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690 |
Yunihastuti E., Rusdi L., Azizi M.S., Estiasari R., Jasirwan C.O.M., Wulandari E.A.T., Purnamasari D., Noviar M.S., Nasution S.A. |
57221273925;57193236387;57299671700;55240204000;55192478000;57211220361;36519537700;57300045000;57189373134; |
Effect of atorvastatin on subclinical atherosclerosis in virallysuppressed HIV-infected patients with CMV seropositivity: a randomized double-blind placebo-controlled trial |
2021 |
F1000Research |
10 |
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11 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117326016&doi=10.12688%2fF1000RESEARCH.28262.1&partnerID=40&md5=8cf9d3ac5f159644680ab91c18126cb9 |
Allergy and Clinical Immunology Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; HIV Integrated Clinic, Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Cardiology Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Neurology Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Hepatobiliary Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Dentistry Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Metabolic Endocrine Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Yunihastuti, E., Allergy and Clinical Immunology Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia, HIV Integrated Clinic, Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Rusdi, L., Cardiology Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Azizi, M.S., Cardiology Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Estiasari, R., Neurology Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Jasirwan, C.O.M., Hepatobiliary Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Wulandari, E.A.T., Dentistry Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Purnamasari, D., Metabolic Endocrine Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Noviar, M.S., HIV Integrated Clinic, Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Nasution, S.A., Cardiology Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Background: Persistent immune activation and inflammation in HIVinfection are linked to excess cardiovascular risk and other noncommunicable diseases. Periodic asymptomatic CMV-reactivity in HIV infected patients over a lifetime may contribute to non-AIDS defining morbidity. Despite undetectable levels of HIV and CMV, these patients continue to have increased levels of biomarkers and immune activations. Statin administration is thought to reduce subclinical atherosclerosis by decreasing LDL-C levels. It may also add beneficial effects against CMV infection. Methods: We are conducting a double-blind placebo-controlled trial in which patients are randomized to receive either atorvastatin or placebo with a ratio of 1:1. This trial aims to study the effect of atorvastatin in statin-naive virally-suppressed HIV-infected patients with stable ART and CMV seropositivity on carotid intima media thickness (CIMT), tool that evaluates subclinical atherosclerosis. The study recruits 80 patients at HIV integrated care unit of Cipto Mangunkusumo hospital. All eligible subjects have CIMT evaluation as primary outcome, along with flow mediated vasodilatation (FMD), liver fibrosis and steatosis evaluation, fasting lipid, neurocognitive test, community periodontal index (CPI), and residual immune activation as secondary outcomes in 48 weeks. Ethics and dissemination: This study has received an ethical approval from Health Research Ethics Commitee–Universitas Indonesia and Cipto Mangunkusumo Hospital. Before joining the study, all participants fill in an informed consent form. At the end of study analysis, the trial results will be published and disseminated in peerreviewed journals. Discussion: The main purpose of our study is to evaluate the effect of atorvastatin administration on CIMT changes in statin naïve virally suppressed HIV-infected patients with stable ART and CMV seropositivity Registration: ClinicalTrials.gov ID NCT04101136; registered on 24 September 2019. © 2021. Yunihastuti E et al. |
atherosclerosis; atorvastatin; cognitive dysfunction; cytomegalovirus; HIV; non alcoholic fatty liver; periodontitis |
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F1000 Research Ltd |
20461402 |
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Article |
Q1 |
1099 |
3793 |
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692 |
Harapan H., Fajar J.K., Supriono S., Soegiarto G., Wulandari L., Seratin F., Prayudi N.G., Dewi D.P., Monica Elsina M.T., Atamou L., Wiranata S., Aprianto D.P., Friska E., Sari Firdaus D.F., Alaidin M., Wardhani F.A., Husnah M., Hidayati N.W., Hendriyanti Y., Wardani K., Evatta A., Manugan R.A., Pradipto W., Rahmawati A., Tamara F., Mahendra A.I., Nainu F., Santoso B., Irawan Primasatya C.A., Tjionganata N., Budiman H.A. |
