No records
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616 |
Soetandyo N., Rinaldi I., Sari R.M., Kosasih A.S., Setiawan L., Winston K. |
6505525162;23475122400;57208474079;55879389300;57053036100;57224165400; |
Rare case of multiple lineage dysplasia myelodysplastic syndrome presenting with only anemia: A case report |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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182 |
188 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117611464&doi=10.3889%2foamjms.2021.6969&partnerID=40&md5=690591c95626ca9c62d16cbf0e9616bb |
Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Soetandyo, N., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Rinaldi, I., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sari, R.M., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Kosasih, A.S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Setiawan, L., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Winston, K., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
BACKGROUND: Myelodysplastic syndrome (MDS) is a heterogeneous group of hematopoietic stem cell disorders which is characterized by ineffective hematopoiesis and risk of progression into acute myeloid leukemia. The diagnosis and classification of MDS are determined from the findings of dysplasia in one or more cell lineage and the percentage of blast cell on bone marrow examination. However, it should be noted that an abnormality in one marrow cell lineage does not necessarily translate to the corresponding clinical phenotype. Here, we present a case of MDS with multilineage dysplasia (MLD) (erythrocyte, leukocyte, and thrombocyte) from bone marrow aspiration, but with anemia as the sole clinical manifestation (single cytopenia). CASE REPORT: A 78-year-old male patient came to our clinic on July 10, 2020, with chief complaint of worsening fatigue which started approximately 1 year before visit. His vital signs during the visit were stable and no other abnormalities observed other than pale conjunctivae. Complete blood count showed macrocytic anemia with no abnormalities in leukocyte count and thrombocyte count, which suggested a single cytopenia. Peripheral blood smear was negative for megaloblasts and hypersegmented neutrophils. The patient’s bone marrow examination showed MDS with MLD. This result was in contrast to complete blood count examination which only showed anemia (single cytopenia). CONCLUSION: This case showed that there could be discrepancy between clinical manifestations of the cytopenia with bone marrow dysplasia, which highlighted the importance of conducting bone marrow examination to properly classify MDS type. © 2021 Noorwati Soetandyo, Ikhwan Rinaldi, Resti Mulya Sari, Agus Susanto Kosasih, Lyana Setiawan, Kevin Winston. |
Anemia; Elderly; Lenalidomide; Leukemia; Myelodysplastic syndrome |
alanine aminotransferase; albumin; aspartate aminotransferase; creatinine; cyanocobalamin; erythropoietin; ferritin; globulin; hemoglobin; lenalidomide; protein; activated partial thromboplastin time; aged; anemia; Article; bleeding time; blood cell count; blood smear; bone marrow examination; case report; chromosome deletion; cytogenetics; cytopenia; dysplasia; erythrocyte concentrate; erythrocyte count; erythrocyte transfusion; estimated glomerular filtration rate; fatigue; granulopoiesis; hematocrit; human; human,clinical article; immunophenotyping; International Prognostic Scoring System; karyotype; leukocyte count; macrocytic anemia; male; mean corpuscular hemoglobin concentration; mean corpuscular volume; megakaryocyte; megakaryopoiesis; metamyelocyte; multiple lineage dysplasia; mye |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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618 |
Djusad S., Meutia A.P., Suastika A., Hidayah G.N., Surya I.U., Priangga M., Fadhly R., Harzif A.K. |
57192276788;57203368133;57226722016;57222671850;57226288663;56320839200;57226710149;57191493435; |
Maternal death caused by severe-critical covid-19 in jakarta: Case series |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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103 |
108 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112449077&doi=10.3889%2foamjms.2021.6250&partnerID=40&md5=e9b76ca77220d8ad24d7f5514bcc5d0d |
Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia |
Djusad, S., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Meutia, A.P., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Suastika, A., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Hidayah, G.N., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Surya, I.U., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Priangga, M., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Fadhly, R., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Harzif, A.K., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia |
BACKGROUND: As of January 2021, Indonesia had the 21st highest number of total COVID-19 cases and the 17th highest total deaths among all countries. COVID-19 infection in pregnant women seems to negatively affect both maternal and neonatal outcomes. CASE REPORT: We describe four cases of pregnant women confirmed with severe and critical COVID-19 that resulted in maternal death from November until December 2020. The first case was complicated with thrombocytopenia, her condition quickly deteriorated post-delivery. Pulmonary embolism was suspected as the cause of death. Second and third cases were complicated with preeclampsia, obesity, and advanced maternal age. Second case came in sepsis condition. Her SARS CoV-2 RTPCR swab test came out after her death. Third patient did not have COVID-19 symptoms at admission. She starts having symptoms on second day and was confirmed positive a day after. She falls in septic shock. Fourth patient has history of fever, cough, and dyspnea. She was confirmed positive on first day and her condition worsened, diagnosed with bacterial co-infection sepsis on day eight. All patients underwent cesarean section. CONCLUSION: Limited information and studies for COVID-19 management in pregnant women are challenging for obstetricians. Management should be individualized weighing the benefit and risks in presence of comorbidities or accompanying disease. © Suskhan Djusad, Alfa Putri Meutia, Arresta Suastika, Gita Nurul Hidayah, Ilham Utama Surya, Muhammad Priangga, Raden Fadhly, Achmad Kemal Harzif. |
Case Series; COVID-19; Indonesia; Maternal Death |
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Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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625 |
Lukito W. |
6701622348; |
Current Evidence in Water and Hydration Science |
2021 |
Annals of nutrition & metabolism |
77 |
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1 |
6 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125594947&doi=10.1159%2f000521769&partnerID=40&md5=dc03696320911a4943e24730854d46e4 |
Postgraduate Program in Physician Specialist-I in Clinical Nutrition/Department of Nutrition, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Lukito, W., Postgraduate Program in Physician Specialist-I in Clinical Nutrition/Department of Nutrition, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
[No abstract available] |
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NLM (Medline) |
14219697 |
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35226915 |
Editorial |
#N/A |
#N/A |
#N/A |
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626 |
Rachman A., Shatri H., Salamat R. |
15056701600;28767986500;57475263300; |
Correlation Between Higher Cumulative Dose of Cisplatin for Concurrent Chemoradiation and Acute Kidney Disease Incidence Among Nasopharyngeal Carcinoma Patients: A Comparative Study |
2021 |
International Journal of General Medicine |
14 |
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10527 |
10539 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125417489&doi=10.2147%2fIJGM.S343644&partnerID=40&md5=5d12476bf92d703d5d6a77517d01d345 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Psychosomatic and Palliative Care, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Rachman, A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Shatri, H., Division of Psychosomatic and Palliative Care, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Salamat, R., Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: Nasopharyngeal carcinoma (NPC) is the most malignant cancer in the head and neck area. According to the stage, the management of NPC includes radiation, chemotherapy, or a combination of both. The standard agent for radiosensitizing chemotherapy is cisplatin. Among the several effects of cisplatin administration, nephrotoxicity raises the most concern, especially in high doses. Acute kidney disease (AKD) is a condition in which an acute kidney injury occurs at >7 days but <90 days. This study aimed to assess whether there is a significant difference in the incidence of AKD between NPC patients who received a cumulative dose of cisplatin up to (≤) 200 mg/m2 and patients who received more than (>) 200 mg/m2. Methods: This is a cohort retrospective study conducted in the radiotherapy unit of Cipto Mangunkusumo General Hospital. Medical records of 540 patients from January 2014 to December 2018 were collected and sorted. After sorting, 120 of the records were analyzed. Results: The analysis showed that 38.4% of patients who received >200 mg/m2 cumulative dose of cisplatin experienced AKD, whereas 38.3% of the patients who received ≤200 mg/m2 cumulative dose of cisplatin experienced AKD. Conclusion: This study found that in patients with locally advanced NPC who received cisplatin chemoradiation, there was no significant difference in the incidence of AKD, recovery of renal function, or progression of chronic kidney disease between patients receiving a cumulative dose of cisplatin ≤200 mg/m2 and those receiving >200 mg/m2 . © 2021 Rachman et al. |
Acute kidney disease; Chemoradiation; Cisplatin; Nasopharyngeal cancer |
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Dove Medical Press Ltd |
11787074 |
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Article |
Q2 |
722 |
6874 |
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628 |
Paradisa R.H., Bustamam A., Victor A.A., Yudantha A.R., Sarwinda D. |
57221562575;36815737800;57191055282;55489644900;56119401500; |
Diabetic Retinopathy Detection using Deep Convolutional Neural Network with Visualization of Guided Grad-CA |
2021 |
Proceedings - 2021 4th International Conference on Computer and Informatics Engineering: IT-Based Digital Industrial Innovation for the Welfare of Society, IC2IE 2021 |
