No records
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839 |
Ayuandari S., Khasanah N., Riyanti I., Dewanto A., Enisar Sangun D., Wiweko B. |
56231262400;57222708996;57222710738;57190580042;57222709491;43061741400; |
Current awareness and attitude toward fertility preservation in Indonesia: A nationwide survey among health-care providers |
2021 |
Journal of Human Reproductive Sciences |
14 |
1 |
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81 |
86 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103760305&doi=10.4103%2fjhrs.jhrs_239_20&partnerID=40&md5=10c9f18d628ded6d4e5658e52f96eb59 |
Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yasmin Ivf Clinic, Dr. Cipto Mangunkusumo General Hospital, Hum. Repro., Infertility and Fam. Plan. Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Indonesia Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia |
Ayuandari, S., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Khasanah, N., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Riyanti, I., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Dewanto, A., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Enisar Sangun, D., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Wiweko, B., Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Yasmin Ivf Clinic, Dr. Cipto Mangunkusumo General Hospital, Hum. Repro., Infertility and Fam. Plan. Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Indonesia Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia |
Context: Fertility preservation (FP) is necessary for cancer patients who develop infertility due to chemotherapy and radiotherapy. In Indonesia, many systematic steps and long-Term continued actions must be taken to establish FP units since there has been an increasing incidence of cancer among people under 45 years old. Aims: This study aimed at a comprehensive evaluation on the awareness and practices of health-care providers (HCPs) toward FP. Settings and Design: This was a descriptive cross-sectional study. Subjects and Methods: A validated nationwide online survey was completed by 160 HCPs as a representative sample from 11 provinces in 2017 that provide medical care to cancer patients at hospitals or clinics. Statistical Analysis Used: Descriptive statistics, analysis of variance, logistic regression, and Pearson correlation tests were used for the statistical analysis. Results: Respondents were specialists (59.4%) and other HCPs (40.6%). Around 60% of the HCPs who performed cancer therapies already discussed the fertility issues with their patients. Meanwhile, the HCPs (60.7%) also tended not to consult and refer their patients to fertility experts (P < 0.05). However, those who discussed the risk of infertility with patients tended to consult with and refer them to a fertility consultant for further FP procedure as the follow-up for their discussions (odds ratio = 8.98, confidence interval 95%, P < 0.05). Conclusions: In Indonesia, FP awareness of the HCPs who performed cancer therapy was high. Nevertheless, attitudes to refer patients to fertility experts for possible FP management still need to be improved. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Attitude; awareness; fertility preservation; health-care providers |
adult; analysis of variance; article; awareness; cancer patient; cancer therapy; controlled study; cross-sectional study; female; fertility preservation; fertility specialist; follow up; health survey; human; human tissue; Indonesia; male; medical care; risk assessment |
Wolters Kluwer Medknow Publications |
09741208 |
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Article |
Q3 |
484 |
10359 |
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No records
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301 |
Utami P.D., Hadi U., Dachlan Y.P., Suryokusumo G., Loeki Enggar Fitri R., Yudo V. |
57221766908;55804160500;6602868510;57205444996;57226796443;57226798501; |
Protection against brain histopathological damage in experimental cerebral malaria models after exposure to hyperbaric oxigent |
2021 |
Research Journal of Pharmacy and Technology |
14 |
7 |
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3833 |
3838 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112730263&doi=10.52711%2f0974-360X.2021.00665&partnerID=40&md5=1e7f971b7e62fc8286374b6c4e534dd9 |
Department of Parasitology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia; Department of Internal Medicine, Dr. Soetomo Hospital, Universitas Airlangga, Surabaya, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Occupational Health, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Microbiology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia |
