No records
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619 |
Makkiyah F., Sadewo W., Nurrizka R.H. |
57210232162;55014544900;57210747260; |
Comparative dose of intracarotid autologous bone marrow mononuclear therapy in chronic ischemic stroke in rats |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
A |
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233 |
243 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107180848&doi=10.3889%2foamjms.2021.5675&partnerID=40&md5=a05eb1c39d7b38d60e04285fce893c7d |
Department of Neurosurgery, Faculty of Medicine, UPN Veteran Jakarta, Depok, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Central Jakarta, Indonesia; Department of Public Health, Universitas Islam Negeri Syarif Hidayatullah Jakarta, South Tangerang, Indonesia |
Makkiyah, F., Department of Neurosurgery, Faculty of Medicine, UPN Veteran Jakarta, Depok, Indonesia; Sadewo, W., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Central Jakarta, Indonesia; Nurrizka, R.H., Department of Public Health, Universitas Islam Negeri Syarif Hidayatullah Jakarta, South Tangerang, Indonesia |
BACKGROUND: Research on chronic ischemic stroke is limited. One of the more promising approaches showing positive effects in the acute stage is mononuclear bone marrow cell therapy. This research may be the first which presents data about the optimum dose of bone marrow mononuclear cells (BM-MNCs) for chronic ischemic stroke in rats and discusses factors influencing recovery in the chronic stage. AIM: To elucidate the optimum dose of BM-MNCs for chronic ischemic stroke and to demonstrate factors influencing recovery in chronic stage of stroke ischemia. METHODS: Thirty-two male Sprague-Dawley rats sourced from the Kalbe Farma Institution (Bandung, Indonesia), aged 6–10 aged months, weighing 350–450 g were used in this study. We performed temporary middle cerebral artery occlusion (MCAO) procedures on the rats which were then randomly assigned to one of two experimental groups in which they were given either low or high doses of autologous BM-MNCs (5 million or 10 million cells per kg body weight intracarotid), after 4 week of MCAO. At 8th or 12 week, rats were necropsied and rat brains were fixed for HE, cluster of differentiation (CD) 31, and doublecortin staining for analysis of the effects. Rat behavior was assessed weekly using the cylinder test and a modified neurological severity score (NSS) test. Cylinder test scores and NSS scores were analyzed by one-way ANOVA repeated measures and post hoc Bonferroni. The size of the infarct zone, the CD 31 vessels, and the DCX-neuroblast were analyzed using one-way ANOVA and a post hoc Bonferroni test. To investigate the degree of correlation between time and dose, two-way ANOVA and simple mass effect analyses were conducted. A linear regression test was used to evaluate the correlation between CD34 and other variables. RESULTS: In the 4 weeks before administration of BM-MNC, cylinder test scores improved to near normal, and NSS test scores improved moderately. The infarct zone decreased significantly (p < 0.01), there was an improvement in angiogenesis (p = 0.1590) and a significant improvement in neurogenesis (p < 0.01). Reduction of the infarct zone was associated with a higher dose whereas both higher and lower doses were found to have a similar effect on improving angiogenesis, and neurogenesis. Recovery was superior after 12 weeks compared with the recovery assessment at 8 weeks. CONCLUSION: A dose of 10 million cells was more effective than a dose of 5 million cells per kg body weight for reducing the infarct zone and ameliorating neurogenesis. There was an improvement of histopathological parameters associated with the longer infarct period. © 2021 Feda Makkiyah, Wismaji Sadewo, Rahmah Hida Nurrizka. |
Bone marrow mononuclear cells; Chronic infarct; Dose; Intracarotid; Rats brain |
CD34 antigen; platelet endothelial cell adhesion molecule 1; adipose derived stem cell; analysis of variance; angiogenesis; animal cell; animal experiment; animal model; animal tissue; arteriotomy; Article; autopsy; body weight; bone marrow derived mononuclear cell; breathing rate; chronic ischemic stroke; controlled study; cylinder test; drug megadose; endothelial progenitor cell; gap junction; histopathology; immunohistochemistry; infarction; interphalangeal joint; intracarotid drug administration; linear regression analysis; low drug dose; micro-computed tomography; middle cerebral artery occlusion; National Institutes of Health Stroke Scale; neuroblast; neurological severity score; nonhuman; rat; Sprague Dawley rat |
Open Access Macedonian Journal of Medical Sciences |
18579655 |
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Article |
