Isolate identification and antimicrobial susceptibility testing were performed using the Vitex2 system. Biofilm-producing bacteria were identified by the Congo Red Agar (CRA) method. A PCR test characterized the virulence genes of dominant bacteria (E. coli). All data were collected and processed for statistical analysis. Results. Out of 109 catheterized patients, 78% of the catheters were culture positive, which was higher than those of the urine samples (37.62%). The most common species isolated from the catheter cultures were Escherichia coli (28.1%), Candida sp. (17.8%), Klebsiella pneumoniae (15.9%), and Enterococcus faecalis (13.1%). E. coli (83.3%) and E. faecalis (78.6%) were the main isolates with a positive CRA. A statistical analysis showed that gender and duration prior to catheterization were associated with an increased risk of biofilm formation p<0.05. Conclusion. E. coli and E. faecalis were the most common biofilm-producing bacteria isolated from the urinary catheter. Gender and duration are two risk factors associated with biofilm formation, therefore determining the risk of CAUTI. The presence of PapC as a virulence gene encoding pili correlates with the biofilm formation. Biofilm-producing bacteria, female gender, duration of catheterization (more than five days), and PapC gene presence have strong correlation with the biofilm formation. To prevent CAUTI, patients with risk factors should be monitored by urinalysis tests to detect earlier the risk of biofilm formation. © 2021 Wani Devita Gunardi et al. |
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Hindawi Limited |
1687918X |
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Article |
Q3 |
696 |
7161 |
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861 |
Umas R.A., Supriadi S., Whulanza Y., Hasan A.A.A.F., Kreshanti P. |
57222252781;16040272500;36807053500;57222257599;36192866200; |
Evaluating the Gear Stress of Novel Reverse Rotation Bit Manual Screwdriver Design for Miniscrew Implants |
2021 |
Journal of Mechanical Engineering |
18 |
1 |
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175 |
192 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102086175&partnerID=40&md5=0196752c2bad6ab9b05bb97c07712c5b |
Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Cleft and Craniofacial Center Cipto Mangunkusumo Hospital, Plastic and Reconstructive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Indonesia |
Umas, R.A., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Supriadi, S., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Hasan, A.A.A.F., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Kreshanti, P., Cleft and Craniofacial Center Cipto Mangunkusumo Hospital, Plastic and Reconstructive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Indonesia |
One of the problems faced by the screwdrivers used for craniomaxillofacial implant fixation is that the maximum torque required for implant removal is significantly higher than the maximum torque needed for inserting implants. Another problem is that the hand torque produced by a right-handed person is lower in the counterclockwise direction, which is the removal direction for miniscrews. The novel design presented here of a manual screwdriver equipped with an epicyclic gear will produce a reverse bit rotation and provide the mechanical advantage of higher torque output. In this study, simulations were conducted by varying the torque input within the range of 0-1000 Nmm with an applied load in each simulation to be adapted based on the epicyclic gear set. The materials used in this study are AISI 316L and Ti6Al4V. The maximum Von Mises stress value was observed in the sun gear from the second gear set at 522.59 MPa (AISI 316L) and 430.76 MPa (Ti6Al4V) for the maximum torque input, which was followed by the planetary and ring gear from the second gear set and then the planetary gear, ring gear, and sun gear from the first gear set. The total deformation also showed the difference between the two materials; the deformation when using AISI 316L as the material was lower than when using Ti6Al4V. © 2021 Faculty of Mechanical Engineering. All Rights Reserved. |
Epicyclic Gear; Maxillofacial Implant; Surgical Screwdriver |
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UiTM Press |
18235514 |
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Article |
Q3 |
216 |
18402 |
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864 |
Indriyani, Liem I.K., Wuyung P.E., Adnindya M.R., Nasution A.A., Wardiansah, Jusuf A.A. |
57195988823;55802927800;57192889605;57195990858;57195984460;57222188547;57192275719; |
The dynamic of afamin and alpha-fetoprotein expression during rat liver development |
2021 |
OnLine Journal of Biological Sciences |
21 |
1 |
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26 |
32 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101833482&doi=10.3844%2fojbsci.2021.26.32&partnerID=40&md5=63694adea4e7ba46c95652e49c319ed0 |
Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Indonesia; Departement of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Department of Anatomy, Faculty of Medicine and Health Science, Universitas Bengkulu, Bengkulu, Indonesia; Departement of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Indriyani, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, Indonesia; Liem, I.K., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Indonesia; Wuyung, P.E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Departement of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Adnindya, M.R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Nasution, A.A., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine and Health Science, Universitas Bengkulu, Bengkulu, Indonesia; Wardiansah, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Jusuf, A.A., Departement of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Liver has a high level of Alpha-fetoprotein which is assumed to