55844857500;56156139600;57218591523;57193717004;52464692000;57291538600;57291762600;57291994900;57291762700;57292451200;57220591122;57292451300;57291762800;57292675300;57291538700;57291315100;57194724156;57291315200;57292218900;57292909500;57292451400;57292219000;57292219100;57292675400;57192950403;57202301766;57120069200;57291762900;57291995000;57291538800;57291763000; |
The prevalence, predictors and outcomes of acute liver injury among patients with COVID-19: A systematic review and meta-analysis |
2021 |
Reviews in Medical Virology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116888408&doi=10.1002%2frmv.2304&partnerID=40&md5=8da649362695a47bd93802e3d5061df1 |
Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Internal Medicine, Division of Gastro-Entero-Hepatology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Internal Medicine, Division of Allergy & Immunology, Universitas Airlangga, Surabaya, Indonesia; Department of Pulmonology and Respiratory Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Paediatric, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Department of Urology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Faculty of Nursing, Universitas Indonesia, Depok, Indonesia; Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Nursing, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Master Program of Biology, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia; Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia; Department of Internal Medicine, RSUD Bangil, Pasuruan, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia |
Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia, Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia, Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Fajar, J.K., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Supriono, S., Department of Internal Medicine, Division of Gastro-Entero-Hepatology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Soegiarto, G., Department of Internal Medicine, Division of Allergy & Immunology, Universitas Airlangga, Surabaya, Indonesia; Wulandari, L., Department of Pulmonology and Respiratory Medicine, Universitas Airlangga, Surabaya, Indonesia; Seratin, F., Department of Paediatric, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Prayudi, N.G., Department of Urology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Dewi, D.P., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Monica Elsina, M.T., Faculty of Nursing, Universitas Indonesia, Depok, Indonesia; Atamou, L., Faculty of Nursing, Universitas Indonesia, Depok, Indonesia; Wiranata, S., Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; Aprianto, D.P., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Friska, E., Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Sari Firdaus, D.F., Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Alaidin, M., Department of Nursing, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Wardhani, F.A., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Husnah, M., Master Program of Biology, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia; Hidayati, N.W., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Hendriyanti, Y., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Wardani, K., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Evatta, A., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Manugan, R.A., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Pradipto, W., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Rahmawati, A., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Tamara, F., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Mahendra, A.I., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Nainu, F., Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia; Santoso, B., Department of Internal Medicine, RSUD Bangil, Pasuruan, Indonesia; Irawan Primasatya, C.A., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Tjionganata, N., Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Budiman, H.A., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia |
The data on the predictors and prognosis of acute liver injury (ALI) among patients in coronavirus disease 2019 (COVID-19) patients are limited. The aim of this study was to determine the prevalence, predictors and outcomes of ALI among patients with COVID-19. A systematic review was conducted up to 10 June 2021. The relevant papers were searched from PubMed, Embase, Cochrane and Web of Science, and the data were analysed using a Z test. A total of 1331 papers were identified and 16 papers consisting of 1254 COVID-19 with ALI and 4999 COVID-19 without ALI were analysed. The cumulative prevalence of ALI among patients with COVID-19 was 22.8%. Male and having low lymphocyte levels were more likely to be associated with ALI compared with female and having higher lymphocyte level, odds ratio (OR): 2.70; 95% confidence interval (CI): 2.03, 3.60 and mean difference (MD) −125; 95% CI: −207, −43, respectively. COVID-19 patients with ALI had higher risk of developing severe COVID-19 compared with those without ALI (OR: 3.61; 95% CI: 2.60, 5.02). Our findings may serve as the additional evaluation for the management of ALI in COVID-19 patients. © 2021 John Wiley & Sons Ltd. |