Utami, P.D., Department of Parasitology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia; Hadi, U., Department of Internal Medicine, Dr. Soetomo Hospital, Universitas Airlangga, Surabaya, Indonesia; Dachlan, Y.P., Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Suryokusumo, G., Department of Occupational Health, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Loeki Enggar Fitri, R., Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Yudo, V., Department of Microbiology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia |
In this study, brain damage caused by cerebral malaria was induced by parasitized erythrocyte rupture and sequestration, which led to inflammation and blood vessel damage. Therefore, this research objective to determine the effect of oxygen administration on the histopathological features and sequestration of CD3 lymphocyte T cells on Plasmodium berghei ANKA/PbA-infected vascular endothelial brain tissue of mice. The study samples consisted of 39 C57BL/6 mice, which were divided into 3 groups: G1 contained normal mice; G2 contained PbA-infected mice; G3 were mice infected with PbA, and administered HBO 2.4 ATA for 10 days straight. Histopathological examination of the of brain tissue and CD3 lymphocyte T cell expression was carried out using immuno-histochemical at the end of the study. Therefore, the results of this study indicate that HBO administration can reduce the level of parasites, can improve the histopathological features of the brain, and can reduce the sequestration of CD3 cells in the brain's blood vessels. According to the results, it can be concluded that 10 sessions of HBO 2.4 ATA exposure can reduce the level of parasites, enhance the histopathological features of brain tissue and decrease the sequestration of CD3 lymphocyte T cells. © RJPT All right reserved. |
CD3 cells; Cerebral malaria; Endothel; Histopathological; Hyperbaric oxygen |
CD3 antigen; cytotoxic T lymphocyte antigen 4; ketamine; reactive oxygen metabolite; tumor necrosis factor; animal cell; animal experiment; animal model; animal tissue; Article; blood brain barrier; blood smear; blood vessel injury; brain damage; brain protection; brain tissue; CD4+ T lymphocyte; CD8+ T lymphocyte; cell adhesion; cerebral malaria; consciousness; controlled study; endothelium; endothelium cell; erythrocyte count; female; gene expression; hematological parameters; histochemistry; histopathology; hyperbaric oxygen therapy; immunohistochemistry; inflammation; leukocyte count; malaria; mortality rate; neutrophil lymphocyte ratio; nonhuman; oxygen therapy; parasitemia; phagocytosis; Plasmodium berghei ANKA; protein expression; T lymphocyte |
Research Journal of Pharmacy and Technology |
09743618 |
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Article |
Q3 |
225 |
17916 |
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No records
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344 |
Susantiningsih T., Makkiyah F.A., Thadeus M.S., Yulianti R., Hadi S. |
57192907038;57210232162;57226238484;57201696813;26534077400; |
Progressive acute liver damage induced by repeated 2-nitropropane: Focused on obese mice |
2021 |
Biomedical and Pharmacology Journal |
14 |
2 |
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695 |
700 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110971235&doi=10.13005%2fbpj%2f2172&partnerID=40&md5=d967f0ab42728fa05df28dd316a8f615 |
Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Chemistry, Universitas Lampung, Bandar Lampung, 35145, Indonesia |
Susantiningsih, T., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Makkiyah, F.A., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Thadeus, M.S., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Yulianti, R., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Hadi, S., Department of Chemistry, Universitas Lampung, Bandar Lampung, 35145, Indonesia |
Obesity is linked to more deaths worldwide. In obesity, there will be a dysregulation of growth signals such as tumorigenesis. Despite the fact that obesity is tend to progress to acute liver damage, not many study using 2-nitropropane (2NP) as a hepatoxicity agent are undertaken especially in obese mice. This study aimed to determine the regime of 2NP that causes acute liver damage. This is an experimental research using a post-test control design group only, with 3 groups of mice ie O1 (obesity), O2+2-NP 1x (induced by 2NP 100 mg/kg BW once), and O2+2-NP 2x (induced by 2NP 100 mg/kg BW twice). At 10 weeks, rats were sacrificed and 100 mg liver tissue were collected for MDA, GSH, MnSOD and CAT enzymes analysis. Analysis statistics were performed by SPSS by one-way Anova and post hoc Tukey. MDA levels of mice were found to be increased in 2NP group than control (3.768 ± 0.407 nmol/ mg) (p < 0,01). Liver GSH, MnSOD and CAT levels of both single injection 2-NP and repeated injection 2-NP groups decreased compared to those of controls (p<0,01). Repeated injection of 2-NP worsen the acute liver damage in obese mice. © 2021 Oriental Scientific Publishing Company. All rights reserved. |
2-NP; CAT; GSH; MDA; MnSOD; Obesity |
