No records
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87 |
Miranda E., Bramono K., Rizky L.A., Hayun |
57208259598;9843236700;57193502812;37053937800; |
Preparation and stability evaluation of ll-37 cream |
2021 |
International Journal of Applied Pharmaceutics |
13 |
6 |
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139 |
143 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121048883&doi=10.22159%2fIJAP.2021V13I6.39639&partnerID=40&md5=1b6a1a02cc0417196461dd2568afa7d5 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Miranda, E., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Bramono, K., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Rizky, L.A., Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Hayun, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Objective: The present study aimed to prepare LL-37 in a cream formulation (O/W emulsion) and evaluate its stability by determining the physical changes in the cream and concentration of LL-37 using validated high-performance liquid chromatography. Methods: The method was conducted at room temperature using a C18 column (5 µm × 250 mm × 4.6 mm) as a stationary phase, a mixture of 0.1% trifluoroacetic acid (TFA)/water (A) and 0.1% TFA/acetonitrile (B) (85:15) as the mobile phase, a flow rate of 1.0mL/min, an d photodiode array set at 228 nm as the detector. The method was validated in compliance with the Association of Official Analytical Chemists and International Conference on Harmonization guidelines. It demonstrated excellent linearity, accuracy, precision, specificity, the limit of detection, and limit of quantitation. Results: The chromatographic analysis indicated minimal degradation of LL-37 during the 12-week, with a predicted expiry time of 99 and 75 mo stored at 4 °C and 28 °C, respectively. Conclusion: LL-37 cream establishes good physical characteristics and stabilizes the active ingredient, especially at 4 °C and 28 °C storage. Therefore, the emulsion delivery system of LL-37 cream is harmless and stable as a novel alternative vehicle of LL-37. © 2021 The Authors. Published by Innovare Academic Sciences Pvt Ltd. |
Cream; High-performance liquid chromatography; LL-37; Stability |
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Innovare Academics Sciences Pvt. Ltd |
09757058 |
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Article |
Q3 |
238 |
17272 |
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846 |
Sitohang I.B.S. |
56734569200; |
Isotretinoin for treating acne vulgaris |
2021 |
International Journal of Applied Pharmaceutics |
13 |
2 |
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20 |
25 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103244010&doi=10.22159%2fijap.2021v13i2.40045&partnerID=40&md5=d324facccc1fd7db650538b96ff62380 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Acne vulgaris (AV) occurs in more than 80% of dermatological cases in adolescents and young adults and affects the quality of life. Oral isotretinoin, a metabolite product of vitamin A, is well-known to be the most effective treatment for severe nodulocystic AV and moderate AV that does not respond to other therapeutic modalities. Thus, this literature review was conducted to explain the mechanism of action, effectiveness, contraindications, side effects, and safety of oral isotretinoin in AV, which provided essential information for dermatologists. Furthermore, isotretinoin is the only treatment modality that has implications for the entire pathogenesis of acne. It contributes to decreasing corneocytes’ adhesion, supporting cellular proliferation and follicular renewal, induction of cell apoptosis, and immune regulation. The effectiveness of AV therapy with isotretinoin has expanded as it is also indicated for moderate to severe AV that does not respond well to topical combination therapy or systemic antibiotics. However, isotretinoin is included in Category X drugs and may induce many side effects from mucocutaneous effects to teratogenicity. From this extensive literature review, it can be concluded that isotretinoin is one of the treatment modalities for acne with good effectivity due to its mechanism of actions that affect the entire acne pathogenesis. Considering the various side effects of isotretinoin, its use requires adequate clinical assessment and monitoring by a dermatologist. © 2021 The Authors. |
Acne vulgaris; Contraindications; Effectiveness; Isotretinoin; Safety; Side effects |
antibiotic agent; isotretinoin; retinoic acid; acne vulgaris; algorithm; apoptosis; cell proliferation; cheilitis; clinical assessment; dermatologist; eczema; epistaxis; eye disease; fatigue; half life time; headache; human; immunoregulation; infection; minimum concentration; pathogenesis; pharmacokinetic parameters; prevalence; Review; skin fragility; teratogenicity |
Innovare Academics Sciences Pvt. Ltd |
09757058 |
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Review |
Q3 |
238 |
17272 |