acute liver injury; COVID-19; outcome; predictor; prevalence |
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John Wiley and Sons Ltd |
10529276 |
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Review |
Q1 |
2060 |
1246 |
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694 |
Kusmardi K., Wiyarta E., Rusdi N.K., Maulana A.M., Estuningtyas A., Sunaryo H. |
56966625300;57221521342;57211475250;57290003500;55650360200;57214674652; |
The potential of lunasin extract for the prevention of breast cancer progression by upregulating E-Cadherin and inhibiting ICAM-1 |
2021 |
F1000Research |
10 |
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902 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116770885&doi=10.12688%2ff1000research.55385.1&partnerID=40&md5=c9ffe7db1754323884964582b04aceb3 |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. Hamka, Limau II Street, Jakarta, 12130, Indonesia; Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Faculty of Medicine, University of Muhammadiyah Purwakarta, KH. Ahmad Dahlan Street, Central Java, 53182, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia |
Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia, Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Rusdi, N.K., Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. Hamka, Limau II Street, Jakarta, 12130, Indonesia, Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Maulana, A.M., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia, Faculty of Medicine, University of Muhammadiyah Purwakarta, KH. Ahmad Dahlan Street, Central Java, 53182, Indonesia; Estuningtyas, A., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Sunaryo, H., Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. Hamka, Limau II Street, Jakarta, 12130, Indonesia, Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia |
Background: Research in natural substances for their anticancer potential has become increasingly popular. Lunasin, a soybean protein, is known to inhibit cancer progression via various pathways. The aim of this study was to investigate the effect of Lunasin Extract (LE) on the expression of Intercellular Adhesion Molecule 1 (ICAM-1) and epithelial cadherins (E-Cadherin) in breast cancer. Methods: In this true-experimental in vivo study, 24 Sprague-Dawley rats that were induced by 7,12-Dimethylbenz[a]anthracene (DMBA), were used. Based on the therapy given, the groups were divided into, normal, positive control (PC), negative control (NC), adjuvant, curative, and preventive. Lunasin was extracted from soybean seeds of the Grobogan variety in Indonesia. Tissue samples were obtained, processed, stained with anti-ICAM-1 and anti-E-Cadherin antibodies, examined under a microscope, and quantified using H-score. The data were analyzed using ANOVA, which was then followed by Duncan's test. Results: Statistically significant difference in ICAM-1 expression was observed between the following groups: adjuvant and NC, normal and NC, PC and NC, adjuvant and preventive, normal and preventive, PC and preventive, adjuvant and curative, normal and curative, PC and curative. E-Cadherin expression was significantly different between preventive and NC, adjuvant and NC, PC and NC, normal and NC, adjuvant and curative, PC and curative, normal and curative, normal and preventive. Significant negative correlation was found between ICAM-1 and E-Cadherin [-0.616 (-0.8165; -0.283)] with p = 0.001. Conclusion: Preventive dose of LE was able to reduce ICAM-1 expression while increasing E-Cadherin expression. © 2021 Kusmardi K et al. |
Breast Cancer; Cancer Prevention; E-Cadherin; ICAM-1; Lunasin |
7,12 dimethylbenz[a]anthracene; intercellular adhesion molecule 1; lunasin; soybean protein; tamoxifen; unclassified drug; uvomorulin; cadherin; intercellular adhesion molecule 1; plant extract; soybean protein; animal experiment; animal model; animal tissue; Article; breast cancer; cancer adjuvant therapy; cancer inhibition; cancer prevention; controlled study; female; in vivo study; Indonesia; microscopy; nonhuman; plant seed; protein expression; rat; soybean; Sprague Dawley rat; statistical significance; treatment duration; upregulation; animal; neoplasm; Animals; Cadherins; Intercellular Adhesion Molecule-1; Neoplasms; Plant Extracts; Rats; Rats, Sprague-Dawley; Soybean Proteins |
F1000 Research Ltd |
20461402 |
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34691393 |
Article |
Q1 |
1099 |
3793 |
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695 |
Adiarto S., Kurnianingsih N., Prasetya I., Nugroho F.W., Uberoi R. |
8603606800;57223044495;56725585200;57290221600;22136581000; |
Successful Primary PCI in Stanford Type A Aortic Dissection Complicated by Inferior ST-Elevation Myocardial Infarction: A Case in a Facility with No Surgical Backup |
