No records
|
684 |
Sukrisman L., Sinto R., Priantono D. |
8661764000;36099377100;57219443427; |
Hematologic profiles and correlation between absolute lymphocyte count and neutrophil/ lymphocyte ratio with markers of inflammation of covid-19 in an indonesian national referral hospital |
2021 |
International Journal of General Medicine |
14 |
|
|
6919 |
6924 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117751905&doi=10.2147%2fIJGM.S337440&partnerID=40&md5=3dd70fba2ee4c7395a09b7807a9e5c42 |
Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Tropical and Infectious Disease, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Sukrisman, L., Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sinto, R., Division of Tropical and Infectious Disease, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Priantono, D., Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: COVID-19 is a pandemic with significant mortality and it is important to differentiate severe and non-severe cases. We conducted a study to evaluate hematologic profiles with inflammation markers in COVID-19 patients and to determine the correlation of neutrophil-lymphocyte ratio (NLR) with disease severity. Methods: A cross-sectional study involving hospitalized COVID-19 patients confirmed with a positive SARS-CoV-2 PCR test in Dr. Cipto Mangunkusumo Hospital. Lymphocyte count, NLR, C-reactive protein (CRP) and ferritin were evaluated in severe and non-severe COVID-19 cases at hospital admission. Data was analyzed using Spearman correlation. Results: There were 41 patients aged 20 to 79 years with COVID-19; 33 (80.5%) were nonsevere, and 8 (19.5%) were severe cases. There is a statistically significant difference in WBC, relative neutrophils and lymphocytes, NLR, and CRP between non-severe and severe cases. There is a strong correlation between NLR and CRP (r = 0.738; p < 0.001). Our findings show that NLR and absolute lymphocyte count, but not ferritin, play a role in differentiating between non-severe and severe COVID-19 cases. Conclusion: In COVID-19 cases, a strong correlation between NLR and CRP might suggest the use of NLR to differentiate between non-severe and severe cases, especially in a remote healthcare facility. © 2021 Sukrisman et al. This work is published and licensed by Dove Medical Press Limited. |
COVID-19; Hematologic profiles; Inflammation; Lymphocyte; NLR |
|
Dove Medical Press Ltd |
11787074 |
|
|
Article |
Q2 |
722 |
6874 |
|
|
No records
|
706 |
Wardhani B.W.K., Louisa M., Watanabe Y., Setiabudy R., Kato M. |
57194342020;41461551400;56040433300;6602316235;57222489115; |
Tgf-β-induced tmepai promotes epithelial– mesenchymal transition in doxorubicin-treated triple-negative breast cancer cells via smad3 and pi3k/akt pathway alteration |
2021 |
Breast Cancer: Targets and Therapy |
13 |
|
|
529 |
538 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115827526&doi=10.2147%2fBCTT.S325429&partnerID=40&md5=0fe888a00b703b194e1cca6235180684 |
Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology, Faculty of Military Pharmacy, Indonesia Defense University, West Java, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan |
Wardhani, B.W.K., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pharmacology, Faculty of Military Pharmacy, Indonesia Defense University, West Java, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Watanabe, Y., Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Setiabudy, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kato, M., Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan |
Introduction: Epithelial–mesenchymal transition (EMT) and overexpression of drug efflux transporters have been reported to cause doxorubicin resistance. Our previous study indicated that TMEPAI (transmembrane prostate androgen-induced protein) attenuated doxorubicin sensitivity in triple-negative breast cancer cells. However, how TMEPAI contributes to doxorubicin resistance in TNBC remains unclear. Thus, the present study aimed to elucidate the mechanism of TMEPAI in doxorubicin resistance in triple-negative breast cancer cells. Methods: We used BT549, triple-negative cells wild type (WT), and BT549 TMEPAI knock-out. Both cells were treated with TGF-β 2 ng/mL for 24 hours, followed by TGF-β 2 ng/mL and doxorubicin 12.9 nM for another 24 hours. Afterward, the cells