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867 |
Ibrahim F., Sahlan M., Ginting M.J., Kartika Pratami D., Hermansyah H., Wijanarko A. |
54886001500;57189182661;57212472114;57222140683;15759436800;6506885367; |
Isolation of protein from the spine venom of pterois volitans found in the indonesian ocean, using a heating process, for anticancer, antiretroviral, antibacterial, and antioxidant assays |
2021 |
International Journal of Applied Pharmaceutics |
13 |
special issue 2 |
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53 |
58 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101657433&doi=10.22159%2fijap.2021.v13s2.10&partnerID=40&md5=7efd709314f7d32aab3f98fec52eeb8d |
Virology and Cancer Pathobiology Research Centre, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, 10320, Indonesia; Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Research Centre for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Pancasila University, South Jakarta, DKI Jakarta, 12640, Indonesia |
Ibrahim, F., Virology and Cancer Pathobiology Research Centre, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, 10320, Indonesia; Sahlan, M., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia, Research Centre for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Ginting, M.J., Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Kartika Pratami, D., Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Pancasila University, South Jakarta, DKI Jakarta, 12640, Indonesia; Hermansyah, H., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Wijanarko, A., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, West Java, 16424, Indonesia |
Objective: This research investigates the antibacterial, anticancer, antioxidant, and antiretroviral activities of the lionfish spine poison extract. Methods: Isolation and purification of the phospholipase A2 (PLA2) protein obtained from the spine poison were conducted through the following stages, including, extraction of the venom by sonication, heating, and purification using gradual saturation levels of ammonium sulfate. Furthermore, the purity and concentration of PLA2 were analyzed using the Lowry test and Marinetti’s method, respectively, while its protein content was ascertained through SDS-PAGE. Toxicity was then evaluated employing the brine shrimp lethality test (BSLT), and its anticancer activity was assessed in human cervical carcinoma cells (HeLa cells). Finally, its antioxidant, antibacterial, and antiretroviral activities were analyzed using the DPPH method, agar diffusion test against Salmonella sp. and E. coli, and SRV-2 and RT-qPCR tests, respectively. Results: The protein demonstrated 37.79% inhibition for anticancer activity, IC50 1312 ppm for antioxidant activity, 98.81%, and 89.28% inhibition of E. coli and Salmonella sp. respectively for antibacterial activity and 98.13% inhibition for antiretroviral activity. Conclusion: It can be concluded that lionfish (Pterois volitans) has the potential to be developed as an antioxidant, anticancer, antibacterial, and antiretroviral agent. Furthermore, the pharmacological activity of its spine venom was determined by isolating PLA2 protein from its extract, using an optimum heating temperature of 70 °C and an ammonium sulfate saturation level of 80%. © 2021 The Authors. Published by Innovare Academic Sciences Pvt Ltd. T. |
Antibacterial; Anticancer; Antioxidant; Antiretroviral; Crude venom; Pterois volitans |
ammonium sulfate; antineoplastic agent; antioxidant; antiretrovirus agent; caspase 3; chloramphenicol; phospholipase A2; venom; agar diffusion; antibacterial activity; antineoplastic activity; antioxidant activity; antiviral activity; Article; bacterial growth; controlled study; cytotoxicity; DNA extraction; DPPH radical scavenging assay; enzyme activity; enzyme inhibition; enzyme linked immunosorbent assay; Escherichia coli; heating; HeLa cell line; human; human cell; hydroxyl radical scavenging assay; IC50; minimum inhibitory concentration; MTT assay; nonhuman; oxygen saturation; polyacrylamide gel electrophoresis; protein content; protein isolation; protein purification; Pterois volitans; Salmonella; shrimp; Staphylococcus aureus; temperature; ultrasound; ultraviolet visible spectroscop |
Innovare Academics Sciences Pvt. Ltd |
09757058 |
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Article |
Q3 |
238 |
17272 |
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No records
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488 |
Djaja Y.P., Prasetia R., Santoso A., Rahyussalim A.J., Mustamsir E., Dilogo I.H. |
57191042059;57196246350;57194659467;55212166100;57196246488;56161962800; |
A decade of evolution in Indonesian orthopedic publication: A bibliographic report |
2021 |
Journal of Clinical Orthopaedics and Trauma |
15 |
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110 |
116 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092623352&doi=10.1016%2fj.jcot.2020.10.016&partnerID=40&md5=54bca8c1ea47f4019dfac052838cc471 |
