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303 |
Samara T., Wibowo H., Liem I., Prijanti A., Andrijono A. |
57208256339;57217690943;55802927800;57190863386;57208264133; |
Cullin 1 as a proangiogenic factor and its relationship with vascular endothelial growth factor and p21 are associated with the length of gestational age of pre-eclampsia |
2021 |
Journal of Natural Science, Biology and Medicine |
12 |
2 |
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140 |
144 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111296351&doi=10.4103%2fjnsbm.JNSBM-123-20&partnerID=40&md5=10efc582ba2ed72d7813100c2ebbc2d5 |
Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Samara, T., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Wibowo, H., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Liem, I., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prijanti, A., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andrijono, A., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Cullin 1 (CUL1), vascular endothelial growth factor (VEGF), and p21 are proteins that play a role in pregnancy. CUL1 and VEGF are proangiogenic factors, whereas p21 is an antiangiogenic factor. An imbalance between proangiogenic and antiangiogenic factors is one of the various factors that cause pre-eclampsia (PE). The aim of this study was to analyze CUL1 levels in the relationship with VEGF levels and p21 levels based on gestational age at delivery in PE. Materials and Methods: This was a cross-sectional study of 70 placentas from PE patients divided in two groups of gestational age at delivery: <34 weeks and ≥34 weeks. Levels of CUL1, VEGF, and p21 were examined by the enzyme-linked immunosorbent assay technique. Statistical analysis was assessed by Spearman correlation test and Chi-square test, with a significant P < 0.05. Results: Low levels of CUL1 and low levels of VEGF were related with <34 weeks of gestational age at delivery, whereas high levels of CUL1 and high levels VEGF were related with ≥34 weeks of gestational age at delivery. There was a negative correlation between the high ratios of p21/CUL1 and <34 weeks of gestational age at delivery in PE. Conclusions: Low levels of CUL1 and low levels VEGF and high ratios of p21/CUL1 were associated with <34 weeks of gestational age at delivery in PE. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Cullin 1; gestational age; p21; pre-eclampsia; vascular endothelial growth factor |
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Wolters Kluwer Medknow Publications |
09769668 |
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Article |
Q3 |
236 |
17374 |
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304 |
Gunawan S., Aulia A., Soetikno V. |
57226331078;57201441066;36769252100; |
Development of rat metabolic syndrome models: A review |
2021 |
Veterinary World |
14 |
7 |
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1774 |
1783 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111179239&doi=10.14202%2fvetworld.2021.1774-1783&partnerID=40&md5=609e64dbfe9d6c9660d991f611abbd71 |
Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia; Doctoral Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Gunawan, S., Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia, Doctoral Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aulia, A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study. © 2021 Veterinary World. All rights reserved. |
High-fat diet; High-fructose diet; High-sucrose diet; Metabolic syndrome; Rat models |
cholesterol; diacylglycerol; glucose; high density lipoprotein cholesterol; leptin receptor; low density lipoprotein cholesterol; triacylglycerol; abdominal circumference; abdominal obesity; animal model; bipolar disorder; body weight; bone metabolism; caloric intake; carbohydrate intake; cardiovascular disease; diastolic blood pressure; dyslipidemia; exercise; fat mass; food intake; gene; glucose blood level; glucose tolerance; high-fructose diet; human; hyperglycemia; insulin resistance; insulin sensitivity; insulin tolerance test; lipid diet; lipid metabolism; lipid storage; lipogenesis; major depression; male; mental disease; metabolic syndrome X; nonalcoholic fatty liver; nonhuman; osmotic stress; oxidative stress; pathogenesis; physical activity; prevalence; rat; Review; risk factor; |
Veterinary World |
09728988 |
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Review |
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550 |
9187 |
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305 |
Firdaus M.D., Artanti N., Hanafi M., Rosmalena |
57226243708;14832374300;26644895300;56891769500; |
Phytochemical constituents, and in vitro antidiabetic and antioxidant properties of various extracts of kenikir (cosmos caudatus) leaves |
2021 |
Pharmacognosy Journal |
13 |
4 |
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890 |
895 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110937044&doi=10.5530%2fpj.2021.13.114&partnerID=40&md5=90452554ceab08be4e58b8af98f14dc7 |
Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia; Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, Banten, South Tangerang, Indonesia |