Q3 |
288 |
15252 |
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620 |
Setyawan H.B., Yulianto R., Santoso W.D., Suryandari N. |
57221951849;57214720503;6506080422;57221947574; |
Fern plant (Pteris vittata) as a phytoremediator of arsenic heavy metal and its effect to the growth and quality of Kale (Ipomea reptans Poir) |
2021 |
IOP Conference Series: Earth and Environmental Science |
637 |
1 |
012066 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100756752&doi=10.1088%2f1755-1315%2f637%2f1%2f012066&partnerID=40&md5=39224fc2c888c20765d655154da66bc5 |
Animal Husbandry Department, Faculty of Agriculture, University of Jember, Indonesia; Internal Medicine Department, Faculty of Medicine, University of Indonesia, Indonesia; Agrotechnology Departement, Faculty of Agriculture, University of Jember, Indonesia |
Setyawan, H.B., Animal Husbandry Department, Faculty of Agriculture, University of Jember, Indonesia; Yulianto, R., Animal Husbandry Department, Faculty of Agriculture, University of Jember, Indonesia; Santoso, W.D., Internal Medicine Department, Faculty of Medicine, University of Indonesia, Indonesia; Suryandari, N., Agrotechnology Departement, Faculty of Agriculture, University of Jember, Indonesia |
Kale (Ipomea reptans Poir) has high nutrition such as vitamin A, B and C as well as various minerals especially iron. Quality of animal feed must be clean from diseases and heavy metal contamination such as Arsenic. Arsenic in the soil can be reduced naturally using phytoremediator plants, one of which is Pteris vittata. The experiment was conducted at the Antirogo Green House, Sumbersari Distric, Jember Regency. Arsenic metal analysis was conducted in BARISTAND, Surabaya and BALITTANAH, Bogor on June 2019 to January 2020. The experimental design used Factorial Complete Random Design consist of 2 factors. The first factor consists of 4 levels of heavy metal arsenic treatment on the fern plant growth media, namely was 0 ppm (D1), 5 ppm (D2), 10 ppm (D3) and 15 ppm (D4). The second factor consists of 2 levels of treatment time of fern: 1 month (P1) and 2 weeks (P2). Each of treatment repeated 4 times. The results showed that the interaction between planting time of fern and arsenic dosage showed no significant effect. The absorption power of ferns reaches 0.27 ppm to 4.589 ppm higher compared to the scale absorptions reaching 0,006 ppm to 0.155 ppm. © 2021 Institute of Physics Publishing. All rights reserved. |
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Agriculture; Arsenic; Heavy metals; Metal analysis; Sustainable development; 2-factors; Absorption power; Animal feed; Heavy metal contamination; Plant growth; Pteris vittata; Treatment time; Vitamin A; Chemical contamination |
IOP Publishing Ltd |
17551307 |
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Conference Paper |
- |
179 |
20770 |
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621 |
George P.M.A., Abdullah S., Rachman A. |
57221954733;57204563168;57217184320; |
Analysis of Hypothyroidism Development in Post-Radiotherapy Nasopharyngeal Cancer Patients using Survival Trees |
2021 |
Journal of Physics: Conference Series |
1722 |
1 |
012095 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100712595&doi=10.1088%2f1742-6596%2f1722%2f1%2f012095&partnerID=40&md5=b152a0810c9274777e385793bf11e707 |
Department of Mathematics, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Department of Oncology, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
George, P.M.A., Department of Mathematics, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Abdullah, S., Department of Mathematics, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Rachman, A., Department of Oncology, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Radiotherapy is one of the treatments for nasopharyngeal cancer (NPC). However, this treatment might produce an unfavorable effect on the thyroid gland, which eventually results in less production of thyroid hormone. This is condition is known as hypothyroidism. The development of hypothyroidism in each patient with post-radiative NPC differs according to several factors. This study aims to analyze the rate of development of hypothyroidism in post-radiated NPC patients. This aim is achieved by identifying subgroups of patients with different hazard rates of developing hypothyroidism, and further identify factors explaining hypothyroidism in each subgroup. Data on ninety-seven NPC post-radiation patients taken from one of the hospitals in Jakarta were analyzed. Survival tree with the relative risk tree algorithm was proposed to analyze the data. We identified three subgroups of patients with relatively slow, medium, and fast developing of hypothyroidism. For the slow subgroup, 26% of the patients developed hypothyroidism at 150+ weeks post-radiation, while it only took less than 30 weeks for those in fast-growing subgroup; and 70 until 130 weeks for the medium subgroup. We also found that sweat production and Zulewski's total score were the important factors in explaining the development rate of hypothyroidism. © 2021 Institute of Physics Publishing. All rights reserved. |