Department of Orthopedic & Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Faculty of Medicine, Department of Orthopaedic Surgery, Universitas Padjadjaran, Bandung, Indonesia; Department of Orthopaedic and Traumatology, Sebelas Maret University, Prof Dr R Soeharso Orthopaedic Hospital, Solo, Indonesia; Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia |
Djaja, Y.P., Department of Orthopedic & Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Prasetia, R., Faculty of Medicine, Department of Orthopaedic Surgery, Universitas Padjadjaran, Bandung, Indonesia; Santoso, A., Department of Orthopaedic and Traumatology, Sebelas Maret University, Prof Dr R Soeharso Orthopaedic Hospital, Solo, Indonesia; Rahyussalim, A.J., Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mustamsir, E., Department of Orthopaedics and Traumatology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia; Dilogo, I.H., Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
During the past decade, there was an increasing interest in orthopedic research in Indonesia. Therefore we aimed to investigate the profile of Indonesian orthopedic trend publication from 2010 to 2019. Systematic research was conducted to identify all orthopedic articles authored by Indonesian orthopedic surgeons. Article details (number of authors, authors’ affiliation, publishing journal), type of author's affiliation, affiliate collaboration, study field, type, and level of evidence (LOE) were recorded and evaluated. Publishing journal metric and author h-index were also recorded. Descriptive statistics were used to summarize the data. Two hundred and twenty articles were included in our study. Clinical studies were the most common article type, followed by case reports and basic science. Among clinical articles, therapeutic studies were found significantly more frequent. On the other hand, economic studies were not found in this study period. The most popular field was oncology, followed by knee and spine. The average number of authors per article was 5.23 with a total of 205 individuals who had contributed during this decade. University hospital was the most common affiliation found and single-center study was the most common affiliate collaboration. The most common level of evidence was level V (case reports). Eighty-seven specific publishing journals were identified. More than 42% of the articles were published in journals with SJR between 0.25 and 0.50. The average author h-index was 3.56 (0–7). Although there was an increasing trend and quantity of publications among Indonesian authors, most articles had level 5 evidence (case reports) and the quality of publishing journals was mostly Q3 with a low-moderate SJR. Improvement of the article's quality and institutional collaboration will be needed for future contribution in global orthopedic society. © 2020 Delhi Orthopedic Association |
Bibliographic; Indonesia; Orthopedic article; Publication trend |
adult; female; human; human experiment; Indonesia; knee; major clinical study; male; orthopedic surgeon; publishing; review; spine; university hospital |
Elsevier B.V. |
09765662 |
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Review |
Q3 |
471 |
10597 |
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No records
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303 |
Samara T., Wibowo H., Liem I., Prijanti A., Andrijono A. |
57208256339;57217690943;55802927800;57190863386;57208264133; |
Cullin 1 as a proangiogenic factor and its relationship with vascular endothelial growth factor and p21 are associated with the length of gestational age of pre-eclampsia |
2021 |
Journal of Natural Science, Biology and Medicine |
12 |
2 |
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140 |
144 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111296351&doi=10.4103%2fjnsbm.JNSBM-123-20&partnerID=40&md5=10efc582ba2ed72d7813100c2ebbc2d5 |
Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Samara, T., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Wibowo, H., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Liem, I., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prijanti, A., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andrijono, A., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Cullin 1 (CUL1), vascular endothelial growth factor (VEGF), and p21 are proteins that play a role in pregnancy. CUL1 and VEGF are proangiogenic factors, whereas p21 is an antiangiogenic factor. An imbalance between proangiogenic and antiangiogenic factors is one of the various factors that cause pre-eclampsia (PE). The aim of this study was to analyze CUL1 levels in the relationship with VEGF levels and p21 levels based on gestational age at delivery in PE. Materials and Methods: This was a cross-sectional study of 70 placentas from PE patients divided in two groups of gestational age at delivery: <34 weeks and ≥34 weeks. Levels of CUL1, VEGF, and p21 were examined by the enzyme-linked immunosorbent assay technique. Statistical analysis was assessed by Spearman correlation test and Chi-square test, with a significant P < 0.05. Results: Low levels of CUL1 and low levels of VEGF were related with <34 weeks of gestational age at delivery, whereas high levels of CUL1 and high levels VEGF were related with ≥34 weeks of gestational age at delivery. There was a negative correlation between the high ratios of p21/CUL1 and <34 weeks of gestational age at delivery in PE. Conclusions: Low levels of CUL1 and low levels VEGF and high ratios of p21/CUL1 were associated with <34 weeks of gestational age at delivery in PE. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Cullin 1; gestational age; p21; pre-eclampsia; vascular endothelial growth factor |