Firdaus, M.D., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia; Artanti, N., Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, Banten, South Tangerang, Indonesia; Hanafi, M., Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, Banten, South Tangerang, Indonesia; Rosmalena, Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Type 2 diabetes mellitus (T2DM) is one of the most common degenerative disorders. For therapeutic use, herbs are commonly used in Indonesia for T2DM treatment, one of them is (Cosmos caudatus) kenikir's leaves. In previous studies, kenikir's leaves have high antidiabetic and antioxidant activity. However, a comparison of antidiabetic activity from many extracts of kenikir's leave is remain unclear. This study will compare the antidiabetic and antioxidant properties of various kenikir's leave extract. Kenikir's leaves are extracted by maceration methods for three days using three different solvents: boiling water, 50% ethanol, dan ethanol 100%.Then, phenolic and flavonoid content will be measured, as well as antioxidant properties by DPPH radical scavenging activity assay, and antidiabetic properties by α-glucosidase inhibition assay, also LCMS/MS will be used to predict the compound from each extract. The result shows that 50% ethanol extract has highest phenolic and flavonoid content than others. It also has significantly higher antioxidant (p<0.05) and antidiabetic (p<0.05) properties than others. Meanwhile, LCMS/MS result of 50% ethanol extract predicts 6 chemical component, that quercetin is the most dominant compound. 50% ethanol extract of kenikir's leaves is superior from other extracts on phenolic and flavonoid content, antioxidant properties, and antidiabetic properties. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
α-Glucosidase |
1,1 diphenyl 2 picrylhydrazyl; 2 beta 3 beta dihydroxy nortropane; alcohol; alpha glucosidase; antidiabetic agent; antioxidant; Cosmos caudatus extract; delta humulene; digiprolactone; flavonoid; genistin; gentiatibetine; glucopyranoside; herbaceous agent; oroxin B; phenol; phenylproprionic acid; phytochemical; plant extract; quercetin; solvent; spathulenol; stearidonic acid; unclassified drug; valine; water; antidiabetic activity; antioxidant activity; Article; boiling point; controlled study; Cosmos (genus); DPPH radical scavenging assay; human; in vitro study; Kenikir leaf; liquid chromatography-mass spectrometry; nonhuman; plant leaf |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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306 |
Rosmalena, Widyastuti P.A., Yazid F., Ambarwati N.S.S., Ahmad I. |
56891769500;57226249984;57207890516;57193830343;57190669391; |
Phytochemicals and antioxidant activities evaluation of origanum vulgare (L.) stem bark extracts |
2021 |
Pharmacognosy Journal |
13 |
4 |
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965 |
970 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110932652&doi=10.5530%2fpj.2021.13.124&partnerID=40&md5=01f50c35c8a94d648081fcd99e50d8fa |
Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Medical Student, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, East Jakarta, Jakarta, 13220, Indonesia; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, East Kalimantan, Samarinda, 75119, Indonesia |
Rosmalena, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Widyastuti, P.A., Medical Student, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Yazid, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Ambarwati, N.S.S., Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, East Jakarta, Jakarta, 13220, Indonesia; Ahmad, I., Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, East Kalimantan, Samarinda, 75119, Indonesia |
The present study aimed to evaluate phytochemical and antioxidant activity (in vitro and in vivo) of Origanum vulgare (L.) ethanolic extract. The phytochemical test was assessed using the Clule method in ethanol, ethyl acetate, and hexane. In vitro evaluation of antioxidant activity was determined by radical scavenging assay using DPPH (2,2-diphenyl-1-picrylhydrazyl) as an artificial free radical activity. In vivo test was conducted to evaluate the effect of malondialdehyde (MDA) level in blood plasma during maximum physical activity treatment. In vivo test was done using 25 male Sprague Dawley rats in pre and post-test control group design. The phytochemical test of O. vulgare ethanol extract was showed some compounds, such as a flavonoid, alkaloid, triterpenoid/steroid, essential oil, and tannin, then in ethyl acetate and hexane. In vitro assay showed that O. vulgare extract has strong antioxidant activity with an IC50 value of 133.47 µg/mL. While in the in vivo test, the most effective dosage is 20 mg/200 gr B.W., represented by a significant decrease of MDA level (0.509 nmol/mL) before and after treatment. So, the ethanolic extract of clove has potency as an herbal antioxidant because of the low level of IC50 and can decrease the MDA level. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
2; 2-diphenyl-1-picrylhydrazyl; Antioxidant activity; Malondialdehyde; Origanum vulgare (L.); Phytochemical |