2021 |
International Journal of Angiology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116762000&doi=10.1055%2fs-0041-1735205&partnerID=40&md5=3716852a47a6df47d93b73adfb8623d6 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Harapan Kita National Cardiovascular Center, Jl. Letjen S. Parman Kav. 87 Slipi, Jakarta, 11420, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Brawijaya University, Dr. Saiful Anwar Hospital, East Java, Malang, Indonesia; Department of Radiology, John Radcliffe Hospital, Headington, Oxford, United Kingdom |
Adiarto, S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Harapan Kita National Cardiovascular Center, Jl. Letjen S. Parman Kav. 87 Slipi, Jakarta, 11420, Indonesia; Kurnianingsih, N., Department of Cardiology and Vascular Medicine, Faculty of Medicine Brawijaya University, Dr. Saiful Anwar Hospital, East Java, Malang, Indonesia; Prasetya, I., Department of Cardiology and Vascular Medicine, Faculty of Medicine Brawijaya University, Dr. Saiful Anwar Hospital, East Java, Malang, Indonesia; Nugroho, F.W., Department of Cardiology and Vascular Medicine, Faculty of Medicine Brawijaya University, Dr. Saiful Anwar Hospital, East Java, Malang, Indonesia; Uberoi, R., Department of Radiology, John Radcliffe Hospital, Headington, Oxford, United Kingdom |
Mortality of type A aortic dissection (TAAD) complicated with coronary malperfusion syndrome is very high even when emergency surgery is performed. Several reports suggested that primary percutaneous coronary intervention (PPCI) followed by immediate corrective surgery may reduce mortality. In many countries, immediate transfer to an aortic surgery center may not be possible. We report a case of TAAD complicated by coronary malperfusion successfully treated with PPCI followed by elective corrective surgery. A 48-year-old man was referred to emergency department with acute inferior ST-elevation myocardial infarction (STEMI) and underwent PPCI. During the procedure, we realized that the cause of STEMI was TAAD. We decided to continue because the patient experienced seizures and bradycardia. Subsequently, echocardiography and computed tomography confirmed the dissection. The patient was discharged and referred to the National Cardiovascular Center where he underwent successful elective surgery. In this patient, immediate revascularization was lifesaving and served as a bridging procedure before surgical correction. © 2021 Georg Thieme Verlag. All rights reserved. |
aortic dissection; coronary intervention; coronary malperfusion syndrome; malperfusion syndrome; primary PCI; STEMI; type A aortic dissection |
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Thieme Medical Publishers, Inc. |
10611711 |
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Article |
Q3 |
293 |
15070 |
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696 |
Nugraha R.A., Muliawan H.S., Nugroho N.T., Ikhsan M., Adiarto S. |
57220785065;57203644653;57211452795;57291104400;8603606800; |
Catastrophic Concomitant Arterial and Venous Thrombosis in a Mild COVID-19-Positive Patient |
2021 |
International Journal of Angiology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116737806&doi=10.1055%2fs-0041-1735200&partnerID=40&md5=35939b91c7ecfee83d98ad94c4b7e884 |
Department of General Medicine, Universitas Indonesia Hospital, Universitas Indonesia, Jl. Prof Bahder Djohan, Pondok Cina, Beji, Depok, 16424, Indonesia; Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia Hospital, Depok, Indonesia; Department of Vascular and Endovascular Surgery, Cipto Mangunkusumo Hospital, Universitas Indonesia Hospital, Depok, Indonesia; Department of Internal Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia Hospital, Depok, Indonesia |
Nugraha, R.A., Department of General Medicine, Universitas Indonesia Hospital, Universitas Indonesia, Jl. Prof Bahder Djohan, Pondok Cina, Beji, Depok, 16424, Indonesia; Muliawan, H.S., Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia Hospital, Depok, Indonesia; Nugroho, N.T., Department of Vascular and Endovascular Surgery, Cipto Mangunkusumo Hospital, Universitas Indonesia Hospital, Depok, Indonesia; Ikhsan, M., Department of Internal Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia Hospital, Depok, Indonesia; Adiarto, S., Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia Hospital, Depok, Indonesia |
Since its first discovery in late 2019, coronavirus disease 2019 (COVID-19) has been a global burden associated with significant morbidity and mortality. COVID-19 has been correlated with the development of hypercoagulable state that predisposes the patients to a higher risk of thromboembolism. Current evidence suggests higher incidence of thrombosis, particularly venous thrombosis, among hospitalized COVID-19 patients, mostly with critical illness. On the other hand, there is currently no data regarding the incidence of vivid thrombosis in ambulatory patients with mild COVID-19 and the incidence of concomitant arterial and venous thrombosis in COVID-19 is extremely rare. Herein, we describe catastrophic outcomes of concomitant lower limb arterial and venous thrombosis in a patient with mild COVID-19. This report highlights the occurrence of concomitant arterial and venous thrombosis in ambulatory setting and that this phenomenon resulted in catastrophic clinical consequences. © 2021 Georg Thieme Verlag. All rights reserved. |