2 nitropropane; catalase; glutathione peroxidase; ketamine; manganese superoxide dismutase; oxygen; reactive oxygen metabolite; superoxide dismutase; triacylglycerol; xylazine; analysis of variance; animal model; animal tissue; Article; body weight; carcinogenesis; centrifugation; controlled study; data analysis software; DNA damage; enzyme activity; liver injury; liver tissue; male; mouse; nonhuman; obesity; oxidative stress; post hoc analysis; protein content; repeated drug dose |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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524 |
Purwaningsih E.H., Oertl A., Freisleben S.K.U., Freisleben H.-J. |
57186723500;6508320409;57192904042;7003437337; |
How can immunosuppression after organ transplantation be made more effective and safer? - A review on liposomal formulations with consideration of archaeal tetraetherlipid |
2021 |
Biomedical and Pharmacology Journal |
14 |
1 |
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33 |
52 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104470529&doi=10.13005%2fbpj%2f2097&partnerID=40&md5=d0059a38fb0687012c274dcda3c60c0f |
Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia; Faculty of Medicine, Goethe-University Frankfurt/Main, Germany; Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany; Faculty of Natural Sciences, University of Indonesia, Jakarta-Depok, Indonesia |
Purwaningsih, E.H., Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia; Oertl, A., Faculty of Medicine, Goethe-University Frankfurt/Main, Germany, Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany; Freisleben, S.K.U., Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany, Faculty of Natural Sciences, University of Indonesia, Jakarta-Depok, Indonesia; Freisleben, H.-J., Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia, Faculty of Medicine, Goethe-University Frankfurt/Main, Germany |
Immune-suppressive agents such as methylprednisolone and cyclosporine exert tremendous side effects, because of high dosage and long-term application required for immune suppression after organ transplantation. Major side effects of methylprednisolone include bleeding of the gastro-intestinal tract, hypertension, and osteoporosis, whereas cyclosporine is nephrotoxic. Liposomes are phospholipid particles that allow delivery of drugs preferentially to the reticuloendothelial system. They can be prepared from phospholipids, such as lecithin from soybean or egg yolk, other specific or modified lipids or from membrane-spanning tetraether lipid (TEL), which can be extracted and purified from archaeal cell membranes. One advantage in the use of liposomal application is reduced toxicity of many drugs. We report on various liposomal preparations of cyclosporine, methylprednisolone (L-MPL) and its palmitate derivative (L-MPLP). It has been documented that liposomal cyclosporine A (L-CsA), 1.75 mg/kg/ day for seven days has potential for use as an immune-suppressive agent in rats with increased efficacy and decreased nephrotoxicity compared to commercially available forms of intravenous CsA. Liposomal methylprednisolone (L-MPL) 2 mg/kg, intravenously (IV), twice a week shows significantly prolonged cardiac allograft survival in rats and tissue-selective sequestration of the drug in comparison with the same dosage regimen of methylprednisolone in solution, administered daily. We report on organ distribution of L-MPLP in rats after intraperitoneal (IP) administration. Conclusion: Liposomal preparations of immunosuppressants have significantly higher immune-suppressive potential and lower toxicity than non-liposomal preparations. Bipolar TEL can be extracted, fractionated and purified from archaea to form stable liposomes which are extremely resistant, even to gastric fluid. Hence, TEL liposomes allow (besides IV and IP) for oral administration of immunosuppressants after organ transplantation with pharmacological and toxicological advantages over common liposomal phospholipid bilayer preparations. © 2021 Oriental Scientific Publishing Company. All rights reserved. |
Absorption; Allograft; Cyclosporine; Gastrointestinal stability; Immunosuppressant; Liposomes; Methylprednisolone; Oral administration; Organ transplantation; Toxicity |
alamethicin; albumin; cholesterol; coumarin; cyclosporine; dexamethasone; globulin; glucocorticoid; interleukin 1; liposome; lymphokine; methylprednisolone; phosphatidylcholine; phosphatidylglycerol; phospholipid; tumor necrosis factor; affinity chromatography; allograft; archaeon; Article; bioavailability; cytotoxicity; drug release; drug therapy; egg yolk; electron microscopy; encapsulation; fluorescence; gastrointestinal tract; gel filtration chromatography; helper cell; histocompatibility; human; hypertension; immune response; immunological tolerance; immunosuppressive treatment; lipophilicity; liposomal delivery; macrophage; nephrotoxicity; organ transplantation; osteoporosis; phagocytosis; reticuloendothelial system; soybean; stomach juice; T lymphocyte; thin layer chromatography |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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525 |