were harvested and counted. Cells were further lysed and used for RT-PCR and Western blot analysis. We determined the expression levels of proliferation, apoptosis, EMT markers, and drug efflux transporters. Additionally, we investigated the expressions of PI3K as well as SMAD3 and AKT phosphorylation. Results: TNBC cells were shown to be less sensitive to doxorubicin in the presence of TMEPAI. TMEPAI was shown to alleviate the mRNA expressions of apoptosis markers: Bax, Bcl2, Caspase-3, and Caspase-9. Our results indicated that the presence of TMEPAI greatly amplifies EMT and increases drug efflux transporter expressions after doxorubicin treatment. Furthermore, our findings demonstrated that TMEPAI reduced the action of doxorubicin in inhibiting SMAD3 phosphorylation. TMEPAI was also shown to modify the effect of doxorubicin by reducing PI3K expressions and Akt phosphorylation in triple-negative breast cancer cells. Conclusion: Our findings indicate that TMEPAI promotes EMT and drug efflux transporters at least in part by shifting doxorubicin action from SMAD3 phosphorylation reduction to PI3K/AKT inhibition in triple-negative breast cancer cells. © 2021 Wardhani et al. |
Drug efflux transporters; E-cadherin; PMEPAI; SMAD3; TGF-β; Vimentin |
ABC transporter subfamily B; caspase 3; caspase 9; complementary DNA; doxorubicin; Ki 67 antigen; membrane protein; protein Bax; Smad3 protein; transforming growth factor beta; transmembrane prostate androgen induced protein; unclassified drug; uvomorulin; vimentin; apoptosis; Article; breast cancer cell line; cell proliferation; cell viability; chemoluminescence; controlled study; CRISPR-CAS9 system; down regulation; epithelial mesenchymal transition; gene expression; gene overexpression; human; human cell; mRNA expression level; Pi3K/Akt signaling; protein expression; protein phosphorylation; real time polymerase chain reaction; RNA extraction; signal transduction; upregulation; Western blotting |
Dove Medical Press Ltd |
11791314 |
|
|
Article |
Q2 |
1190 |
3344 |
|
|
No records
|
705 |
Muharam R., Sumapraja K., Pratama G., Azyati M., Prabowo K.A. |
57191492732;55819683500;57195959221;57274785700;57224859187; |
Impact of ivf on the timing and symptoms of menopause |
2021 |
International Journal of Women's Health |
13 |
|
|
889 |
893 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115838581&doi=10.2147%2fIJWH.S322718&partnerID=40&md5=6d1216144e47b8cdba986eef18fc94e5 |
Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Muharam, R., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Sumapraja, K., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Pratama, G., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Azyati, M., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Prabowo, K.A., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Background: Age-related loss of female fertility is characterized by a decline in both the quantity and quality of ovarian follicles. Symptoms of ovarian stimulation, which is part of the process of in vitro fertilization (IVF), vary among women. This study was conducted to analyze the differences in menopausal timing and symptoms in women who had undergone IVF compared to those who had natural pregnancies. Methodology: In this cross-sectional study, menopausal women were categorized into two groups: those who had undergone IVF (n = 50) and those who had not (n = 50). Clinical data were obtained from the participants’ medical records, and patient interviews were conducted using the menopause rating scale (MRS) questionnaires. Results: The IVF had no significant impact on psychological or somatic symptoms in either group (p>0.05). However, it affected urogenital symptoms (p<0.05). Additionally, there was a significant difference in the age of onset of menopause between the groups (p<0.05). Conclusion: There is a significant correlation between IVF treatment, urogenital symptoms in menopause, and the age of onset of menopause. © 2021 Muharam et al. This work is published and licensed by Dove Medical Press Limited. |
In vitro fertilization; Infertility; Menopause; Psychological symptoms; Urogenital |
adult; anxiety; arthralgia; Article; bladder dysfunction; clinical article; cross-sectional study; depression; exhaustion; female; hot flush; human; in vitro fertilization; irritability; menopause; menopause rating scale; middle aged; myalgia; onset age; rating scale; risk factor; sexual dysfunction; sleep disorder; vaginal dryness |