acute limb ischemia; ambulatory; anticoagulation; deep vein thrombosis; ischemia-reperfusion injury; mild COVID-19; thrombectomy |
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Thieme Medical Publishers, Inc. |
10611711 |
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Article |
Q3 |
293 |
15070 |
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697 |
Mulyani E.Y., Hardinsyah, Briawan D., Santoso B.I., Jus'At I. |
57193083043;7409543837;56157628600;56653822500;6506270119; |
Effect of dehydration during pregnancy on birth weight and length in West Jakarta |
2021 |
Journal of Nutritional Science |
10 |
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e70 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116628377&doi=10.1017%2fjns.2021.59&partnerID=40&md5=1de2e2cc37d1b69be0cd84f9859bffa5 |
Department of Nutrition, Faculty of Health Sciences, Esa Unggul University, Jalan Arjuna Utara No.9, West Jakarta, Kebon Jeruk, 11510, Indonesia; Department of Community Nutrition, Faculty of Human Ecology, Bogor Agricultural University, Bogor, Indonesia; Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Depok, Indonesia |
Mulyani, E.Y., Department of Nutrition, Faculty of Health Sciences, Esa Unggul University, Jalan Arjuna Utara No.9, West Jakarta, Kebon Jeruk, 11510, Indonesia; Hardinsyah, Department of Community Nutrition, Faculty of Human Ecology, Bogor Agricultural University, Bogor, Indonesia; Briawan, D., Department of Community Nutrition, Faculty of Human Ecology, Bogor Agricultural University, Bogor, Indonesia; Santoso, B.I., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Depok, Indonesia; Jus'At, I., Department of Nutrition, Faculty of Health Sciences, Esa Unggul University, Jalan Arjuna Utara No.9, West Jakarta, Kebon Jeruk, 11510, Indonesia |
Nutrition and maternal behavior are critical factors in fetal development. Maternal water intake is necessary to regulate metabolism and may influence fetal growth. This study aims to determine the effect of dehydration during pregnancy on birth weight and length. This cohort-prospective study took place in the area of Kebon Jeruk District Health Centre. A total of 38 subjects of pregnant women in their second trimester were examined. Subject characteristics were collected through direct measurements and interviews. Urine and blood samples were collected at the sixth trimester (32-34 and 35-37 weeks) to determine hydration status. Nutritional status was collected through food recall, while birth weight and length were obtained from the anthropometric measurements 30 min after birth. From a total of 38 subjects, 20 were dehydrated, and 18 were well hydrated. There was a significant relationship between hydration status and water intake, birth weight and length, head circumference, and chest circumference. After being corrected to the level of water intake, the difference in birth weight and length between the two groups were 500.6 g and 0.4 cm, and 0.8 cm and 1.4 cm for the head circumference and chest circumference (P < 0.05). It is recommended for mothers to monitor their weight and ensure fluid intake of 3.0 l per day. Further research requires more subjects to observe the effects of chronic maternal dehydration on pregnancy output and a cohort study that monitors infant development in the first six months of life. © The Author(s), 2021. |
Dehydration; Fetal growth; Maternal nutrition; Pregnancy; Water intake |
biological marker; drinking water; adult; arm circumference; Article; birth length; birth weight; blood sampling; body temperature; calcium intake; caloric intake; carbohydrate intake; chest circumference; child development; clinical article; cohort analysis; controlled study; dehydration; dietary intake; fat intake; female; fluid intake; gestational age; head circumference; hip circumference; human; hydration status; Indonesia; iron intake; maternal nutrition; newborn; nutritional status; placenta weight; plasma osmolality; pregnancy; pregnancy outcome; pregnant woman; prospective study; protein intake; renal system parameters; second trimester pregnancy; serum osmolality; sodium blood level; systolic blood pressure; third trimester pregnancy; urine color; urine osmolality; urine sampling |
Cambridge University Press |
20486790 |
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34527228 |
Article |
Q1 |
749 |
6541 |
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698 |