Pasmanasari E.D., Pawitan J.A. |
57189246168;6508348067; |
The potential of electromyography signals as markers to detect and monitor Parkinson's disease |
2021 |
Biomedical and Pharmacology Journal |
14 |
1 |
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373 |
378 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104382880&doi=10.13005%2fbpj%2f2136&partnerID=40&md5=7df22fa914ed12da461baa35f3e9c2be |
Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia |
Pasmanasari, E.D., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia |
Parkinson disease (PD) is a neurodegenerative disease that causes the loss of dopaminergic neurons in the brain. The imbalance in dopamine production causes motoric disorder that can produce specific electrical signal that can be detected by electromyography. Some methods were developed to diagnose PD and the use of a questionnaire and clinical observation was widely used to diagnose the disease. The limitation of the methods includes the fact that there are some differences in assessment results from clinicians due to the need of experience. The use of electromyography hopefully can obtain an objective assessment that can be easily used by clinicians. Some studies showed differences between normal muscle electric-activity compared to PD related abnormal muscle electric activity. Some methods were developed to use electromyography as a tool to diagnose PD related motoric symptoms, such as rigidity, gait abnormality and tremor. The use of electric signals, which are produce in muscle contraction, as markers to diagnose PD, as well as to monitor complications and the effect of therapy hopefully can be developed. In this review article, we will discuss about the use of electromyography signals that are related to PD. Therefore we will explain about basics of electromyography, the use of electromyography signals to detect tremor and gait abnormalities in PD, the use of electromyography for monitoring PD patients. © 2021 Oriental Scientific Publishing Company. All rights reserved. |
Dysphagia; Electromyography; Gait; Parkinson's disease; Tremor |
biological marker; Article; artificial neural network; dysphagia; electromyography; gait; human; nuclear magnetic resonance imaging; Parkinson disease; positron emission tomography; questionnaire; sensitivity and specificity; single photon emission computed tomography; transcranial Doppler ultrasonography; tremor |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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637 |
Tjoa K., Kusmardi K., Midoen Y.H. |
57222366705;56966625300;57197805109; |
Effects of Industrial Waste Fish Oil Administration on Interleukin-6 (Il-6) Expression at Mice Colon being Induced by Azoxymethane (AOM) and Dextran Sodium Sulphate (DSS) |
2021 |
Biomedical and Pharmacology Journal |
14 |
4 |
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2227 |
2233 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122824976&doi=10.13005%2fbpj%2f2321&partnerID=40&md5=bc79b4fdfe0aaabc3c89256150a440fb |
Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Departement of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Departement of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tjoa, K., Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Kusmardi, K., Departement of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia, Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Midoen, Y.H., Departement of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Colorectal cancer (CRC) is the world's third most cancer and the second highest mortality rate. The searching for new anti-inflammation substances with less adverse effects than aspirin for chemoprevention and adjuvant chemotherapy of CRC is running. The most notable one is fish oil containing omega 3. Kusmardi, et al. studied that industrial waste fish oil omega-3 level comes close enough to conventional fish oil industry. Study aims to reducing the level IL-6 on mice colon tissue being induced CRC using AOM/DSS by fish oil administration. Thirty male Swiss Webster mice are grouped into six treatments: Positive control (aspirin), negative control (physiological saline), normal, high dose (fish oil 6mg/kgBW), medium dose (fish oil 3mg/kgBW), dan solvent control (corn oil). Colon tissue was stained using anti IL-6 antibody. Ten photos per slide were taken by microscope (400x), analyzed for the IL-6 expression by ImageJ®, and quantified for H-score. Data was analyzed using SPSS 24.0 (CI 95%) and p-value <0.05 is consider significant. Data are not normally distributed with median of 161.64 (119.4-260.67). Kruskal-Wallis test is significant in addition with Mann-Whitney test shows only high dose group has significant difference to negative control (p=0.008), medium dose (p=0.016) dan and solvent control (p=0.008). No significant difference reported between high dose and positive control group (p=0.69). High dose industrial waste fish oil can lower IL-6 expression in mice colon tissue induced CRC using AOM/DSS. © 2021 Oriental Scientific Publishing Company. |