Dove Medical Press Ltd |
11791411 |
|
|
Article |
Q1 |
1136 |
3603 |
|
|
No records
|
685 |
Lubis A.M.T., Reksoprodjo A.Y., Kuncoro M.W., Ifran N.N. |
15122639800;57208385626;57214136871;56091403800; |
Post-acl reconstruction graft failure in severe gout arthritis patient |
2021 |
International Medical Case Reports Journal |
14 |
|
|
725 |
730 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117588489&doi=10.2147%2fIMCRJ.S325642&partnerID=40&md5=7d6c96304b0f081df9890285db073149 |
Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Lubis, A.M.T., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Reksoprodjo, A.Y., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kuncoro, M.W., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ifran, N.N., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Pain and instability following an anterior cruciate ligament (ACL) reconstruction remain a significant issue. Common causes include infection and inflammation, and mechanical issues such as graft failure. Case Presentation: A 36-year-old male with an ACL reconstruction six years prior was admitted due to pain and swelling. The ACL graft that had ruptured was found arthrosco-pically. Numerous gout crystals and tophus were observed inside. This finding is suggested as a cause of this kind of complication. Discussion: Biological failure is one of the causes of graft failure. Gout arthritis is associated with internal derangement of the joint structures, which is reported in advanced case. Conclusion: Severe gouty arthritis, even though rare, could be an etiology of graft failure following ACL reconstruction and cause significant morbidity. © 2021 Lubis et al. |
ACL reconstruction; Gout; Graft failure; Tophus |
urate; adult; anterior cruciate ligament reconstruction; arthroscopic debridement; Article; case report; clinical article; gout; graft failure; hamstring graft; human; human tissue; hyperuricemia; joint effusion; joint limitation; joint stiffness; joint swelling; knee arthroscopy; knee instability; knee pain; knee radiography; male; muscle graft |
Dove Medical Press Ltd |
1179142X |
|
|
Article |
Q4 |
198 |
19482 |
|
|
826 |
Irawati Y., Soedarman S., Arianti A., Widyasari A., Reksodiputro M.H. |
57201260313;57222867991;57201999421;57280734100;35090488800; |
Multiple approaches for managing complex ophthalmic blunt trauma: A case report |
2021 |
International Medical Case Reports Journal |
14 |
|
|
205 |
210 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104124100&doi=10.2147%2fIMCRJ.S304193&partnerID=40&md5=1d5a9d9b836b19267fc2e128d84efc72 |
Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irawati, Y., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Soedarman, S., Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Arianti, A., Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Widyasari, A., JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Reksodiputro, M.H., Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Ophthalmic trauma is defined as injuries affecting the ocular structures, including the globe, eyelid, lacrimal system, and surrounding orbital walls. Blunt trauma acts as the leading cause of injury and it may affect both the anterior and posterior parts of the globe. Prompt diagnosis, early management, and sustained follow-up are mandatory for an optimal outcome. Purpose: This report presents a one-step surgery management process for an intricate case of blunt facial trauma with complex ophthalmic and nasal injury. Patients and Methods: A 45-year-old male with blunt force trauma of the left eye from a wooden block, suffered from naso-orbital-ethmoidal fractures, eyelid laceration with canalicular, close-globe injuries of traumatic cataract and vitreous hemorrhage with retinal detachment. A simultaneous one-step surgery was performed by a trauma team of ophthalmological and ENT surgeons during the height of the COVID-19 pandemic to lessen the risk of cross-transmission. After ruling out the possibility of open-globe rupture, traumatic cataract extraction, retinal detachment surgery, the repair of an eyelid laceration with canalicular involvement, and septorhinoplasty were performed on