No records
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333 |
Ngadimin K.D., Stokes A., Gentile P., Ferreira A.M. |
57224568038;57224586577;24478479500;16068361700; |
Biomimetic hydrogels designed for cartilage tissue engineering |
2021 |
Biomaterials Science |
9 |
12 |
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4246 |
4259 |
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15 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107619348&doi=10.1039%2fd0bm01852j&partnerID=40&md5=634f8d458d06a53948b28ba7237188d1 |
Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; Faculty of Medicine, Universitas Indonesia, Indonesia; Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom |
Ngadimin, K.D., Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom, Faculty of Medicine, Universitas Indonesia, Indonesia; Stokes, A., Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom; Gentile, P., Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom; Ferreira, A.M., Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom |
Cartilage regeneration and repair remain a clinical challenge due to the limited capability of cartilage to self-regenerate. Worldwide, the costs associated with cartilage regeneration per patient are estimated on average £30 000 for producing and supplying cells. Regenerative approaches may include the use of cell therapies and tissue engineering by combining relevant cells, scaffolds and instructive biomolecules to stimulate or modulate cartilage repair. Hydrogels have been of great interest within these fields to be used as 3D substrates to cultivate and grow cartilage cells. Currently, biomimetic hydrogels with adequate biological and physicochemical properties, such as mechanical properties, capable of supporting load-bearing capability, are yet to succeed. In this review, biomaterials' advantages and disadvantages for the manufacturing of biomimetic hydrogels for cartilage regeneration are presented. Different studies on the formulation of cartilage-like hydrogels based on materials such as gelatin, chondroitin sulfate, hyaluronic acid and polyethylene glycol are summarised and contrasted in terms of their mechanical properties (e.g. elastic modulus) and ability to enhance cell function such as cell viability and GAG content. Current limitations and challenges of biomimetic hydrogels for cartilage regeneration are also presented. © 2021 The Royal Society of Chemistry. |
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Biomechanics; Biomimetics; Cartilage; Cells; Cytology; Hyaluronic acid; Hydrogels; Mechanical properties; Molecular biology; Physicochemical properties; Scaffolds (biology); Sulfur compounds; Tissue; Biomimetic hydrogels; Cartilage cells; Cartilage regeneration; Cartilage repair; Cartilage tissue engineering; Chondroitin sulfates; Current limitation; Load bearing capabilities; Cell engineering; biomaterial; biomimetic material; chondroitin sulfate; gelatin; hyaluronic acid; hydrogel; macrogol; biological activity; biomimetics; cartilage; cell therapy; cell viability; chemical composition; computer model; cross linking; human; in vitro study; nonhuman; Review; tissue engineering; tissue regeneration; Young modulus; articular cartilage; biomimetics; cartilage; hydrogel; regeneration; tissue |
Royal Society of Chemistry |
20474830 |
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33710205 |
Review |
Q1 |
1422 |
2479 |
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334 |
Yasmon A., Agnes A., Febriani R., Kusumaningrum A., Andriansjah, Sudarmono P. |
41462004500;57352939000;57212580873;57211641695;57352939200;6507855437; |
Identification of nontuberculous mycobacteria (Ntm) species isolated from the sputum, skin and soft tissue of patients in Jakarta, Indonesia |
2021 |
Southeast Asian Journal of Tropical Medicine and Public Health |
52 |
5 |
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644 |
650 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119897125&partnerID=40&md5=fa2f76f9076156267a3d1d05310fb824 |
Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Yasmon, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Agnes, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Febriani, R., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kusumaningrum, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Andriansjah, Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sudarmono, P., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Knowing the species of nontuberculous mycobacteria (NTM) causing disease in a patient population can guide empiric treatment. In this study we aimed to determine the species of NTM causing disease in a selected patient population in Indonesia in order to guide empiric treatment. We retrospectively reviewed the records of all patients treated at 5 hospitals