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253 |
Reksodiputro M.H., Hutauruk S.M., Koento T., Fardizza F., Hakim R.Y.R., Audindra S., Yosia M. |
35090488800;57205105620;35090124600;55091031700;57226286398;57222006228;57204933098; |
Randomised clinical trial: Effect of administering platelet-rich fibrin to autologous fat tissue in injection laryngoplasty for vocal cord paralysis |
2021 |
Annals of Medicine and Surgery |
68 |
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102564 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111006340&doi=10.1016%2fj.amsu.2021.102564&partnerID=40&md5=55d6b3d1b486bec46a872ef4e755dd23 |
Facial Plastic Reconstructive Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Larynx Pharynx Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia |
Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Hutauruk, S.M., Larynx Pharynx Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Koento, T., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Fardizza, F., Larynx Pharynx Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Hakim, R.Y.R., Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Audindra, S., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Yosia, M., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia |
The vocal cord in humans is essential in producing voice used in communication and interaction between us. Vocal cord paralysis causes dysphonia, which interferes with communication, causing disruptions towards social activity and daily activities. One of the managements for vocal cord paralysis is medialization and augmentation of the vocal cord through injection laryngoplasty. Autologous fat is one of the best fillers used in this procedure, but it is highly absorbable and can be reabsorbed very quickly when injected into body tissues. Platelet Rich Fibrin (PRF) is a biomaterial consisting of growth factors that are thought to improve fat tissue viability by increasing adipogenesis and angiogenesis. Improvement in fat viability will improve clinical outcomes after the laryngoplasty procedure, potentially reducing the number of repeated injections needed to achieve a satisfactory resolution to vocal cord paralysis. The study evaluates a combination of PRF and autologous microlobular fat compared with autologous microlobular fat alone on laryngoplasty. This single-blinded randomised control trial recruit a total of 18 patients, which are then randomised into the treatment and control groups. The evaluation was done via computerized acoustic analysis/Multidimensional Voice Program (MDVP) parameters and maximum phonation time. The MDVP results and maximum phonation time in both groups showed clinical improvement after the operation with no statistically significant differences. © 2021 The Authors |
Autologous fat; Injection laryngoplasty; Platelet-rich fibrin; Vocal cord paralysis |
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Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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254 |
Wahyudi M., Alaztha Z. |
57053464800;57219572320; |
Chondrosarcoma arising in monostotic fibrous dysplasia treated with total femur resection and megaprothesis: A case report |
2021 |
International Journal of Surgery Case Reports |
85 |
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106194 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110717734&doi=10.1016%2fj.ijscr.2021.106194&partnerID=40&md5=45372bc574217c458407b12ac52c18ba |
Department of Orthopaedic and Traumatology, Fatmawati General Hospital, Indonesia; Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Indonesia |
Wahyudi, M., Department of Orthopaedic and Traumatology, Fatmawati General Hospital, Indonesia; Alaztha, Z., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Indonesia |
Introduction: Fibrous dysplasia is tumor like lesions of bone which develop as substitution of bone by an expansion of fibrous connective tissue mixed with hard trabeculae. Chondrosarcomas is one of common malignant primary bone tumor derived from heterogenous group of neoplasm producing chondroid matrix. Chondrosarcoma arising in fibrous dysplasia, especially in monostotic fibrous dysplasia is a very rare case. Case report: A 54-year-old male presented with chief complaint of pain on left thigh. Patient with history of pathological fracture on left femoral diaphysis 3 years ago due to fibrous dysplasia and had underwent curettage, open reduction, and internal fixation at other hospital. Plain radiography revealed expansive lytic lesion, interrupted periosteal reaction with plate and screw attached to the lesion, and soft tissue mass. MRI T2FS sequence showed hyperintense mass extending from subtrochanteric to distal of left femoral diaphysis. Histopathological result from biopsy suggested chondrosarcoma. Conclusions: Malignant transformation of monostotic type was less frequently compared to polyostotic type. Among all malignant transformation cases, alteration to chondrosarcoma was more scarce than other malignancy such as osteosarcoma and fibrosarcoma. Wide surgical margin and reconstruction in chondrosarcoma provide good local control and functional outcome. © 2021 The Authors |