concomitantly. Results: Anatomical success was achieved for the repair of the nasoorbitoethmoidal (NOE) type II fracture and close-globe injuries, including the anatomical reattachment of the retina. However, the functional outcome remained unsatisfactory. Visual acuity failed to show further improvement at a later follow-up. Traumatic optic neuropathy was, at the final follow-up, considered to be the cause of the suboptimal visual acuity. Conclusion: A single-step multi-procedure for a complex ophthalmic blunt trauma, as demonstrated in this case, may be beneficial for reducing the complications that might arise due to treatment delay. The complex nature of the injury, however, creates the higher possibility for residual post-operative complications. Risks of residual functional impairment should be considered in such complex trauma prior to surgery, to determine the surgical prognostic value and provide appropriate consent to the patient. © 2021 Irawati et al. |
Blunt trauma; Canalicular laceration; Closed-globe injury; Facial injury; Nasal fracture; Ocular trauma |
adult; Article; blunt trauma; case report; cataract; clinical article; clinical examination; conjunctival hemorrhage; crackle; epistaxis; ethmoid bone; eye injury; eyelid closure; eyelid disease; eyelid reconstruction; face fracture; human; hyphema; Indonesia; laceration; lens implantation; male; middle aged; nasopharyngeal swab; nose injury; nose septum reconstruction; occupational accident; orbit fracture; postoperative care; retina detachment; ultrasound; visual acuity; vitrectomy; vitreous hemorrhage |
Dove Medical Press Ltd |
1179142X |
|
|
Article |
Q4 |
198 |
19482 |
|
|
No records
|
654 |
Librianto D., Dilogo I.H., Kamal A.F., Saleh I., Ipang F., Aprilya D. |
57192894799;56161962800;56648996700;57191511801;57226749417;57193710642; |
Effectiveness of kyphosis reduction using cantilever method in thoracolumbar spondylitis tuberculosis: A short-term follow-up |
2021 |
Orthopedic Research and Reviews |
13 |
|
|
275 |
280 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120573379&doi=10.2147%2fORR.S342365&partnerID=40&md5=36fe8c2722165f6ab5ec3cc315858d37 |
Orthopedic Spine Surgeon, Fatmawati General Hospital, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Librianto, D., Orthopedic Spine Surgeon, Fatmawati General Hospital, Jakarta, Indonesia; Dilogo, I.H., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kamal, A.F., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saleh, I., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ipang, F., Orthopedic Spine Surgeon, Fatmawati General Hospital, Jakarta, Indonesia; Aprilya, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Kyphosis in spondylitis tuberculosis (STb) is more than just a cosmetic issue. It has a potentially detrimental effect on both spine-associated structures and cardiopulmonary function. It can be corrected in any stage of STb; however, the corrective surgery is challenging, especially in the late case, in which the additional stiffness of the spine can come into consideration. To date, the cantilever technique is still a gold standard for sagittal plane deformity correction. However, no study to date has explored its effectiveness for thoracolumbar kyphotic deformity, especially that caused by spondylitis tuberculosis. Methods: This is a retrospective study of 16 consecutive cases of spondylitis tuberculosis with thoracolumbar kyphosis that underwent corrective surgery in our center in the period of 2020–2021. We aim to evaluate the effectiveness of the cantilever technique that we use for kyphotic correction in thoracolumbar STb patients. Results: At the 3-months follow-up, the mean Cobb angle was 14.6°±10.27°, with the mean gain of 20.90°±12.00° and positively correlate with the thoracolumbar kyphosis (TLK) correction (68.69%, r = 0.654, p = 0.001). The mean thoracic kyphosis, lumbar lordosis, and sagittal vertebral axis were 30.6°±13.08°, 39.4°±16.02°, and 1.4±4.09 cm, respectively, with sagittal Cobb difference of 12.70±9.85. Conclusion: The kyphotic Cobb angle reduction by cantilever technique in the thoracolumbar area significantly improved the thoracolumbar kyphosis and realign the spinal sagittal axis. Thus, the cantilever technique remains the gold standard for sagittal plane deformity correction which can be applied for kyphotic deformity correction in thoracolumbar STb cases. © 2021 Librianto et al. |
