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233 |
Sunarno S., Puspandari N., Sariadji K., Febriyana D., Saraswati T.F.R.D., Maha M.S., Handayani S., Lestari C.S.W., Fitriana V.S.F., Yuniar Y., Pracoyo N.E., Pradono J., Siswanto S., Multihartina P., Anggraeni N.D., Hidayati L.N., Sukandar A., Safaat H., Karyanti M.R. |
57441531200;56786591900;57199654249;57222530233;57462625600;6603127192;26023188400;57194534757;57462459800;57219339473;57273150400;57462947000;56613530000;56708801900;57218324975;57463104500;57463428900;57462459900;56290680800; |
Microbiological and Clinical Aspects of Diphtheria-Confirmed Cases from Capital City of Indonesia, Jakarta, and Surrounding Areas in 2017 |
2021 |
Jundishapur Journal of Microbiology |
14 |
8 |
e118751 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125038649&doi=10.5812%2fJJM.118751&partnerID=40&md5=cd6599282018ea61a451d60e8fe3eb1a |
Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Coordinating Ministry of Human Development and Cultural, Jakarta, Indonesia; Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Centre for Research and Development of Public Health Efforts, Jakarta, Indonesia; World Health Organization, South-East Asia Regional Office, New Delhi, India; Jakarta Provincial Health Office, Jakarta, Indonesia; West Java Provincial Health Office, Bandung, Indonesia; Banten Provincial Health Office, Serang, Indonesia; Department of Pediatric, Faculty of Medicine, University of Indonesia, Jawa Barat, Indonesia |
Sunarno, S., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Puspandari, N., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Sariadji, K., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Febriyana, D., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Saraswati, T.F.R.D., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Maha, M.S., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Handayani, S., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Lestari, C.S.W., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Fitriana, V.S.F., Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Yuniar, Y., Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Pracoyo, N.E., Centre for Research and Development of Public Health Efforts, Jakarta, Indonesia; Pradono, J., Centre for Research and Development of Public Health Efforts, Jakarta, Indonesia; Siswanto, S., World Health Organization, South-East Asia Regional Office, New Delhi, India; Multihartina, P., Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Anggraeni, N.D., Coordinating Ministry of Human Development and Cultural, Jakarta, Indonesia; Hidayati, L.N., Jakarta Provincial Health Office, Jakarta, Indonesia; Sukandar, A., West Java Provincial Health Office, Bandung, Indonesia; Safaat, H., Banten Provincial Health Office, Serang, Indonesia; Karyanti, M.R., Department of Pediatric, Faculty of Medicine, University of Indonesia, Jawa Barat, Indonesia |
Background: The World Health Organization reported Indonesia as one of the countries with the most prevalent cases of diphtheria worldwide. The microbiological aspects of diphtheria-inducing bacteria are of great significance in tracing disease transmission and case management. However, clinical aspects are critical for updating clinical features and case management in the field, which may sometimes differ from theoretical foundations. Objectives: This study aimed to identify the microbiological and clinical aspects, including molecular typing and case fatality rates, in diphtheria-confirmed cases from the capital city of Indonesia, Jakarta, and surrounding areas in 2017. Methods: The microbiological aspect of 40 diphtheria-confirmed cases were obtained by re-identify diphtheria-inducing bacteria isolated from the samples, while the clinical aspects of the cases were obtained from the medical records and epidemiological data. The chi-square test was used to examine the correlation between fatal cases and myocarditis and diphtheria antitoxin administra-tion delay. In this study, P ≤ 0.05 was set as the significance level. Results: All 40 diphtheria confirmed cases were induced by toxigenic Corynebacterium diphtheriae with two biotypes, namely inter-medius (60.0%) and mitis (40.0%). There are six sequence types of bacteria with two main sequence types, ie, ST534 (46.4%) and ST377 (35.7%). The proportions of cases that had a fever and sore throat were 72.5% and 77.5%, respectively; however, the prevalence rates of the cases with pseudomembrane and bull neck were 100% and 47%, respectively. Most cases were administered a combination of penicillin or erythromycin with other antibiotics (40%), and 22.5% of the cases only received penicillin. Myocarditis was noticed in three fatal cases, and their relationship was statistically significant (P = 0.000). All five fatal cases (12.5% of cases) received diphtheria antitoxin (DAT) lately or had not received it yet. Conclusions: Toxigenic C. diphtheriae with two biotypes (namely mitis and intermedius) and two main sequence types (ie, ST534 and ST377) was the causative agent of diphtheria-confirmed cases from Jakarta and surrounding areas in 2017. It was also concluded that those fatal cases were correlated with myocarditis complications. © 2021, Author(s). |