Chondrosarcoma; Malignant transformation; Monostotic fibrous dysplasia; Total femur resection |
polyethylene terephthalate; abduction; adult; anamnesis; Article; blood examination; bone biopsy; bone radiography; cancer surgery; cartilage matrix; case report; chondrocyte; chondrosarcoma; clinical article; curettage; femoral shaft; femoral vein; femur; femur diaphysis; femur fracture; femur shaft fracture; follow up; general hospital; greater trochanter; histopathology; human; human cell; incision; laboratory; leg pain; length of stay; male; middle aged; monostotic fibrous dysplasia; nuclear magnetic resonance imaging; open fracture reduction; operative blood loss; orthopedic surgery; osteosynthesis; pathologic fracture; physical examination; psoas muscle; rectus femoris muscle; sartorius muscle; superficial femoral artery; supine position; surgical margin; thigh; tibial tuberosity; va |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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255 |
Surachman A.J.D., Yanuarso, Akbar D.L. |
57222404106;57222408215;57219271823; |
Corrigendum to “Emergency decompression and stabilization of 1st thoracic spinal cord injury and sacral fracture in a Covid-19 patient: A case report” [Int. J. Surg. 81 (2021) 105670] (International Journal of Surgery Case Reports (2021) 81, (S221026122100170X), (10.1016/j.ijscr.2021.105670)) |
2021 |
International Journal of Surgery Case Reports |
85 |
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106162 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110716581&doi=10.1016%2fj.ijscr.2021.106162&partnerID=40&md5=d755a2c74f6f517c9ab61ce17d1d60b7 |
Orthopaedics and Traumatology Department, Indonesia Army Central Hospital, Jakarta, Indonesia; Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo National Central General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Surachman, A.J.D., Orthopaedics and Traumatology Department, Indonesia Army Central Hospital, Jakarta, Indonesia; Yanuarso, Orthopaedics and Traumatology Department, Indonesia Army Central Hospital, Jakarta, Indonesia; Akbar, D.L., Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo National Central General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The authors regret: [1] The published sentence should have read: “For the pubic diastasis, we did not put any fixation since the diastasis was 1 cm (Fig. 4). When we did the follow up, there was unstable on the diastasis, then we did internal fixation on it and the result of the post surgery was evaluated by pelvic radiograph (Fig. 5) [9].” [2] Fig. 5 should have been published as follows: [3] The authors wish to add the following acknowledgement: “Nadya Zaragita, resident of neurosurgery department of Faculty of Medicine, Universitas Indonesia for making illustration of sacral fracture fixation method.” The authors would like to apologise for any inconvenience caused. © 2021 |
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erratum |
Elsevier Ltd |
22102612 |
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Erratum |
Q3 |
232 |
17549 |
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256 |
Farani M., Saldi S.R.F., Maulahela H., Abdullah M., Syam A.F., Makmum D. |
57226146409;55201904000;57189612709;7103393434;8443384400;57226163778; |
Survival, stent patency, and cost-effectiveness of plastic biliary stent versus metal biliary stent for palliation in malignant biliary obstruction in a developing country tertiary hospital |
2021 |
JGH Open |
5 |
8 |
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959 |
965 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110682374&doi=10.1002%2fjgh3.12618&partnerID=40&md5=af5645f91acde4bbed01da739a4f2b1f |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Farani, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Saldi, S.R.F., Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Maulahela, H., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Abdullah, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Makmum, D., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background and Aim: Patients with advanced malignant obstructive jaundice often require biliary drainage. Resources restraint makes clinicians need to outweigh effectiveness of each biliary stents and their costs. Hence, a cost-effectiveness analysis is necessary. Methods: A retrospective cohort study was done on malignant biliary obstruction patients undergoing palliative biliary stenting between January 2015 and December 2018. We evaluated 180-day survival rate using log-rank test and stent patency duration using Mann–Whitney U test. Effectiveness was defined as stent patency, while cost was calculated using hospital perspective using decision tree model and reported as incremental cost-effectiveness ratio. Results: A total of 81 men and 83 women were enrolled in this study. One hundred and eighty days survival rate was 35.9% (median 76 days, 95% confidence interval [CI] 50–102 days) and 33.3% (median 55 days, 95% CI 32–78 days), while average stent patency was 123 (8) days versus 149 (13) days for plastic and metal stent groups, respectively (P > 0.05). Metal stent could save Indonesian Rupiah (IDR) 1 217 750 to get additional 26 days of patency. Conclusion: There were no differences in survival and stent patency between the two groups. Metal biliary stent is more cost-effective than plastic stent for palliation in malignant biliary obstruction. © 2021 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