in Jakarta, Indonesia, diagnosed with NTM infection during January 2018-December 2019. The inclusion criterion for study subjects was having a positive test for NTM and the exclusion criterion was having a positive culture for Mycobacterium tuberculosis complex. Study subjects were confirmed to have NTM by a MPT64 rapid test. The species of NTM were identified by DNA sequencing of Mycobacterium 16S rRNA. A total of 15 patients were determined to have NTM at the study institutions during the study period, 53% male. The average age of study subjects was 45 (range: 4-83) years. The NTM positive specimens were obtained from the sputum (n = 5), skin and soft tissue biopsies (n = 5), and lymphoid tissue biopsies (n = 5). Of the 15 study subjects, 8 (53%) had M. abscessus, 5 (33%) had M. intracellulare, 1 (7%) had M. avium and 1 (7%) had M. cookii. Of the 5 NTM isolates from the sputum, 3 isolates were M. abscessus, 1 isolate was M. intracellulare and 1 isolate was M. Cookii. Of the 5 NTM isolates from skin and soft biopsies, 3 isolates were M. abscessus and the other 2 isolates were M. intracellulare. Of the 5 NTM isolates from lymphoid tissue biopsies, 2 isolates were M. abscessus, 2 isolates were M. intracellulare and 1 isolate was M. Avium. In our study, the most common NTIM isolate was M. abscessus. Empiric treatment of NTM in the study population should include coverage of M. abscessus. Further studies with larger numbers of subjects from multiple institutions are needed to determine if these findings hold true for other parts of Indonesia. © 2021, SEAMEO TROPMED Network. All rights reserved. |
Lymphoid; Mycobacterium; NTM; Skin and soft; Sputum |
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SEAMEO TROPMED Network |
01251562 |
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Article |
Q4 |
214 |
18533 |
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335 |
Anurogo D., Budi N.Y.P., Ngo M.-H.T., Huang Y.-H., Pawitan J.A. |
57224408026;57200656694;57222023578;57154840200;6508348067; |
Cell and gene therapy for anemia: Hematopoietic stem cells and gene editing |
2021 |
International Journal of Molecular Sciences |
22 |
12 |
6275 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107482996&doi=10.3390%2fijms22126275&partnerID=40&md5=fea16158471961b74a29fcf9cb158461 |
International PhD Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Makassar, Makassar, 90221, Indonesia; Research Center of Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Center for Reproductive Medicine, Taipei Medical University Hospital, Taipei, 11031, Taiwan; Comprehensive Cancer Center, Taipei Medical University, Taipei, 11031, Taiwan; Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 11031, Taiwan; PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Anurogo, D., International PhD Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Makassar, Makassar, 90221, Indonesia; Budi, N.Y.P., International PhD Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Ngo, M.-H.T., International PhD Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Huang, Y.-H., International PhD Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Research Center of Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Center for Reproductive Medicine, Taipei Medical University Hospital, Taipei, 11031, Taiwan, Comprehensive Cancer Center, Taipei Medical University, Taipei, 11031, Taiwan, Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 11031, Taiwan, PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Hereditary anemia has various manifestations, such as sickle cell disease (SCD), Fanconi anemia, glucose‐6‐phosphate dehydrogenase deficiency (G6PDD), and thalassemia. The available management strategies for these disorders are still unsatisfactory and do not eliminate the main causes. As genetic aberrations are the main causes of all forms of hereditary anemia, the optimal approach involves repairing the defective gene, possibly through the transplantation of normal hematopoietic stem cells (HSCs) from a normal matching donor or through gene therapy approaches (either in vivo or ex vivo) to correct the patient’s HSCs. To clearly illustrate the importance of cell and gene therapy in hereditary anemia, this paper provides a review of the genetic aberration, epidemiology, clinical features, current management, and cell and gene therapy en-deavors related to SCD, thalassemia, Fanconi anemia, and G6PDD. Moreover, we expound the future research direction of HSC derivation from induced pluripotent stem cells (iPSCs), strategies to edit HSCs, gene therapy risk mitigation, and their clinical perspectives. In conclusion, gene‐corrected hematopoietic stem cell transplantation has promising outcomes for SCD, Fanconi anemia, and thalassemia, and it may overcome the limitation of the source of allogenic bone marrow transplantation. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Anemia; Cell therapy; Gene editing; Gene therapy; Hematopoietic stem cells |