Corynebacterium diphtheriae; Diphtheria; Indonesia; Jakarta |
antibiotic agent; antitoxin; erythromycin; glycerol; penicillin G; adolescent; airway obstruction; Article; bacterium identification; bull neck; case fatality rate; child; clinical assessment; clinical feature; conceptual framework; controlled study; correlation analysis; Corynebacterium diphtheriae; Corynebacterium pseudotuberculosis; descriptive research; diphtheria; disease transmission; female; fever; headache; human; Indonesia; intermedius; major clinical study; male; medical record; microbiology; microscopy; mitis; molecular typing; multilocus sequence typing; polymerase chain reaction; preschool child; pseudomembrane; school child; sequence analysis; sore throat; toxicity testing; vaccination; World Health Organization |
Kowsar Medical Institute |
20083645 |
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Article |
Q3 |
281 |
15495 |
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234 |
Nugroho S.W., Pradhana I., Gunawan K. |
57460519700;57373805000;57195935319; |
New adaptation of neurosurgical practice and residency programs during the Covid-19 pandemic and their effects on neurosurgery resident satisfaction and welfare at the National General Hospital, Jakarta, Indonesia |
2021 |
Heliyon |
7 |
8 |
e07757 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121271314&doi=10.1016%2fj.heliyon.2021.e07757&partnerID=40&md5=09cbd414f0eefb36b6d98b642efa84cf |
Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Nugroho, S.W., Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pradhana, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gunawan, K., Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Many institutions in numerous countries have made changes in their health care services during the COVID-19 pandemic. One change has been to reduce elective neurosurgery cases, which has impacted neurosurgery education. Published literature is lacking about the healthcare services, education, and residents’ well-being during adaptation to the pandemic, especially in national referral hospitals in developing countries. Methods: We conducted a cross-sectional study on current neurosurgical services during 2020. We evaluated 34 neurosurgery residents in Cipto Mangunkusumo National General Hospital using a self-made questionnaire to determine the effects of the COVID-19 pandemic on their surroundings, education process, and satisfaction with the currently adapted education program. We used the modified Maslach Burnout Inventory to assess burnout in the residents before and during the pandemic. Results: Neurosurgical residents spent more time studying neurosurgical theory (Mode 1–1.5h/day, p < 0.05) but spent less time learning neurosurgical skills (Mode 30 min–1 h/day, p < 0.05) compared to before the pandemic. The resident satisfaction mean score (scale 0–10) was 7.58 for live surgery and 8.53 for the microsurgical skills lab training program. On a scale of 1–10, the residents’ stress level increased after the pandemic but the change was not statistically significant (6.61 ± 1.87, p > 0.05). The Modified Maslach Burnout inventory score was 3.02 ± 3.74 during the pandemic, and increased from before the pandemic (2.41 ± 3.18), but the difference was not statistically significant. Conclusion: The COVID-19 pandemics have reduced the working hours and the clinical exposure of neurosurgical residents. Fortunately, this pandemic has led to a new opportunity to find many suitable learning methods which may decrease the risk of burnout. The psychological burden of residents is still worrisome, and planned management is necessary to sustain resident performance. © 2021 |
COVID-19; Education; Neurosurgery; Neurosurgical residency; Pandemic; Residency |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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235 |
Widaty S., Menaldi S.L., Rihatmadja R., Miranda E., Marissa M., Kekalih A., Friska D., Oktarina C., Surya D. |
57208261546;57192918198;56427016700;57208259598;57210795916;55633562200;57202805330;57208263598;57210797458; |
Involvement of non-medical personnel in management of scabies at a boarding school in Indonesia |
2021 |