biliary stent; cost-effectiveness; malignant biliary obstruction |
bilirubin; Article; brain ischemia; cohort analysis; controlled study; cost effectiveness analysis; developing country; endoscopic retrograde cholangiopancreatography; hemodialysis; human; jaundice; liver cirrhosis; log rank test; major clinical study; mortality rate; observational study; overall survival; percutaneous coronary intervention; rank sum test; retrospective study; survival rate |
John Wiley and Sons Inc |
23979070 |
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Article |
Q3 |
546 |
9258 |
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257 |
Moegni F., Kouwagam A.D. |
55450456100;57225978823; |
Secondary pyosalpinx after reconstructive surgery of vaginal agenesis patient with bilateral hematosalpinx: A case report |
2021 |
International Journal of Surgery Case Reports |
85 |
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106166 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109875443&doi=10.1016%2fj.ijscr.2021.106166&partnerID=40&md5=3efbc39e25d5804ce8b775670c949c8c |
Urogynecology and Reconstruction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Moegni, F., Urogynecology and Reconstruction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kouwagam, A.D., Urogynecology and Reconstruction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Congenital or hypoplasia vaginal agenesis is a very rare condition caused by the failure of developmental Mullerian ducts. The prevalence is 0.001%–0.025% populations. This condition often misdiagnosed because the symptom does not appear. Acute symptoms such as abdominal pain may occur due to the obstruction of retrograde menstrual flow. In this case, we presented a case complex management of vaginal atresia with pyosalpinx, hematometra and bilateral hematosalpinx. Presentation of case: A 12 years old teenager, non-sexually active, complained cyclic abdominal pain that worsening in seven months before admission. Patient never had menstrual blood flow during her life. Patient was diagnosed with hematometra, hematocolpos, bilateral hematosalpinx and distal vaginal agenesis. Amnion graft neovagina was performed. Five days after surgery, patient started to have fever. On the seventh days after surgery, amnion graft was removed. The next two days patient still had fever. Because of continuous fever, patient was test of COVID 19. The result was positive. On the eleventh days after the first surgery, patient complained abdominal pain VAS 3–4. Patient was diagnosed with pyosalpinx by ultrasound examination. Laparotomy was done performing adhesiolysis, bilateral salpingectomy, and omentectomy. Discussion: In our case vaginal reconstruction surgery from vaginal approach has been done without management of the bilateral hematosalpinx because the consideration of small caliber of bilateral hematosalpinx. But then complications were developed when vaginal canal was opened, bilateral hematosalpinx were transformed into bilateral pyosalpinx and continue to developed into bilateral tubal abscess. We assume during this process, the bacteria from vagina could fastly infecting the blood and transformed it into pus and grew until tubal abscess. Conclusion: The surgical intervention in vaginal agenesis must be considered as a treatment and not only focus on the reconstruction. Laparoscopy or laparotomy may offered as options for combination treatment with vaginal approach reconstructive surgery for vaginal agenesis with obstruction complications such as hematometra and hematosalpinx to prevent the worst condition like ascending infection or misdiagnosed other severe conditions. © 2021 The Authors |
Case report; Hematosalpinx complication; Neovagina; Secondary pyosalpinx; Vaginal agenesis |
antibiotic agent; abdominal pain; abscess; adhesiolysis; amnion graft neovagina; antibiotic therapy; Article; bilateral hematosalpinx; bilateral tubal abscess; case report; child; clinical article; coronavirus disease 2019; echography; female; fever; hematocolpos; hematometra; human; laparotomy; omentectomy; primary amenorrhea; salpingectomy; school child; secondary pyosalpinx; surgical technique; uterine tube disease; vagina aplasia; vagina reconstruction; visual analog scale |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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258 |
Fudla H., Mudjihartini N., Khusun H. |
57225017143;57191055759;6506676401; |
Effect of four weeks of 5:2 intermittent fasting on energy intake and body mass index among obese male students aged 18-25 |
2021 |
Obesity Medicine |
25 |
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100353 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108976093&doi=10.1016%2fj.obmed.2021.100353&partnerID=40&md5=bfa31843d67d60cf7f528e73f28417a9 |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional (PKGR) Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia |
Fudla, H., Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Mudjihartini, N., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Khusun, H., Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional (PKGR) Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia |
Obesity is a consequence of the metabolic morbidities caused by overconsumption and lack of physical activity. Etiologically, obesity should be preventable, but reviews show that no country has yet been successful in reducing obesity, even though many efforts have been taken around the globe. This study aimed to assess effects of two non-consecutive days fasting per week on energy intake and body mass index (BMI) among obese male students aged 18–25 years at Universitas Indonesia. The collected data including demographic data, anthropometric, socio-economic status, and self-perception of obesity were used as additional information about obesity incidence as the descriptive data. A randomized controlled trial study was conducted on 40 obese male students. Their habitual intake six months before the study was measured through a semi-quantitative food frequency questionnaire. The BMI was measured using a bioelectrical impedance analysis (BIA). Intervention group did two non-consecutive days fasting per week, and recorded their fasting intake by food record diary; while control group did their habitual eating as before, and being recorded by three days 24-h recall. After a four-week intervention, the intervention group saw a significant reduction (P < 0.005) in energy intake and BMI. IF that properly followed the 5:2 protocol reduced energy intake and BMI among obese male students aged 18–25 at Universitas Indonesia in a four-week intervention. © 2021 Elsevier Ltd |
Calorie restriction; Diet; Intermittent fasting; Obesity; Weight reduction |
adult; anthropometry; Article; attitude to health; body mass; caloric intake; clinical article; controlled study; demography; food frequency questionnaire; human; impedance spectroscopy; incidence; Indonesia; intermittent fasting; male; obesity; randomized controlled trial; self concept; social status; student; therapy effect; treatment duration |
Elsevier Ltd |
24518476 |
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Article |
Q3 |
256 |
16455 |
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259 |
Sekarsari D., Handoyo S., Amal M.Y., Kharismarini P. |
57193342279;57224682258;57221702104;57224681914; |
Necrotizing pneumonia with bronchopleural fistula as an uncommon complication of pneumonia in children: a case report |
2021 |
Radiology Case Reports |
16 |
8 |
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2077 |
2080 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108157304&doi=10.1016%2fj.radcr.2021.05.008&partnerID=40&md5=599c73e7c6b4ff903fc62bca8efdf6b7 |
Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Sekarsari, D., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Handoyo, S., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Amal, M.Y., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Kharismarini, P., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Necrotizing pneumonia is an uncommon but severe complication of community acquired pneumonia characterized by the development of necrosis, liquefaction, and cavitation of the lung parenchyma. It occurs infrequently in children, ranging from 0.8% to 7% of community acquired pneumonia cases. We reported a case of 28-month-old female infant with a history of severe dyspnea and fever 5 days before admission. After administration of appropriate antibiotics for pneumonia, the patient's condition was still unresolved. Then, contrast CT scan showed cavitary lesions within consolidated lungs with loss of volume and lack of contrast enhancement that confirmed the diagnosis as necrotizing pneumonia. The presence of pneumothorax in the patient depicts a possible bronchopleural fistula which significantly increase morbidity and mortality risk. Surgical management could not be implemented due to worsening condition of the patient. It is suggested that patients with suspicion of necrotizing pneumonia are subjected to chest CT scan to avoid delay in diagnosis and appropriate management. © 2021 |
Bronchopleural fistula; Children; Imaging; Necrotizing; Pneumonia |
amikacin; antibiotic agent; cefotaxime; ipratropium bromide plus salbutamol; meropenem; salbutamol sulfate; sulbactam; sultamicillin; abnormal respiratory sound; anemia; antibiotic therapy; Article; atelectasis; blood transfusion; bronchopleural fistula; case report; child; clinical article; computer assisted tomography; contrast enhancement; coughing; cytology; drug substitution; dyspnea; female; fever; follow up; heart arrest; hospital admission; hospitalization; human; hydrothorax; loading drug dose; lobectomy; lung consolidation; lung infiltrate; lymphadenopathy; morbidity; mortality risk; nebulization; necrotizing pneumonia; physical examination; pleura effusion; pleura fluid; pleura thickening; pneumothorax; preschool child; resuscitation; thoracotomy; thorax radiography; wheezing |