1,1 diphenyl 2 picrylhydrazyl; acetic acid ethyl ester; alcohol; alkaloid; antioxidant; ascorbic acid; essential oil; flavonoid; free radical; hexane; malonaldehyde; Origanum vulgare ethanolic extract; phytochemical; plant extract; saponin; steroid; tannin; triterpenoid; unclassified drug; animal experiment; animal tissue; antioxidant activity; Article; bark; blood sampling; clove; controlled study; DPPH radical scavenging assay; drug potency; in vitro study; in vivo study; male; nonhuman; physical activity; pretest posttest design; rat; Sprague Dawley rat |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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307 |
Wiguna T., Ismail R.I., Kaligis F., Minayati K., Murtani B.J., Wigantara N.A., Pradana K., Bahana R., Dirgantoro B.P., Nugroho E. |
24367785700;55996895500;36604651700;57218681686;57216652176;57218679014;57220165625;56400946100;57202082268;56493037400; |
Developing and feasibility testing of the Indonesian computer-based game prototype for children with attention deficit/hyperactivity disorder |
2021 |
Heliyon |
7 |
7 |
e07571 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110552291&doi=10.1016%2fj.heliyon.2021.e07571&partnerID=40&md5=8eca39aaa9e8ed828955cacd6838b22f |
Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Computer Science, Bina Nusantara University, Jakarta, Indonesia; Kummara Game Design Studio, Bandung, West Java, Indonesia |
Wiguna, T., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Kaligis, F., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Minayati, K., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wigantara, N.A., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pradana, K., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Bahana, R., Department of Computer Science, Bina Nusantara University, Jakarta, Indonesia; Dirgantoro, B.P., Department of Computer Science, Bina Nusantara University, Jakarta, Indonesia; Nugroho, E., Kummara Game Design Studio, Bandung, West Java, Indonesia |
The aim of this study was to develop an Indonesian computer-based game prototype, including feasibility testing, targeted on attention deficit/hypersensitivity disorder (ADHD) clinical symptoms and executive function. The study comprised five steps. The first to third steps used an exploratory qualitative research design. The Delphi technique with FGD was applied to collect qualitative data. During the study, seven experts participated in ten FGDs. Feasibility testing was conducted as a one group pre- and post-test design that included ten children with drug-naïve ADHD without other mental or physical disorders. Feasibility data were collected before and after 20 training sessions with the Indonesian computer-based game prototype. The framework analysis was performed for qualitative data. Quantitative data were analyzed using the paired t-test, Pearson's correlation and Spearman's rank-order correlation. Outputs of the exploratory qualitative study were the Indonesian computer-based game prototype constructs and general agreements of the prototype,. The Indonesian computer-based game prototype construct comprised six components: reward-related processing, control inhibition, improved sustained attention, specific timing, increased arousal, and improved emotional regulation. After 20 sessions of training, several indicators decreased significantly, such as CATPRS-teacher rating (18.5 [5.31] vs. 12.9 [5.51], p = 0.047), BRIEF-GEC (64.80 [10.21] vs. 57.50 [7.51], p = 0.02), BRIEF-MI (66.1 [7.61] vs. 58.4 [7.56], p = 0.014), BRIEF-Initiate (66.6 [10.15] vs. 54.1 [6.49], p = 0.008), BRIEF-Working Memory (68.0 [6.89] vs. 60.9 [10.05], p = 0.02), and BRIEF-Organization of Material (60.7 [12.88] vs. 49.3 [11.79], p = 0.04). There was a low to moderate correlation between CATPRS-teacher and -parent rating and several BRIEF domains. Feasibility testing output also included the training procedure guideline. The present study indicated that the Indonesian computer-based game prototype could be used as a framework to develop a fixed computer-based game intervention for children with ADHD. However, further randomized controlled studies need to be conducted to show its effectiveness. © 2021 The Author(s) |
ADHD; Behavioral Rating Inventory for Executive Function; Computer-based game; Connors Abbreviated Teacher; Executive function; Indonesia |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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308 |
Sartika A.N., Khoirunnisa M., Meiyetriani E., Ermayani E., Pramesthi I.L., Nur Ananda A.J. |
57221416383;57226010121;57209855172;57207767542;57225987145;57225998001; |
Prenatal and postnatal determinants of stunting at age 0–11 months: A cross-sectional study in Indonesia |
2021 |
PLoS ONE |
16 |
7 July |
e0254662 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110244631&doi=10.1371%2fjournal.pone.0254662&partnerID=40&md5=49e2d8b93ae14f38dd5a7a1c9f3b9765 |
Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; SEAMEO Regional Center for Food and Nutrition, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia |
Sartika, A.N., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Khoirunnisa, M., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Meiyetriani, E., SEAMEO Regional Center for Food and Nutrition, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Ermayani, E., SEAMEO Regional Center for Food and Nutrition, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Pramesthi, I.L., SEAMEO Regional Center for Food and Nutrition, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Nur Ananda, A.J., SEAMEO Regional Center for Food and Nutrition, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia |
Background Childhood stunting remains the most challenging consequence of undernutrition because it is associated with suboptimal brain development and the subsequent increased risk of metabolic diseases and decreased earnings in adult life. The Sambas District in Indonesia has a high prevalence of stunting (28.4%), followed by underweight (25.5.%) and wasting (14.4%) among children, as well chronic energy deficiency (27%) and anemia (62%) among pregnant women. The present study sought to determine significant factors in childhood stunting with a focus on maternal and child nutrition and prenatal and postnatal determinants. Methods This prospective, repeat, cross-sectional study investigated factors associated with stunting among 559 infants age 0–11 months in Sambas District, Indonesia. Anthropometric measurements were performed by trained enumerators. Data from a 2016 survey of pregnant women and a 2017 survey on mothers and their children were used for postnatal data collection to quantify the prevalence of stunting at age 0–11 months. Using 20 potential predictors of stunting categorized by household characteristics, maternal characteristics, antenatal care services, and child characteristics, logistic regression analysis was conducted to assess the adjusted association between stunting and these factors. Results Of 559 children analyzed, 20.8% were stunted. In the model with low birth weight (LBW) as predictor for stunting, the odds of stunting increased significantly among children who weighed <2.500 g at birth; children who had diarrhea in the past 2 weeks and children who had incomplete basic immunization coverage as infants age 9–11 months. In model without LBW, the odds of stunting increased significantly among children who had preterm at birth, short maternal stature and children who had incomplete basic immunization coverage for 9–11 months infants. Conclusions Postnatal factors—preterm birth, low birth weight, diarrhea and complete basic immunization coverage—were associated with infant stunting in Sambas District, Indonesia. The prenatal factors such as short maternal stature were significant in the multivariate model. Policy makers, especially in the government, should recommend measures focused on those prenatal and postnatal factors to prevent stunting in children and to avoid the sequelae of childhood stunting in adult life. Copyright: © 2021 Sartika et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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anthropometry; Article; child nutrition; cross-sectional study; data collection method; diarrhea; female; government; health care policy; household; human; Indonesia; infant; low birth weight; major clinical study; male; maternal nutrition; newborn; perinatal period; predictor variable; premature labor; prenatal care; prenatal period; prevalence; prospective study; stunting; vaccination coverage; growth disorder; multivariate analysis; Anthropometry; Cross-Sectional Studies; Female; Growth Disorders; Humans; Indonesia; Infant; Infant, Newborn; Male; Multivariate Analysis; Prospective Studies |
Public Library of Science |
19326203 |
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34260622 |
Article |
Q1 |
990 |
4434 |
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309 |
Putri N.M., Kreshanti P., Aulia I., Syarif A.N., Tunjung N., Sukasah C.L. |
57192904294;36192866200;57204495153;57247430600;57208446370;57218391534; |
Use of local perforator flaps for closure of a thoraco-omphalopagus conjoined twin defect after separation during the COVID-19 pandemic |
2021 |
Heliyon |
7 |
7 |
e07443 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109574685&doi=10.1016%2fj.heliyon.2021.e07443&partnerID=40&md5=8fe6d81617877cb017dabe11c561c536 |
Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Putri, N.M., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kreshanti, P., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Aulia, I., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Syarif, A.N., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Tunjung, N., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sukasah, C.L., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: Conjoined twins are a rare medical phenomenon that poses unique challenges for surgeons. Separation of conjoined twins involves multidisciplinary teamwork, complex medical management and surgical planning, and multi-stage operations and often still has a high mortality and morbidity rate. In the times of the COVID-19 pandemic, separation of conjoined twins pose even greater challenges. Aiming for the best outcome possible, while minimizing the risk of COVID transmission