Colitis Associated Cancer; Colorectal cancer; Interleukin-6; Omega-3 Fish Oil |
acetylsalicylic acid; CD34 antigen; cytochrome P450 2E1; fish oil; interleukin 6; microRNA; nonsteroid antiinflammatory agent; octamer transcription factor 4; probiotic agent; adjuvant chemotherapy; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; azoxymethane-induced colon carcinogenesis; carcinogenesis; cardiovascular disease; cell proliferation; chemoprophylaxis; colon cancer; colon tissue; colorectal cancer; controlled study; dextran sulfate sodium-induced colitis; DNA methylation; drug megadose; fat intake; genomic instability; histone modification; immunohistochemistry; industrial waste; male; mortality rate; mouse; nonhuman; obesity; peritoneum adhesion; protein expression; quantitative analysis; rheumatoid arthritis; ulcerative colitis |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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No records
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785 |
Kartini D., Taher A., Panigoro S., Setiabudy R., Jusman S., Haryana S., Murdani A., Rustamadji P., Karisyah A., Rasyid S. |
57215490523;7005269743;56790104300;6602316235;36518792100;6507708439;57224770678;55321572200;57224765948;57224779056; |
Melatonin effect on hypoxia inducible factor-1a and clinical response in patients with oral squamous cell carcinoma receiving neoadjuvant chemotherapy: A randomized controlled trial |
2021 |
Journal of Carcinogenesis |
20 |
1 |
5 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108295574&doi=10.4103%2fjcar.JCar_19_20&partnerID=40&md5=7ba744b8de3c6ab6a11dd7b89d27e34a |
Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kartini, D., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Taher, A., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Panigoro, S., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiabudy, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusman, S., Department of Biochemistry and Molecular Genetics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Haryana, S., Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Murdani, A., Division of Gastroenterology and Hepatology, Department of Internal Medicine, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rustamadji, P., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Karisyah, A., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rasyid, S., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Context: Chemoresistance is a major issue in patients with locally advanced oral squamous cell carcinoma (OSCC). In this study, we evaluated the effectiveness of melatonin in conjunction with neoadjuvant chemotherapy (NC) on hypoxia-inducible factor-1α (HIF-1α) expression and clinical response in locally advanced OSCC patients. Aims: To study the effects of melatonin on HIF-1α expression and its effect on the clinical response of patients with locally advanced OSCC. Settings and Design: A randomized controlled trial was conducted, wherein patients were recruited from several hospitals in Jakarta, Indonesia. Patients were randomized into two groups using computerized block randomization. Subjects and Methods: Both groups were given NC, with treatment group receiving melatonin. Outcomes measured in this study were HIF-1α expression from tissue samples and clinical response based on the RECIST 1.1 criteria. Twenty-five patients completed the study protocol and were included in the data analysis. Statistical Analysis Used: Shapiro-Wilk test was used to test the data normality. For data with normal distribution, we conducted an independent t-test to compare between the two groups. Data with abnormal distribution were analyzed using Mann-Whitney U-test. The mean difference between the two groups was analyzed using Shapiro-Wilk normality test. Results: Our study showed a significant decrease in HIF-1α expression in the melatonin group compared to the placebo group (P < 0.05, relative risk 3.08). However, the degree of reduction of HIF-1α expression in the melatonin group did not differ significantly (P = 0.301). Conclusions: Our study showed that melatonin administered at 20 mg/day could reduce the expression of HIF-1α and residual tumor percentage, but did not affect the clinical response in OSCC patients. © 2021 Annual Reviews Inc.. All rights reserved. |
Chemoresistance; hypoxia-inducible factor-1α; melatonin; oral squamous cell carcinoma |