Cantilever technique; Deformity correction; Kyphotic deformity; Spondylitis tuberculosis; Thoracolumbar spine |
|
Dove Medical Press Ltd |
11791462 |
|
|
Article |
Q2 |
707 |
7037 |
|
|
658 |
Gatam A.R., Gatam L., Mahadhipta H., Ajiantoro A., Luthfi O., Aprilya D. |
57189987623;57197708604;57210642162;57357077400;57356571700;57193710642; |
Unilateral biportal endoscopic lumbar interbody fusion: A technical note and an outcome comparison with the conventional minimally invasive fusion |
2021 |
Orthopedic Research and Reviews |
13 |
|
|
229 |
239 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120168036&doi=10.2147%2fORR.S336479&partnerID=40&md5=975bbbda77330a970b9d9c16d7f501be |
Orthopaedic Spine Division, Fatmawati General Hospital, Jakarta, Indonesia; Orthopaedic Spine Division, Tangerang General Hospital, Banten, Indonesia; Orthopaedic Spine Division, Premier Bintaro Hospital, Banten, Indonesia; Orthopedic Spine Division, Adhyaksa General Hospital, Jakarta, Indonesia; Orthopedic and Traumatology Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Gatam, A.R., Orthopaedic Spine Division, Fatmawati General Hospital, Jakarta, Indonesia; Gatam, L., Orthopaedic Spine Division, Fatmawati General Hospital, Jakarta, Indonesia; Mahadhipta, H., Orthopaedic Spine Division, Tangerang General Hospital, Banten, Indonesia; Ajiantoro, A., Orthopaedic Spine Division, Premier Bintaro Hospital, Banten, Indonesia; Luthfi, O., Orthopedic Spine Division, Adhyaksa General Hospital, Jakarta, Indonesia; Aprilya, D., Orthopedic and Traumatology Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: In the past few decades, the minimally invasive technique for spine surgery has developed extensively from the scope of decompression until fusion surgeries to reduce damages to the normal anatomical structure. Unilateral biportal endoscopic lumbar interbody fusion (ULIF) is one of the fusion options which is readily available without a sophisticated minimal invasive instrument. Our aim is to introduce ULIF experience in our center and comparing the result with conventional minimally invasive lumbar interbody fusion (MIS-TLIF). Methods: This is a retrospective cohort study of 145 lumbar spondylolisthesis cases that underwent fusion surgery with either ULIF or the conventional MIS-TLIF. All of the patients were observed within a 12-month follow-up period to evaluate the back pain and leg pain Visual Analogue Score (VAS), the Oswestry Disability Index (ODI), the 36-Item Short Form Health Survey (SF-36), and fusion rate. Results: The leg pain VAS was similarly improved in both groups. ULIF has a significant back pain improvement on direct post operation and at the 3-months follow-up (p value 0.032 and 0.046 respectively). ULIF group also had a significantly better improvement of ODI scores on the early post-operative period (p=0.045). However, both groups similarly showed improvement of ODI score and the SF-36 at the 3-, 6-, and 12-months follow up. Conclusion: Full endoscopic fusion surgery with ULIF offers a comparable long-term outcome and a significantly better back pain VAS reduction in short-term follow up compared to the conventional MIS-TLIF. ULIF, with further improvement, can be the next gold standard in managing degenerative lumbar spine conditions. © 2021 Gatam et al. |
Degenerative spondylolisthesis; Full endoscopic spine surgery; Lumbar interbody fusion; Lumbar spine; Minimally invasive spine surgery; MISS; Unilateral biportal endoscopy |
|
Dove Medical Press Ltd |
11791462 |
|
|
Article |
Q2 |
707 |
7037 |
|
|
735 |
Librianto D., Suwarto S., Imran D., Pramukti H., Saleh I., Ipang F., Utami W.S., Aprilya D. |
57192894799;8443626100;57226756146;57223395589;57191511801;57226749417;57226736196;57193710642; |
An extremely rare case of upper thoracic salmonella infection |
2021 |
Orthopedic Research and Reviews |
13 |
|
|
107 |
112 |
|
3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112502092&doi=10.2147%2fORR.S319616&partnerID=40&md5=02436420140f9c1ad84a7f2eb880eee2 |
Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Jakarta Spine Center, Pondok Indah Hospital, Jakarta, Indonesia; Department of Internal Medicine, Pondok Indah Hospital, Jakarta, Indonesia; Department of Neurology, Pondok Indah Hospital, Jakarta, Indonesia |