and ensuring the safety of the personnel, is paramount. This case report presents thoraco-omphalopagus twins who were successfully separated at 4 months of age. The preoperative planning, operative details, postoperative follow-ups, and outcomes are discussed. Methods: The absence of a tissue expander and the inability to acquire it due to travel restrictions from COVID-19 further complicated the management on this patient. A Routine Polymerase Chain Reaction (PCR) swab test was performed on the patients and personnel. Standardized personnel protective equipment (PPE) was worn during ward and surgical care. After separation of the twins by cardiothoracic and pediatric surgeons, one twin underwent immediate skin closure using a double keystone perforator island flap and a lower abdominal perforator flap. Due to extensive defects, closure was delayed for the second twin. After a series of dressing changes, eventually local perforator flaps could be raised to close the defect using staged tension sutures and skin grafts for secondary defects. Results: Both twins were discharged with no significant morbidity, and no personnel were exposed to COVID-19 infection during the management. Conclusion: Preoperative coordination and planning, multidisciplinary effort, adherence to screening protocols for COVID, and strict use of standardized PPE all contributed to the successful separation of thoraco-omphalopagus conjoined twins during the COVID-19 pandemic. © 2021 The Author(s) |
Case report; COVID-19; Negative pressure wound therapy; Perforator flaps; Thoraco-omphalopagus conjoined twins |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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310 |
Situmorang H., Hestiantoro A., Purbadi S., Flamandita D., Sahlan M. |
57195939562;8743255100;6505677307;57216766308;57189182661; |
IN-SILICO dynamic analysis of Sulawesi propolis as anti-endometriosis drug: Interaction study with TNF alpha receptor, NF-kB, estrogen receptor, progesterone receptor and prostaglandin receptor |
2021 |
Annals of Medicine and Surgery |
67 |
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102459 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109547312&doi=10.1016%2fj.amsu.2021.102459&partnerID=40&md5=0f7d6fdeda084de97c22a80f60f7b2a7 |
Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia |
Situmorang, H., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Hestiantoro, A., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Purbadi, S., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Flamandita, D., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia; Sahlan, M., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia |
Introduction: Endometriosis is a disease that impacts around 10% of all women in reproductive age, with pelvic pain and infertility as its main clinical features. Current medical treatment targeting lowering estrogen activity has not shown sufficient result due its side effects and reproductive function suppression. Propolis has been widely studied, showing anti inflammation and pro-apoptosis property, that could potentially be used in the treatment of endometriosis. This study investigates the interaction between Sulawesi Propolis’ active components and receptors and protein related to endometriosis pathogenesis. Methods: Active components of Sulawesi Propolis were initially identified with their targeted protein receptors. Lipinski rules were used to screen potential components. The ligands and proteins were tested using Autodock program to predict the most active compound and possible binding sites between propolis and some target proteins associated with inflammatory and apoptotic activity in endometriosis models. Receptor modelling is then performed using Swiss-Model. Results: These active components of Sulawesi Propolis showed a strong binding potential towards TNF- α, NF-kb, Estrogen-α, Estrogen-β, progesterone B, PGE2 EP2 and EP3 subtype respectively: Sanggenon C, Sanggenon H, Epicryptoacetalide, Chrysin-7-O-β-D-glucopyranodside, Irilone, Polydatin and Epicryptoacetalide. Compared to its negative ligand, Sulawesi Propolis displayed a stronger binding capacity to TNF-α, Estrogen-α, and Progesterone B receptors. Conclusion: Sulawesi Propolis has the ability to interact with receptors related to reproductive function, apoptotic reactions and inflammatory processes, a significant factor associated with the pathogenesis of endometriosis. © 2021 |
Docking; Endometriosis; Estrogen receptor; In silico; NF-kB; Progesterone receptor; Propolis; Prostaglandin receptor; TNF alpha Receptor |
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Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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311 |
Sunardi D., Bardosono S., Basrowi R.W., Wasito E., Vandenplas Y. |
57192075078;21933841000;57024210400;6506940239;57223670656; |
Dietary determinants of anemia in children aged 6–36 months: A cross-sectional study in Indonesia |
2021 |
Nutrients |
13 |
7 |
2397 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109524537&doi=10.3390%2fnu13072397&partnerID=40&md5=2e8ac565ce8b6f3dd3f70a2de509a9ad |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Brussels, 1090, Belgium |