be important for mammalian development. However, Alpha-fetoprotein knockout studies in mice suggested that despite the absence of Alpha-fetoprotein, mice developed normally; the only abnormality observed was infertility in female mice. There are indications that Afamin, a protein that has a gene sequence located on the same chromosome as Alpha-fetoprotein, may compensate for the absence of Alpha-fetoprotein during embryonic development. Nevertheless, research on the dynamics of Afamin expression and its correlation with Alpha-fetoprotein has not been reported. Therefore, it has been done a baseline study to determine the pattern and distribution of Alpha-fetoprotein expression and its correlation with Afamin expression in the developing rat liver. An analytic observational study was performed to study the expression of Afamin and Alpha-fetoprotein in the rat embryos (embryonic day/ED12.5, ED14.5, ED16.5, ED18.5), neonates and adults using an immunohistochemistry technique by assessing the location and intensity of expression using the Immunohistochemistry Optical density score. Afamin started to express in ED18.5 and was evenly distributed in the hepatocytes and was maintained until adulthood. Whereas, Alpha-fetoprotein has been seen at ED12.5 and was distributed evenly in the hepatoblast. At ED18.5, Alpha-fetoprotein expression reached a peak and decreased dramatically after birth. Spearman correlation test showed that both proteins' expressions were correlated in the opposite direction (P<0.05 and r =-0.695). In conclusion, Afamin and Alpha-fetoprotein have an opposite expression during development. The time point of intersection was ED18.5; implying the peak of hepatoblast proliferation to enter the differentiation process. © 2021 Indriyani, Isabella Kurnia Liem, Puspita Eka Wuyung, Msy Rulan Adnindya, Ahmad Azmi Nasution, Wardiansah and Ahmad Aulia Jusuf. |
Afamin; Alpha-Fetoprotein; Hepatoblast; Hepatocytes; Liver Development |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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877 |
Negara J.D.K., Mudjianto S., Budikayanti A., Adhitya Nugraha P.P. |
57221389254;57193794731;57194713932;57221981778; |
The effect of gamma wave optimization and attention on hitting skills in softball |
2021 |
International Journal of Human Movement and Sports Sciences |
9 |
1 |
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103 |
109 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100846277&doi=10.13189%2fsaj.2021.090114&partnerID=40&md5=572b9a6bf2d4f86222486dfb5b12188a |
Department of Sport Education, Faculty of Sport Education and Health, Universitas Pendidikan Indonesia, Bandung, West Java, 40154, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia |
Negara, J.D.K., Department of Sport Education, Faculty of Sport Education and Health, Universitas Pendidikan Indonesia, Bandung, West Java, 40154, Indonesia; Mudjianto, S., Department of Sport Education, Faculty of Sport Education and Health, Universitas Pendidikan Indonesia, Bandung, West Java, 40154, Indonesia; Budikayanti, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia; Adhitya Nugraha, P.P., Department of Sport Education, Faculty of Sport Education and Health, Universitas Pendidikan Indonesia, Bandung, West Java, 40154, Indonesia |
Hitting the ball is a complicated ability in softball academicie, because in appreciation to prioritizing movement skills, cognitive appearances additionally need to be investigated, one of which is attention. Meanwhile, going to hit the ball requires excellent attention for an individual student. Exhibiting gamma waves further influence arrangements of hitting performance. The objectives of this study were first, to determine the negative functional correlation between gamma brain waves and hitting skills, then second to know the positive functional correlation between attention and hitting skills and third to determine the effect of attention on increasing hitting skills. The method used in this research is an experimental method with a one-group pretest-posttest design research design. The sampling technique in this study was using a saturated sampling technique. This investigation amounted to 20 subjects, in the calculation of the Pearson product-moment correlation test using SPSS v.23. The first results collected were p-value 0.026 with an r square value of 0.25, so there is a significant negative functional correlation between gamma brain waves and hitting skills in softball learning of 25%. The second issue obtained p-value 0.017 with an r square value of 0.28, so there is a significant positive functional correlation between attention and hitting skills in softball learning by 28%. Furthermore, thirdly, the results obtained p-value 0.0001 between pre-test and post-test, with a significant increase in skills of 70.17%, so there is a significant influence between attention and hitting skills. © 2021 by authors, all rights reserved. |
Attention; Gamma Brain Waves; Hitting Skills; Softball Games |
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Horizon Research Publishing |
23814381 |
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Article |
Q4 |
132 |
25155 |
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886 |
Susanto A.D., Yusril N., Zaini J., Nuwidya F. |
57190425587;57221834981;57221833355;57221834238; |
Comparison of serum benzo(a)pyrene diol epoxide - Protein adducts level between kretek cigarette smokers and nonsmokers and the related factors |
2021 |
Journal of Natural Science, Biology and Medicine |
12 |
1 |
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52 |