Elsevier Inc. |
19300433 |
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Article |
Q4 |
221 |
18127 |
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260 |
Saharman Y.R., Karuniawati A., Sedono R., Aditianingsih D., Qi H., Verbrugh H.A., Severin J.A. |
55980934300;54886816200;56660590500;56312263600;57200516838;7103296623;8700385500; |
Multimodal intervention to reduce acquisition of carbapenem-non-susceptible Gram-negative bacteria in intensive care units in the National Referral Hospital of Indonesia: An interrupted time series study |
2021 |
Journal of Critical Care |
64 |
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237 |
244 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107783916&doi=10.1016%2fj.jcrc.2021.04.016&partnerID=40&md5=5958a3646b6b7e60f517ca3456c7f72a |
Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Critical Care Division, Department of Anesthesia and Intensive Care, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Biostatistics, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands |
Saharman, Y.R., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Karuniawati, A., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sedono, R., Critical Care Division, Department of Anesthesia and Intensive Care, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Aditianingsih, D., Critical Care Division, Department of Anesthesia and Intensive Care, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Qi, H., Department of Biostatistics, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Verbrugh, H.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Severin, J.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands |
Purpose: To evaluate a low-cost multimodal intervention on the acquisition of carbapenem-non-susceptible Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa by patients in low-resource intensive care units. Materials and methods: We performed a quasi-experimental study in a referral hospital in Jakarta, Indonesia: pre-intervention phase 1 (2013–2014), intervention phase 2 (2014–2015) and post-intervention phase 3 (2015–2016). The intervention was hand hygiene promotion and environmental cleaning and disinfection combined with patient disinfection and cohorting. The primary outcome was acquisition of resistant bacteria per 100 patient-days at risk, which was assessed by active microbiological surveillance and analysed with a multilevel Poisson segmented regression model. Results: In phase 1 (387 patients), the acquisition rate was 4.3/100 days for carbapenem-non-susceptible A. baumannii versus 1.1/100 days for both K. pneumoniae and P. aeruginosa. There was a significant step change from phase 1 to phase 3 (361 patients) in the acquisition of carbapenem-non-susceptible strains, the incidence rate ratio (IRR) was 0.343 (99%CI: 0.164–0.717). This significant change was mainly due to reduced acquisitions of resistant A. baumannii (IRR 0.4, 99%CI: 0.181–1.061). Negative confounding was observed. Conclusion: A multimodal intervention to prevent acquisition of resistant pathogens is feasible and may be effective in ICUs in lower-middle income countries. © 2021 The Authors |
Acinetobacter baumannii-calcoaceticus complex; Acquisition rate; Carbapenem-non-susceptible; ICU; Indonesia; Klebsiella pneumoniae; Multimodal interventions; Pseudomonas aeruginosa |
carbapenem; antiinfective agent; carbapenem derivative; Acinetobacter baumannii; Acinetobacter calcoaceticus-baumannii complex; adult; aged; antibiotic sensitivity; Article; artificial ventilation; bacterium isolation; cleaning; controlled study; disease surveillance; disinfection; emergency ward; female; human; hygiene; incidence; infection control; information processing; intensive care unit; Klebsiella pneumoniae; length of stay; major clinical study; male; multidrug resistance; outcome assessment; phase 1 clinical trial; phase 2 clinical trial; phase 3 clinical trial; Pseudomonas aeruginosa; quasi experimental study; remission; Sequential Organ Failure Assessment Score; systemic inflammatory response syndrome; time series analysis; cross infection; Gram negative bacterium; hospital; In |
W.B. Saunders |
08839441 |
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34044188 |
Article |
Q1 |
1149 |
3541 |
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261 |
Pravian D., Soesanto A.M., Ambari A.M., Kuncoro B.R.M.A.S., Dwiputra B., Muliawan H.S., Sukmawan R. |
57223935749;56374199000;57189576921;57223920990;57195383994;57203644653;8651025300; |
The effect of external counterpulsation on intrinsic myocardial function evaluated by speckle tracking echocardiography in refractory angina patients: a randomized controlled trial |
2021 |
International Journal of Cardiovascular Imaging |
37 |
8 |
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2483 |