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19 |
24 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124286346&doi=10.1109%2fIC2IE53219.2021.9649326&partnerID=40&md5=e35e1e6e90a4eda5a153a1a2f916ec18 |
Universitas Indonesia, Faculty of Mathematics and Natural Science, Department of Mathematics, Depok, Indonesia; Universitas Indonesia Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Department of Ophthalmology, Jakarta, Indonesia |
Paradisa, R.H., Universitas Indonesia, Faculty of Mathematics and Natural Science, Department of Mathematics, Depok, Indonesia; Bustamam, A., Universitas Indonesia, Faculty of Mathematics and Natural Science, Department of Mathematics, Depok, Indonesia; Victor, A.A., Universitas Indonesia Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Department of Ophthalmology, Jakarta, Indonesia; Yudantha, A.R., Universitas Indonesia, Faculty of Mathematics and Natural Science, Department of Mathematics, Depok, Indonesia; Sarwinda, D., Universitas Indonesia, Faculty of Mathematics and Natural Science, Department of Mathematics, Depok, Indonesia |
One of the complications of diabetes that represents a serious threat to world health is Diabetic Retinopathy (DR). High blood sugar levels in people with diabetes can damage the blood vessels in the retina and causing blindness. DR can be detected by examining the fundus image by an ophthalmologist. However, the limited number of ophthalmologists who can analyze fundus image is an obstacle because the number of DR sufferers continues to increase. Therefore, an automated system is needed to help doctors diagnose the disease. Researchers have developed deep learning techniques as Artificial Intelligence (AI) approach to finding DR in fundus images. In this research, we use the Deep Convolutional Neural Networks method with InceptionV3 structure and various optimizers such as the Stochastic Gradient Descent with Momentum (SGDM), Root Mean Square Propagation (RMSprop), and Adaptive Moment Estimation (Adam). The fundus image dataset previously through the augmentation and preprocessing steps to make it easier for the model to recognize the image. The InceptionV3 model with the Adam optimizer gave the best results in detecting DR lesions from the Kaggle dataset with 96% accuracy. This paper also presents a Grad-CAM guided activation map that can describe the position of the suspicious lesion to explain the results of DR detection. © 2021 IEEE. |
deep convolutional neural network; diabetic retinopathy; guided grad-cam |
Backpropagation; Blood vessels; Convolution; Convolutional neural networks; Eye protection; Gradient methods; Health risks; Image segmentation; Optimization; Stochastic systems; Automated systems; Blood sugar levels; Diabetic retinopathy; Fundus image; Guided grad-cam; Learning techniques; Moment estimation; Neural network method; Optimizers; Stochastic gradient descent; Deep neural networks |
Institute of Electrical and Electronics Engineers Inc. |
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9781665442886 |
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Conference Paper |
#N/A |
#N/A |
#N/A |
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635 |
Rahayu G.R., Findyartini A., Riskiyana R., Thadeus M.S., Meidianawaty V., Sari S.M., Puspadewi N., Bekti R.S., Hermasari B.K., Sudarso S., Utami A.E., Kusumawati W. |
56357905400;56543777300;57201674808;57226238484;57205473406;57428214600;57215214003;57195687179;57211539313;57195505857;57427895500;57160948400; |
Stakeholders’ Views and Confidence Towards Indonesian Medical Doctor National Competency Examination: A Qualitative Study |
2021 |
Journal of Multidisciplinary Healthcare |
14 |
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3411 |
3420 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123507676&doi=10.2147%2fJMDH.S336965&partnerID=40&md5=95b31f286039f9e750174fa41df7c1f1 |
Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia; Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia; Faculty of Medicine, Universitas Mulawarman, Samarinda, Indonesia; Ministry of Research, Technology, and Higher Education, Jakarta, Indonesia; Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia |
Rahayu, G.R., Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Findyartini, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Riskiyana, R., Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Thadeus, M.S., Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Meidianawaty, V., Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia; Sari, S.M., Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia; Puspadewi, N., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Bekti, R.S., Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Hermasari, B.K., Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia; Sudarso, S., Faculty of Medicine, Universitas Mulawarman, Samarinda, Indonesia; Utami, A.E., Ministry of Research, Technology, and Higher Education, Jakarta, Indonesia; Kusumawati, W., Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia |
Introduction: Indonesia is a huge country consisting of 33 provinces with different characteristics. There are 83 medical schools across Indonesia with different accreditation statuses. The Indonesia Medical Doctor National Competency Examination (IMDNCE) has been established to control the quality of medical school graduates. The implementation of IMDNCE needed to be evaluated to determine its impact. To date, there has not been any research in Indonesia that explores the stakeholders’ perceptions toward IMDNCE. This study aimed to explore how the stakeholders in Indonesia perceived the impact of IMDNCE towards performances of medical school graduates in clinical practice. Methods and Study Participants: A qualitative study with phenomenological approach was conducted to investigate perceptions of stakeholders including representatives from consumer organizations, the National Health Coverage, the Ministry of Health, the Indonesian Medical Association, employers (hospital and health center directors), clinical supervisors as well as patients across Indonesia. Data were obtained through focus group discussions (FGDs) and interviews. The study used thematic analysis methods to obtain the results. Results: A total of 90 study participants participated in the study including 10 representatives of consumer watchdog organizations, the National Health Coverage, the Ministry of Health, the Indonesian Medical Association, 31 employers, 32 professionals, and 17 patients. The study found three general themes which represent the perceptions of the stakeholders towards performances of medical school graduates in clinical practice: IMDNCE as an effort to standardize doctor graduates in Indonesia, the results of IMDNCE as a mean to reflect the quality of medical education in Indonesia, and IMDNCE as an effort to improve health services in Indonesia through the quality of graduates. Conclusion: In general, the stakeholders perceived that the IMDNCE was able to standardize medical school graduates from various medical schools across Indonesia. However, the IMDNCE needs to be further developed to maximize its potential in improving the competences of Indonesian medical students. © 2021 Rahayu et al. |
Medical education; Medical school graduates; National competency examination; Stakeholder view |
adult; article; clinical practice; consumer organization; employer; female; guard dog; health center; human; Indonesia; interview; major clinical study; male; medical education; medical school; medical society; medical student; nonhuman; perception; physician; public health; qualitative research; thematic analysis |
Dove Medical Press Ltd |
11782390 |
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Article |
Q1 |
650 |
7731 |
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636 |
Wardhani S.O., Fajar J.K., Soegiarto G., Wulandari L., Maliga H.A., Ilmawan M., Merysa R., Simamora A.B., Aini Q., Noviantari K., Lestari A.W., Harnila M.Y., Syafi'i I., Djianzonie J.A.C., Siagian N., Nining S., Hanim R.Z., Wahyuni W., Aulia F., Juliansyah J., Mahmud R., Tamara F., Mahendra A.I., Wowor A.C., Baladraf F., Hadinata P.H., Ikkeputri A., Nadya H., Kartini D.A., Husnah M., Nainu F., Harapan H. |
57193196381;56156139600;57193717004;52464692000;57222334227;57217182580;57412905100;57413600800;57413736700;57412771300;57413600900;57413601000;57412905200;57221505199;57343359200;57413601100;57413182200;57436727400;57413458400;57412905300;57413049000;57192950403;57202301766;57413182300;57412771400;57412905400;57412771500;57413601200;57223337784;57194724156;57120069200;55844857500; |
The association between therapeutic plasma exchange and the risk of mortality among patients critically ill with COVID-19: A meta-analysis. |
2021 |
F1000Research |
10 |
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1280 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122857082&doi=10.12688%2ff1000research.74972.1&partnerID=40&md5=538e74eb0948ed728ed9150f0537f262 |
Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Pharmacy, Universitas Indonesia, Jakarta, s10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Faculty of Public Health, Universitas Indonesia, Jakarta, 10430, Indonesia; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia |
Wardhani, S.O., Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Fajar, J.K., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Soegiarto, G., Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Wulandari, L., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Maliga, H.A., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Ilmawan, M., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Merysa, R., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Simamora, A.B., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Aini, Q., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Noviantari, K., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Lestari, A.W., Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Harnila, M.Y., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Syafi'i, I., Faculty of Pharmacy, Universitas Indonesia, Jakarta, s10430, Indonesia; Djianzonie, J.A.C., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Siagian, N., Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Nining, S., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Hanim, R.Z., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Wahyuni, W., Faculty of Public Health, Universitas Indonesia, Jakarta, 10430, Indonesia; Aulia, F., Faculty of Public Health, Universitas Indonesia, Jakarta, 