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Clustering algorithms; Diseases; Forestry; Information analysis; Radiotherapy; Development rate; Hazard rates; Jakarta; Nasopharyngeal cancer; Relative risks; Thyroid glands; Thyroid hormones; Tree algorithms; Trees (mathematics) |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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622 |
Budianto I.R., Firmansyah A., Moenadjat Y., Jusuf A.A., Soetikno V. |
56072591000;57430911900;57190371576;57192275719;36769252100; |
In vivo model of Hirschsprung-associated enterocolitis using benzalkonium chloride |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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239 |
244 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123725324&doi=10.13181%2fmji.oa.215339&partnerID=40&md5=0d7ad27ed35c326eece4ebc9bb2d637b |
Biomedical Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, School of Medicine and Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Budianto, I.R., Biomedical Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Surgery, School of Medicine and Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia; Firmansyah, A., Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Moenadjat, Y., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusuf, A.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND Hirschsprung-associated enterocolitis (HAEC) is a life-threatening complication of Hirschsprung’s disease. Studies using animal models on the pathogenesis of HAEC are limited. Thus, this study aimed to establish a rat model of HAEC using topical application of 0.1% benzalkonium chloride (BAC) in the sigmoid colon. METHODS 55 male Sprague Dawley rats aged 10−12 weeks old were separated into 11 groups. The control group (n = 5) was euthanized on day-7, and the other 10 groups (n = 5 in each group) treated with 0.1% BAC in the sigmoid colon for 15 min to induce Hirschsprung’s disease were euthanized on day-7,-10,-12,-14,-17,-19,-21,-23,-25, and-28. The sigmoid colon was excised, fixed in formalin, and sectioned for histological examinations with hematoxylin and eosin staining. The degree of HAEC was compared within all groups. RESULTS Rats that were sacrificed on day-7 to-12 showed the 1st degree or early HAEC, which was most likely caused by BAC application. The 2nd degree of HAEC occurred in rats that were sacrificed on day-14 that showed a macrophage infiltration in the sigmoid colon, thus fulfilled the initial criteria for HAEC (p = 0.0025 versus control). The degree of enterocolitis increased with time, and the highest degree was found in rats that were sacrificed on day-28 (p<0.001 versus control). CONCLUSIONS Topical application of 0.1% BAC for 15 min was successfully produced HAEC model in rats, which was occurred on day-14 after the application. This model provides a useful resource for further research on the pathogenesis of HAEC. © 2021 Authors. |
Animal model; Colitis; Ganglions; Hirschsprung’s disease |
benzalkonium chloride; eosin; hematoxylin; isoflurane; ketamine; xylazine; aganglionosis; animal model; animal tissue; anorexia; Article; autopsy; cell proliferation; cervical spine dislocation; controlled study; crypt cell; enterocolitis; Hirschsprung disease; in vivo study; laparotomy; macrophage; male; mucosa ulceration; necrosis; neutrophil chemotaxis; nonhuman; rat; sham procedure; sigmoid; Sprague Dawley rat; ulcer |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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623 |
Winarto H. |
54080645300; |
The importance of identification for a stress urinary incontinence after pelvic orgaprolapse vaginal repair |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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237 |
238 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123709235&doi=10.13181%2fmji.ed.215971&partnerID=40&md5=ee09f6c4f49a5e6e13609c2191a488f0 |
Medical Journal of Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Winarto, H., Medical Journal of Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
[No abstract available] |
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editorial; Editorial; female; human; pelvic organ prolapse; postoperative complication; stress incontinence; vagina reconstruction |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Editorial |