2490 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106531230&doi=10.1007%2fs10554-021-02289-x&partnerID=40&md5=205259fb7afb6a50c7b9b375ac603918 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Pravian, D., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Soesanto, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Ambari, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Kuncoro, B.R.M.A.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Dwiputra, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Muliawan, H.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Sukmawan, R., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
External Counterpulsation (ECP) is one of the therapeutic options in patients with refractory angina inadequately controlled by medical, interventional, or surgical therapy. The 2D Speckle Tracking Echocardiography (2D-STE) method is considered superior in assessing clinical improvement. We would like to evaluate any improvement of myocardial intrinsic function using 2D-STE in patients underwent standard ECP protocol (35 sessions). We conducted a double-blind randomized controlled trial. Patients with refractory angina who could not be revascularized conventionally were randomized into two groups: (1) the ECP group (300 mmHg) and (2) the Sham/control group (75 mmHg). ECP standard therapy was given for 35 sessions (1 h/day/session). The 2D-STE data, including longitudinal strain and post systolic index (PSI) were obtained before and after therapy. 43 subjects were analyzed, with 22 subjects in ECP group and 21 control subjects (Sham group). A homogenous baseline strain was found either globally (12.42 ± 4.55 vs 12.00 ± 4.92 [− %]; P = 0.774) or segmentally/regionally (12.63 (0.01–25.16) vs 12.43 (0.01–27.20) [− %]; P = 0.570). There was no statistically significant improvement between groups in the left ventricle longitudinal strain globally (P = 0.535) and segmentally/regionally (P = 0.434). PSI parameters showed improvement in the ECP group (P = 0.049), and segments with PSI ≥ 20% seemed to improve longitudinal strains in the ECP group after therapy (P = 0.042). In conclusion, 35 ECP therapy sessions did not improve either global or segmental/regional left ventricular mechanical function in patients with refractory angina. However, the mechanical function of myocardial segments with PSS tends to improve after ECP therapy. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. |
2D speckle tracking echocardiography; External counterpulsation; Post systolic index; Refractory angina; Strain |
adult; aged; angina pectoris; Article; cardiovascular parameters; clinical article; clinical outcome; controlled study; counterpulsation; double blind procedure; female; follow up; heart function; heart left ventricle enddiastolic diameter; heart left ventricle endsystolic diameter; human; left ventricular global longitudinal strain; male; middle aged; post systolic index; post systolic shortening; randomized controlled trial; tricuspid annular plane systolic excursion; two dimensional speckle tracking echocardiography |
Springer Science and Business Media B.V. |
15695794 |
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34037889 |
Article |
Q2 |
726 |
6821 |
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262 |
Uchihara Y., Permata T.B.M., Sato H., Shibata A. |
57221723636;57197808751;55697961900;8323572900; |
Modulation of immune responses by DNA damage signaling |
2021 |
DNA Repair |
104 |
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103135 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106368761&doi=10.1016%2fj.dnarep.2021.103135&partnerID=40&md5=6d7c9e9634795d347738b7c970442465 |
Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Department of Radiation Oncology, Gunma University, Gunma, Japan |
Uchihara, Y., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan; Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Sato, H., Department of Radiation Oncology, Gunma University, Gunma, Japan; Shibata, A., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan |
An accumulation of evidence indicates the importance of DNA damage signaling in modulating immune responses. Indeed, understanding the mechanism that underlies signal transduction originating from DNA damage is vital to overcoming refractory cancer, particularly when cancer immune therapy is applied in combination with DNA damage-dependent radio/chemotherapy. In addition, immune-associated responses to such signals can aggravate the symptoms of infections, allergies, autoimmune disease, and aging. In this review, we discuss how cells transduce signals, triggered by DNA damage, from their origins to neighboring cells and how this affects immune and inflammatory responses. © 2021 Elsevier B.V. |
Cancer therapy; DNA damage signaling; Immune crosstalk; Immune-associated disease; Inflammation |
nucleic acid; DNA; Article; cancer immunotherapy; DNA damage response; down regulation; human; immune response; immunomodulation; immunopathology; immunoregulation; inflammation; priority journal; signal transduction; animal; DNA damage; DNA repair; immunity; immunology; metabolism; neoplasm; signal transduction; Animals; DNA Damage; DNA Repair; DNA, Neoplasm; Humans; Immunity; Inflammation; Neoplasms; Signal Transduction |
Elsevier B.V. |
15687864 |
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34029876 |
Article |
Q1 |
2359 |
1004 |
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