antisickling agent; BRCA1 protein; BRCA2 protein; Fanconi anemia group A protein; Fanconi anemia group b protein; Fanconi anemia group C protein; Fanconi anemia group D2 protein; Fanconi anemia group E protein; Fanconi anemia group F protein; Fanconi anemia group G protein; Fanconi anemia group i protein; Fanconi anemia group j protein; Fanconi anemia group L protein; hematologic agent; hemoglobin beta chain; hemoglobin F; nuclear protein; partner and localizer of BRCA2; Rad51 protein; Rad51c protein; unclassified drug; acute chest syndrome; anemia; aplastic anemia; arm malformation; Article; asplenia; blood transfusion; cafe au lait spot; cell therapy; cerebrovascular accident; chromosome aberration; chronic nonspherocytic hemolytic anemia; clinical feature; clinical outcome; congenital d |
MDPI |
16616596 |
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34200975 |
Article |
Q1 |
1455 |
2384 |
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336 |
Hidayat R., Diafiri D., Zairinal R.A., Arifin G.R., Azzahroh F., Widjaya N., Fani D.N., Mesiano T., Kurniawan M., Rasyid A., Giantini A., Haris S. |
57225289998;57369144600;57214092762;57221703744;57219418635;57424739100;57424721100;57204830976;57196001182;56703146700;12776781400;57222343545; |
Acute Ischaemic Stroke Incidence after Coronavirus Vaccine in Indone-sia: Case Series |
2021 |
Current Neurovascular Research |
18 |
3 |
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360 |
363 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123387853&doi=10.2174%2f1567202618666210927095613&partnerID=40&md5=56196ab18737f980961c6a27a7823638 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia |
Hidayat, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia; Diafiri, D., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia; Zairinal, R.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia; Arifin, G.R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Azzahroh, F., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Widjaya, N., Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia; Fani, D.N., Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia; Mesiano, T., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kurniawan, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rasyid, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Giantini, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia; Haris, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Coronavirus disease-19 (COVID-19) is an infectious disease with high morbidity and mortality rates. Indonesia had reported a 2.8% of mortality rate up to June 2021. Case Presentation: A strategy to control the virus spreading is by vaccination. The Indonesian Food and Drug Monitoring Agency had approved the use of CoronaVac, an inactivated virus vaccine developed by Sinovac. Most Adverse Events Following Immunization (AEFI) for Corona-Vac are mild, and the most common symptoms are injection-site pain, headache, and fatigue. Neu-rovascular adverse events, including thrombosis or ischaemic stroke after receiving CoronaVac have not previously been reported. Conclusion: Correspondingly, we reported three patients with an Acute Ischaemic Stroke (AIS) after the administration of CoronaVac in our hospital. © 2021 Bentham Science Publishers. |
AEFI; CoronaVac; COVID 19; COVID-19; Stroke; Vaccine |
inactivated vaccine; adverse event; aged; brain ischemia; case report; human; incidence; Indonesia; male; middle aged; prevention and control; Aged; COVID-19; COVID-19 Vaccines; Humans; Incidence; Indonesia; Ischemic Stroke; Male; Middle Aged; SARS-CoV-2; Vaccines, Inactivated |
Bentham Science Publishers |
15672026 |
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34579636 |
Article |
Q3 |
592 |
8538 |
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337 |
Pontoh L.A.P., Rahyussalim A.J., Fiolin J. |
57192907426;55212166100;57194498274; |
Patient Height may Predict the Length of the Anterior Cruciate Ligament: A Magnetic Resonance Imaging Study |
2021 |
Arthroscopy, Sports Medicine, and Rehabilitation |
3 |
3 |
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e733 |
e739 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113913987&doi=10.1016%2fj.asmr.2021.01.012&partnerID=40&md5=f360a46041bd0cd832150f6f545b6417 |
Knee Division of Department of Orthopaedic and Traumatology, Fatmawati General Hospital–Faculty of Medicine Universitas Indonesia, Jakarta, Selatan, Indonesia; Spine Division of Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine Universitas Indonesia, Jakarta, Pusat, Indonesia; Jakarta Knee, Shoulder and Orthopaedic Sport Clinic, Pondok Indah Hospital, Jakarta, Indonesia |