carboplatin; cisplatin; docetaxel; fluorouracil; hypoxia inducible factor 1alpha; melatonin; messenger RNA; placebo; adult; advanced cancer; adverse drug reaction; aged; Article; cancer combination chemotherapy; cancer patient; cancer staging; cancer tissue; clinical article; clinical outcome; comparative study; computerized block randomization; controlled study; data analysis software; double blind procedure; drowsiness; fatigue; female; headache; human; human tissue; incisional biopsy; Indonesia; Karnofsky Performance Status; male; microcapsule; mouth squamous cell carcinoma; neoadjuvant chemotherapy; parallel design; protein expression; randomization; randomized controlled trial; real time polymerase chain reaction; response evaluation criteria in solid tumors; risk factor; sleep disord |
Wolters Kluwer Medknow Publications |
09746773 |
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Article |
Q1 |
2771 |
735 |
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No records
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521 |
Gunardi E.R., Putri R.A., Pasidri Y. |
57192910998;57226166006;57226151144; |
A prospective study of effectivity, expulsion, and acceptability of post-placental iud cu t380a insertion using clamp in a tertiary hospital |
2021 |
Journal of SAFOG |
13 |
2 |
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92 |
96 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110568167&doi=10.5005%2fjp-journals-10006-1884&partnerID=40&md5=fce9faf05542751a7f70c62d508122a7 |
Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Putri, R.A., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pasidri, Y., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Aim: Intrauterine device (IUD) has a high effectivity of long-term contraception method. Post-placental IUD increases the number of contraception use and decreases the unmet need for contraception. The purposes of this study were to evaluate the effectivity, expulsion, acceptability, and side effects of post-placental IUD insertion using a clamp at Dr. Cipto Mangunkusumo National General Hospital. Materials and methods: This prospective longitudinal observational study was conducted at a tertiary teaching hospital (Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia) from April 2018 to March 2019. Post-placental IUD was inserted using a clamp. We interviewed the patients at 3 months and 6 months after insertion to evaluate the outcome. A total of 94 women were included in this study. Results: The effectivity was 100%. The expulsion rate was 2.13, 3.45, and 0% at 6 weeks, 3 months, and 6 months, respectively. The total acceptability rate at 6 weeks, 3 months, and 6 months was 96.81, 93.3, and 90.8%, respectively. Most of the subjects were satisfied with the IUD contraception at 3 months and 6 months. Conclusion: Post-placental IUD insertion using a clamp had good safety, effectivity, acceptance, and satisfaction. This data could be used for family planning counseling in daily practice. Post-placentaI IUD insertion should be routinely offered to all eligible postpartum women undergoing institutional deliveries. © Jaypee Brothers Medical Publishers. |
Acceptability; Effectivity; Expulsion; Insertion using a clamp; Post-placental IUD |
abdominal pain; adult; Article; bleeding; cesarean section; clinical outcome; contraception; controlled study; counseling; dyspareunia; family planning; female; follow up; gestational age; health care facility; human; hysterectomy; intrauterine device expulsion; lactation; longitudinal study; major clinical study; menstrual cycle; menstruation disorder; observational study; patient satisfaction; percutaneous coronary intervention; postpartum hemorrhage; postpartum pain; pregnancy; pregnancy outcome; pulse rate; questionnaire; tablet disintegration time; tertiary care center; unwanted pregnancy; vagina bleeding; vagina discharge (disease); vaginal delivery |
Jaypee Brothers Medical Publishers (P) Ltd |
09748938 |
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22 |
Hakim R.W., Fadilah F., Tarigan T.J.E., Jusman S.W.A., Purwaningsih E.H. |
57195939974;56966708600;36057746500;36518792100;57186723500; |
Molecular Study of Acalypha indica to Leptin, Alpha Glucosidase, and its Antihyperglycemic Effect on Alpha Glucosidase |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1639 |
1647 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123002540&doi=10.5530%2fpj.2021.13.211&partnerID=40&md5=fc96d1ad7798feb0ce298321c8f24117 |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Drug Development and Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Bioinformatics Core Facilities, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia |
Hakim, R.W., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Drug Development and Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Fadilah, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Drug Development and Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia, Bioinformatics Core Facilities, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Tarigan, T.J.E., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Purwaningsih, E.H., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Drug Development and Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia |
Introduction: The purpose of this study is to find potential inhibitors of leptin as a proinflammatory adipokine and alpha glucosidase as an enzyme that mediate hyperglycaemia; to alter the chronic complications of obesity from herbal Acalypha indica (Ai). This study was conducted using in silico molecular docking to evaluate the Ai compounds interaction with leptin and alpha glucosidase. The in vitro assay to alpha glucosidase was done to explore antihyperglycemic effect of Ai, as hyperglycaemia is the key process of chronic complication of obesity. Material and Methods: Protein target were leptin and alpha glucosidase; compounds from Ai plant were repundusinic, mauritanin, hesperetin, acaindinin, and glucogalin in pdb format. Molecular docking using autodock vinna. In vitro assay of Ai antihyperglycemic activity was done to alpha glucosidase and was define as IC50 level. Result: The results from the docking analysis demonstrated that compounds from Ai roots contain antihyperglycemic-antiobesity activity which acted by inhibiting leptin and alpha glucosidase receptors. Repundusininc and mauritanin compounds contain hydrogen bond with the greatest leptin enhancer activity on Ser9, Thr35, Glu8, Ser9, Thr25, Gln111, Lys211, Leu7 for repundisinic and Glu8, Thr25, Gly112 and Leu7 for mauritanin. Hesperetin, acaindinin and glucogallin were the most identical compounds with similar affinity binding value to alpha glucosidase. Ai roots was already proven as anti-hyperglycemic-antiobesity which was further confirmed by in vitro assay to alpha glucosidase (IC50 19,429 μg/ml.). Conclusion: The results demonstrated that Ai have anti hyperglycaemic-antiobesity effects and was found to be potentially as antihyperglycemic by in vitro assay to alpha glucosidase. © 2021 Phcogj.Com. |
Acalypha indica; Alpha glucosidase; Antiobesity; Leptin |
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EManuscript Technologies |
09753575 |
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268 |
15961 |
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23 |
Pratiwi R.Y., Elya B., Setiawan H., Solawati A., Rosmalena |
57416375400;14014224500;55292870100;57415864600;56891769500; |
Alterations in Body Weight, Blood Glucose Levels, and Lipid Profiles in High-Fat Diet-Low Dose Streptozotocin-Induced Diabetic Rats |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1562 |
1567 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122997406&doi=10.5530%2fpj.2021.13.199&partnerID=40&md5=81ed302e467e0f8fcf593bb03fe63dd1 |
Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Pratiwi, R.Y., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Elya, B., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Setiawan, H., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Solawati, A., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Rosmalena, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Introduction: New preventive and therapeutic strategies to treat Type 2 diabetes (T2D) continue to be pursued, the complexity of this disease makes it imperative to establish preclinical animal models which must provide accurate similarities to the pathogenesis of diabetes in humans. Making a diabetic animal model using rats with high-fat diet (HFD)-streptozotocin (STZ) induction is popular because it is relatively low cost and simple. Objectives: This study aims to analyse the changes in body weight, blood glucose, and lipid profiles that occur in diabetic rat models created by induction of HFD in combination with lowdose STZ. Methods: This study used forty male Sprague-Dawley rats (200-240 g). After the adaptation period, thirty rats were fed with HFD for 28 days (DM group), while the other ten rats continued to be fed with standard feed (NC group). After then, diabetes was induced to the DM group by low-dose STZ (35 mg/kg BW). The body weight of the rats was measured before and after diet manipulation periods. Blood samples were taken before and after STZ induction to determine lipid profiles and blood glucose levels. Results: During the diet manipulation period, the HFD group experienced a significantly greater weight gain, higher blood glucose levels, and cholesterol (TC) levels. After STZ injection, rats' blood glucose levels, TC, and triglycerides significantly increased. Conclusion: HFD feeding combined with a low-dose STZ effectively work to mimic specific condition that is similar to T2D, and the stability of the experimental animal conditions remains constant for up to 6 weeks. © 2021 Phcogj.Com. |
Diabetes; Diabetic animal model; High-fat diet; Insulin resistance; Low-dose streptozotocin; Stable diabetes type 2 profile |
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09753575 |
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15961 |
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