10430, Indonesia; Juliansyah, J., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Mahmud, R., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Tamara, F., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Mahendra, A.I., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Wowor, A.C., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Baladraf, F., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Hadinata, P.H., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Ikkeputri, A., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Nadya, H., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Kartini, D.A., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Husnah, M., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Nainu, F., Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia; Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia |
Background: Cytokine storm has been widely known to contribute to the development of the critical condition in patients with coronavirus disease 2019 (COVID-19), and studies had been conducted to assess the potential aspect of cytokine storm elimination by performing therapeutic plasma exchange (TPE). However, contradictory findings were observed. The objective of this study was to assess the association between TPE and the reduction of mortality of critically ill COVID-19 patients. Methods: A meta-analysis was conducted by collecting data from PubMed, Scopus, and Web of Science. Data on the mortality rate of critically ill COVID-19 patients treated with TPE plus standard of care and that of patients treated with standard of care alone were analyzed using a Z test. Results: We included a total of four papers assessing the association between TPE and the risk of mortality among critically ill COVID-19 patients. Our findings suggested that critically ill COVID-19 patients treated with TPE had lower risk of mortality compared to those without TPE treatment. Conclusion: Our study has identified the potential benefits of TPE in reducing the risk of mortality among critically ill COVID-19 patients. © 2021 Wardhani SO et al. |
COVID-19therapeutic plasma exchangecytokine stormtreatment |
coronavirus disease 2019; critically ill patient; cytokine storm; human; meta analysis; mortality rate; plasma exchange; Review; systematic review; critical illness; cytokine release syndrome; plasma exchange; COVID-19; Critical Illness; Cytokine Release Syndrome; Humans; Plasma Exchange; SARS-CoV-2 |
F1000 Research Ltd |
20461402 |
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35083038 |
Review |
Q1 |
1099 |
3793 |
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638 |
Wiyono L., Rocha I.C.N., Cedeño T.D.D., Miranda A.V., Lucero-Prisno Iii D.E. |
57207889054;57406221700;57224097138;57222664687;56051373800; |
Dengue and COVID-19 infections in the ASEAN region: a concurrent outbreak of viral diseases |
2021 |
Epidemiology and health |
43 |
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e2021070 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122549130&doi=10.4178%2fepih.e2021070&partnerID=40&md5=0876d7707a72acb2031f56c5f9268d61 |
Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; School of Medicine, Centro Escolar University, Manila, Philippines; Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom; Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Philippines |
Wiyono, L., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Rocha, I.C.N., School of Medicine, Centro Escolar University, Manila, Philippines; Cedeño, T.D.D., School of Medicine, Centro Escolar University, Manila, Philippines; Miranda, A.V., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Lucero-Prisno Iii, D.E., Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Philippines |
Member countries of the Association of Southeast Asian Nations (ASEAN) have faced dengue outbreaks for decades, and the region has one of the highest rates of dengue globally. Outbreaks continue to occur concurrently with the coronavirus disease 2019 (COVID-19) pandemic in the 10 ASEAN countries. Both infectious diseases pose a tremendous burden in these countries related to both infection control and the economy. Increases in the number of dengue cases occurred in part due to disruptions in the pathogen-host-vector relationship caused by changes in human behaviour in response to the COVID-19 pandemic. The spread of dengue was further aggravated by the implementation of lockdowns and social distancing policies. These measures limited the coverage of dengue preventive programs and delayed the medical management of both diseases due to co-infection and misdiagnosis. It is of the utmost importance for the population to remain aware of both diseases, and dengue vector control strategies must be devised to properly address outbreaks using digitalization and remote surveillance. Similarly, critical triage algorithms and further research are also needed to combat co-infection and misdiagnosis. Controlling the spread of COVID-19 though vaccination should also be undertaken to reduce the impact of the pandemic. |
Asia; COVID-19; Dengue; Infection control |
communicable disease control; dengue; epidemic; human; pandemic; Communicable Disease Control; COVID-19; Dengue; Disease Outbreaks; Humans; Pandemics; SARS-CoV-2 |
NLM (Medline) |
20927193 |
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34607402 |