Pontoh, L.A.P., Knee Division of Department of Orthopaedic and Traumatology, Fatmawati General Hospital–Faculty of Medicine Universitas Indonesia, Jakarta, Selatan, Indonesia; Rahyussalim, A.J., Spine Division of Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine Universitas Indonesia, Jakarta, Pusat, Indonesia; Fiolin, J., Jakarta Knee, Shoulder and Orthopaedic Sport Clinic, Pondok Indah Hospital, Jakarta, Indonesia |
Purpose: The purpose of this study was to measure the length and width of anterior cruciate ligament (ACL) tibial footprint using magnetic resonance imaging (MRI) and to evaluate correlation between patients’ weight and height with the tibial footprint size. Methods: In total, 207 eligible patients underwent MRI scanning from June 2018 to June 2020. One hundred seventeen knees from patients aged 18 to 40 years old with intact ACL were included in this study. Data of weight, height, body mass index (BMI) from physical examination and tibial footprint length and width from MRI were obtained. Relationship of ACL tibial footprint length <14 mm and association between ACL tibial footprint sizes of MRI with height, weight, and BMI were analyzed. Results: The ACL tibial footprint length and width were, respectively, 11.9 ± 1.8 mm and 10 ± 1.5 mm. Proportion of ACL footprint <14 mm in length was 89.7%. Patient height ≥170 cm was the best predictor of ACL tibial footprint length <14 mm (P =.025). There was a statistically significant relationship between the height of the patients and the length of the ACL tibial footprint. The length of the ACL tibial footprint could be predicted by the formula: length = −7.362 + 11.48 × (height in meters). Conclusion: The height of the patients may predict the length of the ACL tibial footprint. Although patient's age, sex, and BMI correlate poorly with ACL tibial footprint width, there was no correlation between patient's weight and ACL tibial footprint size. Clinical Relevance: Before ACL reconstruction surgery, an estimation of ACL tibial footprint size might aid in the graft harvesting preparation. © 2021 Arthroscopy Association of North America |
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adult; anterior cruciate ligament; anterior cruciate ligament reconstruction; article; body mass; body weight; clinical evaluation; controlled study; female; graft harvesting; human; major clinical study; male; nuclear magnetic resonance imaging; physical examination |
Elsevier Inc. |
2666061X |
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Article |
#N/A |
#N/A |
#N/A |
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338 |
SITOHANG I.B.S., SOEBARYO R.W., KANOKO M. |
56734569200;6506868173;6507911148; |
Acne lesion extraction versus oral doxycycline for moderate acne vulgaris: A randomized clinical trial |
2021 |
Journal of Clinical and Aesthetic Dermatology |
14 |
6 |
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E61 |
E65 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113565099&partnerID=40&md5=84d3ad669270477356a8236dc4266b13 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
SITOHANG, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; SOEBARYO, R.W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; KANOKO, M., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Acne vulgaris is a polymorphic skin condition comprising inflamed and noninflamed lesions. In addition to topical retinoids, systemic antibiotics play a role as a main therapy for acne with inflamed papules and cysts. However, due to the increasing tendency for bacterial resistance, alternatives to antibiotics are needed. OBJECTIVE: The aim of this study was to evaluate the effectiveness of acne lesion extraction compared to oral doxycycline for moderate acne vulgaris and to explore the impact of both treatments on Hypoxia-inducible factor (HIF)-1 alpha. METHODS: This randomized clinical trial was conducted in two teaching hospitals in 2016. Subjects with moderate acne vulgaris (N=140) were divided into two groups. Each subject in both groups received 0.05% tretinoin cream, applied to the entire face each night, and 2.5% benzoyl peroxide gel, applied to the acne lesions in the morning and afternoon. One group was also treated with oral doxycycline 100mg once daily and the other was treated with acne lesion extraction performed on all facial lesions every two weeks; the patients were evaluated via patient-reported self-assessment and lesion counts every two weeks for six weeks. HIF-1 alpha expression of the biopsied lessions was examined via immunohistochemistry. RESULTS: 128 subjects completed the study. Among these 128 subjects there was a prominent decrease in inflamed lesions at Week 6 in the lesion extraction group compared to the oral doxycycline group (p<0.05). HIF-1 alpha expression of the biopsied lesions was found in 7 of 9 samples taken from the oral doxycycline group, while 3 of 4 samples in the lesion extraction group were found negative. CONCLUSION: According to our results, acne lesion extraction appeared to be more effective than oral doxycycline in treating this sample of patients with moderate acne vulgaris. Additionally, HIF-1 alpha expression appeared to be decreased after acne lesion extraction. © 2021 Matrix Medical Communications. All rights reserved. |