Q4 |
164 |
21905 |
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624 |
Djusad S., Nizomy I.R., Hakim S., Priyatini T., Moegni F., Meutia A.P., Imsantoso B. |
57192276788;57267769100;57192276095;57192265423;55450456100;57203368133;57431312700; |
Incidence and characteristics of de novo stress urinary incontinence after pelvic organ prolapse vaginal repair |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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245 |
249 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123677566&doi=10.13181%2fmji.oa.204163&partnerID=40&md5=9b2deb933d7d42f78f8cd27103bdad59 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Lambung Mangkurat, Ulin General Hospital, South Kalimantan, Indonesia |
Djusad, S., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nizomy, I.R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Lambung Mangkurat, Ulin General Hospital, South Kalimantan, Indonesia; Hakim, S., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Priyatini, T., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Moegni, F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Meutia, A.P., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Imsantoso, B., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND Some patients who undergo pelvic floor reconstruction for pelvic organ prolapse (POP) may experience a de novo stress urinary incontinence (SUI) postoperatively. We aimed to investigate the incidence and characteristics of de novo SUI in patients who underwent pelvic floor reconstruction at the national referral hospital in Indonesia. METHODS This cross-sectional study evaluated 108 patients who underwent pelvic floor reconstruction due to POP between January 2016 and December 2017. Per the inclusion criteria, 75 women were enrolled using a consecutive sampling. The incidence of de novo SUI was determined 6–12 months postoperatively using the Indonesian version of the questionnaire for urinary incontinence diagnosis and objectively using the cough stress test during gynecologic examination after a negative preoperative prolapse reduction stress test. RESULTS The average age, parity, body mass index, and years since menopause onset were 56.17 (4.67) years, 3.17 (1.07), 28.58 (5.18) kg/m2, and 12.8 (7.0) years, respectively. De novo SUI was seen in 8.0% (6 of 75) patients at 6–7 months postoperatively, with 3 (50.0%) had severe POP and 3 (50.0%) had a mild POP. Most of these patients (4 of 6, 66.7%) had undergone procedures other than colpocleisis for POP reconstruction. CONCLUSIONS The incidence of de novo SUI after gynecologic surgery for POP at a national referral hospital in Indonesia is 8%. Most patients were aged <60 years, had a parity of <4, were nonobese, were menopausal, and had diabetes. © 2021 Authors. |
Gynecologic surgery; Pelvic organ prolapse; Tertiary referral center; Urinary stress incontinence |
adult; Article; bladder function test; body mass; cough stress test; cross-sectional study; diabetes mellitus; female; gynecological examination; human; incidence; major clinical study; middle aged; parity; pelvic organ prolapse; preoperative prolapse reduction stress test; stress incontinence; vagina reconstruction |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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625 |
Lukito W. |
6701622348; |
Current Evidence in Water and Hydration Science |
2021 |
Annals of nutrition & metabolism |
77 |
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1 |
6 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125594947&doi=10.1159%2f000521769&partnerID=40&md5=dc03696320911a4943e24730854d46e4 |
Postgraduate Program in Physician Specialist-I in Clinical Nutrition/Department of Nutrition, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Lukito, W., Postgraduate Program in Physician Specialist-I in Clinical Nutrition/Department of Nutrition, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
[No abstract available] |
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NLM (Medline) |
14219697 |
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35226915 |
Editorial |
#N/A |
#N/A |
#N/A |
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626 |
Rachman A., Shatri H., Salamat R. |
15056701600;28767986500;57475263300; |
Correlation Between Higher Cumulative Dose of Cisplatin for Concurrent Chemoradiation and Acute Kidney Disease Incidence Among Nasopharyngeal Carcinoma Patients: A Comparative Study |
2021 |
International Journal of General Medicine |
14 |
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10527 |