Article |
Q1 |
1109 |
3739 |
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641 |
Rustamadji P., Wiyarta E., Bethania K.A. |
55321572200;57221521342;57226320454; |
CD44 Variant Exon 6 Isoform Expression as a Potential Predictor of Lymph Node Metastasis in Invasive Breast Carcinoma of No Special Type |
2021 |
International Journal of Breast Cancer |
2021 |
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1586367 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122178964&doi=10.1155%2f2021%2f1586367&partnerID=40&md5=d1d81f9245419dc6421070e419983e36 |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rustamadji, P., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bethania, K.A., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. Invasive breast carcinoma of no special type (IBC-NST) is the most widespread invasive carcinoma subtype causing primarily regional metastases of the lymphatic node (LNM). The capacity of CD44 variant exon 6 (CD44v6) expression as an LNM predictor biomarker in IBC-NST was explored. Methods. We conducted a cross-sectional research with 48 paraffin blocks containing IBC-NST primary tumors that were divided into two groups by LNM. The assessment has been carried out in terms of age, tumor size, tumor grade, lymphovascular invasion (LVI), and CD44v6 expression. The expression of CD44v6 was analyzed on the grounds of immunohistochemical (IHC) staining, while other data were taken from archives. Statistical analysis is carried out by univariate, multivariate, and AUROC. Results. CD44v6 exhibits a dominant expression in IBC-NST tumor cells. Univariate analysis revealed a significant association between CD44v6 and LNM status (p=0.001). Multiple logistic regression results showed that CD44v6 expression and LVI were significantly associated with LNM with OR 10.7 (95% CI: 2.43 to 47.08) and 6.22 (95% CI: 1.4 to 27.88), respectively. CD44v6 expression was able to discriminate against LNM with AUROC 0.863±0.053 (95% CI: 0.759 to 0.967) at the H-score cut-off 133.889 (75% sensitivity and 83.3% specificity). Conclusion. CD44v6 expression and LVI are potential predictors of LNM in IBC-NST. The H-score cut-off of the CD44v6 expression can also be used as a threshold for classification in further investigation. © 2021 Primariadewi Rustamadji et al. |
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Hindawi Limited |
20903170 |
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Article |
Q3 |
552 |
9149 |
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643 |
Bangun K., Halim J., Tania V. |
36902624600;57219398869;57394760300; |
Repair of Protruding Bilateral Cleft Lip and Palate With Staged Premaxilla Setback Osteotomy, Cheiloplasty, and Palatoplasty in Trisomy 17p Patient: A Review of Syndromic Clinical Characteristic |
2021 |
Cleft Palate-Craniofacial Journal |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122134129&doi=10.1177%2f10556656211069820&partnerID=40&md5=065c5cf3acef75c03e60e1e90acf33a2 |
Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Indonesia |
Bangun, K., Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Indonesia; Halim, J., Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Indonesia; Tania, V., Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Indonesia |
Objective : Chromosome 17 duplication is correlated with an increased risk of developmental delay, birth defects, and intellectual disability. Here, we reported a female patient with trisomy 17 on the whole short arm with bilateral complete cleft lip and palate (BCLP). This study will review the surgical strategies to reconstruct the protruding premaxillary segment, cleft lip, and palate in trisomy 17p patient. Case Presentation : The patient had heterozygous pathogenic duplication of chromosomal region chr17:526-18777088 on almost the entire short arm of chromosome 17. Beside the commonly found features of trisomy 17p, the patient also presented with BCLP with a prominent premaxillary portion. Premaxillary setback surgery was first performed concomitantly with cheiloplasty. The ostectomy was performed posterior to the vomero-premaxillary suture (VPS). The premaxilla was firmly adhered to the lateral segment and the viability of philtral flap was not compromised. Two-flap palatoplasty with modified intravelar veloplasty (IVV) was performed 4 months after. Conclusion : Successful positioning of the premaxilla segment, satisfactory lip aesthetics, and vital palatal flap was obtained from premaxillary setback, primary cheiloplasty, and subsequent palatoplasty in our trisomy 17p patient presenting with BLCP. Postoperative premaxillary stability and patency of the philtral and palatal flap were achieved. Longer follow-up is needed to evaluate the long-term effects of our surgical techniques on inhibition of midfacial growth. However, the benefits that the patient received from the surgery in improving feeding capacity and facial appearance early in life outweigh the cost of possible maxillary retrusion. © 2021, American Cleft Palate-Craniofacial Association. |
bilateral cleft lip and palate; premaxillary osteotomy; trisomy 17 |
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SAGE Publications Ltd |
10556656 |
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Review |
Q2 |
641 |
7859 |
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