56 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100352390&doi=10.4103%2fjnsbm.JNSBM_100_20&partnerID=40&md5=b1c54ebf4ef8452d480f9da52582dabe |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Susanto, A.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Yusril, N., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Zaini, J., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Nuwidya, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Benzopyrene is a carcinogenic agent found in cigarette smoke. Benzo(a)pyrene diol epoxide (BPDE) is one of the benzopyrene metabolites. In this study, we investigated the level of serum BPDE in kretek cigarette smokers compared to non-smokers. Methods: A cross-sectional study which involved 32 "healthy" kretek cigarette smokers and 32 "healthy" nonsmokers were conducted. We collected the blood sample and the serum BPDE level was assayed using enzyme-linked immunosorbent assay kit. The BPDE serum level in kretek cigarette smokers was compared to the level in nonsmokers. Results: A total of 32 kretek smokers and 32 controls underwent an examination of the BPDE-protein adducts level. In the kretek smokers group, 59.4% were aged over 45 years and 56.3% have a high educational background, while in the control group, 87.5% were aged under 45 years and 75% have high educational backgrounds. The level of BPDE-protein adducts in the kretek smokers subject was 12.15 (8.87-33.55) ng/ml and the levels in the control group were 11.4 (3.87-13.27) ng/ml, P = 0.004. The factors which influence the levels BDPE-protein adducts in smokers cigarettes, as determined by multivariate analysis, were sucking pattern (P = 0.002) and the degree of addiction (P = 0.047). Conclusion: The serum BPDE-protein adducts level was higher in smokers compared to nonsmokers, and the sucking pattern and degree of addiction are the influencing factors. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Benzo(a)pyrene diol epoxide-protein adducts; nonsmokers; smokers |
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Wolters Kluwer Medknow Publications |
09769668 |
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Article |
Q3 |
236 |
17374 |
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887 |
Arliny Y., Yunus F., Burhan E., Andarini S., Jusman S.W.A., Yunir E., Kekalih A., Soeroton A.Y., Nurwidya F. |
57221832635;57194486277;36058554600;8716259500;36518792100;36520254800;55633562200;57221832157;55221773800; |
Diagnostic predictors of active tuberculosis infection in diabetic patients with latent tuberculosis: A review on cathelicidin and 1,25-dihydroxyvitamin d3 |
2021 |
Journal of Natural Science, Biology and Medicine |
12 |
1 |
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117 |
123 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100332647&doi=10.4103%2fjnsbm.JNSBM_26_20&partnerID=40&md5=bcbc06659ad7db8063dc7a77d40a3bd0 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Syiah Kuala, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia; Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Respirology and Critical Illness, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia |
Arliny, Y., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Syiah Kuala, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Yunus, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Syiah Kuala, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Andarini, S., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia; Yunir, E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kekalih, A., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soeroton, A.Y., Division of Respirology and Critical Illness, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia; Nurwidya, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia |
Background: Diabetes Mellitus has been identified as one of factors causing increased risks of latent TB infection. The roles of cathelicidin LL-37, 1.25(OH)2D3 as well as their correlation with specific IFN-γ in latent TB has not been extensively identified. Aims and Objectives: Our study was aimed to identify proportion of latent TB infection in patients with DM and to identify the role of cathelicidin, 1.25(OH)2D3, vitamin D and other clinical factors as predictors for active TB infection in diabetic patients with latent TB. Methods: Our study was conducted in 2 stages. The first-stage study was a cross-sectional study to identify the proportion of latent TB infection in patients with DM without any history of TB, which was continued with a case-control study to identify the roles of predictive biomarkers (cathelicidin LL-37, 25(OH) D3, 1.25(OH)2D3 and IFN-γ) as well as clinical predictive factors for active TB infection in diabetic patients with latent TB. Results: Out of 242 diabetic patients without any history of TB who underwent screening test for latent TB, there were 78 (33.2%) subjects with a diagnosis of latent TB and 1 subject was diagnosed with active TB. There was significant association on the level of cathelicidin LL-37 in DM patient with latent TB, active TB and without TB infection (23.49 ng/mL vs. 49.6 ng/mL vs. 10.46 ng/mL, P < 0,005). Almost all of subjects with DM showed low levels of vitamin D, most in subject with active TB (97%). There was no significant association between 1.25(OH)2D3 and 25(OH)D3 in DM patients with latent TB, active TB and without TB infection. There was a significant association on the levels of IFN-γ ((TB1 1.4 IU/mL vs. 0.03 IU/mL P < 0.005; TB2 1.4 IU/mL vs. 0.04 IU/mL P < 0.005) in DM subjects with latent TB and those without TB infection; however, no significant association was found in DM subjects with latent TB and active TB. History of smoking, HbA1C > 9.5% and cathelicidin LL-37 levels of > 30 ng/mL were predictors for latent TB into active TB in DM patients. Conclusion: Cathelicidin LL-37 can serve as a biomarker of latent TB progressiveness in patients with DM. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
1,25 (OH)2D3; cathelicidin; diabetes; latent tuberculosis infection; Vitamin D |
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Wolters Kluwer Medknow Publications |
09769668 |
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Article |
Q3 |
236 |
17374 |
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