10539 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125417489&doi=10.2147%2fIJGM.S343644&partnerID=40&md5=5d12476bf92d703d5d6a77517d01d345 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Psychosomatic and Palliative Care, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Rachman, A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Shatri, H., Division of Psychosomatic and Palliative Care, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Salamat, R., Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: Nasopharyngeal carcinoma (NPC) is the most malignant cancer in the head and neck area. According to the stage, the management of NPC includes radiation, chemotherapy, or a combination of both. The standard agent for radiosensitizing chemotherapy is cisplatin. Among the several effects of cisplatin administration, nephrotoxicity raises the most concern, especially in high doses. Acute kidney disease (AKD) is a condition in which an acute kidney injury occurs at >7 days but <90 days. This study aimed to assess whether there is a significant difference in the incidence of AKD between NPC patients who received a cumulative dose of cisplatin up to (≤) 200 mg/m2 and patients who received more than (>) 200 mg/m2. Methods: This is a cohort retrospective study conducted in the radiotherapy unit of Cipto Mangunkusumo General Hospital. Medical records of 540 patients from January 2014 to December 2018 were collected and sorted. After sorting, 120 of the records were analyzed. Results: The analysis showed that 38.4% of patients who received >200 mg/m2 cumulative dose of cisplatin experienced AKD, whereas 38.3% of the patients who received ≤200 mg/m2 cumulative dose of cisplatin experienced AKD. Conclusion: This study found that in patients with locally advanced NPC who received cisplatin chemoradiation, there was no significant difference in the incidence of AKD, recovery of renal function, or progression of chronic kidney disease between patients receiving a cumulative dose of cisplatin ≤200 mg/m2 and those receiving >200 mg/m2 . © 2021 Rachman et al. |
Acute kidney disease; Chemoradiation; Cisplatin; Nasopharyngeal cancer |
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Dove Medical Press Ltd |
11787074 |
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Article |
Q2 |
722 |
6874 |
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627 |
Aninditha T., Pratama P.Y., Sofyan H.R., Imran D., Estiasari R., Octaviana F., Iskandar M.M., Odilo J., Werdhani R.A., Aman R.A., Ranakusuma T.A.S. |
57189611205;57450416000;57328366500;57203976849;55240204000;26029958700;57205414462;57450963600;57189088848;36848942500;7801656487; |
Adults brain tumor in Cipto Mangunkusumo General Hospital: A descriptive epidemiology |
2021 |
Romanian Journal of Neurology/ Revista Romana de Neurologie |
20 |
4 |
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480 |
484 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124554663&doi=10.37897%2fRJN.2021.4.13&partnerID=40&md5=b5302d49e5e258bb7f13476b33682fdc |
Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Department of Neurology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia; Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia |
Aninditha, T., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Pratama, P.Y., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Sofyan, H.R., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Imran, D., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Estiasari, R., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Octaviana, F., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Iskandar, M.M., Department of Neurology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia; Odilo, J., Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Werdhani, R.A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Aman, R.A., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Ranakusuma, T.A.S., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia |
Background. Brain tumor is a rare tumor with low incidence. Although it is a rare tumor, the mortality of brain tumor is disproportionately high. Many countries have already published epidemiology of brain tumor. However, the epidemiology of brain tumor in Indonesia remains to be investigated. This article aimed to provide descriptive epidemiology of brain tumor. Methods. The data of brain tumor acquired from Department of Neurology and Neurosurgery Cipto Mangunkusumo General Hospital from 2014 to 2016. The histopathology classification of primary intracranial tumors was based on WHO classification of CNS tumors 2016 while brain metastasis was classified based on other histopathological types. The vari-ables were analyzed and presented descriptively. Results. There were 316 subjects acquired in this study. Most of the subjects (68%) were women. The mean age of this study was 43.8 (11.7). Most of the subjects (86.1%) had primary histopathology. Lung cancer was the most commonly found brain metastasis in this study (34.1%). Conclusions. This is a pilot study of brain tumor epidemiology in Indonesia. Collaboration with other centers in Indonesia is needed to give a more representative insight of brain tumor in Indonesia. © 2021, Editura Medicala. All rights reserved. |