Librianto, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Jakarta Spine Center, Pondok Indah Hospital, Jakarta, Indonesia; Suwarto, S., Department of Internal Medicine, Pondok Indah Hospital, Jakarta, Indonesia; Imran, D., Department of Neurology, Pondok Indah Hospital, Jakarta, Indonesia; Pramukti, H., Department of Internal Medicine, Pondok Indah Hospital, Jakarta, Indonesia; Saleh, I., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ipang, F., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Jakarta Spine Center, Pondok Indah Hospital, Jakarta, Indonesia; Utami, W.S., Jakarta Spine Center, Pondok Indah Hospital, Jakarta, Indonesia; Aprilya, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Vertebral osteomyelitis is rare. Finding the right etiological agent is important to administer antibiotic regimen accordingly. The occurrence of this disease in endemic countries raises the susceptibility of a more common infection such as tuberculosis and pyogenic bacteria. Salmonella spp. infection is also common in endemic countries; however, extra-intestinal manifestation is very rare. Methods: We present an extremely rare case of salmonella vertebral osteomyelitis (SVO) in the upper thoracic vertebrae of a 64-year-old patient with history of cardiac surgery and other pre-existing comorbidities. SVO was treated by antibiotics, surgical debridement and spinal stabilization. Results: Three weeks after surgery and intravenous antibiotics, the patient recovered and was discharged without fever and back pain, with excellent motoric improvement. Conclusion: Salmonella infection must be considered to be one of possible etiological agents in patients with suggestive spondylitis in emerging countries, especially in those with comorbidities. © 2021 Librianto et al. |
Osteomyelitis; Salmonella; Spondylitis; Thoracic spine |
|
Dove Medical Press Ltd |
11791462 |
|
|
Article |
Q2 |
707 |
7037 |
|
|
No records
|
711 |
Atmakusuma T.D., Tenggara J.B. |
57216961785;26028154300; |
Correlation of transferrin saturation and serum ferritin with bone mass density in adult transfusion dependent beta-thalassemia patients |
2021 |
Journal of Blood Medicine |
12 |
|
|
827 |
832 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115292368&doi=10.2147%2fJBM.S328547&partnerID=40&md5=136e30d4eafe0cf460ffe633d41e4fd8 |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tenggara, J.B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Division of Hematology-Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia |
Background: The use of regular blood transfusions and iron chelation therapy to treat thalassemia has improved survival and increased the incidence of osteoporosis. Moreover, iron toxicity is one of the contributing factors that reduce bone mass density in adult transfusion-dependent beta-thalassemia patients. Therefore, this study aims to determine the proportion of low bone mass density in adult thalassemia patients and transferrin saturation, as well as serum ferritin, which correlates to the skeletal condition. Methods: This is a cross-sectional study conducted in Thalassemia and Hematology Medical Oncology Clinics of Cipto Mangunkusumo Hospital in March 2016. The anthropo-metric data and hemoglobin levels were obtained before transfusion. Subsequently, the average ferritin levels, bone mineral density, and radiographic results were obtained. Results: The percentage of adult thalassemia major and intermedia patients with low bone mass density was 68%. Also, there was a weak inverse correlation between bone mass density and transferrin saturation (r = −0.329, p = 0.01), while no correlation was shown between bone mass density and ferritin (r = −0.088, p = 0.504). The transferrin saturation cutoff point value used to distinguish the incidence of low and normal bone density in patients with transfusion-dependent beta-thalassemia was 89.5%. In addition, there was weak correlation between Singh index and bone mass density (r = 0.273, p = 0.038). Conclusion: Among the transfusion-dependent beta-thalassemia patients, 68% had low bone mass density, which inversely correlated to transferrin saturation. Furthermore, the cutoff value of transferrin saturation to differentiate the incidence of low and normal bone density in thalassemia major compared to thalassemia intermedia was 89.5%. Singh Index correlates weakly with bone mass density and might be used to detect low bone mass density in remote healthcare facilities. © 2021 Atmakusuma and Tenggara. |