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Wolters Kluwer Medknow Publications |
09769668 |
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Article |
Q3 |
236 |
17374 |
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886 |
Susanto A.D., Yusril N., Zaini J., Nuwidya F. |
57190425587;57221834981;57221833355;57221834238; |
Comparison of serum benzo(a)pyrene diol epoxide - Protein adducts level between kretek cigarette smokers and nonsmokers and the related factors |
2021 |
Journal of Natural Science, Biology and Medicine |
12 |
1 |
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52 |
56 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100352390&doi=10.4103%2fjnsbm.JNSBM_100_20&partnerID=40&md5=b1c54ebf4ef8452d480f9da52582dabe |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Susanto, A.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Yusril, N., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Zaini, J., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Nuwidya, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Benzopyrene is a carcinogenic agent found in cigarette smoke. Benzo(a)pyrene diol epoxide (BPDE) is one of the benzopyrene metabolites. In this study, we investigated the level of serum BPDE in kretek cigarette smokers compared to non-smokers. Methods: A cross-sectional study which involved 32 "healthy" kretek cigarette smokers and 32 "healthy" nonsmokers were conducted. We collected the blood sample and the serum BPDE level was assayed using enzyme-linked immunosorbent assay kit. The BPDE serum level in kretek cigarette smokers was compared to the level in nonsmokers. Results: A total of 32 kretek smokers and 32 controls underwent an examination of the BPDE-protein adducts level. In the kretek smokers group, 59.4% were aged over 45 years and 56.3% have a high educational background, while in the control group, 87.5% were aged under 45 years and 75% have high educational backgrounds. The level of BPDE-protein adducts in the kretek smokers subject was 12.15 (8.87-33.55) ng/ml and the levels in the control group were 11.4 (3.87-13.27) ng/ml, P = 0.004. The factors which influence the levels BDPE-protein adducts in smokers cigarettes, as determined by multivariate analysis, were sucking pattern (P = 0.002) and the degree of addiction (P = 0.047). Conclusion: The serum BPDE-protein adducts level was higher in smokers compared to nonsmokers, and the sucking pattern and degree of addiction are the influencing factors. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Benzo(a)pyrene diol epoxide-protein adducts; nonsmokers; smokers |
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Wolters Kluwer Medknow Publications |
09769668 |
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Article |
Q3 |
236 |
17374 |
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887 |
Arliny Y., Yunus F., Burhan E., Andarini S., Jusman S.W.A., Yunir E., Kekalih A., Soeroton A.Y., Nurwidya F. |
57221832635;57194486277;36058554600;8716259500;36518792100;36520254800;55633562200;57221832157;55221773800; |
Diagnostic predictors of active tuberculosis infection in diabetic patients with latent tuberculosis: A review on cathelicidin and 1,25-dihydroxyvitamin d3 |
2021 |
Journal of Natural Science, Biology and Medicine |
12 |
1 |
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117 |
123 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100332647&doi=10.4103%2fjnsbm.JNSBM_26_20&partnerID=40&md5=bcbc06659ad7db8063dc7a77d40a3bd0 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Syiah Kuala, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia; Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Respirology and Critical Illness, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia |
Arliny, Y., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Syiah Kuala, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Yunus, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Syiah Kuala, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Andarini, S., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia; Yunir, E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kekalih, A., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soeroton, A.Y., Division of Respirology and Critical Illness, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia; Nurwidya, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia |
Background: Diabetes Mellitus has been identified as one of factors causing increased risks of latent TB infection. The roles of cathelicidin LL-37, 1.25(OH)2D3 as well as their correlation with specific IFN-γ in latent TB has not been extensively identified. Aims and Objectives: Our study was aimed to identify proportion of latent TB infection in patients with DM and to identify the role of cathelicidin, 1.25(OH)2D3, vitamin D and other clinical factors as predictors for active TB infection in diabetic patients with latent TB. Methods: Our study was conducted in 2 stages. The first-stage study was a cross-sectional study to identify the proportion of latent TB infection in patients with DM without any history of TB, which was continued with a case-control study to identify the roles of predictive biomarkers (cathelicidin LL-37, 25(OH) D3, 1.25(OH)2D3 and IFN-γ) as well as clinical predictive factors for active TB infection in diabetic patients with latent TB. Results: Out of 242 diabetic patients without any history of TB who underwent screening test for latent TB, there were 78 (33.2%) subjects with a diagnosis of latent TB and 1 subject was diagnosed with active TB. There was significant association on the level of cathelicidin LL-37 in DM patient with latent TB, active TB and without TB infection (23.49 ng/mL vs. 49.6 ng/mL vs. 10.46 ng/mL, P < 0,005). Almost all of subjects with DM showed low levels of vitamin D, most in subject with active TB (97%). There was no significant association between 1.25(OH)2D3 and 25(OH)D3 in DM patients with latent TB, active TB and without TB infection. There was a significant association on the levels of IFN-γ ((TB1 1.4 IU/mL vs. 0.03 IU/mL P < 0.005; TB2 1.4 IU/mL vs. 0.04 IU/mL P < 0.005) in DM subjects with latent TB and those without TB infection; however, no significant association was found in DM subjects with latent TB and active TB. History of smoking, HbA1C > 9.5% and cathelicidin LL-37 levels of > 30 ng/mL were predictors for latent TB into active TB in DM patients. Conclusion: Cathelicidin LL-37 can serve as a biomarker of latent TB progressiveness in patients with DM. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
1,25 (OH)2D3; cathelicidin; diabetes; latent tuberculosis infection; Vitamin D |
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Wolters Kluwer Medknow Publications |
09769668 |
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Article |
Q3 |
236 |
17374 |
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No records
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116 |
Munadzilah S., Hegar B., Sekartini R., Vandenplas Y. |
57346126700;6506273944;57224503576;57223670656; |
Association between milk consumption and lactose malabsorption in Indonesian children |
2021 |
Chinese Journal of Contemporary Pediatrics |
23 |
10 |
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975 |
980 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119440135&doi=10.7499%2fj.issn.1008-8830.2105030&partnerID=40&md5=80626db7ac7feaae0925a1057b4f77eb |
Department of Child Health, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kidz Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium |
Munadzilah, S., Department of Child Health, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hegar, B., Department of Child Health, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekartini, R., Department of Child Health, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Vandenplas, Y., Kidz Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium |
Objective To study the association between milk consumption and lactose malabsorption in Indonesian children aged 3-12 years. Methods This cross sectional study was conducted in randomly selected presumed healthy children with good nutritional status aged 3-12 years in Central Jakarta, Indonesia (n=174), including 72 children aged 3-5 years and 102 children aged 6-12 years. Results The prevalence of lactose malabsorption in children aged 3-5 years and children aged 6-12 years was 20.8% (15/72) and 35.3% (36/102), respectively. There was no association between milk or milk product consumption and lactose malabsorption (P>0.05). In the 51 children with lactose malabsorption, the predominant clinical symptoms were diarrhea (62%), abdominal pain (52%), and nausea (5%) during the hydrogen breath test. Conclusions There is no association between milk consumption and lactose malabsorption in Indonesian children aged 3-12 years, suggesting that genetic predisposition may be more important than adaptive mechanisms to lactose consumption. © 2021 Xiangya Hospital of CSU. All rights reserved. |
Child; Hydrogen breath test; Lactose malabsorption; Milk consumption; Prevalence |