Susanto A.D., Rozaliyani A., Prasetyo B., Agustin H., Baskoro H., Arifin A.R., Pratama S., Zaini J., Hasto B.D., Ratmono T., Savitri A.I., Samoedro E., Husain B., Nawas A., Burhan E. |
57190425587;57203065912;57193735900;56135125000;56436836700;57223139966;57288146100;57221833355;57210897107;57288146200;56401804100;57192995312;57287062900;36490293900;36058554600; |
Epidemiological and clinical features of covid-19 patients at national emergency hospital wisma atlet kemayoran, jakarta, Indonesia |
2021 |
Kesmas |
16 |
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11 |
16 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116538242&doi=10.21109%2fkesmas.v0i0.5233&partnerID=40&md5=82245a20a3432d82a3f500c9b5968696 |
National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia; Siena Clinical: Academic Research Organization, Jakarta, Indonesia |
Susanto, A.D., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia, Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rozaliyani, A., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia; Prasetyo, B., Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Agustin, H., Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Baskoro, H., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia, Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Arifin, A.R., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia, National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia; Pratama, S., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia, National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia; Zaini, J., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia, Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hasto, B.D., National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia; Ratmono, T., National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia; Savitri, A.I., Siena Clinical: Academic Research Organization, Jakarta, Indonesia; Samoedro, E., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia; Husain, B., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia; Nawas, A., Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Burhan, E., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia, Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
The emergency hospital is intended to prevent transmission of COVID-19 in the community by isolating patients without symptoms, with mild or moderate symptoms. This study evaluated the clinical characteristics and outcomes of COVID-19 patients who were admitted to this facility. This retrospective study re-viewed data of patients treated at the National Emergency Hospital Wisma Atlet Kemayoran in Jakarta, Indonesia, from March 23 to April 30, 2020. Patient characteristics (clinical symptoms, laboratory test results, Chest X-Ray, SARS-CoV-2 immunoserology, and RT-PCR results from nasopharyngeal/ oropharyngeal preparations) were compared between severity groups. There were 413 COVID-19 cases analyzed, of which 190 (46%) were asymptomatic, 93 (22.5%) were mild, and 130 (31.5%) were moderate cases. Most asymptomatic cases were male, with young age, and without comorbidity. Mild cases were dominated by female and young patients, while most moderate cases were male and older patients. The number of patients with comorbidities was higher in mild and mod-erate cases. The patient's overall outcome was good and did not differ based on the severity of symptoms. Despite the many challenges, patients with moderate symptoms can be safely treated in the emergency hospital. © 2021 Sciendo. All rights reserved. |
Asymptomatic; COVID-19; Emergency hospital |
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Universitas Indonesia, Faculty of public health |
19077505 |
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Article |
Q4 |
146 |
23606 |
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699 |
Putri K.T., Prasetyono T.O.H. |
57205299147;26646993900; |
A critical review on the potential role of adipose-derived stem cells for future treatment of hypertrophic scars |
2021 |
Journal of Cosmetic Dermatology |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116423050&doi=10.1111%2fjocd.14385&partnerID=40&md5=76adc3d0cee033ca6ae3fe7ec706fe72 |
Undergraduate Study Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Putri, K.T., Undergraduate Study Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prasetyono, T.O.H., Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: Adipose-derived stem cells (ASCs) have recently gained researchers’ interest as a solution to various diseases and conditions, including hypertrophic scar. This literature review aims to elucidate ASCs as a potential solution to alleviate hypertrophic scar in human subjects. Methods: Literature search was done in databases which includes PubMed, MEDLINE, and ProQuest using terms ‘adipose derived stem cells’, ‘adipose cells’, ‘fat graft’, ‘fat grafting’, ‘autologous fat graft’, ‘fat injection’, ‘lipofilling’, ‘scar management’, ‘scar treatment’, ‘burn scar’, and ‘wound