Brain tumor; Cancer; Descriptive study; Epidemiology |
adenoma; adult; Article; brain hemorrhage; brain metastasis; brain tumor; cancer grading; cancer localization; cancer staging; central nervous system tumor; cross-sectional study; female; general condition; general hospital; glioblastoma; glioma; histopathology; human; human tissue; immunohistochemistry; intracranial metastasis; intracranial tumor; lung cancer; major clinical study; male; meningioma; middle aged; neurosurgery; pilot study; retrospective study |
Editura Medicala |
20696094 |
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Article |
Q4 |
111 |
28569 |
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629 |
Kartika R.W., Alwi I., Reksodiputro M.H., Yunir E., Waspadji S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Bardosono S., Suyatna F.D. |
57223447932;15055173800;35090488800;36520254800;8678136400;57272979000;56275255400;57016857300;6507225348;21933841000;56039633100; |
Combination of Hyaluronic Acid with Advance-Platelet Rich Fibrin to Reduce Chronic Inflammation: a study in IL-6 and Granulation Index |
2021 |
Jordan Journal of Biological Sciences |
14 |
5 |
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983 |
989 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123993135&doi=10.54319%2fJJBS%2f140516&partnerID=40&md5=b5a893eb952c904c665bb27f1cef51cb |
Department of Surgery, Faculty of Medical and Health Science, Krida Wacana Christian University, Jakarta, Indonesia; Doctoral Program in Medical, Science Faculty of Medicine Universitas, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Kartika, R.W., Department of Surgery, Faculty of Medical and Health Science, Krida Wacana Christian University, Jakarta, Indonesia, Doctoral Program in Medical, Science Faculty of Medicine Universitas, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Type-2 Diabetes mellitus patients have risk of diabetic foot ulcers (DFUs) ranging from 15% to 25% with morbidity of 5% in the first 12 months, and the mortality rate at 5 years is around 42%. AIM: This research was conducted to study the novelty of a combining Hyaluronic Acid (HA) with Advanced Platelet Rich Fibrin (A-PRF) to reduce inflammation in DFUs healing through raising granulation index. METHODS: The study used a randomized control trial design, done from July 2019-March 2020 at Gatot Soebroto Army Hospital and Koja District Hospital, Jakarta. Subjects were DFU wound area < 40 cm2. At the start of the study all subjects received the same treatment, debridement and standard wound care. Twenty subjects were recruited according to the rule of thumb and were randomly divided into two groups namely topical A-PRF + HA (n = 10) and NaCl 0.9% (control) groups (n = 10). A part of the sample was processed into lysate and stored in -80oC. The rest is applied as a topical therapy in DFU base on intervention (A-PRF+HA or NaCl as a control). We analyzed the inflammation use swab sampling in DFU and analyze use ELISA on day- 3 and day-7. We also measured the wound area by a digital photograph and analyzed using ImageJ at the same time. RESULT: From this research, it was obtained 20 DFU subjects with Wagner 2 classification. We also performed analysis of IL-6 from swab topical DFU. A-PRF+HA group was significantly lower than NaCl (control) from swab DFU on day -3 (p = 0,,049) and day-7 (p = 0.041). In A-PRF+HA group affected on increase epithelialization process/ decrease wound area on day-3 (p = 0.016), day-7 (p = 0.048), and day-14 (p= 0.03 CONSLUSION: With the homogeneous gel formation of A-PRF + HA, it will accelerate the formation of granulation tissue compared to conventional NaCl therapy through reduce inflammation by decrease IL-6 levels. In addition, the combination A-PRF + HA has the effect of accelerating the formation of epithelialization shown by decreasing wound area in intervention group. © 2021 Jordan Journal of Biological Sciences. All Rights Reserved. |
Diabetic Foot Ulcer- Advanced Platetelet Rich Fibrin- Hyaluronic Acid-Granulation |
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Hashemite University |
19956673 |
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Article |
Q3 |
216 |
18398 |
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