Southeast Asian Journal of Tropical Medicine and Public Health |
52 |
4 |
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527 |
537 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119906461&partnerID=40&md5=3b9a6a331f595bc79905a0e28fbc7d70 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Widaty, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Menaldi, S.L., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Rihatmadja, R., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Miranda, E., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Marissa, M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Kekalih, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Friska, D., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktarina, C., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Surya, D., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
One of the most common neglected tropical skin diseases in Indonesia is scabies, commonly associated with overcrowding, poor hygiene and poor nutritional status. Boarding schools are at risk of harboring infected populations. As recurrence is common, non-medical personnel need to be involved in management of scabies. This study aimed to investigate how non-medical personnel, in this case, the boarding school teachers, could manage scabies in a boarding school in Indonesia. We trained the teachers using the education module for early scabies detection approach, namely DeSkab program, to be able to identify three major signs of scabies in the students. Impact of this approach was evaluated in 2017 and 2018 at a religious boarding school in Bogor, Indonesia involving 127 and 202 students, consecutively. An education module was given to 16 boarding school teachers expecting them to be able to examine students prior to school admission and before and after mid-semester break. Teachers’ knowledge increased significantly after the training (p <0.001). This knowledge improvement is an important basis for teachers as non-medical personnel to implement independent scabies monitoring process during the educational year to find students with suspected scabies. Those suspected scabies students were directly referred to nearby public health clinic and treated with 5% permethrin and re-treated one week later. Prevalence of scabies decreased from 76% in 2017 to 49% in 2018 in 69 students who can be followed-up in two consecutive years (p-value = 0.014). In conclusion, involvement of non-medical personnel is an essential and effective strategy to improve management of scabies. © 2021, SEAMEO TROPMED Network. All rights reserved. |
Boarding school; DeSkab; Non-medical personnel; Prevention; Scabies |
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SEAMEO TROPMED Network |
01251562 |
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Article |
Q4 |
214 |
18533 |
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236 |
Lancaster K.E., Mollan K.R., Hanscom B.S., Shook-Sa B.E., Ha T.V., Dumchev K., Djoerban Z., Rose S.M., Latkin C.A., Metzger D.S., Go V.F., Dvoriak S., Reifeis S.A., Piwowar-Manning E.M., Richardson P., Hudgens M.G., Hamilton E.L., Eshleman S.H., Susami H., Chu V.A., Djauzi S., Kiriazova T., Nhan D.T., Burns D.N., Miller W.C., Hoffman I.F. |
55503210000;26659057900;6603650318;55990940100;36988527800;8923601900;23472548200;12544917400;57235096800;35944632400;7102536801;57205192774;57193208279;35783326900;57203639655;6603567044;56450237600;7004740977;57202642757;57195576444;23495847800;55757875500;57317058700;7403171278;7406061778;7006682600; |
Engaging People Who Inject Drugs Living with HIV in Antiretroviral Treatment and Medication for Opioid Use Disorder: Extended Follow-up of HIV Prevention Trials Network (HPTN) 074 |
2021 |
Open Forum Infectious Diseases |
8 |
8 |
ofab281 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118242331&doi=10.1093%2fofid%2fofab281&partnerID=40&md5=6133eea6e10cff9e76240789c9b5b783 |
Division of Epidemiology, College of Public Health, Ohio State University, 1841 Neil Ave, 334 Cunz Hall, Columbus, OH 43210-1351, United States; Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; UNC Vietnam, Hanoi, Viet Nam; Ukrainian Institute on Public Health Policy, Kyiv, Ukraine; Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Science Facilitation Department, FHI 360, Durham, NC, United States; Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States; HIV Prevention Research Division, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Academy of Labor, Social Relations and Tourism, Kyiv, Ukraine; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Vietnam Administration of HIV/AIDS Control, Hanoi, Viet Nam; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States |