management’. The included articles which were published during year 2000-November 2020 must describe the use of ASCs or fat grafting or lipofilling as an attempt to alleviate hypertrophic scar. Remarks: Clinically, ASCs improve hypertrophic scars in terms of scar color, elasticity, texture, thickness, and size. Histologically, ASCs promotes healthy tissue regeneration, reduction in fibroblasts, and reorganisation of collagen, resembling those of normal skin. In terms of molecular aspects, ASCs alleviates hypertrophic scars through direct differentiation and paracrine mechanisms. Conclusion: Adipose-derived stem cells, emerge to be a potential solution for alleviating hypertrophic scar, as demonstrated in various studies. However, there has been no studies conducted in human subjects to investigate the effect of ASCs on hypertrophic scar. © 2021 Wiley Periodicals LLC |
adipocytes; cicatrix; fibroblast; intercellular signaling peptides and proteins; stem cells |
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John Wiley and Sons Inc |
14732130 |
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Review |
Q2 |
626 |
8066 |
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700 |
Rinaldi I., Prasetyawaty F., Fazlines S., Winston K., Samudera Nurrobi Y.A., Leoni J., Restu Tulus Maha I.H., Wicaksono S., Wicaksono A.Y., Aslani A.O., Ikhsani R. |
23475122400;57285017300;57284131900;57224165400;57283687900;57285017400;57285017500;57204717310;57283688000;57283914100;57283688100; |
Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review |
2021 |
Case Reports in Medicine |
2021 |
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5554664 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116367653&doi=10.1155%2f2021%2f5554664&partnerID=40&md5=dd3f8e177d1b2f8c901c2f67e106f921 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prasetyawaty, F., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fazlines, S., Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Winston, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Samudera Nurrobi, Y.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Leoni, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Restu Tulus Maha, I.H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wicaksono, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wicaksono, A.Y., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aslani, A.O., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ikhsani, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. Acquired hemophilia A (AHA) is a potentially life-threatening autoimmune hemostatic disorder where autoantibodies that disrupt the functions of factor VIII (FVIII) are present in the circulation. The early diagnosis of AHA is difficult since the symptoms of AHA differ from those of congenital hemophilia A. Furthermore, the management of AHA is also more complex due to the presence of autoantibodies against FVIII (FVIII inhibitors). Here, we present three case reports and conduct a literature review of AHA with the aim to increase awareness and knowledge regarding the diagnosis and treatment of AHA. Case Presentations. We present three patients diagnosed with AHA in these case reports. The first patient was a young female, while the second and third patients were middle-aged and elderly males, respectively. All patients presented with a chief complaint of bruises without hemarthrosis and a history of bleeding. Laboratory examinations of the patients revealed isolated prolonged aPTT, normal PT, and the presence of autoantibodies against factor VIII, which are characteristics of AHA. Patients were then treated with corticosteroids to reduce the titer level of autoantibodies and received factor VIII transfusion to stop bleeding. Conclusion. AHA can be suspected in patients presenting with symptoms of bruises without hemarthrosis and without the history of bleeding. Isolated aPTT elevation with normal PT should raise high suspicion of AHA. The presence of FVIII inhibitors can help to confirm the diagnosis of AHA. Treatment consists of factor VIII transfusion and corticosteroid therapy. Bypassing agents are recommended as an alternative to FVIII transfusion. © 2021 Ikhwan Rinaldi et al. |
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autoantibody; blood clotting factor 8; blood clotting factor 8 antibody; blood clotting factor 8 inhibitor; cyclophosphamide; fresh frozen plasma; methylprednisolone; mycophenolate mofetil; prednisone; prothrombin; recombinant blood clotting factor 8; tranexamic acid; acquired hemophilia A; activated partial thromboplastin time; adult; aged; antibody titer; bleeding; blood cell count; case report; chronic kidney failure; clinical article; contusion; corticosteroid therapy; drug dose reduction; erythrocyte concentrate; erythrocyte transfusion; female; follow up; hand swelling; hemarthrosis; hemophilia A; human; laboratory test; male; medical history; middle aged; ovariectomy; ovary cyst; physical examination; prothrombin time; Review; surgical wound; treatment duration; very elderly; young |