Acne lesion extraction; Hypoxia-inducible factor-1 alpha; Moderate acne vulgaris; Oral doxycycline |
benzoyl peroxide; doxycycline; hypoxia inducible factor 1alpha; retinoic acid; acne vulgaris; adult; Article; clinical evaluation; comparative effectiveness; controlled study; disease severity; extraction; face; female; histopathology; human; human tissue; immunohistochemistry; major clinical study; male; night; protein expression; randomized controlled trial; self evaluation |
Matrix Medical Communications |
19412789 |
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Article |
Q2 |
600 |
8425 |
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339 |
Agustina R., Wirawan F., Sadariskar A.A., Setianingsing A.A., Nadiya K., Prafiantini E., Asri E.K., Purwanti T.S., Kusyuniati S., Karyadi E., Raut M.K. |
57214141404;57205313463;57210125132;57226321426;57216508166;57193088368;57190772302;57205062492;57205061970;6603080272;57216503454; |
Associations of Knowledge, Attitude, and Practices toward Anemia with Anemia Prevalence and Height-for-Age Z-Score among Indonesian Adolescent Girls |
2021 |
Food and Nutrition Bulletin |
42 |
1_suppl |
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S92 |
S108 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111145577&doi=10.1177%2f03795721211011136&partnerID=40&md5=d0a997eb61ed43eeeaf66ad5f9bb416a |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Study Program, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nutrition International Country Office, Jakarta, Indonesia; Former Nutrition International Country Office, Jakarta, Indonesia; Nutrition International, Asia Regional Office, New Delhi, India |
Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wirawan, F., Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sadariskar, A.A., Medical Study Program, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Setianingsing, A.A., Medical Study Program, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nadiya, K., Medical Study Program, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Prafiantini, E., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Asri, E.K., Nutrition International Country Office, Jakarta, Indonesia; Purwanti, T.S., Nutrition International Country Office, Jakarta, Indonesia; Kusyuniati, S., Nutrition International Country Office, Jakarta, Indonesia; Karyadi, E., Former Nutrition International Country Office, Jakarta, Indonesia; Raut, M.K., Nutrition International, Asia Regional Office, New Delhi, India |
Background: Crucial gaps persist in knowledge, attitude, and practice (KAP) of adolescent girls that affect anemia and linear growth failure. Objective: To understand the role of KAP as a risk factor of anemia and linear growth problem in adolescent girls. Methods: We conducted a cross-sectional survey of 335 adolescent girls selected by clustered random sampling. The KAP questionnaire had 18 variables consisting of 9 knowledge, 3 attitude, and 6 practice components. Twelve variables addressed nutrition, dietary diversity, and health environments related to both anemia and stunting. The questionnaire was adapted from the 2014 Food and Agriculture Organization nutrition-related KAP guidelines for anemia. Dietary practice was evaluated from 2-day 24-hour recalls and a semi-quantitative food-frequency questionnaire. Associations between KAP and anemia, and height-for-age z-score (HAZ), were analyzed using multivariate logistic and linear regression models, respectively. Results: The mean hemoglobin (Hb) level was 119.7 g/L, with 44% of the adolescent girls being anemic (Hb < 120 g/L) and mean height was 151.0 cm with 25% being stunted (HAZ < −2 standard deviation [SD]). The median KAP score was 7 and ranged from 3 to 10. Low to moderate KAP scores were not significantly associated with being anemic (adjusted odds ratio [AOR] = 1.26; P =.43), however 1-point KAP score increment was associated with an increase of HAZ by 0.037 SD (P =.012). Conclusions: The KAP related to diet and healthy environments was not associated with anemia prevalence, but was positively associated with increased HAZ among adolescent girls. Strategy to reduce anemia risk in this population should combine KAP improvement with other known effective nutrition interventions. © The Author(s) 2021. |
adolescent girls; anemia; hemoglobin; knowledge-attitude-practice; linear growth |