Lancaster, K.E., Division of Epidemiology, College of Public Health, Ohio State University, 1841 Neil Ave, 334 Cunz Hall, Columbus, OH 43210-1351, United States; Mollan, K.R., Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Hanscom, B.S., Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Shook-Sa, B.E., Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Ha, T.V., Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, UNC Vietnam, Hanoi, Viet Nam; Dumchev, K., Ukrainian Institute on Public Health Policy, Kyiv, Ukraine; Djoerban, Z., Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rose, S.M., Science Facilitation Department, FHI 360, Durham, NC, United States; Latkin, C.A., Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States; Metzger, D.S., HIV Prevention Research Division, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Go, V.F., Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Dvoriak, S., Academy of Labor, Social Relations and Tourism, Kyiv, Ukraine; Reifeis, S.A., Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Piwowar-Manning, E.M., Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Richardson, P., Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Hudgens, M.G., Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Hamilton, E.L., Science Facilitation Department, FHI 360, Durham, NC, United States; Eshleman, S.H., Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Susami, H., Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Chu, V.A., UNC Vietnam, Hanoi, Viet Nam; Djauzi, S., Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kiriazova, T., Ukrainian Institute on Public Health Policy, Kyiv, Ukraine; Nhan, D.T., Vietnam Administration of HIV/AIDS Control, Hanoi, Viet Nam; Burns, D.N., Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Miller, W.C., Division of Epidemiology, College of Public Health, Ohio State University, 1841 Neil Ave, 334 Cunz Hall, Columbus, OH 43210-1351, United States; Hoffman, I.F., Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States |
Background: People who inject drugs (PWID) living with HIV experience inadequate access to antiretroviral treatment (ART) and medication for opioid use disorders (MOUD). HPTN 074 showed that an integrated intervention increased ART use and viral suppression over 52 weeks. To examine durability of ART, MOUD, and HIV viral suppression, participants could re-enroll for an extended follow-up period, during which standard-of-care (SOC) participants in need of support were offered the intervention. Methods: Participants were recruited from Ukraine, Indonesia and Vietnam and randomly allocated 3:1 to SOC or intervention. Eligibility criteria included: HIV-positive; active injection drug use; 18-60 years of age; ≥1 HIV-uninfected injection partner; and viral load ≥1,000 copies/mL. Re-enrollment was offered to all available intervention and SOC arm participants, and SOC participants in need of support (off-ART or off-MOUD) were offered the intervention. Results: The intervention continuation group re-enrolled 89 participants, and from week 52 to 104, viral suppression (<40 copies/mL) declined from 41% to 29% (estimated 9.4% decrease per year, 95% CI-17.0%;-1.8%). The in need of support group re-enrolled 94 participants and had increased ART (re-enrollment: 55%, week 26: 69%) and MOUD (re-enrollment: 16%, week 26: 25%) use, and viral suppression (re-enrollment: 40%, week 26: 49%). Conclusions: Viral suppression declined in year 2 for those who initially received the HPTN 074 intervention and improved maintenance support is warranted. Viral suppression and MOUD increased among in need participants who received intervention during the study extension. Continued efforts are needed for widespread implementation of this scalable, integrated intervention. © 2021 The Author(s). |
antiretroviral therapy; HIV infection; injection drug use; methadone/therapeutic use; viral load |
antiretrovirus agent; buprenorphine; methadone; adult; Article; CD4 lymphocyte count; Consolidated Standards of Reporting Trial; controlled study; disease transmission; epidemic; evaluation and follow up; female; health care quality; health education; hepatitis C; human; Human immunodeficiency virus infection; incidence; injection drug user; integrated health care system; intervention study; interview; major clinical study; male; medication compliance; medication for opioid use disorder; medication for opioid use disorder; middle aged; opiate addiction; outcome assessment; paramedical personnel; practice guideline; psychosocial development; randomized controlled trial; telephone interview; viral suppression; virus load; World Health Organization; young adult |
Oxford University Press |
23288957 |
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Article |