Hindawi Limited |
16879627 |
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Review |
Q4 |
200 |
19317 |
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703 |
Massenburg B.B., Hopper R.A., Crowe C.S., Morrison S.D., Alonso N., Calis M., Donkor P., Kreshanti P., Yuan J. |
55859007400;57277146200;55976347800;45661573100;7004026436;53263345100;15063876600;36192866200;57278294200; |
Global Burden of Orofacial Clefts and the World Surgical Workforce |
2021 |
Plastic and Reconstructive Surgery |
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568E |
580E |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115936193&doi=10.1097%2fPRS.0000000000008334&partnerID=40&md5=b6aab0e1c64506de878c4f09a9d86d70 |
Division of Plastic and Reconstructive Surgery, University of Washington, Seattle, WA, United States; Division of Craniofacial and Plastic Surgery, Seattle Children's Hospital, Division of Plastic Surgery, Department of Surgery, University of São Paulo, São Paulo, Brazil; Department of Plastic, Reconstructive, and Aesthetic Surgery, Hacettepe University, Ankara, Turkey; Department of Surgery, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cleft and Craniofacial Center Dr. Cipto Mangunkusumo Hospital; and School of Medicine, Shanghai Jiao Tong University, Shanghai, China |
Massenburg, B.B., Division of Plastic and Reconstructive Surgery, University of Washington, Seattle, WA, United States; Hopper, R.A., Division of Plastic and Reconstructive Surgery, University of Washington, Seattle, WA, United States; Crowe, C.S., Division of Craniofacial and Plastic Surgery, Seattle Children's Hospital, Division of Plastic Surgery, Department of Surgery, University of São Paulo, São Paulo, Brazil; Morrison, S.D., Department of Plastic, Reconstructive, and Aesthetic Surgery, Hacettepe University, Ankara, Turkey; Alonso, N., Department of Plastic, Reconstructive, and Aesthetic Surgery, Hacettepe University, Ankara, Turkey; Calis, M., Department of Surgery, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Donkor, P., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kreshanti, P., Cleft and Craniofacial Center Dr. Cipto Mangunkusumo Hospital; and School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Yuan, J., Division of Plastic and Reconstructive Surgery, University of Washington, Seattle, WA, United States |
Background: Orofacial clefts are one of the most common congenital anomalies, but this disease burden is unevenly distributed worldwide. The authors hypothesize that this burden falls disproportionately on the countries with the smallest surgical workforce or lowest Socio-Demographic Index, rather than those with the highest prevalence of disease. Methods: The authors estimated the prevalence and disease burden of orofacial clefting from 1990 to 2017 in 195 countries using the Global Burden of Disease methodology. Prevalence and disability-adjusted life-years were compared geographically, temporally, and against the size of the national surgical workforce, Socio-Demographic Index, and income status. Linear and logarithmic regressions were performed. Results: In 2017, the prevalence of orofacial clefting was estimated to be 10.8 million people, representing a disease burden of 652,084 disability-adjusted life-years, with most of this disease burden experienced by low- and middle-income countries (94.1%). From 1990 to 2017, there was a decrease in disease burden (-70.2%) and prevalence (-4.9%). There was negative logarithmic association between surgical workforce size and disease burden, with a surgical workforce of greater than six providers per 100,000 population (3.6 disability-adjusted life-years versus 22.4 disability-adjusted life-years per 100,000 population; p < 0.0001). Conclusions: Burden of orofacial clefting has a strong negative association with the size of the surgical workforce, suggesting that strengthening the surgical workforce will help alleviate this burden. Epidemiologic data on countries and regions with inadequate surgical workforces and high disease burden should guide future research efforts and allocation of resources, and guide the treatment and educational goals of international charitable organizations. © 2021 Lippincott Williams and Wilkins. All rights reserved. |
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cleft lip; cleft palate; global disease burden; global health; health service; human; organization and management; prevalence; reconstructive surgery; Cleft Lip; Cleft Palate; Global Burden of Disease; Global Health; Health Services Needs and Demand; Health Workforce; Humans; Prevalence; Reconstructive Surgical Procedures |
Lippincott Williams and Wilkins |
00321052 |
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34550940 |
Article |
Q1 |
1841 |
1560 |
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