adolescence; anemia; attitudinal survey; disease prevalence; hemoglobin; risk factor |
SAGE Publications Inc. |
03795721 |
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34282657 |
Article |
Q1 |
649 |
7743 |
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340 |
Rah J.H., Melse-Boonstra A., Agustina R., van Zutphen K.G., Kraemer K. |
8298189500;6603151574;57214141404;57200080421;24724460700; |
The Triple Burden of Malnutrition Among Adolescents in Indonesia |
2021 |
Food and Nutrition Bulletin |
42 |
1_suppl |
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S4 |
S8 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111111554&doi=10.1177%2f03795721211007114&partnerID=40&md5=863a09d51aa051b285f86121637fe0a5 |
UNICEF Indonesia, Jakarta, Indonesia; Division of Human Nutrition and Health, Wageningen University Research, Wageningen, Netherlands; Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Center (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sight and Life, Basel, Switzerland; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States |
Rah, J.H., UNICEF Indonesia, Jakarta, Indonesia; Melse-Boonstra, A., Division of Human Nutrition and Health, Wageningen University Research, Wageningen, Netherlands; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Center (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; van Zutphen, K.G., Division of Human Nutrition and Health, Wageningen University Research, Wageningen, Netherlands, Sight and Life, Basel, Switzerland; Kraemer, K., Sight and Life, Basel, Switzerland, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States |
Background: Indonesia is a prime example of the triple burden of malnutrition. Indonesian adolescents are among the hardest hit, with approximately one in four adolescent girls suffering from anemia, while nearly one in seven adolescents is overweight or obese. Objectives: The present editorial provides a snapshot of the various research papers included in this Supplement, which calls for increased attention to adolescent nutrition in Indonesia and beyond. Results: Despite major steps to reduce undernutrition and overweight, including a renewed focus on anemia among adolescent girls, major gaps remain in our understanding of various nutrition issues concerning adolescents. These include various drivers and determinants of the triple burden of malnutrition, evidence-based interventions that are supported by large-scale implementation research and evaluation, and effective delivery platforms to reach the most vulnerable groups of adolescents. Conclusion: The time has come to position adolescent nutrition as central to development, and mainstream it into health sector plans, strategies, and policies. It is our hope that this issue will stimulate the urgently needed interventions, implementation research and required programs that will safeguard the nutritional wellbeing of today's forgotten generation. © The Author(s) 2021. |
adolescents; anemia; health; Indonesia; nutrition; overweight |
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SAGE Publications Inc. |
03795721 |
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34282654 |
Editorial |
Q1 |
649 |
7743 |
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|
341 |
Rustamadji P., Wiyarta E., Bethania K.A., Kusmardi K. |
55321572200;57221521342;57226320454;56966625300; |
Potential of AKT2 expression as a predictor of lymph-node metastasis in invasive breast carcinoma of no special type |
2021 |
Journal of Pathology and Translational Medicine |
51 |
3 |
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271 |
278 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111106383&doi=10.4132%2fjptm.2021.04.26&partnerID=40&md5=25c257f935b27c34728f8cc05fdeca15 |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rustamadji, P., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bethania, K.A., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer and mainly causes regional lymph-node metastasis (LNM). We investigated the potential for AKT2 expression as a predictive biomarker for LNM in IBC-NST. Methods: Forty-eight paraffin blocks containing IBC-NST primary tumors were divided into two groups based on presence or absence of LNM. Age, tumor grade, tumor size, lymphovascular invasion (LVI), and AKT expression were assessed. AKT2 expression was assessed based on immunohistochemical staining, while other data were collected from archives. Results: Multiple logistic regression results showed that AKT2 expression and LVI were significantly associated with LNM (odds ratio [OR], 5.32; 95% confidence interval [CI], 1.42 to 19.93 and OR, 4.46; 95% CI, 1.17 to 16.97, respectively). AKT2 expression was able to discriminate against LNM (area under the receiver operating characteristic, 0.799 ± 0.063; 95% CI, 0.676 to 0.921) at an H-score cutoff of 104.62 (83.3% sensitivity, 62.5% specificity). Conclusions: AKT2 expression has potential as a predictor of LNM in IBC-NST. The H-score cutoff for AKT2 expression can be used as a classification guide in future studies. © 2021 The Korean Society of Pathologists/The Korean Society for Cytopathology. |