Q1 |
1546 |
2161 |
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237 |
Suhaeri M., Kim Y.-M., Yunarti R.T., Song S.-C. |
56183087500;57294592700;56086215900;7403350156; |
Thermoresponsive and suspension forming cyclotriphosphazene conjugate for delivery vehicle of antitumor drug camptothecin |
2021 |
Journal of Drug Delivery Science and Technology |
64 |
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102049 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116958285&doi=10.1016%2fj.jddst.2020.102049&partnerID=40&md5=e52dca3896e5c2ec2892116e880dc19c |
Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Depok, 16424, Indonesia; Medical Technology Research Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia; Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia; Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 02792, South Korea; Inorganic Chemistry Research Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus UI Baru, Depok, Jawa Barat 16424, Indonesia; Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, South Korea |
Suhaeri, M., Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Depok, 16424, Indonesia, Medical Technology Research Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia; Kim, Y.-M., Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 02792, South Korea, Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, South Korea; Yunarti, R.T., Inorganic Chemistry Research Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus UI Baru, Depok, Jawa Barat 16424, Indonesia; Song, S.-C., Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 02792, South Korea, Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, South Korea |
Camptothecin (CPT) has been used as antitumor drug against a wide range of cancer cells. However, its clinical application is greatly hindered by insolubility and instability issues under physiological condition. Therefore, an appropriate CPT administration technique directed for living system is greatly anticipated. In this study, a delivery method for CPT in the form of thermoresponsive system was prescribed. A conjugate of cyclotriphosphazene and CPT was synthesized by substituting hexachlorocyclotriphosphazene with sodium salt of methoxy-poly (ethylene glycol) (Mw = 350), 20-O-trifluoroglycinylCPT, and isoleucine ethyl ester, respectively. The resulting cyclotriphosphazene-CPT was characterized via multinuclear (1H and 31P) NMR as well as FT-IR. The current conjugate showed temperature induced phase transition (solution to suspension) with a lower critical solution temperature at 31 °C. Our result indicated that the stability issue related to the use of CPT in aqueous solution could be handled by acylation at 20-OH moiety. Additionally, antitumor activity of cyclotriphosphazene-CPT, to some extent, was found to be more profound than that of CPT alone as evaluated against human colorectal cancer cell HCT-116. Altogether, the current cyclotriphosphazene-CPT conjugate might offer a facile method in delivering CPT as a minimally invasive system for treating cancer. © 2020 Elsevier B.V. |
Antitumor; Camptothecin; Conjugate; Cyclotriphosphazene; Drug delivery; Thermoresponsive |
camptothecin; hexachlorocyclotriphosphazene; isoleucine; macrogol; polymer; sodium; unclassified drug; antineoplastic activity; Article; critical solution temperature; drug conjugation; drug delivery system; drug structure; drug synthesis; Fourier transform infrared spectroscopy; HCT 116 cell line; human; human cell; phase transition; phosphorus nuclear magnetic resonance; proton nuclear magnetic resonance; temperature |
Editions de Sante |
17732247 |
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Article |
Q2 |
663 |
7562 |
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238 |
Heltty H., Sitorus R., Nusdwinuringtyas N., Martha E. |
57262112500;57194329674;56608215500;55841280100; |
Effect of Self-Regulation and Social Support Intervention on the Life Quality in Patients with Post-Stroke Urinary Incontinence |
2021 |
Korean Journal of Adult Nursing |
33 |
4 |
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399 |
405 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115059615&doi=10.7475%2fkjan.2021.33.4.399&partnerID=40&md5=167ab64de29a0974bb46e8b9444819a3 |
Doctoral Student of Nursing Faculty, Universitas Indonesia, Depok Indonesia, Jl. Prof. Dr. Bahder Djohan, Kampus UI Depok Jawa Barat, Indonesia; Professor of Nursing, Faculty of Nursing, Universitas Indonesia, Jl. Prof. Dr. Bahder Djohan, Kampus UI Depok Jawa Barat, Indonesia; Associate Professor Ph.D, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Associate Professor Ph.D M.Kes (health), Faculty of Public Health, Universitas Indonesia, Depok, Indonesia |