Bone mass density; Ferritin; Thalassemia; Transferrin; Transfusion dependent beta |
C reactive protein; calcium; chloride; magnesium; phosphate; potassium; sodium; adult; aged; anthropometry; Article; beta thalassemia; blood transfusion; bone densitometry; bone density; correlational study; cross-sectional study; dual energy X ray absorptiometry; female; ferritin blood level; hemoglobin blood level; human; major clinical study; male; radiography; receiver operating characteristic; scoring system; sensitivity and specificity; singh index; transferrin saturation |
Dove Medical Press Ltd |
11792736 |
|
|
Article |
Q3 |
676 |
7401 |
|
|
730 |
Atmakusuma T.D., Hasibuan F.D., Purnamasari D. |
57216961785;57227028400;36519537700; |
The correlation between iron overload and endocrine function in adult transfusion-dependent beta-thalassemia patients with growth retardation |
2021 |
Journal of Blood Medicine |
12 |
|
|
749 |
753 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113290577&doi=10.2147%2fJBM.S325096&partnerID=40&md5=dd85b4afdd08b0c54b3857a4d69f80f1 |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Yarsi Hospital, Jakarta, Indonesia; Endocrine and Metabolic Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hasibuan, F.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Yarsi Hospital, Jakarta, Indonesia; Purnamasari, D., Endocrine and Metabolic Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Iron overload is a major problem in patients with transfusion-dependent beta-thalassemia (TDT). Reports on the correlation between iron overload and endocrine function with growth retardation in such a population in Indonesia have not been established. Therefore, this study aims to obtain a profile of iron load and endocrine function of adult transfusion dependent beta-thalassemia patients and their correlation with growth retardation. Methods: A cross-sectional study was performed, involving adult homozygous and HbE beta-thalassemia patients receiving blood transfusions at the Cipto Mangunkusumo Hospital, Jakarta. Iron overload was represented by serum ferritin (FS) and transferrin saturation (TS), while the endocrine function was examined by the Thyroid Stimulating Hormone-sensitive (TSHs), free T4 (fT4), and insulin-like growth factor-1 (IGF-1). The results were analyzed using bivariate analysis plus Pearson and Spearman correlation tests. Results: In general, 58 subjects were selected from 224 adult transfusion dependent beta-thalassemia patients, consisting of 31 males (53.4%) and 27 females (46.6%). Furthermore, their median age was 21 (18–24) years, while the subclinical hypothyroid proportion was 32.7% and low IGF-1 levels were detected in 79.3% of the total population. There was a weak negative correlation between FS and fT4 (Spearman rho=−0.361; p=0.003), as well as IGF-1 (Spearman rho=−0.313; p=0.008), but FS and TSHs had no correlation (Spearman rho=0.074; p=0.29). Also, there was no correlation between ST with TSHs (Spearman rho=0.003; p=0.492), fT4 (Spearman rho=0.018; p=0.448), and IGF-1 (Spearman rho= −0.142; p=0.143). Conclusion: Based on serum ferritin, iron overload is discovered to have a negative correlation with free T4 and insulin-like growth factor-1. © 2021 Atmakusuma et al. |
FT4; IGF-1; Serum ferritin; Transferrin saturation; Transfusion-dependent thalassemia; TSHs |
ferritin; hemoglobin; somatomedin C; thyroid antibody; thyroid stimulating immunoglobulin; thyrotropin; transferrin; adult; Article; body mass; chemiluminescence immunoassay; controlled study; correlation analysis; cross-sectional study; endocrine disease; endocrine function; female; ferritin blood level; free thyroxine index; gene expression; hemoglobin E-beta thalassemia; high performance liquid chromatography; human; human tissue; hypothyroidism; iron binding capacity; iron load; iron overload; major clinical study; male; nuclear magnetic resonance imaging; prevalence; protein expression; subclinical hypothyroidism; thyroid function; transferrin saturation; transfusion dependent thalassemia |
Dove Medical Press Ltd |
11792736 |
|
|
Article |
Q3 |
676 |
7401 |
|
|