AKT2; Breast neoplasms; Immunohistochemistry; Metastasis |
biological marker; protein kinase B beta; adult; aged; Article; breast carcinoma; cancer grading; clinical article; confidence interval; controlled study; female; human; human tissue; immunohistochemistry; lymph vessel metastasis; multivariate logistic regression analysis; odds ratio; predictive value; protein expression; receiver operating characteristic; sensitivity and specificity; tumor invasion; tumor volume |
Seoul National University |
23837837 |
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Article |
Q2 |
684 |
7312 |
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342 |
Sparrow R., Agustina R., Bras H., Sheila G., Rieger M., Yumna A., Feskens E., Melse-Boonstra A. |
57205017055;57214141404;6701410272;57226298367;57205307158;55785938100;7005435520;6603151574; |
Adolescent Nutrition—Developing a Research Agenda for the Second Window of Opportunity in Indonesia |
2021 |
Food and Nutrition Bulletin |
42 |
1_suppl |
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S9 |
S20 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111099959&doi=10.1177%2f0379572120983668&partnerID=40&md5=69aa26692477cd183f7001a03be4e684 |
Development Economics Group, Wageningen University, Netherlands; International Institute of Social Studies, Erasmus University Rotterdam, Netherlands; Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Economic and Social History, University of Groningen, Netherlands; The SMERU Research Institute, Jakarta, Indonesia; Division of Human Nutrition and Health, Wageningen University, Netherlands |
Sparrow, R., Development Economics Group, Wageningen University, Netherlands, International Institute of Social Studies, Erasmus University Rotterdam, Netherlands; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bras, H., Economic and Social History, University of Groningen, Netherlands; Sheila, G., Human Nutrition Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rieger, M., International Institute of Social Studies, Erasmus University Rotterdam, Netherlands; Yumna, A., The SMERU Research Institute, Jakarta, Indonesia; Feskens, E., Division of Human Nutrition and Health, Wageningen University, Netherlands; Melse-Boonstra, A., Division of Human Nutrition and Health, Wageningen University, Netherlands |
Background: Recently, adolescence has been identified as a second window of opportunity for the correction of nutritional inadequacies. However, there is a lack of knowledge on evidence-based integrated nutrition strategies for adolescents in Indonesia. Objective: To provide a research agenda and the prioritization of research actions to tackle outstanding knowledge gaps on adolescent nutrition in Indonesia. Methods: A preliminary set of research topics was listed based on a desk study of the academic literature and policy documents. Second, a stakeholder meeting was held to further identify and discuss research topics related to adolescent nutrition in Indonesia. Third, an online survey was conducted in which respondents were asked to indicate priority research themes for the next 3 to 5 years and to rank a total of 23 research questions. Results: Most (52%) of the respondents who returned the survey (n = 27) prioritize research on implementation and program evaluation, while 30% prefer descriptive and explanatory research, and 19% place priority with intervention and discovery research. However, when we followed up with specific topics for each of these broad research areas, a more nuanced picture emerged, with intervention and discovery research taking a more prominent standing. Conclusions: In order to support the design, implementation, and effectiveness of integrated nutrition programs for Indonesian adolescents, in-depth studies should question the best intervention strategies, modes of delivery, and long-term outcomes, while nationwide and disaggregated data should investigate associations and trends over time and identify vulnerable groups. © The Author(s) 2021. |
adolescents; Indonesia; nutrition; research agenda |
adolescence; nutrition; prioritization; stakeholder; adolescent; adolescent nutrition; article; clinical article; controlled study; female; human; Indonesia; Indonesian; male; program evaluation; Indonesia |
SAGE Publications Inc. |
03795721 |
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34282651 |
Article |
Q1 |
649 |
7743 |
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