Heltty, H., Doctoral Student of Nursing Faculty, Universitas Indonesia, Depok Indonesia, Jl. Prof. Dr. Bahder Djohan, Kampus UI Depok Jawa Barat, Indonesia; Sitorus, R., Professor of Nursing, Faculty of Nursing, Universitas Indonesia, Jl. Prof. Dr. Bahder Djohan, Kampus UI Depok Jawa Barat, Indonesia; Nusdwinuringtyas, N., Associate Professor Ph.D, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Martha, E., Associate Professor Ph.D M.Kes (health), Faculty of Public Health, Universitas Indonesia, Depok, Indonesia |
Purpose: This study aimed to determine the effect of self-regulation and social support on post-stroke patients experiencing urinary incontinence. Methods: This quasi-experimental study was conducted in Kota Kendari, Indonesia. Through consecutive sampling, 53 participants were selected: 26 in the experimental groups and 27 in the control group, studied over a period of four weeks. The self-regulation intervention included education about properly following recommended exercises to overcome urinary incontinence, focusing on goals, being optimistic, and having emotional control. The social support intervention included the provision of family and peer support during patient care. Differences in participants' quality of life was measured at three different stages during the study, using the Incontinence Quality of Life instrument. Data were analyzed using descriptive statistics, independent t-tests, and repeated measures ANOVA. Results: There was homogeneity of variance in both groups. Significant differences in quality of life were seen in the second and third measurements (p<.001). The interventions improved patients' quality of life by 6.43 times at 4 weeks, and 13 times at 8 weeks. Conclusion: Self-regulation and social support played an important role in improving the quality of life of post-stroke urinary incontinence patients. Further studies with longer intervention periods are required to validate our results and contribute to better patient experiences. © 2021. All Rights Reserved. |
Emotional regulation; Quality of life; Social support; Stroke; Urinary incontinence |
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Korean Society of Adult Nursing |
12254886 |
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Article |
Q3 |
253 |
16577 |
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239 |
Sobri F.B., Bachtiar A., Panigoro S.S., Rahmaania J.C., Yuswar P.W., Krisnuhoni E., Tandiari N. |
57217500979;56683183900;56790104300;57252632900;57253490900;35310982200;57252633000; |
Strategy for diagnosing breast cancer in Indonesia during the COVID-19 pandemic: Switching to ultrasound-guided percutaneous core needle biopsy |
2021 |
Kesmas |
16 |
3 |
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151 |
157 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114650507&doi=10.21109%2fkesmas.v16i3.4359&partnerID=40&md5=dbf4756507a59d7c2f87cc7eb69f6787 |
Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Department of Surgical Oncology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pathology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Department of Radiology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia |
Sobri, F.B., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia, Department of Surgical Oncology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Bachtiar, A., Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Panigoro, S.S., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmaania, J.C., Department of Surgery, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Yuswar, P.W., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Krisnuhoni, E., Department of Pathology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Tandiari, N., Department of Radiology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia |
In this era of COVID-19, suspected breast cancer patients experience delay in diagnosis due to the fear of contracting the virus and reduction of non-COVID-19 health services. Furthermore, it may lead to potential increase in the incidence of advanced cancers in the future. Ultrasound-guided (US-guided) percutaneous core needle biopsy (CNB) is a great option for the diagnosis of cancer but it is poorly utilized. This study aimed to prove that the US-guided CNB is accurate when performed in a local setting and a potential solution for diagnosing breast cancer patients in this pandemic. In addition, it was a single health center cross-sectional study, and the participants were all breast cancer patients that had US-guided CNB from 2013-2019. The pathology results from US-guided CNB were compared to specimens from post-CNB surgeries. The data were collected from medical records and the immunohistochemistry (IHC) examinations were carried out for malignancy. There were 163 patients who were included in this study, 86 had malignancies and 77 had benign tumor reported in their CNB results. The US-guided CNB had 100% sensitivity and specificity compared to surgery. With its lower cost, time usage, and patient exposure to the hospital environment, US-guided CNB should replace open surgery biopsy for diagnosing suspicious breast cancers during the pandemic in Indonesia. Copyright © 2021, Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal). |