Sunardi, D., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Basrowi, R.W., Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Wasito, E., Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Vandenplas, Y., Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Brussels, 1090, Belgium |
Anemia has been acknowledged as worldwide problem, including in Indonesia. This cross-sectional study aims to explore dietary determinants as risk factors for anemia in children aged 6–36 months living in a poor urban area of Jakarta. The study was done in Kampung Melayu sub-district in Jakarta, Indonesia. Data was collected within two weeks in September–October 2020. A structured questionnaire for a 24-h recall and a semi-quantitative Food Frequency Questionnaire (FFQ) were used to collect the dietary intake data, and venous blood was withdrawn to determine the hemoglobin levels. Bivariate chi-square and multiple logistic regression tests were executed to explore the dietary determinant factors for anemia. We recruited 180 subjects. The average hemoglobin concentration was 11.4 ± 1.7 mg/dL; the anemia prevalence was 29.4%. The following variables were significantly associated with higher risk of anemia: no cow’s milk formula consumption, inadequate intake of fats, protein, calcium, vitamin D, iron, zinc, vitamin A, vitamin C, vitamin B6, and vitamin B12. Only cow’s milk formula consumption and zinc intake were revealed as the determinant factors of anemia. In conclusion, the prevalence of anemia was 29.4% among children aged 6–36 months old. Anemia was significantly associated with two dietary determinants as risk factors that are cow’s milk formula consumption and zinc intake. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Anemia; Cow’s milk; Cow’s milk formula; Indonesia; Toddler; Zinc |
biological marker; hemoglobin; zinc; adverse event; age; anemia; artificial milk; blood; bottle feeding; cross-sectional study; diet; female; human; Indonesia; infant; infant nutrition; male; metabolism; nutritional status; pathophysiology; preschool child; prevalence; risk assessment; risk factor; urban health; Age Factors; Anemia; Biomarkers; Bottle Feeding; Child, Preschool; Cross-Sectional Studies; Diet; Diet Surveys; Female; Hemoglobins; Humans; Indonesia; Infant; Infant Formula; Infant Nutritional Physiological Phenomena; Male; Nutritional Status; Prevalence; Risk Assessment; Risk Factors; Urban Health; Zinc |
MDPI AG |
20726643 |
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34371908 |
Article |
Q1 |
1418 |
2497 |
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312 |
Mantiri B.J., Sigumonrong Y. |
57211646737;57209291346; |
Bilateral adrenal tumor: A case report and current challenges |
2021 |
International Journal of Surgery Case Reports |
84 |
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106134 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109442036&doi=10.1016%2fj.ijscr.2021.106134&partnerID=40&md5=6e73ca95877115564bd2d8829933ec42 |
Urology Resident of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia; Urology Consultant of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia |
Mantiri, B.J., Urology Resident of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia; Sigumonrong, Y., Urology Consultant of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia |
Introduction: A bilateral adrenal tumor is a rare case. It differs significantly from unilateral adrenal mass since it is related strongly to genetic and family history. Adrenocortical Carcinoma might cause related hormonal syndromes such as Cushing syndrome, Conn syndrome, and virilization. Aim: This study aims to report an uncommon presentation of a 15-year-old female with bilateral Adrenal Tumor since an early age with virilization as the main symptoms. Case presentation: The patient is a 15-year-old girl with female genitalia presentation. She complained of a bulging mass on her right flank with pain four years ago. The mass size grew progressively and initially painless. However, the patient started to feel pain a year ago. Since she was six years old, the mass started to appear on the left flank, and then it also started to appear on the right side. The mass appearance is simultaneous with virilization symptom development, such as the emergence of facial hair, mustache, and sideburns. In 2020, MRI showed a lesion on the right suprarenal with contrast enhancement with 14.5 × 11.5 cm in size, and a 5.6 × 4 cm recurrent left suprarenal lesion. The patient underwent right adrenalectomy resection surgery on January 21st, 2021. The immunohistochemistry examination suggested Adrenocortical Carcinoma. Conclusion: Adrenocortical Carcinoma is a hormone-secreting tumor that might affect the patient's condition systematically. Neglected cases of adrenal cortical carcinoma might affect secondary sexual organ development in the long term. Thus, an early diagnosis and treatment are paramount for this case. © 2021 |
Adrenalectomy; Bilateral adrenocortical carcinoma; Virilization |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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