abdominal pain; adult; Article; child; cross-sectional study; dairy product; diarrhea; disease association; female; genetic predisposition; human; hydrogen breath test; lactose intolerance; male; milk; nausea; prevalence; animal; breath analysis; Indonesia; lactose intolerance; milk; Animals; Breath Tests; Child; Cross-Sectional Studies; Humans; Indonesia; Lactose Intolerance; Milk |
Central South University |
10088830 |
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34719410 |
Article |
Q3 |
174 |
21112 |
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No records
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321 |
Kalaij A.G.I., Sugiyanto M., Ilham A.F. |
57223906853;57223907058;57223916865; |
Factors Associated With Vaccination Compliance in Southeast Asian Children: A Systematic Review |
2021 |
Asia-Pacific Journal of Public Health |
33 |
5 |
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479 |
488 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106426931&doi=10.1177%2f10105395211014640&partnerID=40&md5=5913c1adcdd2be2c2d07170aba4e2029 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kalaij, A.G.I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiyanto, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ilham, A.F., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Although vaccination coverage has reached a peak of 86% globally, around 19.9 million infants and children are yet to receive routine vaccinations—with Asia holding the highest prevalence of noncompliance. This implies notable gaps in vaccination coverage among some regions in the world. This study aims to analyze the factors associated with compliance toward childhood vaccination in Southeast Asia. A systematic review of observational studies was conducted using the following databases: PubMed, Scopus, and Cochrane. Included studies analyze factors affecting compliance with childhood vaccination in Southeast Asia, and assessed with Joanna Briggs Institute (JBI) and Newcastle-Ottawa Scale’s criteria. Sixteen observational studies were included, with a total of 41 956 subjects, consisting of 15 cross-sectional studies and one case-control study. Our results suggested that parental personal–related, children and family status–related, socioeconomic, and health care–related factors strongly affected subjects’ compliance with immunization. Prominent determinants were older maternal age, higher economics groups, parents in government or health care sectors, and frequent antenatal care visits. On the other hand, noncompliance were associated with younger age, large quantity of family members, lower economic groups, lower education, and unemployed parents. We hope that this comprehensive assessment thoroughly addresses challenges and inform strategies to raise compliance toward childhood vaccination in Southeast Asia. © 2021 APJPH. |
childhood vaccination; compliance; factors; Southeast Asia |
case control study; child; childhood; controlled study; cross-sectional study; education; educational status; female; government; health care cost; human; human experiment; infant; male; maternal age; Medline; Newcastle-Ottawa scale; observational study; prenatal care; review; Scopus; Southeast Asia; Southeast Asian; systematic review; unemployment; vaccination; article |
SAGE Publications Inc. |
10105395 |
|
34013786 |
Review |
Q2 |
572 |
8837 |
|
|
322 |
Fuady A., Khoe L.C., Azzahra T.B., Lestari H.M., Sutanto R.L., Yo E.C., Suryoadji K.A., Sudarsono N.C., Findyartini A. |
37085331400;56586245200;57223601523;57223631169;57222060277;57213188908;57223633894;57201862518;56543777300; |
Good Knowledge but Poor Practice Toward COVID-19 Among Indonesian Youth |
2021 |
Asia-Pacific Journal of Public Health |
33 |
5 |
|
605 |
607 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105912511&doi=10.1177%2f10105395211015048&partnerID=40&md5=eeb26dde9d980d4470234af3a533b0c1 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Medical Program, Faculty of Medicine, Indonesia; Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Center for Sports and Exercise Studies, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia; Department of Medical Education, Faculty of Medicine, Indonesia |
Fuady, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Khoe, L.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Azzahra, T.B., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Lestari, H.M., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Sutanto, R.L., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Yo, E.C., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Suryoadji, K.A., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Sudarsono, N.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Center for Sports and Exercise Studies, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia; Findyartini, A., Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Medical Education, Faculty of Medicine, Indonesia |
[No abstract available] |
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SAGE Publications Inc. |
10105395 |
|
33998316 |
Article |
Q2 |
572 |
8837 |
|
|