Breast cancer; Core needle biopsy; COVID-19; Health cost; Resources |
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Universitas Indonesia, Faculty of public health |
19077505 |
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Article |
Q4 |
146 |
23606 |
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240 |
Nathania M., Sunardi D. |
57245860300;57192075078; |
The importance of balanced nutrition to fortify the immune system during the covid-19 outbreak [La importancia de una nutrición equilibrada para aumentar el sistema inmunológico durante el brote de covid-19] |
2021 |
Revista Chilena de Nutricion |
48 |
4 |
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620 |
629 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114246311&doi=10.4067%2fS0717-75182021000400620&partnerID=40&md5=c999acae5c75b659b516d0fbb8b1815b |
Department of Nutrition, Faculty of Medicine, University of Indonesia-Ciptomangunkusumo National Hospital, Jakarta Pusat, 10430, Indonesia |
Nathania, M., Department of Nutrition, Faculty of Medicine, University of Indonesia-Ciptomangunkusumo National Hospital, Jakarta Pusat, 10430, Indonesia; Sunardi, D., Department of Nutrition, Faculty of Medicine, University of Indonesia-Ciptomangunkusumo National Hospital, Jakarta Pusat, 10430, Indonesia |
COVID-19, first reported in December 2019 in Wuhan, China, quickly spread worldwide and was announced as a pandemic in March 2020. As symptoms and outcomes are varied, the elderly and those who have at least one comorbidity (diabetes, cardiovascular disorders or other chronic diseases) are considered to be at high risk and are generally have lower immunity. An optimal immune system is critical for survival, as it protects the body against infectious agents. Nutrition is an essential factor in the immune system, contributing to components in physical barriers, biochemical, innate and adaptive immunity. Research advances show that nutritional deficiencies, namely the inadequacy of energy, macronutrients and micronutrients, affect the immune system and increase infection risk. The following discussion explains the comprehensive role of nutrition in the immune system, nutrition recommendations that can be used as precautions and the need for supplementation during this outbreak. © 2021, Sociedad Chilena de Nutricion Bromatologia y Toxilogica. All rights reserved. |
COVID-19; Immune; Nutrition; Pandemic; Supplementation |
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Sociedad Chilena de Nutricion Bromatologia y Toxilogica |
07177518 |
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Review |
Q4 |
182 |
20570 |
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241 |
Dharmawan Y., Fuady A., Korfage I., Richardus J.H. |
57189353850;37085331400;6506984424;7003977198; |
Individual and community factors determining delayed leprosy case detection: A systematic review |
2021 |
PLoS Neglected Tropical Diseases |
15 |
8 |
e0009651 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114085346&doi=10.1371%2fjournal.pntd.0009651&partnerID=40&md5=cd44ee5b8798b15d9e0def1be72603ab |
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Faculty of Public Health, Universitas Diponegoro, Semarang, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Dharmawan, Y., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, Faculty of Public Health, Universitas Diponegoro, Semarang, Indonesia; Fuady, A., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Korfage, I., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Richardus, J.H., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands |
Background The number of new leprosy cases is declining globally, but the disability caused by leprosy remains an important disease burden. The chance of disability is increased by delayed case detection. This review focusses on the individual and community determinants of delayed leprosy case detection. Methods This study was conducted according to the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). The study protocol is registered in PROS-PERO (code: CRD42020189274). To identify determinants of delayed detection, data was collected from five electronic databases: Embase.com, Medline All Ovid, Web of Science, Cochrane CENTRAL, and the WHO Global Health Library. Results We included 27 papers from 4315 records assessed. They originated in twelve countries, had been published between January 1, 2000, and January 31, 2021, and described the factors related to delayed leprosy case detection, the duration of the delayed case, and the percentage of Grade 2 Disability (G2D). The median delay in detection ranged from 12 to 36 months, the mean delay ranged from 11.5 to 64.1 months, and the percentage of G2D ranged from 5.6 to 43.2%. Health-service-seeking behavior was the most common factor associated with delayed detection. The most common individual factors were older age, being male, having a lower disease-symptom perception, having multibacillary leprosy, and lack of knowledge. The most common socioeconomic factors were living in a rural area, perform-ing agricultural labor, and being unemployed. Stigma was the most common social and community factor. Conclusions Delayed leprosy case detection is clearly correlated with increased disability and should therefore be a priority of leprosy programs. Interventions should focus on determinants of delayed case detection such as health-service-seeking behavior, and should consider rele-vant individual, socioeconomic, and community factors, including stigmatization. Further study is required of the health service-related factors contributing to delay. : © 2021 Dharmawan et al. |
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age distribution; attitude to health; awareness; delayed diagnosis; diagnosis time; disability; educational status; geographic distribution; help seeking behavior; human; leprosy; multibacillary leprosy; occupation; Review; risk perception; sex ratio; social belief; social determinants of health; social stigma; socioeconomics; systematic review; unemployment; complication; delayed diagnosis; disabled person; leprosy; patient attitude; psychology; risk factor; time to treatment; Delayed Diagnosis; Disabled Persons; Humans; Leprosy; Patient Acceptance of Health Care; Risk Factors; Social Stigma; Socioeconomic Factors; Time-to-Treatment |
Public Library of Science |
19352727 |
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34383768 |
Review |
Q1 |
1990 |
1322 |
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242 |
Bintoro D.A., Nareswari I. |
57237633100;57194336586; |
The Role of Electroacupuncture in the Regulation of Appetite-Controlling Hormone and Inflammatory Response in Obesity |
2021 |
Medical Acupuncture |
33 |
4 |
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264 |
268 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113821541&doi=10.1089%2facu.2020.1500&partnerID=40&md5=b4a919cddf828d9f0978d90ea651ac42 |
Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Central Jakarta, Jakarta, Indonesia |
Bintoro, D.A., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Central Jakarta, Jakarta, Indonesia; Nareswari, I., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Central Jakarta, Jakarta, Indonesia |
Objective: Obesity, a condition with serious complications, needs special attention. It is a complex and multifactorial problem and regulation of calorie balance involving various humoral and central factors is the main key for managing obesity. In addition, there is an increase in various proinflammatory cytokines and an increase in oxidative stress. There is a need to discover a useful therapy for obesity management. The goal of this review was to examine the literature on electroacupuncture (EA) as a potential therapy. Methods: This review explores the literature on EA, which has proven to be effective for inducing weight loss in experimental human and animal studies. Both continuous and dense-disperse EA waves have their own roles in hormone regulation of obesity using ST 25, CV 9, CV 12, CV 4, SP 6, ST 36, and ST 44; this is discussed the associated mechanism related to this is through suppression of various orexigenic peptides, enhancement of anorexigenic peptides, suppression of inflammatory factors, and improvement in the balance of pro-oxidants and antioxidants. Conclusions: The absence of another definitive therapy for obesity and EA's minimal side-effects make it a potential therapy for managing obesity. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
electroacupuncture; inflammation; obesity; oxidative stress |
ghrelin; acupuncture; appetite; body weight loss; electroacupuncture; food intake; human; inflammation; nonhuman; obesity; oxidative stress; pathophysiology; Review |
Mary Ann Liebert Inc. |
19336586 |
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Review |
Q2 |
281 |
15498 |
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